| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rodica Trăistaru, Otilia Rogoveanu, Roxana Popescu, Viorela Enăchescu, Mirela Ghiluş. Periarticular diffuse neurofibroma of the upper limb. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 52. issue 4. 2012-04-23. PMID:22203949. |
in this report, we presented an adult patient, without nf1 diagnosed, who developed invalidate status of left upper limb due to a giant diffuse neurofibroma involving the left brachial plexus, with a high growth diffuse pattern and plexiform architecture imagistic, grossly and without results at both surgical interventions. |
2012-04-23 |
2023-08-12 |
Not clear |
| Eline Beert, Hilde Brems, Bruno Daniëls, Ivo De Wever, Frank Van Calenbergh, Joseph Schoenaers, Maria Debiec-Rychter, Olivier Gevaert, Thomas De Raedt, Annick Van Den Bruel, Thomy de Ravel, Karen Cichowski, Lan Kluwe, Victor Mautner, Raf Sciot, Eric Legiu. Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors. Genes, chromosomes & cancer. vol 50. issue 12. 2012-04-13. PMID:21987445. |
little is known about the origin and nature of atypical neurofibromas in nf1 patients. |
2012-04-13 |
2023-08-12 |
Not clear |
| Eline Beert, Hilde Brems, Bruno Daniëls, Ivo De Wever, Frank Van Calenbergh, Joseph Schoenaers, Maria Debiec-Rychter, Olivier Gevaert, Thomas De Raedt, Annick Van Den Bruel, Thomy de Ravel, Karen Cichowski, Lan Kluwe, Victor Mautner, Raf Sciot, Eric Legiu. Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors. Genes, chromosomes & cancer. vol 50. issue 12. 2012-04-13. PMID:21987445. |
in this study, we classified the atypical neurofibromas in the spectrum of nf1-associated pnsts by analyzing 65 tumor samples from 48 nf1 patients. |
2012-04-13 |
2023-08-12 |
Not clear |
| Jianqiang Wu, Eva Dombi, Edwin Jousma, R Scott Dunn, Diana Lindquist, Beverly M Schnell, Mi-Ok Kim, Aerang Kim, Brigitte C Widemann, Timothy P Cripe, Nancy Ratne. Preclincial testing of sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging. Pediatric blood & cancer. vol 58. issue 2. 2012-01-31. PMID:21319287. |
neurofibromatosis type 1 (nf1) is an inherited disease predisposing affected patients to variable numbers of benign neurofibromas. |
2012-01-31 |
2023-08-12 |
mouse |
| I Demarchi, G Genoni, F Prodam, A Petri, A Busti, L Cortese, M Negro, S Bellone, G Acucella, G Bon. [Neurofibromatosis type 1 and hypertension in pediatrics: case report]. Minerva pediatrica. vol 63. issue 4. 2012-01-12. PMID:21909069. |
neurofibromatosis type 1 (nf1) is an autosomal dominant disorder characterized by cafe-au-lait spots, axillary and inguinal freckling, cutaneous neurofibromas with a variable clinical expression, iris lisch nodules, and multiple tumors, in particular optic nerve and other central nervous system gliomas. |
2012-01-12 |
2023-08-12 |
Not clear |
| Carles Garcia-Linares, Juana Fernández-Rodríguez, Ernest Terribas, Jaume Mercadé, Eva Pros, Llúcia Benito, Yolanda Benavente, Gabriel Capellà, Anna Ravella, Ignacio Blanco, Hildegard Kehrer-Sawatzki, Conxi Lázaro, Eduard Serr. Dissecting loss of heterozygosity (LOH) in neurofibromatosis type 1-associated neurofibromas: Importance of copy neutral LOH. Human mutation. vol 32. issue 1. 2011-12-19. PMID:21031597. |
dermal neurofibromas (dnfs) are benign tumors of the peripheral nervous system typically associated with neurofibromatosis type 1 (nf1) patients. |
2011-12-19 |
2023-08-12 |
Not clear |
| Carles Garcia-Linares, Juana Fernández-Rodríguez, Ernest Terribas, Jaume Mercadé, Eva Pros, Llúcia Benito, Yolanda Benavente, Gabriel Capellà, Anna Ravella, Ignacio Blanco, Hildegard Kehrer-Sawatzki, Conxi Lázaro, Eduard Serr. Dissecting loss of heterozygosity (LOH) in neurofibromatosis type 1-associated neurofibromas: Importance of copy neutral LOH. Human mutation. vol 32. issue 1. 2011-12-19. PMID:21031597. |
genes controlling the integrity of the dna are likely to influence the number of neurofibromas developed because dnfs are caused by somatic mutational inactivation of the nf1 gene, frequently evidenced by loss of heterozygosity (loh). |
2011-12-19 |
2023-08-12 |
Not clear |
| Antonio Pizzuti, Irene Bottillo, Francesca Inzana, Valentina Lanari, Francesca Buttarelli, Isabella Torrente, Anna Teresa Giallonardo, Alessandro De Luca, Bruno Dallapiccol. Familial spinal neurofibromatosis due to a multiexonic NF1 gene deletion. Neurogenetics. vol 12. issue 3. 2011-12-19. PMID:21365283. |
we report the detailed clinical presentation and molecular features of a spinal neurofibromatosis familial case where a 40-year-old woman, presenting with multiple bilateral spinal neurofibromas and no other clinical feature of neurofibromatosis type 1 (nf1), inherited a paternal large multiexonic deletion (c.5944-?_7126+?del) which resulted in nf1 gene haploinsufficiency at the rna level. |
2011-12-19 |
2023-08-12 |
Not clear |
| Tracy Tucker, Vincent M Riccardi, Carolyn Brown, John Fee, Margaret Sutcliffe, Juergen Vielkind, Janine Wechsler, Pierre Wolkenstein, Jan M Friedma. S100B and neurofibromin immunostaining and X-inactivation patterns of laser-microdissected cells indicate a multicellular origin of some NF1-associated neurofibromas. Journal of neuroscience research. vol 89. issue 9. 2011-12-05. PMID:21674567. |
neurofibromatosis 1 (nf1) is an autosomal dominant disease that predisposes individuals to developing benign neurofibromas. |
2011-12-05 |
2023-08-12 |
Not clear |
| Tracy Tucker, Vincent M Riccardi, Carolyn Brown, John Fee, Margaret Sutcliffe, Juergen Vielkind, Janine Wechsler, Pierre Wolkenstein, Jan M Friedma. S100B and neurofibromin immunostaining and X-inactivation patterns of laser-microdissected cells indicate a multicellular origin of some NF1-associated neurofibromas. Journal of neuroscience research. vol 89. issue 9. 2011-12-05. PMID:21674567. |
we showed that, although some neurofibromas include a subpopulation of s100b(+) /nfn(-) cells consistent with clonal expansion of a schwann cell progenitor that has lost function of both nf1 alleles, other neurofibromas do not show evidence of monoclonal proliferation of schwann cells. |
2011-12-05 |
2023-08-12 |
Not clear |
| Giovanni Ponti, Lorena Losi, Davide Martorana, Manuela Priola, Elisa Boni, Annamaria Pollio, Tauro Maria Neri, Stefania Seidenar. Clinico-pathological and biomolecular findings in Italian patients with multiple cutaneous neurofibromas. Hereditary cancer in clinical practice. vol 9. 2011-11-10. PMID:21838856. |
neurofibroma occurs as isolated or multiple lesions frequently associated with neurofibromatosis type 1 (nf1), a common autosomal dominant disorder affecting 1 in 3500 individuals. |
2011-11-10 |
2023-08-12 |
Not clear |
| Mauro Geller, Spyros G E Mezitis, Fabio Pereira Nunes, Marcia G Ribeiro, Alexandra Prufer de Q C Araújo, Marcello D Bronstein, Rodrigo Siqueira-Batista, Andréia Patrícia Gomes, Lisa Oliveira, Karin Soares Gonçalves Cunh. Progesterone and Estrogen Receptors in Neurofibromas of Patients with NF1. Clinical medicine. Pathology. vol 1. 2011-11-10. PMID:21876657. |
progesterone and estrogen receptors in neurofibromas of patients with nf1. |
2011-11-10 |
2023-08-12 |
Not clear |
| Mauro Geller, Spyros G E Mezitis, Fabio Pereira Nunes, Marcia G Ribeiro, Alexandra Prufer de Q C Araújo, Marcello D Bronstein, Rodrigo Siqueira-Batista, Andréia Patrícia Gomes, Lisa Oliveira, Karin Soares Gonçalves Cunh. Progesterone and Estrogen Receptors in Neurofibromas of Patients with NF1. Clinical medicine. Pathology. vol 1. 2011-11-10. PMID:21876657. |
one of the most remarkable characteristics of this disease is the development of benign tumors of the nervous system (neurofibromas).the purpose of this study was to test tissue samples taken from neurofibromas and plexiform neurofibromas of nf1 patients for the presence of estrogen and progesterone receptors. |
2011-11-10 |
2023-08-12 |
Not clear |
| Mauro Geller, Spyros G E Mezitis, Fabio Pereira Nunes, Marcia G Ribeiro, Alexandra Prufer de Q C Araújo, Marcello D Bronstein, Rodrigo Siqueira-Batista, Andréia Patrícia Gomes, Lisa Oliveira, Karin Soares Gonçalves Cunh. Progesterone and Estrogen Receptors in Neurofibromas of Patients with NF1. Clinical medicine. Pathology. vol 1. 2011-11-10. PMID:21876657. |
we suggest further studies to investigate in greater depth possible hormonal influences on the development and growth of neurofibromas and plexiform neurofibromas in nf1. |
2011-11-10 |
2023-08-12 |
Not clear |
| Eric Pasmant, Julien Masliah-Planchon, Pascale Lévy, Ingrid Laurendeau, Nicolas Ortonne, Béatrice Parfait, Laurence Valeyrie-Allanore, Karen Leroy, Pierre Wolkenstein, Michel Vidaud, Dominique Vidaud, Ivan Bièch. Identification of genes potentially involved in the increased risk of malignancy in NF1-microdeleted patients. Molecular medicine (Cambridge, Mass.). vol 17. issue 1-2. 2011-11-04. PMID:20844836. |
patients with nf1 microdeletion develop more neurofibromas at a younger age, and have an increased risk of malignant peripheral nerve sheath tumors (mpnsts). |
2011-11-04 |
2023-08-12 |
human |
| Debra A Mayes, Tilat A Rizvi, Jose A Cancelas, Nathan T Kolasinski, Georgianne M Ciraolo, Anat O Stemmer-Rachamimov, Nancy Ratne. Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation. Cancer research. vol 71. issue 13. 2011-09-29. PMID:21551249. |
perinatal or adult nf1 inactivation using tamoxifen-inducible plpcre each cause neurofibroma formation. |
2011-09-29 |
2023-08-12 |
mouse |
| Debra A Mayes, Tilat A Rizvi, Jose A Cancelas, Nathan T Kolasinski, Georgianne M Ciraolo, Anat O Stemmer-Rachamimov, Nancy Ratne. Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation. Cancer research. vol 71. issue 13. 2011-09-29. PMID:21551249. |
to understand whether neurofibroma formation is possible after birth, we induced nf1 loss of function with an inducible proteolipid protein cre allele. |
2011-09-29 |
2023-08-12 |
mouse |
| Lu Q Le, Chiachi Liu, Tracey Shipman, Zhiguo Chen, Ueli Suter, Luis F Parad. Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development. Cancer research. vol 71. issue 13. 2011-09-29. PMID:21551250. |
neurofibromas arise from the schwann cell lineage following loss of function at the nf1 locus, which initiates a cascade of interactions with other cell types in the microenvironment and additional cell autonomous modifications. |
2011-09-29 |
2023-08-12 |
Not clear |
| Lu Q Le, Chiachi Liu, Tracey Shipman, Zhiguo Chen, Ueli Suter, Luis F Parad. Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development. Cancer research. vol 71. issue 13. 2011-09-29. PMID:21551250. |
in this study, we sought to identify whether a temporal "window of opportunity" exists during which cells of the schwann cell lineage can give rise to neurofibromas following loss of nf1. |
2011-09-29 |
2023-08-12 |
Not clear |
| Lu Q Le, Chiachi Liu, Tracey Shipman, Zhiguo Chen, Ueli Suter, Luis F Parad. Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development. Cancer research. vol 71. issue 13. 2011-09-29. PMID:21551250. |
we showed that acute loss of nf1 in both embryonic and adult schwann cells can lead to neurofibroma formation. |
2011-09-29 |
2023-08-12 |
Not clear |