| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan Zhu, Pritam Ghosh, Patrick Charnay, Dennis K Burns, Luis F Parad. Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science (New York, N.Y.). vol 296. issue 5569. 2002-05-30. PMID:11988578. |
nf1 encodes a tumor suppressor whose functional loss results in the development of benign neurofibromas that can progress to malignancy. |
2002-05-30 |
2023-08-12 |
Not clear |
| S Pinson, A Créange, S Barbarot, J F Stalder, Y Chaix, D Rodriguez, M Sanson, A Bernheim, M d'Incan, F Doz, C Stoll, P Combemale, C Kalifa, J Zeller, D Teillac-Hamel, S Lyonnet, M Zerah, J P Lacour, B Guillot, P Wolkenstei. [Neurofibromatosis 1: recommendations for management]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. vol 9. issue 1. 2002-03-18. PMID:11865551. |
bibliography was obtained through a medline of articles from 1966 to 1999 for the terms neurofibromatosis, nf1, neurofibroma and from textbooks. |
2002-03-18 |
2023-08-12 |
Not clear |
| D Kaufmann, S Tinschert, B Algermisse. Is the distribution of dermal neurofibromas in neurofibromatosis type 1 (NF1) related to the pattern of the skin surface temperature? European journal of dermatology : EJD. vol 11. issue 6. 2001-12-18. PMID:11701400. |
is the distribution of dermal neurofibromas in neurofibromatosis type 1 (nf1) related to the pattern of the skin surface temperature? |
2001-12-18 |
2023-08-12 |
Not clear |
| D Kaufmann, S Tinschert, B Algermisse. Is the distribution of dermal neurofibromas in neurofibromatosis type 1 (NF1) related to the pattern of the skin surface temperature? European journal of dermatology : EJD. vol 11. issue 6. 2001-12-18. PMID:11701400. |
the formation of dermal neurofibromas is a hallmark of the neurofibromatosis type 1 (nf1). |
2001-12-18 |
2023-08-12 |
Not clear |
| D Kaufmann, S Tinschert, B Algermisse. Is the distribution of dermal neurofibromas in neurofibromatosis type 1 (NF1) related to the pattern of the skin surface temperature? European journal of dermatology : EJD. vol 11. issue 6. 2001-12-18. PMID:11701400. |
a total loss of the nf1 gene product by stochastic events inactivating the wild type allele in schwann cells should precede the development of neurofibromas. |
2001-12-18 |
2023-08-12 |
Not clear |
| D Kaufmann, S Tinschert, B Algermisse. Is the distribution of dermal neurofibromas in neurofibromatosis type 1 (NF1) related to the pattern of the skin surface temperature? European journal of dermatology : EJD. vol 11. issue 6. 2001-12-18. PMID:11701400. |
we suggest that the regulation of skin temperature is also involved in the formation of nf1 dermal neurofibromas and is related to the intrafamilial variability in nf1. |
2001-12-18 |
2023-08-12 |
Not clear |
| H Ogata, H Sato, J Takatsuka, L M De Luc. Human breast cancer MDA-MB-231 cells fail to express the neurofibromin protein, lack its type I mRNA isoform and show accumulation of P-MAPK and activated Ras. Cancer letters. vol 172. issue 2. 2001-11-01. PMID:11566491. |
mutations in the nf1 gene cause neurofibromatosis type 1, nf1, an autosomal dominant disease with a diverse spectrum of clinical manifestations, including neurofibromas. |
2001-11-01 |
2023-08-12 |
human |
| L Garavelli, A Donadio, M Sigorini, L Grassi, G Banchin. [Genetics of type 1 neurofibromatosis]. Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma. vol 71. issue 3-4. 2001-10-18. PMID:11424621. |
neurofibromatosis type 1 (nf1) is an autosomal dominant disorder characterised by cafè au lait spots, multiple neurofibromas and lisch nodules of the iris, with marked variability of expression. |
2001-10-18 |
2023-08-12 |
Not clear |
| D E Jenne, S Tinschert, H Reimann, W Lasinger, G Thiel, H Hameister, H Kehrer-Sawatzk. Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions. American journal of human genetics. vol 69. issue 3. 2001-09-06. PMID:11468690. |
since patients with the nf1 large-deletion syndrome have a significantly increased risk of neurofibroma development and mental retardation, hemizygosity for genes from the deleted region around the neurofibromin locus (cytor4, flj12735, flj22729, hsa272195 (centaurin-alpha2), nf1, omgp, evi2a, evi2b, wi-9521, hsa272196, hca66, kiaa0160, and wi-12393) may contribute to the severe phenotype of these patients. |
2001-09-06 |
2023-08-12 |
Not clear |
| C López-Correa, M Dorschner, H Brems, C Lázaro, M Clementi, M Upadhyaya, D Dooijes, U Moog, H Kehrer-Sawatzki, J L Rutkowski, J P Fryns, P Marynen, K Stephens, E Legiu. Recombination hotspot in NF1 microdeletion patients. Human molecular genetics. vol 10. issue 13. 2001-08-30. PMID:11440991. |
neurofibromatosis type 1 (nf1) patients that are heterozygous for an nf1 microdeletion are remarkable for an early age at onset and an excessive burden of dermal neurofibromas. |
2001-08-30 |
2023-08-12 |
Not clear |
| B J Fortman, B S Kuszyk, B A Urban, E K Fishma. Neurofibromatosis type 1: a diagnostic mimicker at CT. Radiographics : a review publication of the Radiological Society of North America, Inc. vol 21. issue 3. 2001-08-02. PMID:11353109. |
classic computed tomographic (ct) findings in nf1 with thoracic involvement include small, well-defined subcutaneous neurofibromas, focal thoracic scoliosis, posterior vertebral scalloping, enlarged neural foramina, and characteristic rib abnormalities due to bone dysplasia or erosion from adjacent neurofibromas. |
2001-08-02 |
2023-08-12 |
Not clear |
| E Serra, T Rosenbaum, M Nadal, U Winner, E Ars, X Estivill, C Lázar. Mitotic recombination effects homozygosity for NF1 germline mutations in neurofibromas. Nature genetics. vol 28. issue 3. 2001-08-02. PMID:11431704. |
mitotic recombination effects homozygosity for nf1 germline mutations in neurofibromas. |
2001-08-02 |
2023-08-12 |
Not clear |
| E Serra, T Rosenbaum, M Nadal, U Winner, E Ars, X Estivill, C Lázar. Mitotic recombination effects homozygosity for NF1 germline mutations in neurofibromas. Nature genetics. vol 28. issue 3. 2001-08-02. PMID:11431704. |
pure populations of neurofibroma-derived schwann cells bearing both nf1 mutated alleles (nf1-/-) have been isolated from different neurofibromas showing loss of heterozygosity of nearly the entire 17q chromosome. |
2001-08-02 |
2023-08-12 |
Not clear |
| D A Ingram, K Hiatt, A J King, L Fisher, R Shivakumar, C Derstine, M J Wenning, B Diaz, J B Travers, A Hood, M Marshall, D A Williams, D W Clap. Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro. The Journal of experimental medicine. vol 194. issue 1. 2001-08-02. PMID:11435472. |
mutations in the nf1 tumor suppressor gene cause neurofibromatosis type i (nf1), a disease characterized by the formation of cutaneous neurofibromas infiltrated with a high density of degranulating mast cells. |
2001-08-02 |
2023-08-12 |
mouse |
| S Birindelli, F Perrone, M Oggionni, C Lavarino, B Pasini, B Vergani, G N Ranzani, M A Pierotti, S Pilott. Rb and TP53 pathway alterations in sporadic and NF1-related malignant peripheral nerve sheath tumors. Laboratory investigation; a journal of technical methods and pathology. vol 81. issue 6. 2001-07-05. PMID:11406645. |
thus, we investigated the occurrence of tp53 and p16(ink4a) gene deregulation and the presence of microsatellite alterations at markers located at 17p, 17q, 9p21, 22q, 11q, 1p, or 2q loci in mpnsts and neurofibromas either related (14 cases) or unrelated (14 cases) to nf1. |
2001-07-05 |
2023-08-12 |
Not clear |
| E Serra, E Ars, A Ravella, A Sánchez, S Puig, T Rosenbaum, X Estivill, C Lázar. Somatic NF1 mutational spectrum in benign neurofibromas: mRNA splice defects are common among point mutations. Human genetics. vol 108. issue 5. 2001-06-28. PMID:11409870. |
somatic nf1 mutational spectrum in benign neurofibromas: mrna splice defects are common among point mutations. |
2001-06-28 |
2023-08-12 |
Not clear |
| E Serra, E Ars, A Ravella, A Sánchez, S Puig, T Rosenbaum, X Estivill, C Lázar. Somatic NF1 mutational spectrum in benign neurofibromas: mRNA splice defects are common among point mutations. Human genetics. vol 108. issue 5. 2001-06-28. PMID:11409870. |
somatic point mutations or the presence of "two hits" in the nf1 gene have only been reported for a few neurofibromas. |
2001-06-28 |
2023-08-12 |
Not clear |
| E Serra, E Ars, A Ravella, A Sánchez, S Puig, T Rosenbaum, X Estivill, C Lázar. Somatic NF1 mutational spectrum in benign neurofibromas: mRNA splice defects are common among point mutations. Human genetics. vol 108. issue 5. 2001-06-28. PMID:11409870. |
here, we present the somatic nf1 mutational analysis of the whole set of neurofibromas studied by our group and consisting in 126 tumors derived from 32 nf1 patients. |
2001-06-28 |
2023-08-12 |
Not clear |
| G A Mashour, N Ratner, G A Khan, H L Wang, R L Martuza, A Kurt. The angiogenic factor midkine is aberrantly expressed in NF1-deficient Schwann cells and is a mitogen for neurofibroma-derived cells. Oncogene. vol 20. issue 1. 2001-03-29. PMID:11244508. |
loss of the tumor suppressor gene nf1 in neurofibromatosis type 1 (nf1) contributes to the development of a variety of tumors, including malignant peripheral nerve sheath tumors (mpnst) and benign neurofibromas. |
2001-03-29 |
2023-08-12 |
mouse |
| G A Mashour, N Ratner, G A Khan, H L Wang, R L Martuza, A Kurt. The angiogenic factor midkine is aberrantly expressed in NF1-deficient Schwann cells and is a mitogen for neurofibroma-derived cells. Oncogene. vol 20. issue 1. 2001-03-29. PMID:11244508. |
furthermore, mk demonstrated potent mitogenic activity for human systemic and brain endothelial cells in vitro and stimulated proliferation and soft agar colony formation of human mpnst derived s100 positive cells and fibroblastoid cells derived from an nf1 neurofibroma. |
2001-03-29 |
2023-08-12 |
mouse |