| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fangxin Guo, Xudi Qin, Jian Mao, Yan Xu, Jianping Xi. Potential Protective Effects of Pungent Flavor Components in Neurodegenerative Diseases. Molecules (Basel, Switzerland). vol 29. issue 23. 2024-12-17. PMID:39683859. |
studies have shown that some plant extracts with pungent flavor components have a certain neuroprotective effect in neurodegenerative diseases, and their mechanisms mainly involve inhibiting neuronal apoptosis, promoting neuronal regeneration, reducing mitochondrial degeneration, and reducing the production of oxides such as reactive oxygen species in cells, which are of great significance for exploring the treatment of neurodegenerative diseases. |
2024-12-17 |
2024-12-21 |
Not clear |
| Naina Gaikwad, Rucha Sarwade, Sourav Halder, Gaurav Agarwal, Vasudevan Seshadr. HuD regulates apoptosis in N2a cells by regulating Msi2 expression. PloS one. vol 19. issue 12. 2024-12-16. PMID:39680531. |
apoptosis is one of the underlying causes of neurodegenerative diseases like alzheimer's disease. |
2024-12-16 |
2024-12-21 |
mouse |
| Seul-Ki Kim, Yong-Jin Kwon, Eun-Bi Seo, Hyun-Seung Lee, Jie Ohn Sohn, Hyun Mu Shin, Sung Joon Kim, Sang-Kyu Y. Neuroprotective Effects of STAT3 Inhibitor on Hydrogen Peroxide-Induced Neuronal Cell Death via the ERK/CREB Signaling Pathway. Neurochemical research. vol 50. issue 1. 2024-12-08. PMID:39648181. |
this study investigates the neuroprotective potential of stat3 inhibition in reducing oxidative stress-induced neuronal damage and apoptosis, a major factor contributing to the onset and progression of neurodegenerative diseases, including alzheimer's disease (ad). |
2024-12-08 |
2024-12-11 |
Not clear |
| Jiahui Lv, Xinmiao Zhao, Linjie Zhao, Chengjun Gong, Wanjie Zheng, Li Guo, Jun Wang, Tingming Lian. The Notable Role of Telomere Length Maintenance in Complex Diseases. Biomedicines. vol 12. issue 11. 2024-11-27. PMID:39595175. |
in addition, the association between telomeres and neurodegenerative diseases is discussed, detailing how telomere attrition heightens disease risk and outlining multiple pathways by which telomerase protects neurons from damage and apoptosis. |
2024-11-27 |
2024-11-29 |
Not clear |
| Ruiying Yuan, Dan Gao, Guibing Yang, Dongzhi Zhuoma, Zhen Pu, Yangzhen Ciren, Bin Li, Jianqing Y. Oxysophocarpine Prevents the Glutamate-Induced Apoptosis of HT-22 Cells via the Nrf2/HO-1 Signaling Pathway. Current issues in molecular biology. vol 46. issue 11. 2024-11-26. PMID:39590371. |
these results suggest that osc can exert neuroprotective effects by regulating the nrf2/ho-1 pathway to inhibit neuronal cell apoptosis, potentially aiding in the treatment of neurodegenerative diseases. |
2024-11-26 |
2024-11-29 |
Not clear |
| Luodan A, Linghui Qu, Juncai He, Lingling Ge, Hui Gao, Xiaona Huang, Tianjing You, Hong Gong, Qingle Liang, Siyu Chen, Jing Xie, Haiwei X. Exosomes derived from IFNγ-stimulated mesenchymal stem cells protect photoreceptors in RCS rats by restoring immune homeostasis through tsRNAs. Cell communication and signaling : CCS. vol 22. issue 1. 2024-11-14. PMID:39538308. |
retinitis pigmentosa is a neurodegenerative disease with major pathologies of photoreceptor apoptosis and immune imbalance. |
2024-11-14 |
2024-11-17 |
rat |
| Quynh Dieu Trinh, Huynh Nhu Mai, Duc Toan Pha. Application of mesenchymal stem cells for neurodegenerative diseases therapy discovery. Regenerative therapy. vol 26. 2024-11-14. PMID:39524179. |
recent studies suggested the roles of neuroinflammation, apoptosis, and oxidative stress in neurodegenerative diseases. |
2024-11-14 |
2024-11-17 |
Not clear |
| Soudabeh Naderi, Fariba Khodagholi, Mahyar Janahmadi, Fereshteh Motamedi, Abolfazl Torabi, Zahra Batool, Mahshad Fadaeimoghadam Heydarabadi, Hamid Gholami Pourbadi. Ferroptosis and Cognitive Impairment: Unraveling the Link and Potential Therapeutic Targets. Neuropharmacology. 2024-11-09. PMID:39521042. |
unlike apoptosis or necrosis, ferroptosis offers a novel therapeutic avenue due to its distinct biochemical and genetic underpinnings, making it a promising target in neurodegenerative disease treatment. |
2024-11-09 |
2024-11-17 |
Not clear |
| Dan Li, Wang Rongchun, Weihong Lu, Ying M. Exploring the potential of MFG-E8 in neurodegenerative diseases. Critical reviews in food science and nutrition. 2024-10-29. PMID:39468823. |
this review summarizes the effects and mechanisms of mfg-e8 in neurodegenerative diseases (ndds), emphasizing its roles in inflammation, apoptosis, and oxidative stress. |
2024-10-29 |
2024-10-31 |
Not clear |
| Qiongxia Lv, Wenjing Xu, Fan Yang, Jiahui Li, Wenjuan Wei, Xiaoguang Chen, Yumei Liu, Ziqiang Zhan. Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review. International journal of molecular sciences. vol 25. issue 20. 2024-10-26. PMID:39456789. |
through oxidative stress, immunosuppression, apoptosis, autophagy, and mitochondrial dysfunction, zea leads to hepatitis, neurodegenerative diseases, cancer, abortion, and stillbirth in female animals, and decreased sperm motility in male animals. |
2024-10-26 |
2024-10-29 |
human |
| Satyam Chaubey, Lovedeep Sing. Deciphering the mechanisms underlying the neuroprotective potential of kaempferol: a comprehensive investigation. Naunyn-Schmiedeberg's archives of pharmacology. 2024-10-16. PMID:39414700. |
kaempferol demonstrates multifaceted potential in mitigating neuroinflammation, apoptosis, and oxidative stress in different neurodegenerative diseases through the modulation of various pathways including nrf-2, nadph oxidase, tlr-4/mapk, and tlr-4/nf-κb. |
2024-10-16 |
2024-10-19 |
Not clear |
| Shengli Dong, Suresh K Alahar. Small molecule Mcl-1 inhibitor for triple negative breast cancer therapy. Frontiers in cell and developmental biology. vol 12. 2024-10-07. PMID:39372954. |
dysregulation of apoptosis can contribute to the pathogenesis of malignant tumors and neurodegenerative diseases. |
2024-10-07 |
2024-10-09 |
Not clear |
| Dong Guo, Zhihao Liu, Jinglin Zhou, Chongrong Ke, Daliang L. Significance of Programmed Cell Death Pathways in Neurodegenerative Diseases. International journal of molecular sciences. vol 25. issue 18. 2024-09-28. PMID:39337436. |
in this review, we summarize the molecular processes and features of different modalities of pcd, including apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, and other novel forms of pcd, and their effects on the pathogenesis of neurodegenerative diseases, such as alzheimer's disease (ad), parkinson's disease (pd), huntington's disease (hd), amyotrophic lateral sclerosis (als), spinal muscular atrophy (sma), multiple sclerosis (ms), traumatic brain injury (tbi), and stroke. |
2024-09-28 |
2024-10-01 |
Not clear |
| Nathalia Delazeri de Carvalho, Henrique Krambeck Rofatto, Karina de Senna Villar, Roberta Fiusa Magnelli, P I Silva Junior, Ronaldo Zucatelli Mendonç. Proteins with Anti-apoptotic Action in the Hemolymph of Caterpillars of the Megalopygidae Family Acts by Maintaining the Structure of the Cellular Cytoskeleton. Molecular biotechnology. 2024-09-27. PMID:39333334. |
by acting on the mitochondrial pathway of death by apoptosis, and by maintaining the structure of the cytoskeleton and cellular functions, pathway that can cause disorders and diseases neurodegenerative, the substances present in the hemolymph of these and other caterpillars could be good candidates in studies for the treatment of neurodegenerative diseases such as parkinson's disease and alzheimer's. |
2024-09-27 |
2024-10-01 |
Not clear |
| Jinping Liang, Yuchen Zhu, Shasha Liu, Boyu Kuang, Zhifeng Tian, Ling Zhang, Songwei Yang, Meiyu Lin, Naihong Chen, Xuan Liu, Qidi Ai, Yantao Yan. Progress of Exosomal MicroRNAs and Traditional Chinese Medicine Monomers in Neurodegenerative Diseases. Phytotherapy research : PTR. 2024-09-03. PMID:39225243. |
notably, tcm monomers, serving as active constituents within herbal medicine, assume a critical role in the treatment of neurodegenerative diseases, particularly in mitigating oxidative stress, inhibiting apoptosis, and reducing inflammation. |
2024-09-03 |
2024-09-05 |
Not clear |
| Ya-Xi Ye, Jian-Cheng Pan, Hai-Chao Wang, Xing-Tao Zhang, Hai-Liang Zhu, Xin-Hua Li. Advances in small-molecule fluorescent probes for the study of apoptosis. Chemical Society reviews. 2024-08-12. PMID:39129564. |
mounting research indicates that the unique modality of cell apoptosis is directly or indirectly related to different diseases including cancer, autoimmune diseases, viral diseases, neurodegenerative diseases, |
2024-08-12 |
2024-08-14 |
Not clear |
| Eui-Hwan Choi, Mi-Hye Kim, Sun-Ji Par. Targeting Mitochondrial Dysfunction and Reactive Oxygen Species for Neurodegenerative Disease Treatment. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39063194. |
in this review, we provide an overview of the main functions of mitochondria, with a focus on recent progress highlighting the critical role of ros-induced oxidative stress, dysregulated mitochondrial dynamics, mitochondrial apoptosis, mitochondria-associated inflammation, and impaired mitochondrial function in the pathogenesis of age-related neurodegenerative diseases, such as ad and pd. |
2024-07-27 |
2024-07-29 |
Not clear |
| Mateusz Kciuk, Nitika Garg, Sanchit Dhankhar, Monika Saini, Somdutt Mujwar, Sushma Devi, Samrat Chauhan, Thakur Gurjeet Singh, Randhir Singh, Beata Marciniak, Adrianna Gielecińska, Renata Konte. Exploring the Comprehensive Neuroprotective and Anticancer Potential of Afzelin. Pharmaceuticals (Basel, Switzerland). vol 17. issue 6. 2024-06-27. PMID:38931368. |
both cancer and neurodegenerative diseases involve the deregulation of cellular processes such as apoptosis, proliferation, and dna repair and pose a significant global health challenge. |
2024-06-27 |
2024-06-29 |
Not clear |
| Xiaoqing Peng, Yuanyuan Yang, Ruirui Hou, Longbiao Zhang, Can Shen, Xiaoyan Yang, Zhigang Luo, Zongzhi Yin, Yunxia Ca. MTCH2 in Metabolic Diseases, Neurodegenerative Diseases, Cancers, Embryonic Development and Reproduction. Drug design, development and therapy. vol 18. 2024-06-17. PMID:38882047. |
recent studies revealed the physiological and pathological function of mtch2 in metabolic diseases, neurodegenerative diseases, cancers, embryonic development and reproduction via regulating mitochondrial apoptosis, metabolic shift between glycolysis and oxidative phosphorylation, mitochondrial fusion/fission, epithelial-mesenchymal transition, etc. |
2024-06-17 |
2024-06-19 |
Not clear |
| Ning Zhao, Junyi Wang, Shan Huang, Jingyu Zhang, Jin Bao, Haisen Ni, Xinhang Gao, Chunlong Zhan. The landscape of programmed cell death-related lncRNAs in Alzheimer's disease and Parkinson's disease. Apoptosis : an international journal on programmed cell death. 2024-06-09. PMID:38853201. |
we propose a new framework pcdlnc, and identified 20 significant lncrnas, including heih, snhg15, and snhg5, associated with pcd gene sets, which were known for roles in proliferation and apoptosis in neurodegenerative diseases. |
2024-06-09 |
2024-06-14 |
Not clear |