| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giuseppe Caruso, Margherita Grasso, Annamaria Fidilio, Fabio Tascedda, Filippo Drago, Filippo Carac. Antioxidant Properties of Second-Generation Antipsychotics: Focus on Microglia. Pharmaceuticals (Basel, Switzerland). vol 13. issue 12. 2020-12-29. PMID:33322693. |
opposite to haloperidol, second-generation antipsychotics (or atypical antipsychotics) such as risperidone, clozapine, and olanzapine exert a strong antioxidant activity in experimental models of schizophrenia by rescuing the antioxidant system, with an increase in superoxide dismutase and glutathione (gsh) serum levels. |
2020-12-29 |
2023-08-13 |
Not clear |
| Yuya Mizuno, Robert A McCutcheon, Stefan P Brugger, Oliver D Howe. Heterogeneity and efficacy of antipsychotic treatment for schizophrenia with or without treatment resistance: a meta-analysis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 4. 2020-12-28. PMID:31766049. |
two important clinical questions are whether there is a subtype of schizophrenia which responds differently to clozapine relative to other antipsychotics, and whether greater efficacy of clozapine is dependent on the degree of treatment-resistance. |
2020-12-28 |
2023-08-13 |
Not clear |
| Yuya Mizuno, Robert A McCutcheon, Stefan P Brugger, Oliver D Howe. Heterogeneity and efficacy of antipsychotic treatment for schizophrenia with or without treatment resistance: a meta-analysis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 4. 2020-12-28. PMID:31766049. |
the authors address this by examining both variability and magnitude of response in patients treated with clozapine and other antipsychotics for both treatment-resistant schizophrenia (trs) and non-resistant schizophrenia. |
2020-12-28 |
2023-08-13 |
Not clear |
| Yuya Mizuno, Robert A McCutcheon, Stefan P Brugger, Oliver D Howe. Heterogeneity and efficacy of antipsychotic treatment for schizophrenia with or without treatment resistance: a meta-analysis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 4. 2020-12-28. PMID:31766049. |
double-blind randomised controlled trials comparing clozapine with other antipsychotics in patients with schizophrenia were identified using five databases. |
2020-12-28 |
2023-08-13 |
Not clear |
| Yuya Mizuno, Robert A McCutcheon, Stefan P Brugger, Oliver D Howe. Heterogeneity and efficacy of antipsychotic treatment for schizophrenia with or without treatment resistance: a meta-analysis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 4. 2020-12-28. PMID:31766049. |
these findings do not support a subtype of schizophrenia which responds specifically to clozapine. |
2020-12-28 |
2023-08-13 |
Not clear |
| Yuya Mizuno, Robert A McCutcheon, Stefan P Brugger, Oliver D Howe. Heterogeneity and efficacy of antipsychotic treatment for schizophrenia with or without treatment resistance: a meta-analysis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 4. 2020-12-28. PMID:31766049. |
clozapine is more effective than other antipsychotics irrespective of treatment-resistance, arguing for its use more generally in schizophrenia. |
2020-12-28 |
2023-08-13 |
Not clear |
| Ishwary Damodaran, Koh Ong Hui, Amer Siddiq Amer Nordin, Anne Yee, Jesjeet Singh Gill, Benedict Francis, Fatin Liyana Azhar, Ahmad Hatim Sulaima. An Open-Label, Head to Head Comparison Study between Prucalopride and Lactulose for Clozapine Induced Constipation in Patients with Treatment Resistant Schizophrenia. Healthcare (Basel, Switzerland). vol 8. issue 4. 2020-12-26. PMID:33287162. |
an open-label, head to head comparison study between prucalopride and lactulose for clozapine induced constipation in patients with treatment resistant schizophrenia. |
2020-12-26 |
2023-08-13 |
Not clear |
| Ishwary Damodaran, Koh Ong Hui, Amer Siddiq Amer Nordin, Anne Yee, Jesjeet Singh Gill, Benedict Francis, Fatin Liyana Azhar, Ahmad Hatim Sulaima. An Open-Label, Head to Head Comparison Study between Prucalopride and Lactulose for Clozapine Induced Constipation in Patients with Treatment Resistant Schizophrenia. Healthcare (Basel, Switzerland). vol 8. issue 4. 2020-12-26. PMID:33287162. |
clozapine remains as the gold standard for the management of treatment resistant schizophrenia. |
2020-12-26 |
2023-08-13 |
Not clear |
| Ishwary Damodaran, Koh Ong Hui, Amer Siddiq Amer Nordin, Anne Yee, Jesjeet Singh Gill, Benedict Francis, Fatin Liyana Azhar, Ahmad Hatim Sulaima. An Open-Label, Head to Head Comparison Study between Prucalopride and Lactulose for Clozapine Induced Constipation in Patients with Treatment Resistant Schizophrenia. Healthcare (Basel, Switzerland). vol 8. issue 4. 2020-12-26. PMID:33287162. |
male and female patients on clozapine between the age of 18-60 with an established diagnosis of treatment resistant schizophrenia with ≤2 spontaneous complete bowel movement per week were recruited in this study. |
2020-12-26 |
2023-08-13 |
Not clear |
| Xingqin Zhou, Gangming Cai, Shishi Mao, Dong Xu, Xijie Xu, Rongjun Zhang, Zhiwen Ya. Modulating NMDA receptors to treat MK-801-induced schizophrenic cognition deficit: effects of clozapine combining with PQQ treatment and possible mechanisms of action. BMC psychiatry. vol 20. issue 1. 2020-12-21. PMID:32143671. |
clozapine has remarkable efficacy on both negative and cognitive symptoms of schizophrenia due to its slight activation of nmda receptor. |
2020-12-21 |
2023-08-13 |
Not clear |
| Xingqin Zhou, Gangming Cai, Shishi Mao, Dong Xu, Xijie Xu, Rongjun Zhang, Zhiwen Ya. Modulating NMDA receptors to treat MK-801-induced schizophrenic cognition deficit: effects of clozapine combining with PQQ treatment and possible mechanisms of action. BMC psychiatry. vol 20. issue 1. 2020-12-21. PMID:32143671. |
the aim of this study was to enhance nmdar function and improve cognitive ability in schizophrenia by pqq combined with clozapine. |
2020-12-21 |
2023-08-13 |
Not clear |
| Xinyu Fang, Lingfang Yu, Dandan Wang, Yan Chen, Yewei Wang, Zenan Wu, Ruimei Liu, Juanjuan Ren, Wei Tang, Chen Zhan. Association Between SIRT1, Cytokines, and Metabolic Syndrome in Schizophrenia Patients With Olanzapine or Clozapine Monotherapy. Frontiers in psychiatry. vol 11. 2020-12-17. PMID:33324265. |
association between sirt1, cytokines, and metabolic syndrome in schizophrenia patients with olanzapine or clozapine monotherapy. |
2020-12-17 |
2023-08-13 |
Not clear |
| Edward Silva, Melanie Higgins, Barbara Hammer, Paul Stephenso. Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide. BMC psychiatry. vol 20. issue 1. 2020-12-15. PMID:32503471. |
clozapine remains the only drug treatment likely to benefit patients with treatment resistant schizophrenia. |
2020-12-15 |
2023-08-13 |
Not clear |
| Yağmur Kır, Bora Baskak, Adnan Kuşman, Damla Sayar-Akaslan, Fezile Özdemir, Nilay Sedes-Baskak, Halit Sinan Süzen, Zeynel Bara. The relationship between plasma levels of clozapine and N-desmethyclozapine as well as M1 receptor polymorphism with cognitive functioning and associated cortical activity in schizophrenia. Psychiatry research. Neuroimaging. vol 303. 2020-12-14. PMID:32593951. |
the relationship between plasma levels of clozapine and n-desmethyclozapine as well as m1 receptor polymorphism with cognitive functioning and associated cortical activity in schizophrenia. |
2020-12-14 |
2023-08-13 |
human |
| Yağmur Kır, Bora Baskak, Adnan Kuşman, Damla Sayar-Akaslan, Fezile Özdemir, Nilay Sedes-Baskak, Halit Sinan Süzen, Zeynel Bara. The relationship between plasma levels of clozapine and N-desmethyclozapine as well as M1 receptor polymorphism with cognitive functioning and associated cortical activity in schizophrenia. Psychiatry research. Neuroimaging. vol 303. 2020-12-14. PMID:32593951. |
studies that examined the effect of clozapine on cognitive functions in schizophrenia provided contradictory results. |
2020-12-14 |
2023-08-13 |
human |
| Yağmur Kır, Bora Baskak, Adnan Kuşman, Damla Sayar-Akaslan, Fezile Özdemir, Nilay Sedes-Baskak, Halit Sinan Süzen, Zeynel Bara. The relationship between plasma levels of clozapine and N-desmethyclozapine as well as M1 receptor polymorphism with cognitive functioning and associated cortical activity in schizophrenia. Psychiatry research. Neuroimaging. vol 303. 2020-12-14. PMID:32593951. |
we investigated the association of plasma clozapine (pclz), ndmc (pndmc) levels and the rs2067477 polymorphism with cognitive functions and cortical activity measured by functional near infrared spectroscopy during the n-back task in subjects with schizophrenia (n = 50) who are under antipsychotic monotherapy with clozapine. |
2020-12-14 |
2023-08-13 |
human |
| Tsuyoshi Okada, Jun Kumakura, Manabu Yasuda, Shiro Sud. Treatment-resistant schizophrenia successfully maintained with brexpiprazole following abrupt withdrawal of clozapine due to neutropenia. Asian journal of psychiatry. vol 47. 2020-12-10. PMID:31677398. |
treatment-resistant schizophrenia successfully maintained with brexpiprazole following abrupt withdrawal of clozapine due to neutropenia. |
2020-12-10 |
2023-08-13 |
Not clear |
| Matea Nikolac Perkovic, Marina Sagud, Maja Zivkovic, Suzana Uzun, Gordana Nedic Erjavec, Oliver Kozumplik, Dubravka Svob Strac, Ninoslav Mimica, Alma Mihaljevic Peles, Nela Piva. Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia. Scientific reports. vol 10. issue 1. 2020-12-10. PMID:32572118. |
the study assessed the association of the comt rs4680 and rs4818 polymorphisms with therapeutic response to olanzapine, risperidone, clozapine or other antipsychotic medication after 8 weeks of monotherapy in patients with schizophrenia. |
2020-12-10 |
2023-08-13 |
Not clear |
| Matea Nikolac Perkovic, Marina Sagud, Maja Zivkovic, Suzana Uzun, Gordana Nedic Erjavec, Oliver Kozumplik, Dubravka Svob Strac, Ninoslav Mimica, Alma Mihaljevic Peles, Nela Piva. Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia. Scientific reports. vol 10. issue 1. 2020-12-10. PMID:32572118. |
521 caucasian patients with schizophrenia received a monotherapy with olanzapine (10-20 mg/day; n = 190), risperidone (3-6 mg/day; n = 99), or clozapine (100-500 mg/day; n = 102). |
2020-12-10 |
2023-08-13 |
Not clear |
| Royun Park, Seoyoung Kim, Euitae Ki. Relationship of Change in Plasma Clozapine/N-desmethylclozapine Ratio with Cognitive Performance in Patients with Schizophrenia. Psychiatry investigation. vol 17. issue 11. 2020-12-10. PMID:33198433. |
the aim of this study is to determine whether clozapine has influence on cognitive performance in accordance with changes in the clozapine/ndmc in patients with schizophrenia. |
2020-12-10 |
2023-08-13 |
Not clear |