| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhihui Zhu, Georg Reise. The small heat shock proteins, especially HspB4 and HspB5 are promising protectants in neurodegenerative diseases. Neurochemistry international. vol 115. 2019-09-17. PMID:29425965. |
for neuroprotective mechanisms, shsps attenuate mitochondrial dysfunctions, reduce accumulation of misfolded proteins, block oxidative/nitrosative stress, and minimize neuronal apoptosis and neuroinflammation, which are molecular mechanisms commonly accepted to mirror the progression and development of neurodegenerative diseases. |
2019-09-17 |
2023-08-13 |
mouse |
| Leandro Bueno Berganti. Hypertension, Diabetes and Neurodegenerative Diseases: Is there a Clinical Link through the Ca2+/cAMP Signalling Interaction? Current hypertension reviews. vol 15. issue 1. 2019-08-13. PMID:30117399. |
the virtual mechanism of action could be attributed to a restoration and maintenance of ca2+ homeostasis, which is dysregulated in the neurodegenerative diseases, including also a reduction of neuronal apoptosis as part of these ccbs pleiotropic effects. |
2019-08-13 |
2023-08-13 |
Not clear |
| Olena Y Glushakova, Andriy O Glushakov, Cesar V Borlongan, Alex B Valadka, Ronald L Hayes, Alexander V Glushako. Role of Caspase-3-Mediated Apoptosis in Chronic Caspase-3-Cleaved Tau Accumulation and Blood-Brain Barrier Damage in the Corpus Callosum after Traumatic Brain Injury in Rats. Journal of neurotrauma. vol 35. issue 1. 2019-07-08. PMID:28637381. |
chronic tbi is associated with several pathological features that are also characteristic of neurodegenerative diseases, including tau pathologies, caspase-3-mediated apoptosis, neuroinflammation, and microvascular alterations. |
2019-07-08 |
2023-08-13 |
rat |
| H Lou, D Kang, Q Yang, C Lian, C Zhang, Z Li, H Tian, L Lu, G-T Xu, G Xu, J Zhan. Erythropoietin Protects Retina Against Ceramide 2-Induced Damage in Rat. Current molecular medicine. vol 17. issue 10. 2019-06-11. PMID:29577857. |
ceramide plays critical roles in cell proliferation, senescence and apoptosis, and is implicated in neurodegenerative diseases, etc. |
2019-06-11 |
2023-08-13 |
rat |
| Todd McLaughlin, Marek Falkowski, Joshua J Wang, Sarah X Zhan. Molecular Chaperone ERp29: A Potential Target for Cellular Protection in Retinal and Neurodegenerative Diseases. Advances in experimental medicine and biology. vol 1074. 2019-05-06. PMID:29721972. |
we summarize the diverse activities of erp29 in protein trafficking, cell survival and apoptosis, and er homeostasis and highlight a potential role of erp29 in neuroprotection in retinal and neurodegenerative diseases. |
2019-05-06 |
2023-08-13 |
Not clear |
| Hyun Ji Ha, Sunghark Kwon, Eui Man Jeong, Chang Min Kim, Ki Baek Lee, In-Gyu Kim, Hyun Ho Par. Structure of natural variant transglutaminase 2 reveals molecular basis of gaining stability and higher activity. PloS one. vol 13. issue 10. 2019-03-14. PMID:30321187. |
multi-functional transglutaminase 2 (tg2), which possesses protein cross-linking and gtp hydrolysis activities, is involved in various cellular processes, including apoptosis, angiogenesis, wound healing, and neuronal regeneration, and is associated with many human diseases, including inflammatory disease, celiac disease, neurodegenerative disease, diabetes, tissue fibrosis, and cancers. |
2019-03-14 |
2023-08-13 |
human |
| Youngchul Kim, Young Seo Kim, Hyun Young Kim, Min-Young Noh, Ji Young Kim, Young-Jun Lee, Jeongmin Kim, Jiseon Park, Seung Hyun Ki. Early Treatment with Poly(ADP-Ribose) Polymerase-1 Inhibitor (JPI-289) Reduces Infarct Volume and Improves Long-Term Behavior in an Animal Model of Ischemic Stroke. Molecular neurobiology. vol 55. issue 9. 2019-02-04. PMID:29383691. |
in patients with stroke and neurodegenerative diseases, overactivation of poly(adp-ribose) polymerase-1 (parp-1) causes harmful effects by inducing apoptosis, necrosis, neuroinflammation, and immune dysregulation. |
2019-02-04 |
2023-08-13 |
Not clear |
| Siqi Li, Yongdui Chen, Desen Sun, Rongpai Bai, Xiangwei Gao, Yi Yang, Jinghao Sheng, Zhengping X. Angiogenin Prevents Progranulin A9D Mutation-Induced Neuronal-Like Cell Apoptosis Through Cleaving tRNAs into tiRNAs. Molecular neurobiology. vol 55. issue 2. 2019-01-10. PMID:28127696. |
taken together, we hypothesize that pgrn a9d leads to the retention of ang in the cytoplasm to protect cells from pgrn a9d-induced apoptosis, implying that pgrn and ang act in concert to regulate the progress of neurodegenerative disease. |
2019-01-10 |
2023-08-13 |
human |
| Hao Huang, Peipei Yan, Taoping Sun, Xiaoxing Mo, Jiawei Yin, Peiyun Li, Yalun Zhu, Shuang Rong, Wei Yang, Xiaoyi Chen, Liegang Li. Procyanidins Extracted from Lotus Seedpod Ameliorate Amyloid- Oxidative medicine and cellular longevity. vol 2018. 2019-01-07. PMID:30538801. |
procyanidins extracted from lotus seedpod ameliorate amyloid- alzheimer's disease (ad) is a progressive neurodegenerative disease, which is characterized by extracellular senile plaque deposits, intracellular neurofibrillary tangles, and neuronal apoptosis. |
2019-01-07 |
2023-08-13 |
Not clear |
| Huanhuan Luo, Liying Cao, Xuan Liang, Ana Du, Ting Peng, He L. Herp Promotes Degradation of Mutant Huntingtin: Involvement of the Proteasome and Molecular Chaperones. Molecular neurobiology. vol 55. issue 10. 2018-12-18. PMID:29430620. |
in neurodegenerative diseases, pathogenic proteins tend to misfold and form aggregates that are difficult to remove and able to induce excessive endoplasmic reticulum (er) stress, leading to neuronal injury and apoptosis. |
2018-12-18 |
2023-08-13 |
Not clear |
| Dinesh Kumar Verma, Sonam Gupta, Joyshree Biswas, Neeraj Joshi, Abhishek Singh, Parul Gupta, Shubhangini Tiwari, K Sivarama Raju, Swati Chaturvedi, M Wahajuddin, Sarika Sing. New therapeutic activity of metabolic enhancer piracetam in treatment of neurodegenerative disease: Participation of caspase independent death factors, oxidative stress, inflammatory responses and apoptosis. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 6 Pt A. 2018-12-11. PMID:29551729. |
new therapeutic activity of metabolic enhancer piracetam in treatment of neurodegenerative disease: participation of caspase independent death factors, oxidative stress, inflammatory responses and apoptosis. |
2018-12-11 |
2023-08-13 |
rat |
| Bin Yu, Shan Li, Wenying Qiu, Minghui Wang, Junwei Du, Yusen Zhang, Xing Che. Prediction of subcellular location of apoptosis proteins by incorporating PsePSSM and DCCA coefficient based on LFDA dimensionality reduction. BMC genomics. vol 19. issue 1. 2018-12-11. PMID:29914358. |
apoptosis is associated with some human diseases, including cancer, autoimmune disease, neurodegenerative disease and ischemic damage, etc. |
2018-12-11 |
2023-08-13 |
human |
| Sujuan Chen, Dandan Guo, Wei Zhang, Yunfei Xie, Haijie Yang, Binfeng Cheng, Lei Wang, Rui Yang, Jiajia Bi, Zhiwei Fen. Biglycan, a Nitric Oxide-Downregulated Proteoglycan, Prevents Nitric Oxide-Induced Neuronal Cell Apoptosis via Targeting Erk1/2 and p38 Signaling Pathways. Journal of molecular neuroscience : MN. vol 66. issue 1. 2018-11-09. PMID:30088173. |
nitric oxide (no), a gaseous signaling molecule, induces apoptosis and mediates neurodegenerative diseases and brain injury. |
2018-11-09 |
2023-08-13 |
human |
| Jing Fan, Ted M Dawson, Valina L Dawso. Cell Death Mechanisms of Neurodegeneration. Advances in neurobiology. vol 15. 2018-11-01. PMID:28674991. |
besides apoptosis, necroptosis, and autophagy, an important form of death termed parthanatos plays a prominent role in stroke and several neurodegenerative diseases, which is due to parp-1 overactivation, par accumulation, nuclear translocation of the mitochondria protein aif, and large-scale dna cleavage. |
2018-11-01 |
2023-08-13 |
Not clear |
| Hai-Jie Yang, Fei Ju, Xin-Xin Guo, Shuang-Ping Ma, Lei Wang, Bin-Feng Cheng, Rui-Juan Zhuang, Bin-Bin Zhang, Xiang Shi, Zhi-Wei Feng, Mian Wan. RNA-binding protein RBM3 prevents NO-induced apoptosis in human neuroblastoma cells by modulating p38 signaling and miR-143. Scientific reports. vol 7. 2018-10-24. PMID:28134320. |
nitric oxide (no)-induced apoptosis in neurons is an important cause of neurodegenerative disease in humans. |
2018-10-24 |
2023-08-13 |
human |
| Adaze Bijou Enogieru, William Haylett, Donavon Charles Hiss, Soraya Bardien, Okobi Eko Ekp. Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disorders. Oxidative medicine and cellular longevity. vol 2018. 2018-10-22. PMID:30050657. |
a wide range of neurodegenerative diseases (nds), including alzheimer's disease, parkinson's disease, huntington's disease, and prion diseases, share common mechanisms such as neuronal loss, apoptosis, mitochondrial dysfunction, oxidative stress, and inflammation. |
2018-10-22 |
2023-08-13 |
Not clear |
| Y Chandrasekhar, G Phani Kumar, E M Ramya, K R Anilakuma. Gallic Acid Protects 6-OHDA Induced Neurotoxicity by Attenuating Oxidative Stress in Human Dopaminergic Cell Line. Neurochemical research. vol 43. issue 6. 2018-10-15. PMID:29671234. |
these findings indicate that gallic acid is able to protect the neuronal cells against 6-ohda induced injury and proved that gallic acid might potentially serve as an agent for prevention of several human neurodegenerative diseases caused by oxidative stress and apoptosis. |
2018-10-15 |
2023-08-13 |
human |
| Fatma Helvacioglu, Ersin Kandemir, Busra Karabacak, Idil Karatas, Ahmet Pecen, Ipek Ercan, Tugce Sencelikel, Attila Dagdevire. Effect of Creatine on Rat Sciatic Nerve Injury: A Comparative Ultrastructural Study. Turkish neurosurgery. vol 28. issue 1. 2018-06-20. PMID:27858383. |
as it is expected to prevent apoptosis and diminish oxidative stress, it is also studied in a number of neurodegenerative diseases for its beneficial effect in recent years. |
2018-06-20 |
2023-08-13 |
rat |
| Tae-Ho Jang, In-Hye Lim, Chang Min Kim, Jae Young Choi, Eun-Ae Kim, Tae-Jin Lee, Hyun Ho Par. Rescuing neuronal cell death by RAIDD- and PIDD- derived peptides and its implications for therapeutic intervention in neurodegenerative diseases. Scientific reports. vol 6. 2018-05-02. PMID:27502430. |
our peptides are novel neuronal cell apoptosis inhibitors that might serve as a prototype for development of drugs for the treatment of neurodegenerative diseases. |
2018-05-02 |
2023-08-13 |
Not clear |
| Alejandro O Sodero, Monica Rodriguez-Silva, Chiara Salio, Marco Sassoè-Pognetto, Jeremy W Chamber. Sab is differentially expressed in the brain and affects neuronal activity. Brain research. vol 1670. 2018-04-26. PMID:28606781. |
sab (sh3 binding protein 5 or sh3bp5) is a mitochondrial scaffold protein involved in signaling associated with mitochondrial dysfunction and apoptosis; furthermore, sab is a crucial signaling platform for neurodegenerative disease. |
2018-04-26 |
2023-08-13 |
mouse |