| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael C Schmale, Dale Vicha, Saul M Caca. Degranulation of eosinophilic granule cells in neurofibromas and gastrointestinal tract in the bicolor damselfish. Fish & shellfish immunology. vol 17. issue 1. 2004-08-25. PMID:15145417. |
these observations support the hypothesis that the egc present in neurofibromas and mpnst in dnf are equivalent to the mast cell component in neurofibromas in nf1. |
2004-08-25 |
2023-08-12 |
Not clear |
| Alessandro De Luca, Laura Bernardini, Caterina Ceccarini, Lorenzo Sinibaldi, Antonio Novelli, Sandra Giustini, Innocenzi Daniele, Stefano Calvieri, Rita Mingarell. Fluorescence in situ hybridization analysis of allelic losses involving the long arm of chromosome 17 in NF1-associated neurofibromas. Cancer genetics and cytogenetics. vol 150. issue 2. 2004-06-30. PMID:15066327. |
if we assume that dual-color fish analysis is sensitive enough to detect the majority of large somatic deletions present, then other mutational mechanisms affecting the nf1 gene are probably involved in neurofibroma formation, and other tumor suppressor genes may play an important role in nf1 tumorigenesis. |
2004-06-30 |
2023-08-12 |
Not clear |
| K S G Cunha, E P Barboza, E P Dias, F M Oliveir. Neurofibromatosis type I with periodontal manifestation. A case report and literature review. British dental journal. vol 196. issue 8. 2004-06-18. PMID:15105854. |
a case of a nf1 patient with a gingival neurofibroma in the attached gingiva of the lingual aspect of the lower central incisors is presented. |
2004-06-18 |
2023-08-12 |
human |
| Nikola Holtkamp, Victor-F Mautner, Reinhard E Friedrich, Anja Harder, Christian Hartmann, Agota Theallier-Janko, Karl T Hoffmann, Andreas von Deimlin. Differentially expressed genes in neurofibromatosis 1-associated neurofibromas and malignant peripheral nerve sheath tumors. Acta neuropathologica. vol 107. issue 2. 2004-04-05. PMID:14673600. |
neurofibromas represent one of the hallmarks of neurofibromatosis 1 (nf1) patients. |
2004-04-05 |
2023-08-12 |
Not clear |
| U Schick, J Bleyen, W Hassle. Treatment of orbital schwannomas and neurofibromas. British journal of neurosurgery. vol 17. issue 6. 2004-03-22. PMID:14756482. |
one patient showed bilateral orbital neurofibromas, plexiform cutaneous neurofibroma (nf1) and glaucoma due to a coexisting marfan's syndrome. |
2004-03-22 |
2023-08-12 |
Not clear |
| Cagatay Oktenli, Mutlu Saglam, Seref Demirbas, Peter Thompson, Meena Upadhyaya, Claudia Consoli, Hakan Ulucan, Cem Koz, Ali Hakan Durukan, Ali Bozkurt, Bayram Koc, Ismail Hakki Kocar, Davut Gu. A large deletion (1.5 Mb) encompassing the neurofibromatosis type 1 (NF1) gene in a patient with sporadic NF1 associated with dysmorphism, mental retardation, and unusual ocular and skeletal features. Clinical dysmorphology. vol 12. issue 3. 2004-03-15. PMID:14564162. |
several nf1 patients with a large nf1 deletion and associated dysmorphism, and a large number of neurofibromas for their age have been described. |
2004-03-15 |
2023-08-12 |
Not clear |
| Bilge Bilgic, Lora Esberk Ates, Misten Demiryont, Harzem Ozger, Yavuz Dizda. Malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1. Pathology oncology research : POR. vol 9. issue 3. 2004-02-26. PMID:14530818. |
in a majority of nf1 patients mpnst emerges from a preexisting neurofibroma. |
2004-02-26 |
2023-08-12 |
Not clear |
| Verena Wiest, Ingrid Eisenbarth, Claudia Schmegner, Winfrid Krone, Günter Assu. Somatic NF1 mutation spectra in a family with neurofibromatosis type 1: toward a theory of genetic modifiers. Human mutation. vol 22. issue 6. 2004-01-26. PMID:14635100. |
neurofibromatosis type 1 (nf1), an autosomal dominantly-inherited disorder, is mainly characterized by the occurrence of multiple dermal neurofibromas and is caused by mutations in the nf1 gene, a tumor suppressor gene. |
2004-01-26 |
2023-08-12 |
Not clear |
| Verena Wiest, Ingrid Eisenbarth, Claudia Schmegner, Winfrid Krone, Günter Assu. Somatic NF1 mutation spectra in a family with neurofibromatosis type 1: toward a theory of genetic modifiers. Human mutation. vol 22. issue 6. 2004-01-26. PMID:14635100. |
the analysis of somatic nf1 gene mutations in neurofibromas from nf1 patients revealed that each neurofibroma results from an individual second hit mutation, indicating that factors that influence somatic mutation rates may be regarded as potential modifiers of nf1. |
2004-01-26 |
2023-08-12 |
Not clear |
| Verena Wiest, Ingrid Eisenbarth, Claudia Schmegner, Winfrid Krone, Günter Assu. Somatic NF1 mutation spectra in a family with neurofibromatosis type 1: toward a theory of genetic modifiers. Human mutation. vol 22. issue 6. 2004-01-26. PMID:14635100. |
a mutational screen of numerous neurofibromas from two nf1 patients presented here revealed a predominance of point mutations, small deletions, and insertions as second hit mutations in both patients. |
2004-01-26 |
2023-08-12 |
Not clear |
| David H Viskochi. It takes two to tango: mast cell and Schwann cell interactions in neurofibromas. The Journal of clinical investigation. vol 112. issue 12. 2004-01-21. PMID:14679174. |
these results set the stage for rational development of therapeutics that could influence the multicellular microenvironment of neurofibromas to inhibit the development and/or progression of these tumors in human nf1. |
2004-01-21 |
2023-08-12 |
human |
| Feng-Chun Yang, David A Ingram, Shi Chen, Cynthia M Hingtgen, Nancy Ratner, Kelly R Monk, Travis Clegg, Hilary White, Laura Mead, Mary Jo Wenning, David A Williams, Reuben Kapur, Simon J Atkinson, D Wade Clap. Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells. The Journal of clinical investigation. vol 112. issue 12. 2004-01-21. PMID:14679180. |
somatic inactivation of murine nf1 in schwann cells is necessary, but not sufficient, to initiate neurofibroma formation. |
2004-01-21 |
2023-08-12 |
mouse |
| Feng-Chun Yang, David A Ingram, Shi Chen, Cynthia M Hingtgen, Nancy Ratner, Kelly R Monk, Travis Clegg, Hilary White, Laura Mead, Mary Jo Wenning, David A Williams, Reuben Kapur, Simon J Atkinson, D Wade Clap. Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells. The Journal of clinical investigation. vol 112. issue 12. 2004-01-21. PMID:14679180. |
neurofibromas occur with high penetrance in mice in which nf1 is ablated in schwann cells in the context of a heterozygous mutant (nf1+/-) microenvironment. |
2004-01-21 |
2023-08-12 |
mouse |
| K S G Cunha, E P Barboza, E C Da Fonsec. Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1. Journal of clinical pathology. vol 56. issue 10. 2003-11-10. PMID:14514779. |
the hallmark of neurofibromatosis type 1 (nf1) is the development of multiple neurofibromas. |
2003-11-10 |
2023-08-12 |
Not clear |
| K S G Cunha, E P Barboza, E C Da Fonsec. Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1. Journal of clinical pathology. vol 56. issue 10. 2003-11-10. PMID:14514779. |
solitary neurofibroma may occur in an individual who does not have nf1, but multiple neurofibromas tend to develop only in those with nf1. |
2003-11-10 |
2023-08-12 |
Not clear |
| K S G Cunha, E P Barboza, E C Da Fonsec. Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1. Journal of clinical pathology. vol 56. issue 10. 2003-11-10. PMID:14514779. |
it has been suggested that hormones may influence the neurofibromas of patients with nf1. |
2003-11-10 |
2023-08-12 |
Not clear |
| K S G Cunha, E P Barboza, E C Da Fonsec. Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1. Journal of clinical pathology. vol 56. issue 10. 2003-11-10. PMID:14514779. |
the evidence that hormones may influence the growth of neurofibromas comes mainly from the observation that localised neurofibromas of patients with nf1 commonly grow during puberty and pregnancy. |
2003-11-10 |
2023-08-12 |
Not clear |
| Jerzy Lasota, Bartek Wasag, Agnieszka Dansonka-Mieszkowska, Danuta Karcz, Carl L Millward, Janusz Ryś, Jerzy Stachura, Leslie H Sobin, Markku Miettine. Evaluation of NF2 and NF1 tumor suppressor genes in distinctive gastrointestinal nerve sheath tumors traditionally diagnosed as benign schwannomas: s study of 20 cases. Laboratory investigation; a journal of technical methods and pathology. vol 83. issue 9. 2003-10-07. PMID:13679444. |
similarly, a significant percentage of neurofibromas show loh at nf1 and/or nf1 inactivating mutations. |
2003-10-07 |
2023-08-12 |
Not clear |
| M Malerba, A Garofal. [A rare case of nerve-sheath sarcoma with rhabdomyoblastic differentiation (malignant triton tumor)]. Tumori. vol 89. issue 4 Suppl. 2003-09-05. PMID:12903608. |
seventeen months before, when the patient underwent surgery at the same department for both a left-sided paravertebral inferior mediastinal neurofibroma and a right-sided axillary neurofibroma, diagnosis of von recklinghausen disease (nf1) was made, according to the criteria established by the nih consensus development. |
2003-09-05 |
2023-08-12 |
Not clear |
| L Kluwe, M Tatagiba, C Fünsterer, V-F Mautne. NF1 mutations and clinical spectrum in patients with spinal neurofibromas. Journal of medical genetics. vol 40. issue 5. 2003-08-05. PMID:12746402. |
nf1 mutations and clinical spectrum in patients with spinal neurofibromas. |
2003-08-05 |
2023-08-12 |
Not clear |