| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Rutkowski, K Wu, D H Gutmann, P J Boyer, E Legiu. Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1. Human molecular genetics. vol 9. issue 7. 2000-06-23. PMID:10767330. |
our findings further indicate that additional molecular events aside from nf1 inactivation in schwann cells and/or other neural crest derivatives contribute to neurofibroma formation. |
2000-06-23 |
2023-08-12 |
Not clear |
| J E DeClue, S Heffelfinger, G Benvenuto, B Ling, S Li, W Rui, W C Vass, D Viskochil, N Ratne. Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal models. The Journal of clinical investigation. vol 105. issue 9. 2000-05-25. PMID:10791998. |
nevertheless, immunoblotting, northern analysis, and immunohistochemistry revealed that each of 3 malignant peripheral nerve sheath tumor (mpnst) cell lines from nf1 patients expressed the egf-r, as did 7 of 7 other primary mpnsts, a non-nf1 mpnst cell line, and the s100(+) cells from each of 9 benign neurofibromas. |
2000-05-25 |
2023-08-12 |
mouse |
| I Eisenbarth, K Beyer, W Krone, G Assu. Toward a survey of somatic mutation of the NF1 gene in benign neurofibromas of patients with neurofibromatosis type 1. American journal of human genetics. vol 66. issue 2. 2000-03-30. PMID:10677298. |
toward a survey of somatic mutation of the nf1 gene in benign neurofibromas of patients with neurofibromatosis type 1. |
2000-03-30 |
2023-08-12 |
Not clear |
| I Eisenbarth, K Beyer, W Krone, G Assu. Toward a survey of somatic mutation of the NF1 gene in benign neurofibromas of patients with neurofibromatosis type 1. American journal of human genetics. vol 66. issue 2. 2000-03-30. PMID:10677298. |
here we describe a systematic approach of searching for somatic inactivation of the nf1 gene in neurofibromas. |
2000-03-30 |
2023-08-12 |
Not clear |
| I Eisenbarth, K Beyer, W Krone, G Assu. Toward a survey of somatic mutation of the NF1 gene in benign neurofibromas of patients with neurofibromatosis type 1. American journal of human genetics. vol 66. issue 2. 2000-03-30. PMID:10677298. |
three tumor-specific point mutations and two loh events were detected among seven neurofibromas from four different nf1 patients. |
2000-03-30 |
2023-08-12 |
Not clear |
| I Eisenbarth, K Beyer, W Krone, G Assu. Toward a survey of somatic mutation of the NF1 gene in benign neurofibromas of patients with neurofibromatosis type 1. American journal of human genetics. vol 66. issue 2. 2000-03-30. PMID:10677298. |
our results suggest that small subtle mutations occur with similar frequency to that of loh in benign neurofibromas and that somatic inactivation of the nf1 gene is a general event in these tumors. |
2000-03-30 |
2023-08-12 |
Not clear |
| D A Ingram, F C Yang, J B Travers, M J Wenning, K Hiatt, S New, A Hood, K Shannon, D A Williams, D W Clap. Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo. The Journal of experimental medicine. vol 191. issue 1. 2000-02-07. PMID:10620616. |
neurofibromatosis type 1 (nf1) is a common autosomal-dominant disorder characterized by cutaneous neurofibromas infiltrated with large numbers of mast cells, melanocyte hyperplasia, and a predisposition to develop malignant neoplasms. |
2000-02-07 |
2023-08-12 |
mouse |
| G P Nielsen, A O Stemmer-Rachamimov, Y Ino, M B Moller, A E Rosenberg, D N Loui. Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation. The American journal of pathology. vol 155. issue 6. 1999-12-28. PMID:10595918. |
patients with neurofibromatosis 1 (nf1) are predisposed to develop multiple neurofibromas (nfs) and are at risk for transformation of nfs to malignant peripheral nerve sheath tumors (mpnsts). |
1999-12-28 |
2023-08-12 |
Not clear |
| K Cichowski, T S Shih, E Schmitt, S Santiago, K Reilly, M E McLaughlin, R T Bronson, T Jack. Mouse models of tumor development in neurofibromatosis type 1. Science (New York, N.Y.). vol 286. issue 5447. 1999-12-23. PMID:10591652. |
unlike humans, mice that are heterozygous for a mutation in nf1 do not develop neurofibromas. |
1999-12-23 |
2023-08-12 |
mouse |
| J M Woodruf. Pathology of tumors of the peripheral nerve sheath in type 1 neurofibromatosis. American journal of medical genetics. vol 89. issue 1. 1999-10-18. PMID:10469433. |
there are five forms of neurofibroma; three of them-localized cutaneous neurofibroma when multiple, plexiform neurofibroma, and massive soft-tissue neurofibroma-are highly specific for nf1. |
1999-10-18 |
2023-08-12 |
Not clear |
| E J Piovesan, R H Scola, L C Werneck, V H Zétola, E M Nóvak, F M Iwamoto, L M Piovesa. Neurofibromatosis, stroke and basilar impression. Case report. Arquivos de neuro-psiquiatria. vol 57. issue 2B. 1999-10-12. PMID:10450358. |
neurofibromatosis type 1 (nf1) can virtually affect any organ, presenting most frequently with "cafe au lait" spots and neurofibromas. |
1999-10-12 |
2023-08-12 |
Not clear |
| D Kaufmann, B Bartelt, S Hoffmeyer, R Mülle. Posttranslational regulation of neurofibromin content in melanocytes of neurofibromatosis type 1 patients. Archives of dermatological research. vol 291. issue 6. 1999-09-08. PMID:10421056. |
neurofibromatosis type 1 (nf1) is a common autosomal dominantly inherited disorder characterized by neurofibromas and café-au-lait macules. |
1999-09-08 |
2023-08-12 |
Not clear |
| B L Strauss, D H Gutmann, L P Dehner, A Hirbe, X Zhu, E F Marley, H Liapi. Molecular analysis of malignant triton tumors. Human pathology. vol 30. issue 8. 1999-09-03. PMID:10452514. |
individuals affected with nf1 harbor mutations in the nf1 tumor suppressor gene and develop neurofibromas and mpnsts. |
1999-09-03 |
2023-08-12 |
Not clear |
| L Kluwe, R Friedrich, V F Mautne. Loss of NF1 allele in Schwann cells but not in fibroblasts derived from an NF1-associated neurofibroma. Genes, chromosomes & cancer. vol 24. issue 3. 1999-09-02. PMID:10451710. |
loss of nf1 allele in schwann cells but not in fibroblasts derived from an nf1-associated neurofibroma. |
1999-09-02 |
2023-08-12 |
Not clear |
| L Kluwe, R Friedrich, V F Mautne. Loss of NF1 allele in Schwann cells but not in fibroblasts derived from an NF1-associated neurofibroma. Genes, chromosomes & cancer. vol 24. issue 3. 1999-09-02. PMID:10451710. |
this result suggests that genetic alterations of the nf1 gene in schwann cells are responsible for the development of neurofibromas. |
1999-09-02 |
2023-08-12 |
Not clear |
| R P Atit, M J Crowe, D G Greenhalgh, R J Wenstrup, N Ratne. The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblasts. The Journal of investigative dermatology. vol 112. issue 6. 1999-07-13. PMID:10383727. |
thus nf1 is a key regulator of fibroblast responses to injury, and nf1 mutation in mouse fibroblasts causes abnormalities characteristic of human neurofibromas. |
1999-07-13 |
2023-08-12 |
mouse |
| D Kaufmann, S Gruener, F Braun, M Stark, J Griesser, S Hoffmeyer, B Bartel. EVI2B, a gene lying in an intron of the neurofibromatosis type 1 (NF1) gene, is as the NF1 gene involved in differentiation of melanocytes and keratinocytes and is overexpressed in cells derived from NF1 neurofibromas. DNA and cell biology. vol 18. issue 5. 1999-07-01. PMID:10360836. |
evi2b, a gene lying in an intron of the neurofibromatosis type 1 (nf1) gene, is as the nf1 gene involved in differentiation of melanocytes and keratinocytes and is overexpressed in cells derived from nf1 neurofibromas. |
1999-07-01 |
2023-08-12 |
Not clear |
| D Kaufmann, S Gruener, F Braun, M Stark, J Griesser, S Hoffmeyer, B Bartel. EVI2B, a gene lying in an intron of the neurofibromatosis type 1 (NF1) gene, is as the NF1 gene involved in differentiation of melanocytes and keratinocytes and is overexpressed in cells derived from NF1 neurofibromas. DNA and cell biology. vol 18. issue 5. 1999-07-01. PMID:10360836. |
here, the amounts of nf1 and evi2b mrna were investigated in detail in cells involved in nf1 manifestations as café-au-lait macules and neurofibromas. |
1999-07-01 |
2023-08-12 |
Not clear |
| M E Baser, P H Birch, G R Evans, J M Friedma. Association of superficial plexiform and paraspinal neurofibromas in neurofibromatosis 1 (NF1) Neurology. vol 52. issue 7. 1999-05-17. PMID:10227658. |
association of superficial plexiform and paraspinal neurofibromas in neurofibromatosis 1 (nf1) |
1999-05-17 |
2023-08-12 |
Not clear |
| H Suzuki, K Takahashi, K Yasumoto, S Amae, M Yoshizawa, N Fuse, S Shibahar. Role of neurofibromin in modulation of expression of the tyrosinase-related protein 2 gene. Journal of biochemistry. vol 124. issue 5. 1999-02-11. PMID:9792924. |
neurofibromin is the protein product of a gene linked to neurofibromatosis type 1 (nf1), which is characterized by multiple neurofibromas and abnormalities in skin pigmentation. |
1999-02-11 |
2023-08-12 |
human |