| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gaetano Magro, Paolo Amico, Giada Maria Vecchio, Rosario Caltabiano, Marine Castaing, Denisa Kacerovska, Dmitry V Kazakov, Michal Micha. Multinucleated floret-like giant cells in sporadic and NF1-associated neurofibromas: a clinicopathologic study of 94 cases. Virchows Archiv : an international journal of pathology. vol 456. issue 1. 2010-02-04. PMID:19937344. |
our clinicopathologic findings suggest that mnfgcs in an otherwise typical neurofibroma are not a reliable marker of nf1, likely representing a morphological reactive change of the indigenous dermal or endoneurial fibroblasts or dendritic cells in response to unknown microenvironmental stimuli. |
2010-02-04 |
2023-08-12 |
Not clear |
| Simona Parrinello, Alison C Lloy. Neurofibroma development in NF1--insights into tumour initiation. Trends in cell biology. vol 19. issue 8. 2009-12-22. PMID:19615906. |
neurofibroma development in nf1--insights into tumour initiation. |
2009-12-22 |
2023-08-12 |
mouse |
| A Coulon, S Milin, E Laban, C Debiais, C Jamet, J-M Goujo. [Pathologic characteristics of the most frequent peripheral nerve tumors]. Neuro-Chirurgie. vol 55. issue 4-5. 2009-12-03. PMID:19744677. |
neurofibromas are most often associated with neurofibromatosis nf1 and may be localized, diffuse, or plexiform. |
2009-12-03 |
2023-08-12 |
Not clear |
| Daniela Cabibi, Monica Zerilli, Giuseppe Caradonna, Loredana Schillaci, Beatrice Belmonte, Vito Rodolic. Diagnostic and prognostic value of CD10 in peripheral nerve sheath tumors. Anticancer research. vol 29. issue 8. 2009-09-30. PMID:19661328. |
neurofibromas are sporadic or associated with type 1 neurofibromatosis (nf1), with a higher risk of malignant progression. |
2009-09-30 |
2023-08-12 |
Not clear |
| G Spurlock, E Bennett, N Chuzhanova, N Thomas, H-Ping Jim, L Side, S Davies, E Haan, B Kerr, S M Huson, M Upadhyay. SPRED1 mutations (Legius syndrome): another clinically useful genotype for dissecting the neurofibromatosis type 1 phenotype. Journal of medical genetics. vol 46. issue 7. 2009-09-23. PMID:19443465. |
mutations of the spred1 gene, one of a family of sprouty (spry)/spred proteins known to "downregulate" mitogen activated protein kinase (mapk) signalling, have been identified in patients with a mild neurofibromatosis type 1 (nf1) phenotype with pigmentary changes but no neurofibromas (legius syndrome).to ascertain the frequency of spred1 mutations as a cause of this phenotype and to investigate whether other spred/spry genes may be causal, a panel of unrelated mild nf1 patients were screened for mutations of the spred1-3 and the spry1-4 genes. |
2009-09-23 |
2023-08-12 |
Not clear |
| Meena Upadhyaya, Gill Spurlock, Lan Kluwe, Nadia Chuzhanova, Emma Bennett, Nick Thomas, Abhijit Guha, Victor Mautne. The spectrum of somatic and germline NF1 mutations in NF1 patients with spinal neurofibromas. Neurogenetics. vol 10. issue 3. 2009-09-16. PMID:19221814. |
the spectrum of somatic and germline nf1 mutations in nf1 patients with spinal neurofibromas. |
2009-09-16 |
2023-08-12 |
Not clear |
| Meena Upadhyaya, Gill Spurlock, Lan Kluwe, Nadia Chuzhanova, Emma Bennett, Nick Thomas, Abhijit Guha, Victor Mautne. The spectrum of somatic and germline NF1 mutations in NF1 patients with spinal neurofibromas. Neurogenetics. vol 10. issue 3. 2009-09-16. PMID:19221814. |
we have studied 22 spinal neurofibromas derived from 14 unrelated nf1 patients. |
2009-09-16 |
2023-08-12 |
Not clear |
| Meena Upadhyaya, Gill Spurlock, Lan Kluwe, Nadia Chuzhanova, Emma Bennett, Nick Thomas, Abhijit Guha, Victor Mautne. The spectrum of somatic and germline NF1 mutations in NF1 patients with spinal neurofibromas. Neurogenetics. vol 10. issue 3. 2009-09-16. PMID:19221814. |
this is the first study to describe nf1 somatic mutations in spinal neurofibromas. |
2009-09-16 |
2023-08-12 |
Not clear |
| Lu Q Le, Tracey Shipman, Dennis K Burns, Luis F Parad. Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas. Cell stem cell. vol 4. issue 5. 2009-08-20. PMID:19427294. |
development of malignant nerve tumors and neurofibromas occurs frequently in nf1. |
2009-08-20 |
2023-08-12 |
Not clear |
| Lu Q Le, Tracey Shipman, Dennis K Burns, Luis F Parad. Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas. Cell stem cell. vol 4. issue 5. 2009-08-20. PMID:19427294. |
in this study, we identify a population of stem/progenitor cells residing in the dermis termed skin-derived precursors (skps) that, through loss of nf1, form neurofibromas. |
2009-08-20 |
2023-08-12 |
Not clear |
| Christian Thiel, Martin Wilken, Martin Zenker, Heinrich Sticht, Raimund Fahsold, Gabriele-Charlotte Gusek-Schneider, Anita Rauc. Independent NF1 and PTPN11 mutations in a family with neurofibromatosis-Noonan syndrome. American journal of medical genetics. Part A. vol 149A. issue 6. 2009-07-30. PMID:19449407. |
contrarily, absence of both cutaneous neurofibromas and ns features in her relatives with the same nf1 mutation, suggests that the index patient's typical nfns phenotype is caused by an additive effect of mutations in both nf1 and ptpn11. |
2009-07-30 |
2023-08-12 |
Not clear |
| B Bartelt-Kirbach, M Wuepping, M Dodrimont-Lattke, D Kaufman. Expression analysis of genes lying in the NF1 microdeletion interval points to four candidate modifiers for neurofibroma formation. Neurogenetics. vol 10. issue 1. 2009-07-13. PMID:18850118. |
expression analysis of genes lying in the nf1 microdeletion interval points to four candidate modifiers for neurofibroma formation. |
2009-07-13 |
2023-08-12 |
Not clear |
| B Bartelt-Kirbach, M Wuepping, M Dodrimont-Lattke, D Kaufman. Expression analysis of genes lying in the NF1 microdeletion interval points to four candidate modifiers for neurofibroma formation. Neurogenetics. vol 10. issue 1. 2009-07-13. PMID:18850118. |
the hallmark of neurofibromatosis type 1 (nf1) are multiple dermal neurofibromas. |
2009-07-13 |
2023-08-12 |
Not clear |
| B Bartelt-Kirbach, M Wuepping, M Dodrimont-Lattke, D Kaufman. Expression analysis of genes lying in the NF1 microdeletion interval points to four candidate modifiers for neurofibroma formation. Neurogenetics. vol 10. issue 1. 2009-07-13. PMID:18850118. |
nf1 patients presenting microdeletions spanning nf1 and several contiguous genes have an earlier onset and higher number of dermal neurofibromas than classical nf1 patients, pointing to one of the deleted genes as modifier. |
2009-07-13 |
2023-08-12 |
Not clear |
| Yllka Kodra, Sandra Giustini, Luigina Divona, Roberto Porciello, Stefano Calvieri, Pierre Wolkenstein, Domenica Tarusci. Health-related quality of life in patients with neurofibromatosis type 1. A survey of 129 Italian patients. Dermatology (Basel, Switzerland). vol 218. issue 3. 2009-06-17. PMID:19088462. |
neurofibromatosis type 1 (nf1), a genetic condition most commonly characterized by the presence of dermal neurofibromas and café au lait macules, has a significant impact upon quality of life (qol). |
2009-06-17 |
2023-08-12 |
Not clear |
| Irene Bottillo, Terje Ahlquist, Helge Brekke, Stine A Danielsen, Eva van den Berg, Fredrik Mertens, Ragnhild A Lothe, Bruno Dallapiccol. Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours. The Journal of pathology. vol 217. issue 5. 2009-05-26. PMID:19142971. |
in addition, dna from peripheral blood and cutaneous neurofibroma biopsies from, respectively, 14/25 and 7/25 of the nf1 patients were analysed. |
2009-05-26 |
2023-08-12 |
Not clear |
| Joanna A Gibson, Jason L Hornic. Mucosal Schwann cell "hamartoma": clinicopathologic study of 26 neural colorectal polyps distinct from neurofibromas and mucosal neuromas. The American journal of surgical pathology. vol 33. issue 5. 2009-05-07. PMID:19065103. |
the aim of this study was to evaluate the clinicopathologic and immunohistochemical features of these lesions, in comparison to colorectal neurofibromas from known nf1 patients. |
2009-05-07 |
2023-08-12 |
Not clear |
| Joanna A Gibson, Jason L Hornic. Mucosal Schwann cell "hamartoma": clinicopathologic study of 26 neural colorectal polyps distinct from neurofibromas and mucosal neuromas. The American journal of surgical pathology. vol 33. issue 5. 2009-05-07. PMID:19065103. |
the findings were compared with those in mucosal biopsies of 5 submucosal neurofibromas from nf1 patients. |
2009-05-07 |
2023-08-12 |
Not clear |
| Sushma Kashinath Gabhane, Mrunamayi Nishikant Kotwal, Sudhakar K Bobhat. Morphological spectrum of peripheral nerve sheath tumors: a series of 126 cases. Indian journal of pathology & microbiology. vol 52. issue 1. 2009-03-12. PMID:19136775. |
a malignant transformation in pre-existing neurofibroma was seen in 1 patient with nf1. |
2009-03-12 |
2023-08-12 |
Not clear |
| Katharina Steinmann, Lan Kluwe, Reinhard E Friedrich, Victor-Felix Mautner, David N Cooper, Hildegard Kehrer-Sawatzk. Mechanisms of loss of heterozygosity in neurofibromatosis type 1-associated plexiform neurofibromas. The Journal of investigative dermatology. vol 129. issue 3. 2009-03-11. PMID:18800150. |
plexiform neurofibromas constitute a serious burden for patients with neurofibromatosis type 1 (nf1), a common autosomal dominant disorder characterized by pigmentary changes and tumorous skin lesions (neurofibromas). |
2009-03-11 |
2023-08-12 |
Not clear |