| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bhavpreet S Dham, Daniel M Kwa, Joseph V Campellon. Postpartum paraparesis from spinal neurofibroma. The spine journal : official journal of the North American Spine Society. vol 12. issue 7. 2013-04-15. PMID:22939192. |
although spinal neurofibromas occur in up to 40% of patients with nf1, they rarely cause neurologic sequelae, especially in the young. |
2013-04-15 |
2023-08-12 |
Not clear |
| Karl Staser, Feng-Chun Yang, D Wade Clap. Pathogenesis of plexiform neurofibroma: tumor-stromal/hematopoietic interactions in tumor progression. Annual review of pathology. vol 7. 2013-04-12. PMID:22077553. |
these observations parallel findings in other nf1 disease manifestations and are clearly relevant to medical management of these neurofibromas. |
2013-04-12 |
2023-08-12 |
mouse |
| Emilie Sbidian, Smaïl Hadj-Rabia, Vincent M Riccardi, Laurence L Valeyrie-Allanore, Sébastien Barbarot, Olivier Chosidow, Salah Ferkal, Diana Rodriguez, Pierre Wolkenstein, Sylvie Bastuji-Gari. Clinical characteristics predicting internal neurofibromas in 357 children with neurofibromatosis-1: results from a cross-selectional study. Orphanet journal of rare diseases. vol 7. 2013-04-10. PMID:22943186. |
to identify clinical characteristics associated with internal neurofibromas in children with nf1, as a means of ensuring the early identification of patients at high risk for malignant peripheral nerve-sheath tumors developed from preexisting internal neurofibromas. |
2013-04-10 |
2023-08-12 |
Not clear |
| Saeed Asgary, Neda Aminzade. Unilateral gingival enlargement in patient with neurofibromatosis type I. The New York state dental journal. vol 78. issue 6. 2013-04-10. PMID:23488326. |
gingival neurofibroma in nf1 is uncommon. |
2013-04-10 |
2023-08-12 |
Not clear |
| Saeed Asgary, Neda Aminzade. Unilateral gingival enlargement in patient with neurofibromatosis type I. The New York state dental journal. vol 78. issue 6. 2013-04-10. PMID:23488326. |
the purpose of this report is to present a case of nf1 with a unilateral gingival neurofibroma in the buccal attached gingiva of the lower left molars, along with a review of the literature. |
2013-04-10 |
2023-08-12 |
Not clear |
| Walter J Jessen, Shyra J Miller, Edwin Jousma, Jianqiang Wu, Tilat A Rizvi, Meghan E Brundage, David Eaves, Brigitte Widemann, Mi-Ok Kim, Eva Dombi, Jessica Sabo, Atira Hardiman Dudley, Michiko Niwa-Kawakita, Grier P Page, Marco Giovannini, Bruce J Aronow, Timothy P Cripe, Nancy Ratne. MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. The Journal of clinical investigation. vol 123. issue 1. 2013-03-11. PMID:23221341. |
neurofibromatosis type 1 (nf1) patients develop benign neurofibromas and malignant peripheral nerve sheath tumors (mpnst). |
2013-03-11 |
2023-08-12 |
mouse |
| Walter J Jessen, Shyra J Miller, Edwin Jousma, Jianqiang Wu, Tilat A Rizvi, Meghan E Brundage, David Eaves, Brigitte Widemann, Mi-Ok Kim, Eva Dombi, Jessica Sabo, Atira Hardiman Dudley, Michiko Niwa-Kawakita, Grier P Page, Marco Giovannini, Bruce J Aronow, Timothy P Cripe, Nancy Ratne. MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. The Journal of clinical investigation. vol 123. issue 1. 2013-03-11. PMID:23221341. |
we used a highly selective pharmacological inhibitor of mek, pd0325901, to test whether sustained ras/raf/mek/erk signaling contributes to neurofibroma growth in a neurofibromatosis mouse model (nf1(fl/fl);dhh-cre) or in nf1 patient mpnst cell xenografts. |
2013-03-11 |
2023-08-12 |
mouse |
| G Cavallaro, G Pedullà, D Crocetti, G D'Ermo, S Giustini, S Calvieri, G De Tom. Vacuum-assisted closure treatment of leg skin necrosis after angiographic embolization of a giant plexiform neurofibroma. Il Giornale di chirurgia. vol 33. issue 6-7. 2013-02-26. PMID:22958807. |
our case report is about the surgical management of a giant neurofibroma of the right gluteal fold in a 46-year-old male with nf1. |
2013-02-26 |
2023-08-12 |
Not clear |
| T El Khassawna, D Toben, M Kolanczyk, K Schmidt-Bleek, I Koennecke, H Schell, S Mundlos, G N Dud. Deterioration of fracture healing in the mouse model of NF1 long bone dysplasia. Bone. vol 51. issue 4. 2013-01-28. PMID:22868293. |
nf1 manifests as a heritable susceptibility to tumours of neural tissue mainly located in the skin (neurofibromas) and pigmented skin lesions. |
2013-01-28 |
2023-08-12 |
mouse |
| Tanja Mußotter, Lan Kluwe, Josef Högel, Rosa Nguyen, David N Cooper, Victor-Felix Mautner, Hildegard Kehrer-Sawatzk. Non-coding RNA ANRIL and the number of plexiform neurofibromas in patients with NF1 microdeletions. BMC medical genetics. vol 13. 2013-01-17. PMID:23101500. |
nf1 is characterised by tumours of the peripheral nerve sheaths, the pathognomonic neurofibromas. |
2013-01-17 |
2023-08-12 |
Not clear |
| Reinhard E Friedrich, Karim Gawad, Thorsten Derlin, Jozef Zustin, Christian Hage. Surgery for atypical plexiform neurofibromas of the trunk in NF1 with high standardised uptake value (SUV) in positron-emission tomography (PET) expressing podoplanin: a long-term follow-up. Anticancer research. vol 32. issue 10. 2013-01-14. PMID:23060584. |
current studies on atypical neurofibroma in nf1 suggest podoplanin expression in subtypes of transformed schwann cells, resembling schwannoma-like areas in neurofibroma. |
2013-01-14 |
2023-08-12 |
Not clear |
| Hildegard Kehrer-Sawatzki, Julia Vogt, Tanja Mußotter, Lan Kluwe, David N Cooper, Victor-Felix Mautne. Dissecting the clinical phenotype associated with mosaic type-2 NF1 microdeletions. Neurogenetics. vol 13. issue 3. 2013-01-11. PMID:22581253. |
by contrast, a previous study indicated a high burden of cutaneous neurofibromas (n > 1,000) in 50% of adult patients with germline type-1 nf1 deletions. |
2013-01-11 |
2023-08-12 |
Not clear |
| H-X Tong, M Li, Y Zhang, J Zhu, W-Q L. A novel NF1 mutation in a Chinese patient with giant café-au-lait macule in neurofibromatosis type 1 associated with a malignant peripheral nerve sheath tumor and bone abnormality. Genetics and molecular research : GMR. vol 11. issue 3. 2013-01-08. PMID:22869071. |
neurofibromatosis type 1 (nf1; omim#162200) is a common neurocutaneous disorder that is characterized by multiple café-au-lait, skinfold freckling, lisch nodules, and neurofibromas. |
2013-01-08 |
2023-08-12 |
Not clear |
| Deanna M Patmore, Sara Welch, Patricia C Fulkerson, Jianqiang Wu, Kwangmin Choi, David Eaves, Jennifer J Kordich, Margaret H Collins, Timothy P Cripe, Nancy Ratne. In vivo regulation of TGF-β by R-Ras2 revealed through loss of the RasGAP protein NF1. Cancer research. vol 72. issue 20. 2012-12-26. PMID:22918885. |
as a general approach to this question, we activated all ras proteins in vivo by genetic deletion of the rasgap protein nf1 and examined mice doubly deficient in a ras protein to determine its requirement in formation of tgf-β-dependent neurofibromas that arise in nf1-deficient mice. |
2012-12-26 |
2023-08-12 |
mouse |
| Deanna M Patmore, Sara Welch, Patricia C Fulkerson, Jianqiang Wu, Kwangmin Choi, David Eaves, Jennifer J Kordich, Margaret H Collins, Timothy P Cripe, Nancy Ratne. In vivo regulation of TGF-β by R-Ras2 revealed through loss of the RasGAP protein NF1. Cancer research. vol 72. issue 20. 2012-12-26. PMID:22918885. |
animals lacking nf1 and the ras-related protein r-ras2/tc21 displayed a delay in formation of neurofibromas but an acceleration in formation of brain tumors and sarcomas. |
2012-12-26 |
2023-08-12 |
mouse |
| Christian Hagel, Timo Behrens, Peter Prehm, Claudia Schnabel, Markus Glatzel, Reinhard E Friedric. Hyaluronan in intra-operative edema of NF1-associated neurofibromas. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 32. issue 4. 2012-11-20. PMID:22129111. |
the tumor suppressor disorder neurofibromatosis type 1 (nf1) is associated with development of multiple neurofibromas which may grow intraneurally as plexiform neurofibromas (pnf) or intracutaneously (cnf). |
2012-11-20 |
2023-08-12 |
Not clear |
| Ignacio Pascual-Castroviejo, Samuel-Ignacio Pascual-Pascual, Juan Viaño, Ramón Velazquez-Fragua, Juan-Carlos López-Gutierre. Bilateral spinal neurofibromas in patients with neurofibromatosis 1. Brain & development. vol 34. issue 7. 2012-11-08. PMID:21999966. |
this presentation appears to be earlier than in familial spinal neurofibromas in nf1 (fsnf1). |
2012-11-08 |
2023-08-12 |
Not clear |
| Ignacio Pascual-Castroviejo, Samuel-Ignacio Pascual-Pascual, Juan Viaño, Ramón Velazquez-Fragua, Juan-Carlos López-Gutierre. Bilateral spinal neurofibromas in patients with neurofibromatosis 1. Brain & development. vol 34. issue 7. 2012-11-08. PMID:21999966. |
bilateral spinal neurofibromas are found in both patients who inherited the nf1 and in those due to de novo mutations. |
2012-11-08 |
2023-08-12 |
Not clear |
| Ole Kjærulff, Hans Wandal. [Neurofibromatosis 1: pathogenesis and therapeutic strategies--a systematic review]. Ugeskrift for laeger. vol 174. issue 10. 2012-10-22. PMID:22395013. |
neurofibromatosis 1 (nf1, von recklinghausen's disease) is a dominantly inherited multi-organ disease defined primarily by café au lait patches and neurofibromas. |
2012-10-22 |
2023-08-12 |
Not clear |
| Su-Jin Lee, Ho-Jin Park, Young-Hwa Kim, Bo-Young Kim, Hyun-Seok Jin, Hyon J Kim, Jae-Ho Han, Hyunee Yim, Seon-Yong Jeon. Inhibition of Bcl-xL by ABT-737 enhances chemotherapy sensitivity in neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor cells. International journal of molecular medicine. vol 30. issue 2. 2012-10-19. PMID:22664653. |
downregulation of the nf1 gene by rna interference (rnai) induced an increase in bcl-xl expression and a decrease in its sensitivity to apoptosis in the benign neurofibroma cell line and primary normal cells. |
2012-10-19 |
2023-08-12 |
Not clear |