| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gwyn T Williams, Jane P Hughes, Victoria Stoneman, Claire L Anderson, Nicola J McCarthy, Mirna Mourtada-Maarabouni, Mark Pickard, Vanessa L Hedge, Ian Trayner, Farzin Farzane. Isolation of genes controlling apoptosis through their effects on cell survival. Gene therapy & molecular biology. vol 10. issue B. 2020-09-30. PMID:17372619. |
we have applied forward genetics approaches to the identification of the critical genes involved in the control of apoptosis in mammalian cells, since defective control of apoptosis underlies many diseases, including cancer and neurodegenerative diseases. |
2020-09-30 |
2023-08-12 |
Not clear |
| Zili He, Yulong Zhou, Yan Huang, Qingqing Wang, Binbin Zheng, Hongyu Zhang, Jiawei Li, Yanlong Liu, Fenzan Wu, Xie Zhang, Songlin Tong, Maofeng Wang, Zhouguang Wang, Huacheng He, Huazi Xu, Jian Xia. Dl-3-n-butylphthalide improves functional recovery in rats with spinal cord injury by inhibiting endoplasmic reticulum stress-induced apoptosis. American journal of translational research. vol 9. issue 3. 2020-09-30. PMID:28386335. |
dl-3-n-butylphthalide (nbp) exerts an neuroprotective effects against both ischemic brain injury and neurodegenerative diseases; however, the relationship between er stress-induced apoptosis and the therapeutic effect of nbp in sci remains unclear. |
2020-09-30 |
2023-08-13 |
rat |
| Larissa Takser, Nora Benachour, Barry Husk, Hubert Cabana, Denis Gri. Cyanotoxins at low doses induce apoptosis and inflammatory effects in murine brain cells: Potential implications for neurodegenerative diseases. Toxicology reports. vol 3. 2020-09-30. PMID:28959538. |
cyanotoxins at low doses induce apoptosis and inflammatory effects in murine brain cells: potential implications for neurodegenerative diseases. |
2020-09-30 |
2023-08-13 |
Not clear |
| Giorgia Manzo, Ilaria Serra, Andrea Magrí, Mariano Casu, Vito De Pinto, Matteo Ceccarelli, Mariano Andrea Scorciapin. Folded Structure and Membrane Affinity of the N-Terminal Domain of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion-Selective Channel. ACS omega. vol 3. issue 9. 2020-09-30. PMID:30320261. |
in particular, their role in energy-related nucleotide exchange has many implications in apoptosis, cancer, and neurodegenerative diseases. |
2020-09-30 |
2023-08-13 |
human |
| Kyoungjoo Ch. Emerging Roles of Complement Protein C1q in Neurodegeneration. Aging and disease. vol 10. issue 3. 2020-09-30. PMID:31165008. |
because c1q participates in the clearance of pathogens, its interaction with novel receptors is expected to facilitate apoptosis induction, which could prevent the onset or progression of neurodegenerative diseases and could delay the aging process. |
2020-09-30 |
2023-08-13 |
Not clear |
| Muhammad Ayaz, Abdul Sadiq, Muhammad Junaid, Farhat Ullah, Muhammad Ovais, Ikram Ullah, Jawad Ahmed, Muhammad Shahi. Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders. Frontiers in aging neuroscience. vol 11. 2020-09-30. PMID:31293414. |
flavonoids also hamper the progression of pathological symptoms of neurodegenerative diseases by inhibiting neuronal apoptosis induced by neurotoxic substances including free radicals and β-amyloid proteins (aβ). |
2020-09-30 |
2023-08-13 |
Not clear |
| Quan Li, Bai-Ling Wang, Fu-Rong Sun, Jie-Qiong Li, Xi-Peng Cao, Lan Ta. The role of Annals of translational medicine. vol 6. issue 10. 2020-09-29. PMID:29951500. |
the role of alzheimer's disease (ad) is a chronic progressive neurodegenerative disease in adults characterized by the deposition of extracellular plaques of β-amyloid protein (aβ), intracellular neurofibrillary tangles (nfts), synaptic loss and neuronal apoptosis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Huntington Potter, Heidi J Chial, Julbert Caneus, Mihret Elos, Nina Elder, Sergiy Borysov, Antoneta Grani. Chromosome Instability and Mosaic Aneuploidy in Neurodegenerative and Neurodevelopmental Disorders. Frontiers in genetics. vol 10. 2020-09-28. PMID:31788001. |
evidence from multiple laboratories has accumulated to show that mosaic neuronal aneuploidy and consequent apoptosis characterizes and may underlie neuronal loss in many neurodegenerative diseases, particularly alzheimer's disease and frontotemporal dementia. |
2020-09-28 |
2023-08-13 |
Not clear |
| Arianna Bellucci, Luigi Bubacco, Francesca Longhena, Edoardo Parrella, Gaia Faustini, Vanessa Porrini, Federica Bono, Cristina Missale, Marina Pizz. Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson's Disease. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32265684. |
nuclear factor-κb (nf-κb) transcription factors, key regulators of inflammation and apoptosis, are involved in the brain programming of systemic aging as well as in the pathogenesis of several neurodegenerative diseases. |
2020-09-28 |
2023-08-13 |
mouse |
| Gemma Serrano-Heras, Inmaculada Díaz-Maroto, Beatriz Castro-Robles, Blanca Carrión, Ana B Perona-Moratalla, Julia Gracia, Sandra Arteaga, Francisco Hernández-Fernández, Jorge García-García, Oscar Ayo-Martín, Tomás Segur. Isolation and Quantification of Blood Apoptotic Bodies, a Non-invasive Tool to Evaluate Apoptosis in Patients with Ischemic Stroke and Neurodegenerative Diseases. Biological procedures online. vol 22. 2020-09-28. PMID:32765191. |
isolation and quantification of blood apoptotic bodies, a non-invasive tool to evaluate apoptosis in patients with ischemic stroke and neurodegenerative diseases. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hui Zhao, Yan Feng, Changjuan Wei, Yan Li, Hongshan Ma, Xuejiao Wang, Zhigang Cui, Wei-Na Jin, Fu-Dong Sh. Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway. Neuroscience. vol 416. 2020-09-24. PMID:31374230. |
colivelin is a neuroprotective humanin family peptide with potent long-term capacity against aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. |
2020-09-24 |
2023-08-13 |
mouse |
| Bei Li, Yuan Zhao, ManYu Song, HaiLin Cui, XiuJing Feng, TianYuan Yang, Hong-Gang Fa. Role of c-Myc/chloride intracellular channel 4 pathway in lipopolysaccharide-induced neurodegenerative diseases. Toxicology. vol 429. 2020-08-17. PMID:31693917. |
lps-induced neuronal apoptosis leads to neurodegenerative diseases (nds). |
2020-08-17 |
2023-08-13 |
Not clear |
| Karin Aistleitner, Tina Clark, Cheryl Dooley, Ted Hackstad. Selective fragmentation of the trans-Golgi apparatus by Rickettsia rickettsii. PLoS pathogens. vol 16. issue 5. 2020-07-21. PMID:32421751. |
fragmentation of the golgi apparatus is observed during a number of physiological processes including mitosis and apoptosis, but also occurs in pathological states such as neurodegenerative diseases and some infectious diseases. |
2020-07-21 |
2023-08-13 |
Not clear |
| Wenqing Jiang, Peng Jin, Wenfeng Wei, Wei Jian. Apoptosis in cerebrospinal fluid as outcome predictors in severe traumatic brain injury: An observational study. Medicine. vol 99. issue 26. 2020-07-07. PMID:32590803. |
apoptosis plays a pathogenic role in a series of neurological disorders, from neurodegenerative diseases to acute neurological lesions.in this study, we analyzed the association between apoptosis and the glasgow outcome scale (gos), to examine the potential of apoptosis as a biomarker for a tbi outcome. |
2020-07-07 |
2023-08-13 |
human |
| Angélique Sadlon, Petros Takousis, Panagiotis Alexopoulos, Evangelos Evangelou, Inga Prokopenko, Robert Perneczk. miRNAs Identify Shared Pathways in Alzheimer's and Parkinson's Diseases. Trends in molecular medicine. vol 25. issue 8. 2020-06-30. PMID:31221572. |
mirnas relevant to both neurodegenerative diseases are related to axonal guidance, apoptosis, and inflammation, therefore, ad and pd likely arise from similar underlying biological pathway defects. |
2020-06-30 |
2023-08-13 |
Not clear |
| Wen Li, Yue Ma, Zhenshu Li, Xin Lv, Xinyan Wang, Dezheng Zhou, Suhui Luo, John X Wilson, Guowei Huan. Folic Acid Decreases Astrocyte Apoptosis by Preventing Oxidative Stress-Induced Telomere Attrition. International journal of molecular sciences. vol 21. issue 1. 2020-05-15. PMID:31861819. |
astrocytes are the most widely distributed cells in the brain, and astrocyte apoptosis may play an important role in the pathogenesis of neurodegenerative diseases. |
2020-05-15 |
2023-08-13 |
Not clear |
| Si-Tong Feng, Zhen-Zhen Wang, Yu-He Yuan, Hong-Mei Sun, Nai-Hong Chen, Yi Zhan. Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer's and Parkinson's disease models. Pharmacological research. vol 146. 2020-05-11. PMID:31271846. |
alzheimer's disease (ad) and parkinson's disease (pd) are recognized as the universal neurodegenerative diseases, with the involvement of misfolded proteins pathology, leading to oxidative stress, glial cells activation, neuroinflammation, mitochondrial dysfunction, and cellular apoptosis. |
2020-05-11 |
2023-08-13 |
rat |
| Celeste M Pilato, Jae Hong Park, Lingling Kong, Constantin d'Ydewalle, David Valdivia, Karen S Chen, Irene Griswold-Prenner, Charlotte J Sumne. Motor neuron loss in SMA is not associated with somal stress-activated JNK/c-Jun signaling. Human molecular genetics. vol 28. issue 19. 2020-05-11. PMID:31272106. |
the c-jun nh2-terminal kinases (jnks) are stress-activated kinases with multiple substrates including c-jun, which can be activated during neuronal injury and neurodegenerative disease leading to neuronal apoptosis. |
2020-05-11 |
2023-08-13 |
mouse |
| Yuanbo Wu, Meiqiao Chen, Jielong Jian. Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling. Mitochondrion. vol 49. 2020-05-06. PMID:31288090. |
most central pathological feature of the neurodegenerative diseases is apoptosis which is regulated by mitochondria. |
2020-05-06 |
2023-08-13 |
Not clear |
| Zhihao Qi, Zhen Huang, Feng Xie, Linxi Che. Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30515821. |
here, we will give a detailed review about the recent developments in regards to dynamin-related protein 1 (drp1) induced unbalanced mitochondrial dynamics, excessive mitochondrial division, and neuronal injury in neural system dysfunctions and neurodegenerative diseases, including the drp1 knockout induced mice embryonic death, the dysfunction of the drp1-dependent mitochondrial division induced neuronal cell apoptosis and impaired neuronal axonal transportation, the abnormal interaction between drp1 and amyloid β (aβ) in alzheimer's disease (ad), the mutant huntingtin (htt) in huntington's disease (hd), and the drp1-associated pathogenesis of other neurodegenerative diseases such as parkinson's disease (pd) and amyotrophic lateral sclerosis (als). drp1 is required for mitochondrial division determining the size, shape, distribution, and remodeling as well as maintaining of mitochondrial integrity in mammalian cells. |
2020-05-04 |
2023-08-13 |
mouse |