| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lauren Fishbein, Xuelian Zhang, Lori B Fisher, Hua Li, Martha Campbell-Thompson, Anthony Yachnis, Allan Rubenstein, David Muir, Margaret R Wallac. In vitro studies of steroid hormones in neurofibromatosis 1 tumors and Schwann cells. Molecular carcinogenesis. vol 46. issue 7. 2007-08-23. PMID:17393410. |
immunohistochemistry and real-time pcr showed that estrogen receptors (ers), progesterone receptor (pr), and androgen receptor are differentially expressed in primary neurofibromas and in nf1 tumor-derived schwann cell cultures compared to normal schwann cells. |
2007-08-23 |
2023-08-12 |
human |
| Anne Katrin Detjen, Sigrid Tinschert, Dieter Kaufmann, Bernd Algermissen, Peter Nürnberg, Markus Schuelk. Analysis of mitochondrial DNA in discordant monozygotic twins with neurofibromatosis type 1. Twin research and human genetics : the official journal of the International Society for Twin Studies. vol 10. issue 3. 2007-08-21. PMID:17564507. |
mtdna was extracted from nucleated blood cells of four pairs of discordant mz twins with nf1 and from cutaneous neurofibromas of one twin pair. |
2007-08-21 |
2023-08-12 |
Not clear |
| Maria Teresa Fadda, Sandra S Giustini, Giuseppe G Verdino, Davina D Bartoli, Maria Cristina Mustazza, Giorgio G Iannetti, Stefano S Calvier. Role of maxillofacial surgery in patients with neurofibromatosis type I. The Journal of craniofacial surgery. vol 18. issue 3. 2007-08-09. PMID:17538307. |
role of maxillofacial surgery in patients with neurofibromatosis type i. neurofibromas are a clinical manifestation of neurofibromatos is type i (nf1). |
2007-08-09 |
2023-08-12 |
Not clear |
| George Q Perrin, Lauren Fishbein, Susanne A Thomson, Stacey L Thomas, Karen Stephens, James Y Garbern, George H DeVries, Anthony T Yachnis, Margaret R Wallace, David Mui. Plexiform-like neurofibromas develop in the mouse by intraneural xenograft of an NF1 tumor-derived Schwann cell line. Journal of neuroscience research. vol 85. issue 6. 2007-07-18. PMID:17335073. |
plexiform-like neurofibromas develop in the mouse by intraneural xenograft of an nf1 tumor-derived schwann cell line. |
2007-07-18 |
2023-08-12 |
mouse |
| George Q Perrin, Lauren Fishbein, Susanne A Thomson, Stacey L Thomas, Karen Stephens, James Y Garbern, George H DeVries, Anthony T Yachnis, Margaret R Wallace, David Mui. Plexiform-like neurofibromas develop in the mouse by intraneural xenograft of an NF1 tumor-derived Schwann cell line. Journal of neuroscience research. vol 85. issue 6. 2007-07-18. PMID:17335073. |
we report a practical and reproducible animal model of plexiform-like neurofibroma by xenograft of an immortal human nf1 tumor-derived schwann cell line into the peripheral nerve of scid mice. |
2007-07-18 |
2023-08-12 |
mouse |
| Stefano Trovarelli, Valeria Tallis, Sergio Tripodi, Clelia Miracco, Roberto Ponchiett. [Extratesticular intraescrotal neurofibroma: case report]. Archivos espanoles de urologia. vol 59. issue 9. 2007-04-26. PMID:17190215. |
we report a rare case of intrascrotal neurofibroma in an adult patient not affected by neurofibromatosis (nf1). |
2007-04-26 |
2023-08-12 |
Not clear |
| Pascale Lévy, Hugues Ripoche, Ingrid Laurendeau, Vladimir Lazar, Nicolas Ortonne, Béatrice Parfait, Karen Leroy, Janine Wechsler, Isabelle Salmon, Pierre Wolkenstein, Philippe Dessen, Michel Vidaud, Dominique Vidaud, Ivan Bièch. Microarray-based identification of tenascin C and tenascin XB, genes possibly involved in tumorigenesis associated with neurofibromatosis type 1. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 13. issue 2 Pt 1. 2007-04-24. PMID:17202312. |
the hallmark of nf1 is the onset of heterogeneous (dermal or plexiform) benign neurofibromas. |
2007-04-24 |
2023-08-12 |
Not clear |
| Todd D Nebesio, Wenyu Ming, Shi Chen, Travis Clegg, Jin Yuan, Yanzhu Yang, Selina A Estwick, Yan Li, Xiaohong Li, Cynthia M Hingtgen, Feng-Chun Yan. Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy. Glia. vol 55. issue 5. 2007-03-20. PMID:17236191. |
neurofibromas are the clinical hallmark of neurofibromatosis type 1 (nf1), a genetic disorder caused by mutations of the nf1 tumor suppressor gene, which encodes neurofibromin that functions as a gtpase activating protein (gap) for ras. |
2007-03-20 |
2023-08-12 |
Not clear |
| Todd D Nebesio, Wenyu Ming, Shi Chen, Travis Clegg, Jin Yuan, Yanzhu Yang, Selina A Estwick, Yan Li, Xiaohong Li, Cynthia M Hingtgen, Feng-Chun Yan. Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy. Glia. vol 55. issue 5. 2007-03-20. PMID:17236191. |
as lpa modulates excessive cell survival and motility of nf1-/- scs, which are the tumorigenic cells in nf1, targeting pi3-k may be a potential therapeutic approach in diminishing the development and progression of neurofibromas in pregnant women with nf1. |
2007-03-20 |
2023-08-12 |
Not clear |
| M Upadhyaya, S M Huson, M Davies, N Thomas, N Chuzhanova, S Giovannini, D G Evans, E Howard, B Kerr, S Griffiths, C Consoli, L Side, D Adams, M Pierpont, R Hachen, A Barnicoat, H Li, P Wallace, J P Van Biervliet, D Stevenson, D Viskochil, D Baralle, E Haan, V Riccardi, P Turnpenny, C Lazaro, L Messiae. An absence of cutaneous neurofibromas associated with a 3-bp inframe deletion in exon 17 of the NF1 gene (c.2970-2972 delAAT): evidence of a clinically significant NF1 genotype-phenotype correlation. American journal of human genetics. vol 80. issue 1. 2007-02-12. PMID:17160901. |
an absence of cutaneous neurofibromas associated with a 3-bp inframe deletion in exon 17 of the nf1 gene (c.2970-2972 delaat): evidence of a clinically significant nf1 genotype-phenotype correlation. |
2007-02-12 |
2023-08-12 |
human |
| M Upadhyaya, S M Huson, M Davies, N Thomas, N Chuzhanova, S Giovannini, D G Evans, E Howard, B Kerr, S Griffiths, C Consoli, L Side, D Adams, M Pierpont, R Hachen, A Barnicoat, H Li, P Wallace, J P Van Biervliet, D Stevenson, D Viskochil, D Baralle, E Haan, V Riccardi, P Turnpenny, C Lazaro, L Messiae. An absence of cutaneous neurofibromas associated with a 3-bp inframe deletion in exon 17 of the NF1 gene (c.2970-2972 delAAT): evidence of a clinically significant NF1 genotype-phenotype correlation. American journal of human genetics. vol 80. issue 1. 2007-02-12. PMID:17160901. |
neurofibromatosis type 1 (nf1) is characterized by cafe-au-lait spots, skinfold freckling, and cutaneous neurofibromas. |
2007-02-12 |
2023-08-12 |
human |
| M Upadhyaya, S M Huson, M Davies, N Thomas, N Chuzhanova, S Giovannini, D G Evans, E Howard, B Kerr, S Griffiths, C Consoli, L Side, D Adams, M Pierpont, R Hachen, A Barnicoat, H Li, P Wallace, J P Van Biervliet, D Stevenson, D Viskochil, D Baralle, E Haan, V Riccardi, P Turnpenny, C Lazaro, L Messiae. An absence of cutaneous neurofibromas associated with a 3-bp inframe deletion in exon 17 of the NF1 gene (c.2970-2972 delAAT): evidence of a clinically significant NF1 genotype-phenotype correlation. American journal of human genetics. vol 80. issue 1. 2007-02-12. PMID:17160901. |
we identified 21 unrelated probands with nf1 (14 familial and 7 sporadic cases) who were all found to have the same c.2970-2972 delaat (p.990delm) mutation but no cutaneous neurofibromas or clinically obvious plexiform neurofibromas. |
2007-02-12 |
2023-08-12 |
human |
| William Lavery, Veronica Hall, James C Yager, Alex Rottgers, Michelle C Wells, Michael Ster. Phosphatidylinositol 3-kinase and Akt nonautonomously promote perineurial glial growth in Drosophila peripheral nerves. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 2. 2007-02-02. PMID:17215387. |
growth and proliferation within mammalian peripheral nerves are increased by ras pathway activation: loss-of-function mutations in nf1, which encodes the ras inhibitor neurofibromin, cause the human genetic disorder neurofibromatosis, which is characterized by formation of neurofibromas (tumors of peripheral nerves). |
2007-02-02 |
2023-08-12 |
human |
| Thomas de Raedt, Jan Cools, Maria Debiec-Rychter, Hilde Brems, Nicole Mentens, Raf Sciot, Jacques Himpens, Ivo de Wever, Patrick Schöffski, Peter Marynen, Eric Legiu. Intestinal neurofibromatosis is a subtype of familial GIST and results from a dominant activating mutation in PDGFRA. Gastroenterology. vol 131. issue 6. 2007-01-30. PMID:17087943. |
patients present with neurofibromas limited to the intestine in the absence of any other typical features of nf1 and nf2. |
2007-01-30 |
2023-08-12 |
Not clear |
| Zrinjka Pastar, Jasna Lipozencić, Dragomir Budimcić, Mirna Tomljanović-Veselsk. Neurofibromatosis--review of the literature and case report. Acta dermatovenerologica Croatica : ADC. vol 14. issue 3. 2007-01-19. PMID:17010267. |
all patients showed neurofibromas accompanied by fibromas, café au lait spots, cases showed five axillary freckling (lentigines) and one case showed five plexiform neurofibromas and pruritus belonging to nf1 category. |
2007-01-19 |
2023-08-12 |
Not clear |
| M Lammert, J M Friedman, H J Roth, R E Friedrich, L Kluwe, D Atkins, T Schooler, V-F Mautne. Vitamin D deficiency associated with number of neurofibromas in neurofibromatosis 1. Journal of medical genetics. vol 43. issue 10. 2006-12-04. PMID:16571643. |
we measured serum 25-hydroxyvitamin d concentrations in 55 patients with nf1 and 58 healthy controls, and correlated the findings in the patients with nf1 with their estimated number of dermal neurofibromas. |
2006-12-04 |
2023-08-12 |
Not clear |
| M Lammert, J M Friedman, H J Roth, R E Friedrich, L Kluwe, D Atkins, T Schooler, V-F Mautne. Vitamin D deficiency associated with number of neurofibromas in neurofibromatosis 1. Journal of medical genetics. vol 43. issue 10. 2006-12-04. PMID:16571643. |
the serum vitamin d concentration and number of dermal neurofibromas reported by patients with nf1 were inversely correlated (spearman's rho = -0.572, p<0.00001). |
2006-12-04 |
2023-08-12 |
Not clear |
| Feng-Chun Yang, Shi Chen, Travis Clegg, Xiaohong Li, Trent Morgan, Selina A Estwick, Jin Yuan, Waleed Khalaf, Sarah Burgin, Jeff Travers, Luis F Parada, David A Ingram, D Wade Clap. Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling. Human molecular genetics. vol 15. issue 16. 2006-11-13. PMID:16835260. |
neurofibromas are common tumors found in neurofibromatosis type 1 (nf1) patients. |
2006-11-13 |
2023-08-12 |
human |
| Patricia Z Page, Grier P Page, Emmanuel Ecosse, Bruce R Korf, Alain Leplege, Pierre Wolkenstei. Impact of neurofibromatosis 1 on Quality of Life: a cross-sectional study of 176 American cases. American journal of medical genetics. Part A. vol 140. issue 18. 2006-10-24. PMID:16906549. |
neurofibromatosis 1 (nf1), a genetic condition most commonly characterized by the presence of dermal neurofibromas and café au lait macules, has a significant impact on quality of life (qol). |
2006-10-24 |
2023-08-12 |
human |
| Ming-Jen Lee, Yi-Ning Su, Huey-Ling You, Shinn-Chong Chiou, Li-Chu Lin, Chih-Chao Yang, Wang-Chao Lee, Wu-Liang Hwu, Fon-Jou Hsieh, Dennis A Stephenson, Chia-Li Y. Identification of forty-five novel and twenty-three known NF1 mutations in Chinese patients with neurofibromatosis type 1. Human mutation. vol 27. issue 8. 2006-10-16. PMID:16835897. |
neurofibromatosis type 1 (nf1), characterized by skin neurofibromas and an excess of café-au-lait spots, is due to mutations in the neurofibromin (nf1) gene. |
2006-10-16 |
2023-08-12 |
Not clear |