| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas De Raedt, Ophélia Maertens, Magdalena Chmara, Hilde Brems, Ine Heyns, Raf Sciot, Elisa Majounie, Meena Upadhyaya, Sofie De Schepper, Frank Speleman, Ludwine Messiaen, Joris Robert Vermeesch, Eric Legiu. Somatic loss of wild type NF1 allele in neurofibromas: Comparison of NF1 microdeletion and non-microdeletion patients. Genes, chromosomes & cancer. vol 45. issue 10. 2006-10-03. PMID:16830335. |
somatic loss of wild type nf1 allele in neurofibromas: comparison of nf1 microdeletion and non-microdeletion patients. |
2006-10-03 |
2023-08-12 |
Not clear |
| Thomas De Raedt, Ophélia Maertens, Magdalena Chmara, Hilde Brems, Ine Heyns, Raf Sciot, Elisa Majounie, Meena Upadhyaya, Sofie De Schepper, Frank Speleman, Ludwine Messiaen, Joris Robert Vermeesch, Eric Legiu. Somatic loss of wild type NF1 allele in neurofibromas: Comparison of NF1 microdeletion and non-microdeletion patients. Genes, chromosomes & cancer. vol 45. issue 10. 2006-10-03. PMID:16830335. |
neurofibromatosis type i (nf1) is an autosomal dominant familial tumor syndrome characterized by the presence of multiple benign neurofibromas. |
2006-10-03 |
2023-08-12 |
Not clear |
| Thomas De Raedt, Ophélia Maertens, Magdalena Chmara, Hilde Brems, Ine Heyns, Raf Sciot, Elisa Majounie, Meena Upadhyaya, Sofie De Schepper, Frank Speleman, Ludwine Messiaen, Joris Robert Vermeesch, Eric Legiu. Somatic loss of wild type NF1 allele in neurofibromas: Comparison of NF1 microdeletion and non-microdeletion patients. Genes, chromosomes & cancer. vol 45. issue 10. 2006-10-03. PMID:16830335. |
we studied the frequency of loss of heterozygosity (loh) in the nf1 region as a mechanism of somatic nf1 inactivation in neurofibromas from nf1 patients with and without a microdeletion. |
2006-10-03 |
2023-08-12 |
Not clear |
| Thomas De Raedt, Ophélia Maertens, Magdalena Chmara, Hilde Brems, Ine Heyns, Raf Sciot, Elisa Majounie, Meena Upadhyaya, Sofie De Schepper, Frank Speleman, Ludwine Messiaen, Joris Robert Vermeesch, Eric Legiu. Somatic loss of wild type NF1 allele in neurofibromas: Comparison of NF1 microdeletion and non-microdeletion patients. Genes, chromosomes & cancer. vol 45. issue 10. 2006-10-03. PMID:16830335. |
none of the 40 neurofibromas from six different nf1 microdeletion patients showed loh, whereas loh was observed in 6/28 neurofibromas from five patients with an intragenic nf1 mutation (p = 0.0034, fisher's exact). |
2006-10-03 |
2023-08-12 |
Not clear |
| Ophélia Maertens, Hilde Brems, Jo Vandesompele, Thomas De Raedt, Ine Heyns, Thorsten Rosenbaum, Sofie De Schepper, Anne De Paepe, Geert Mortier, Sandra Janssens, Frank Speleman, Eric Legius, Ludwine Messiae. Comprehensive NF1 screening on cultured Schwann cells from neurofibromas. Human mutation. vol 27. issue 10. 2006-10-02. PMID:16941471. |
comprehensive nf1 screening on cultured schwann cells from neurofibromas. |
2006-10-02 |
2023-08-12 |
Not clear |
| Ophélia Maertens, Hilde Brems, Jo Vandesompele, Thomas De Raedt, Ine Heyns, Thorsten Rosenbaum, Sofie De Schepper, Anne De Paepe, Geert Mortier, Sandra Janssens, Frank Speleman, Eric Legius, Ludwine Messiae. Comprehensive NF1 screening on cultured Schwann cells from neurofibromas. Human mutation. vol 27. issue 10. 2006-10-02. PMID:16941471. |
neurofibromatosis type 1 (nf1) is mainly characterized by the occurrence of benign peripheral nerve sheath tumors or neurofibromas. |
2006-10-02 |
2023-08-12 |
Not clear |
| Ophélia Maertens, Hilde Brems, Jo Vandesompele, Thomas De Raedt, Ine Heyns, Thorsten Rosenbaum, Sofie De Schepper, Anne De Paepe, Geert Mortier, Sandra Janssens, Frank Speleman, Eric Legius, Ludwine Messiae. Comprehensive NF1 screening on cultured Schwann cells from neurofibromas. Human mutation. vol 27. issue 10. 2006-10-02. PMID:16941471. |
we developed an improved somatic mutation detection strategy on cultured schwann cells derived from neurofibromas and investigated 38 tumors from nine nf1 patients. |
2006-10-02 |
2023-08-12 |
Not clear |
| Ophélia Maertens, Hilde Brems, Jo Vandesompele, Thomas De Raedt, Ine Heyns, Thorsten Rosenbaum, Sofie De Schepper, Anne De Paepe, Geert Mortier, Sandra Janssens, Frank Speleman, Eric Legius, Ludwine Messiae. Comprehensive NF1 screening on cultured Schwann cells from neurofibromas. Human mutation. vol 27. issue 10. 2006-10-02. PMID:16941471. |
together, these data clearly illustrate that two inactivating nf1 mutations, in a subpopulation of the schwann cells, are required for neurofibroma formation in nf1 tumorigenesis. |
2006-10-02 |
2023-08-12 |
Not clear |
| Fang Li, Amy M Munchhof, Hilary A White, Laura E Mead, Theresa R Krier, Amy Fenoglio, Shi Chen, Xiaohua Wu, Shanbao Cai, Feng-Chun Yang, David A Ingra. Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells. Human molecular genetics. vol 15. issue 11. 2006-09-21. PMID:16644864. |
further, nf1 patients develop vascular neurofibromas where tumor vessels are invested in a dense pericyte sheath. |
2006-09-21 |
2023-08-12 |
mouse |
| Amy M Munchhof, Fang Li, Hilary A White, Laura E Mead, Theresa R Krier, Amy Fenoglio, Xiaohong Li, Jin Yuan, Feng-Chun Yang, David A Ingra. Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells. Human molecular genetics. vol 15. issue 11. 2006-09-21. PMID:16648142. |
somatic inactivation of the nf1 tumor suppressor gene, which encodes neurofibromin, is necessary but not sufficient to initiate neurofibroma development. |
2006-09-21 |
2023-08-12 |
mouse |
| Amy M Munchhof, Fang Li, Hilary A White, Laura E Mead, Theresa R Krier, Amy Fenoglio, Xiaohong Li, Jin Yuan, Feng-Chun Yang, David A Ingra. Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells. Human molecular genetics. vol 15. issue 11. 2006-09-21. PMID:16648142. |
in contrast, neurofibromas occur with high penetrance in mice in which nf1 is ablated in schwann cells in the context of a heterozygous mutant (nf1+/-) microenvironment. |
2006-09-21 |
2023-08-12 |
mouse |
| Baki S Albayrak, Askin Gorgulu, Turgay Kos. A case of intra-dural malignant peripheral nerve sheath tumor in thoracic spine associated with neurofibromatosis type 1. Journal of neuro-oncology. vol 78. issue 2. 2006-09-05. PMID:16598431. |
it must always be considered the possibility of a rare but a devastating tumor, mpnst beside schwannomas and neurofibromas in patients with nf1 when an intra-spinal mass is diagnosed. |
2006-09-05 |
2023-08-12 |
Not clear |
| Anja Overdiek, Hartmut Feifel, Jörg Schaper, Ertan Mayatepek, Thorsten Rosenbau. Diagnostic delay of NF1 in hemifacial hypertrophy due to plexiform neurofibromas. Brain & development. vol 28. issue 5. 2006-07-26. PMID:16481142. |
hemifacial hypertrophy due to an underlying neurofibroma is a typical manifestation of nf1 in young children although the overall frequency of facial involvement is low. |
2006-07-26 |
2023-08-12 |
Not clear |
| Vappu Sirén, Juha Peltonen, Antti Vaher. Plasminogen activators and their inhibitor gene expression in cutaneous NF1-related neurofibromas. Archives of dermatological research. vol 297. issue 9. 2006-07-25. PMID:16408192. |
cutaneous neurofibromatosis 1 (nf1)-related neurofibromas are benign tumors and composed of schwann cells, perineurial cells and/or fibroblasts, endothelial cells, mast cells and macrophages. |
2006-07-25 |
2023-08-12 |
Not clear |
| Zhongmin Che, Woong Nam, Won-Se Park, Hyung-Jun Kim, In-Ho Cha, Hyun-Sil Kim, Jong-In Yook, Jin Kim, Sang-Hwy Le. Intraosseous nerve sheath tumors in the jaws. Yonsei medical journal. vol 47. issue 2. 2006-06-15. PMID:16642559. |
neurofibroma is one of the most common nerve sheath tumors occurring in the soft tissue and generally appears in neurofibromatosis 1 (nf1 or von recklinghausen's disease). |
2006-06-15 |
2023-08-12 |
Not clear |
| M Wu, M R Wallace, D Mui. Nf1 haploinsufficiency augments angiogenesis. Oncogene. vol 25. issue 16. 2006-05-23. PMID:16288202. |
mutations in the nf1 tumor-suppressor gene underlie neurofibromatosis type 1 (nf1), in which patients are predisposed to certain tumors such as neurofibromas and may associate with vascular disorder. |
2006-05-23 |
2023-08-12 |
mouse |
| M Wu, M R Wallace, D Mui. Nf1 haploinsufficiency augments angiogenesis. Oncogene. vol 25. issue 16. 2006-05-23. PMID:16288202. |
the development of neurofibromas requires loss of both nf1 alleles in schwann cells destined to become neoplastic and may be exacerbated by nf1 heterozygosity in other non-neoplastic cells. |
2006-05-23 |
2023-08-12 |
mouse |
| M Wu, M R Wallace, D Mui. Nf1 haploinsufficiency augments angiogenesis. Oncogene. vol 25. issue 16. 2006-05-23. PMID:16288202. |
these findings support the conclusion that nf1 heterozygosity in endothelial cells and perhaps inflammatory cells augments angiogenesis, which may promote neurofibroma formation in nf1. |
2006-05-23 |
2023-08-12 |
mouse |
| Oren N Gottfried, David H Viskochil, Daniel W Fults, William T Couldwel. Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications. Neurosurgery. vol 58. issue 1. 2006-05-23. PMID:16385324. |
neurofibromatosis 1 (nf1) is a common autosomal dominant disease characterized by complex and multicellular neurofibroma tumors. |
2006-05-23 |
2023-08-12 |
Not clear |
| Oren N Gottfried, David H Viskochil, Daniel W Fults, William T Couldwel. Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications. Neurosurgery. vol 58. issue 1. 2006-05-23. PMID:16385324. |
this review summarizes the most recent nf1 and neurofibroma literature describing the pathogenesis and treatment of nerve sheath tumors. |
2006-05-23 |
2023-08-12 |
Not clear |