| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Steven L Carroll, Nancy Ratne. How does the Schwann cell lineage form tumors in NF1? Glia. vol 56. issue 14. 2009-03-05. PMID:18803326. |
neurofibromas are benign tumors of peripheral nerve that occur sporadically or in patients with the autosomal dominant tumor predisposition syndrome neurofibromatosis type 1 (nf1). |
2009-03-05 |
2023-08-12 |
mouse |
| Steven L Carroll, Nancy Ratne. How does the Schwann cell lineage form tumors in NF1? Glia. vol 56. issue 14. 2009-03-05. PMID:18803326. |
multiple neurofibroma subtypes exist which differ in their site of occurrence, their association with nf1, and their tendency to undergo transformation to become malignant peripheral nerve sheath tumors (mpnsts), the most common malignancy associated with nf1. |
2009-03-05 |
2023-08-12 |
mouse |
| Steven L Carroll, Nancy Ratne. How does the Schwann cell lineage form tumors in NF1? Glia. vol 56. issue 14. 2009-03-05. PMID:18803326. |
neurofibromas develop in these patients when an unknown cell type in the schwann cell lineage loses its remaining functional nf1 gene and initiates a complex series of interactions with other cell types; these interactions may be influenced by aberrant expression of growth factors and growth factor receptors and the action of modifier genes. |
2009-03-05 |
2023-08-12 |
mouse |
| Brian L Swic. Floret-like multinucleated giant cells in a neurofibromatosis type 1-associated neurofibroma. The American Journal of dermatopathology. vol 30. issue 6. 2009-02-13. PMID:19033946. |
i report herein a case of floret-like multinucleated giant cells (fmgcs) in a neurofibroma (nf) from a patient with neurofibromatosis type 1 (nf1). |
2009-02-13 |
2023-08-12 |
Not clear |
| Maria Rita Bongiorno, Angelo B Cefalù, Mario Aricò, Maurizio Avern. Clinical, pathologic, and genetic features of massive soft tissue neurofibromas in a Sicilian patient. Dermatologic therapy. vol 21 Suppl 3. 2009-02-12. PMID:19076627. |
in this report we present one case of massive soft tissue neurofibromas arising in a sicilian patient with nf1. |
2009-02-12 |
2023-08-12 |
human |
| Julius C Poon, Travis Ogilvie, Elijah Dixo. Neurofibroma of the porta hepatis. Journal of hepato-biliary-pancreatic surgery. vol 15. issue 3. 2009-01-27. PMID:18535773. |
neurofibromas are generally well-circumscribed tumors of the nervous system, often found in association with neurofibromatosis 1 (nf1). |
2009-01-27 |
2023-08-12 |
Not clear |
| Jon P Williams, Jianqiang Wu, Gunnar Johansson, Tilat A Rizvi, Shyra C Miller, Hartmut Geiger, Punam Malik, Wenling Li, Yoh-suke Mukouyama, Jose A Cancelas, Nancy Ratne. Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. Cell stem cell. vol 3. issue 6. 2009-01-09. PMID:19041782. |
nf1 mutation expands an egfr-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. |
2009-01-09 |
2023-08-12 |
mouse |
| Jon P Williams, Jianqiang Wu, Gunnar Johansson, Tilat A Rizvi, Shyra C Miller, Hartmut Geiger, Punam Malik, Wenling Li, Yoh-suke Mukouyama, Jose A Cancelas, Nancy Ratne. Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. Cell stem cell. vol 3. issue 6. 2009-01-09. PMID:19041782. |
dhhcre;nf1(fl/fl) mouse neurofibromas contain a progenitor population with similar growth requirements, potential, and marker expression. |
2009-01-09 |
2023-08-12 |
mouse |
| Y S Pata, M Unal, A Pola. Malignant fibrous histiocytoma of the larynx in a patient with neurofibromatosis type 1. B-ENT. vol 4. issue 2. 2008-12-16. PMID:18681209. |
neurofibromatosis type 1 (nf1), or von recklinghausen disease, is an autosomal dominant condition characterized by the development of multiple neurofibromas that can transform into aggressive sarcomas. |
2008-12-16 |
2023-08-12 |
Not clear |
| Karlyne M Reilly, Terry Van Dyk. It takes a (dysfunctional) village to raise a tumor. Cell. vol 135. issue 3. 2008-11-24. PMID:18984150. |
(2008) demonstrate that mast cells heterozygous for the nf1 gene promote the growth of neurofibromas in a mouse model of neurofibromatosis and that genetic and pharmacological inhibition of these cells is sufficient to block tumor growth. |
2008-11-24 |
2023-08-12 |
mouse |
| Feng-Chun Yang, David A Ingram, Shi Chen, Yuan Zhu, Jin Yuan, Xiaohong Li, Xianlin Yang, Scott Knowles, Whitney Horn, Yan Li, Shaobo Zhang, Yanzhu Yang, Saeed T Vakili, Menggang Yu, Dennis Burns, Kent Robertson, Gary Hutchins, Luis F Parada, D Wade Clap. Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow. Cell. vol 135. issue 3. 2008-11-24. PMID:18984156. |
germline mutations in the nf1 tumor suppressor gene cause neurofibromatosis type 1 (nf1), a common genetic disorder characterized by complex tumors called neurofibromas. |
2008-11-24 |
2023-08-12 |
Not clear |
| Feng-Chun Yang, David A Ingram, Shi Chen, Yuan Zhu, Jin Yuan, Xiaohong Li, Xianlin Yang, Scott Knowles, Whitney Horn, Yan Li, Shaobo Zhang, Yanzhu Yang, Saeed T Vakili, Menggang Yu, Dennis Burns, Kent Robertson, Gary Hutchins, Luis F Parada, D Wade Clap. Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow. Cell. vol 135. issue 3. 2008-11-24. PMID:18984156. |
however, in the physiologic state, schwann cell loss of heterozygosity is not sufficient for neurofibroma formation and nf1 haploinsufficiency in at least one additional nonneoplastic lineage is required for tumor progression. |
2008-11-24 |
2023-08-12 |
Not clear |
| Feng-Chun Yang, David A Ingram, Shi Chen, Yuan Zhu, Jin Yuan, Xiaohong Li, Xianlin Yang, Scott Knowles, Whitney Horn, Yan Li, Shaobo Zhang, Yanzhu Yang, Saeed T Vakili, Menggang Yu, Dennis Burns, Kent Robertson, Gary Hutchins, Luis F Parada, D Wade Clap. Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow. Cell. vol 135. issue 3. 2008-11-24. PMID:18984156. |
here, we establish that nf1 heterozygosity of bone marrow-derived cells in the tumor microenvironment is sufficient to allow neurofibroma progression in the context of schwann cell nf1 deficiency. |
2008-11-24 |
2023-08-12 |
Not clear |
| Victor-F Mautner, Florence A Asuagbor, Eva Dombi, Carsten Fünsterer, Lan Kluwe, Ralf Wenzel, Brigitte C Widemann, Jan M Friedma. Assessment of benign tumor burden by whole-body MRI in patients with neurofibromatosis 1. Neuro-oncology. vol 10. issue 4. 2008-10-21. PMID:18559970. |
people with neurofibromatosis 1 (nf1) have multiple benign neurofibromas and a 10% lifetime risk of developing malignant peripheral nerve sheath tumors (mpnsts). |
2008-10-21 |
2023-08-12 |
Not clear |
| Victor-F Mautner, Florence A Asuagbor, Eva Dombi, Carsten Fünsterer, Lan Kluwe, Ralf Wenzel, Brigitte C Widemann, Jan M Friedma. Assessment of benign tumor burden by whole-body MRI in patients with neurofibromatosis 1. Neuro-oncology. vol 10. issue 4. 2008-10-21. PMID:18559970. |
we studied 13 nf1 patients with mpnsts and 26 age- and sex-matched controls (nf1 patients who did not have mpnsts) with detailed clinical examinations and whole-body mri to characterize their body burden of internal benign neurofibromas. |
2008-10-21 |
2023-08-12 |
Not clear |
| Victor-F Mautner, Florence A Asuagbor, Eva Dombi, Carsten Fünsterer, Lan Kluwe, Ralf Wenzel, Brigitte C Widemann, Jan M Friedma. Assessment of benign tumor burden by whole-body MRI in patients with neurofibromatosis 1. Neuro-oncology. vol 10. issue 4. 2008-10-21. PMID:18559970. |
all six of the nf1 patients with mpnsts under 30 years of age had neurofibromas visualized on whole-body mri, compared to only 3 of 11 matched nf1 controls under age 30 (p < 0.05). |
2008-10-21 |
2023-08-12 |
Not clear |
| Anja Overdiek, Ursula Winner, Ertan Mayatepek, Thorsten Rosenbau. Schwann cells from human neurofibromas show increased proliferation rates under the influence of progesterone. Pediatric research. vol 64. issue 1. 2008-08-21. PMID:18360307. |
these data suggest that progesterone plays an important role in the development of neurofibromas in nf1. |
2008-08-21 |
2023-08-12 |
human |
| Feyzi Birol Sarica, Melih Cekinmez, Kadir Tufan, Bülent Erdoğan, Orhan Sen, Mehmet Nur Altinör. A rare case of massive NF1 with invasion of entire spinal axis by neurofibromas: case report. Turkish neurosurgery. vol 18. issue 1. 2008-07-15. PMID:18382989. |
a rare case of massive nf1 with invasion of entire spinal axis by neurofibromas: case report. |
2008-07-15 |
2023-08-12 |
Not clear |
| Feyzi Birol Sarica, Melih Cekinmez, Kadir Tufan, Bülent Erdoğan, Orhan Sen, Mehmet Nur Altinör. A rare case of massive NF1 with invasion of entire spinal axis by neurofibromas: case report. Turkish neurosurgery. vol 18. issue 1. 2008-07-15. PMID:18382989. |
in the present paper, we discuss an nf1 case in which paraspinal neurofibromas were observed along the complete spinal axis of a 32-year-old male patient who arrived at the clinic reporting increasingly intense pins and needles and weakness. |
2008-07-15 |
2023-08-12 |
Not clear |
| Therese M Roth, Poornapriya Ramamurthy, David Muir, Margaret R Wallace, Yuan Zhu, Lou Chang, Kate F Baral. Influence of hormones and hormone metabolites on the growth of Schwann cells derived from embryonic stem cells and on tumor cell lines expressing variable levels of neurofibromin. Developmental dynamics : an official publication of the American Association of Anatomists. vol 237. issue 2. 2008-06-16. PMID:18213578. |
the number and size of neurofibromas in nf1 patients have been shown to increase during pregnancy. |
2008-06-16 |
2023-08-12 |
mouse |