| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G A Mashour, N Ratner, G A Khan, H L Wang, R L Martuza, A Kurt. The angiogenic factor midkine is aberrantly expressed in NF1-deficient Schwann cells and is a mitogen for neurofibroma-derived cells. Oncogene. vol 20. issue 1. 2001-03-29. PMID:11244508. |
the data support a possible central role for mk as a mediator of angiogenesis and neurofibroma growth in nf1. |
2001-03-29 |
2023-08-12 |
mouse |
| G Magro, M Piana, C Venti, A Lacagnina, M Ruggier. Solitary neurofibroma of the mesentery: report of a case and review of the literature. Pathology, research and practice. vol 196. issue 10. 2001-03-01. PMID:11087058. |
a critical review of the literature revealed that only seven cases of solitary neurofibromas (snfs) of the mesentery (six in the ileal mesentery; one in the gastrocolic mesentery) have been reported in patients without stigmata of nf1. |
2001-03-01 |
2023-08-12 |
Not clear |
| E Serra, T Rosenbaum, U Winner, R Aledo, E Ars, X Estivill, H G Lenard, C Lázar. Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations. Human molecular genetics. vol 9. issue 20. 2001-02-22. PMID:11115850. |
schwann cells harbor the somatic nf1 mutation in neurofibromas: evidence of two different schwann cell subpopulations. |
2001-02-22 |
2023-08-12 |
human |
| E Serra, T Rosenbaum, U Winner, R Aledo, E Ars, X Estivill, H G Lenard, C Lázar. Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations. Human molecular genetics. vol 9. issue 20. 2001-02-22. PMID:11115850. |
neurofibromas are one of the most characteristic features of neurofibromatosis type 1 (nf1), an inherited autosomal-dominant neurogenetic disorder affecting 1 in 3500 individuals worldwide. |
2001-02-22 |
2023-08-12 |
human |
| E Serra, T Rosenbaum, U Winner, R Aledo, E Ars, X Estivill, H G Lenard, C Lázar. Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations. Human molecular genetics. vol 9. issue 20. 2001-02-22. PMID:11115850. |
we cultured pure populations of scs and fibroblasts derived from 10 neurofibromas with characterized nf1 mutations and found that scs but not fibroblasts harbored a somatic mutation at the nf1 locus in all studied tumors. |
2001-02-22 |
2023-08-12 |
human |
| E Serra, T Rosenbaum, U Winner, R Aledo, E Ars, X Estivill, H G Lenard, C Lázar. Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations. Human molecular genetics. vol 9. issue 20. 2001-02-22. PMID:11115850. |
these data strongly support the idea that nf1 mutations in scs, but not in fibroblasts, correlate to neurofibroma formation and demonstrate that only a portion of scs in neurofibromas have mutations in both nf1 alleles. |
2001-02-22 |
2023-08-12 |
human |
| M Luijten, S Redeker, M M van Noesel, D Troost, A Westerveld, T J Hulsebo. Microsatellite instability and promoter methylation as possible causes of NF1 gene inactivation in neurofibromas. European journal of human genetics : EJHG. vol 8. issue 12. 2001-02-22. PMID:11175282. |
microsatellite instability and promoter methylation as possible causes of nf1 gene inactivation in neurofibromas. |
2001-02-22 |
2023-08-12 |
Not clear |
| M Luijten, S Redeker, M M van Noesel, D Troost, A Westerveld, T J Hulsebo. Microsatellite instability and promoter methylation as possible causes of NF1 gene inactivation in neurofibromas. European journal of human genetics : EJHG. vol 8. issue 12. 2001-02-22. PMID:11175282. |
since the nf1 gene is supposed to be a tumour suppressor gene, these neurofibromas should develop upon inactivation of both nf1 alleles. |
2001-02-22 |
2023-08-12 |
Not clear |
| M Luijten, S Redeker, M M van Noesel, D Troost, A Westerveld, T J Hulsebo. Microsatellite instability and promoter methylation as possible causes of NF1 gene inactivation in neurofibromas. European journal of human genetics : EJHG. vol 8. issue 12. 2001-02-22. PMID:11175282. |
we analysed 20 neurofibromas and three neurofibrosarcomas, but did not find evidence for microsatellite instability or nf1 promoter methylation in any of the tumours. |
2001-02-22 |
2023-08-12 |
Not clear |
| R Gutzmer, R A Herbst, S Mommert, P Kiehl, F Matiaske, A Rütten, A Kapp, J Weis. Allelic loss at the neurofibromatosis type 1 (NF1) gene locus is frequent in desmoplastic neurotropic melanoma. Human genetics. vol 107. issue 4. 2001-01-04. PMID:11129335. |
mutations of the tumour-suppressor gene nf1 (neurofibromatosis 1) have been observed in neurofibromas and neurofibrosarcomas of patients with von recklinghausen's disease and in sporadic nerve sheath tumours. |
2001-01-04 |
2023-08-12 |
Not clear |
| T Rosenbaum, C Rosenbaum, U Winner, H W Müller, H G Lenard, C O Haneman. Long-term culture and characterization of human neurofibroma-derived Schwann cells. Journal of neuroscience research. vol 61. issue 5. 2000-11-30. PMID:10956422. |
neurofibromas are benign tumors arising from the peripheral nerve sheath and are a typical finding in neurofibromatosis type 1 (nf1). |
2000-11-30 |
2023-08-12 |
human |
| A L Weber, C Montandon, C D Robso. Neurogenic tumors of the neck. Radiologic clinics of North America. vol 38. issue 5. 2000-11-14. PMID:11054970. |
the plexiform neurofibroma and multiple localized neurofibromas are characteristic of nf1. |
2000-11-14 |
2023-08-12 |
Not clear |
| S L Karvonen, M Kallioinen, H Ylä-Outinen, M Pöyhönen, A Oikarinen, J Peltone. Occult neurofibroma and increased S100 protein in the skin of patients with neurofibromatosis type 1: new insight to the etiopathomechanism of neurofibromas. Archives of dermatology. vol 136. issue 10. 2000-11-01. PMID:11030766. |
there is evidence that the appearance and growth of neurofibromas may be associated with prior or ongoing mechanical trauma in patients with neurofibromatosis type 1 (nf1). |
2000-11-01 |
2023-08-12 |
Not clear |
| L S Sherman, R Atit, T Rosenbaum, A D Cox, N Ratne. Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts. The Journal of biological chemistry. vol 275. issue 39. 2000-10-27. PMID:10900196. |
in dissociated neurofibroma cells from nf1 patients, ras-gtp was elevated in schwann cells but not fibroblasts. |
2000-10-27 |
2023-08-12 |
mouse |
| M P Horan, D N Cooper, M Upadhyay. Hypermethylation of the neurofibromatosis type 1 (NF1) gene promoter is not a common event in the inactivation of the NF1 gene in NF1-specific tumours. Human genetics. vol 107. issue 1. 2000-09-21. PMID:10982032. |
however, since all other cpg sites were unmethylated in all tissues examined, it is unlikely that cpg hypermethylation within the nf1 promoter represents a common mutational mechanism leading to neurofibroma formation. |
2000-09-21 |
2023-08-12 |
Not clear |
| S A Rasmussen, J Overman, S A Thomson, S D Colman, C R Abernathy, R E Trimpert, R Moose, G Virdi, K Roux, M Bauer, A M Rojiani, B L Maria, D Muir, M R Wallac. Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1. Genes, chromosomes & cancer. vol 28. issue 4. 2000-09-14. PMID:10862051. |
neurofibromatosis type 1 (nf1) is a common autosomal dominant condition characterized by benign tumor (neurofibroma) growth and increased risk of malignancy. |
2000-09-14 |
2023-08-12 |
Not clear |
| S A Rasmussen, J Overman, S A Thomson, S D Colman, C R Abernathy, R E Trimpert, R Moose, G Virdi, K Roux, M Bauer, A M Rojiani, B L Maria, D Muir, M R Wallac. Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1. Genes, chromosomes & cancer. vol 28. issue 4. 2000-09-14. PMID:10862051. |
loss of heterozygosity (loh) for nf1 has been reported in some neurofibromas and nf1 malignancies, but plexiform tumors have been poorly represented. |
2000-09-14 |
2023-08-12 |
Not clear |
| H Schmidt, H Taubert, A Meye, P Würl, M Bache, F Bartel, H J Holzhausen, R Hinz. Gains in chromosomes 7, 8q, 15q and 17q are characteristic changes in malignant but not in benign peripheral nerve sheath tumors from patients with Recklinghausen's disease. Cancer letters. vol 155. issue 2. 2000-07-19. PMID:10822134. |
by means of comparative genomic hybridization (cgh) gained results from six benign neurofibromas and 14 malignant peripheral nerve sheath tumors (mpnsts) were compared with four benign peripheral nerve sheath tumors (bpnsts) from patients without nf1. |
2000-07-19 |
2023-08-12 |
Not clear |
| J L Rutkowski, K Wu, D H Gutmann, P J Boyer, E Legiu. Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1. Human molecular genetics. vol 9. issue 7. 2000-06-23. PMID:10767330. |
these neurofibromas presumably arise from nf1 inactivation in s100(+)schwann cells, but there is no formal proof for this mechanism. |
2000-06-23 |
2023-08-12 |
Not clear |
| J L Rutkowski, K Wu, D H Gutmann, P J Boyer, E Legiu. Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1. Human molecular genetics. vol 9. issue 7. 2000-06-23. PMID:10767330. |
we demonstrate that fibro-blasts isolated from neurofibromas carried at least one normal nf1 allele and expressed both nf1 mrna and protein, whereas the s100(+)cells typically lacked the nf1 transcript. |
2000-06-23 |
2023-08-12 |
Not clear |