| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Riaz Ahmad, Amjad Khan, Inayat Ur Rehman, Hyeon Jin Lee, Ibrahim Khan, Myeong Ok Ki. Lupeol Treatment Attenuates Activation of Glial Cells and Oxidative-Stress-Mediated Neuropathology in Mouse Model of Traumatic Brain Injury. International journal of molecular sciences. vol 23. issue 11. 2022-06-10. PMID:35682768. |
previous studies have established that lupeol provides neuroprotection through modulation of inflammation, oxidative stress, and apoptosis in aβ and lps model and neurodegenerative disease. |
2022-06-10 |
2023-08-14 |
mouse |
| Agnieszka Fus-Kujawa, Łukasz Sieroń, Estera Dobrzyńska, Łukasz Chajec, Barbara Mendrek, Natalia Jarosz, Łukasz Głowacki, Kamila Dubaj, Wojciech Dubaj, Agnieszka Kowalczuk, Karolina Bajdak-Rusine. Star Polymers as Non-Viral Carriers for Apoptosis Induction. Biomolecules. vol 12. issue 5. 2022-05-28. PMID:35625536. |
apoptosis is a widely controlled, programmed cell death, defects in which are the source of various diseases such as neurodegenerative diseases as well as cancer. |
2022-05-28 |
2023-08-13 |
human |
| Miguel A Jiménez-Acosta, Lory Jhenifer Rochin Hernández, Mayte Lizeth Padilla Cristerna, Marco A Meraz-Río. Mini-Review: Mesenchymal stem cells. New alternatives for nervous system disorders. Current stem cell research & therapy. 2022-05-13. PMID:35546750. |
these cells could facilitate functional recovery in multiple models of neurodegenerative diseases and nervous system injuries by using their trophic capacities, reducing inflammation in the injured area, reducing apoptosis, and enhancing endogenous neurogenesis through the secretion of bioactive factors. |
2022-05-13 |
2023-08-13 |
Not clear |
| Rui Han, Yao Yu, Kanghong Zhao, Jing Wei, Yuhu Hui, Jin-Ming Ga. Lignans from Eucommia ulmoides Oliver leaves exhibit neuroprotective effects via activation of the PI3K/Akt/GSK-3β/Nrf2 signaling pathways in H Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 101. 2022-04-29. PMID:35487038. |
lignans from eucommia ulmoides oliver leaves exhibit neuroprotective effects via activation of the pi3k/akt/gsk-3β/nrf2 signaling pathways in h neuronal apoptosis and oxidative stress have the most crucial influence on neurodegenerative diseases, including parkinson's disease. |
2022-04-29 |
2023-08-13 |
rat |
| Xiaoting Dang, Xuejie Huan, Xixun Du, Xi Chen, Mingxia Bi, Chunling Yan, Qian Jiao, Hong Jian. Correlation of Ferroptosis and Other Types of Cell Death in Neurodegenerative Diseases. Neuroscience bulletin. 2022-04-28. PMID:35482278. |
this review focuses on current research on ferroptosis and summarizes the cross-talk among ferroptosis, apoptosis, and autophagy that are implicated in neurodegenerative diseases. |
2022-04-28 |
2023-08-13 |
Not clear |
| Christy Lite, Ajay Guru, Melita Juliet, Jesu Arockiara. Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety-like neurobehavioral response associated with oxidative stress and apoptosis in the head of zebrafish larvae. Environmental toxicology. 2022-04-26. PMID:35470536. |
the primary cause for the impairment in cognitive and emotional neurobehvioural outcomes in neurodegenerative disease was found to be associated with neuronal apoptosis. |
2022-04-26 |
2023-08-13 |
human |
| Elle E M Scheijen, David M Wilso. Genome Integrity and Neurological Disease. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35456958. |
while the precise molecular mechanisms that underlie neuronal cell loss remain under debate, evidence indicates that the accumulation of genomic dna damage and consequent cellular responses can promote apoptosis and neurodegenerative disease. |
2022-04-23 |
2023-08-13 |
Not clear |
| Dhiraj Kumar, Md Imtaiyaz Hassa. Targeted protein degraders march towards the clinic for neurodegenerative diseases. Ageing research reviews. 2022-04-04. PMID:35378298. |
researchers strive to develop clinical candidates employing chemical degraders' technologies, including hydrophobic tagging, molecular glues, proteolysis targeting chimeras (protacs), specific and nongenetic inhibitor of apoptosis protein (iap)-dependent protein erasers (snipers), autophagy targeted chimeras, and autophagosome-tethered compounds for targeted degradation of pathological markers in neurodegenerative disease. |
2022-04-04 |
2023-08-13 |
Not clear |
| Luis Varela, Maria E R Garcia-Renduele. Oncogenic Pathways in Neurodegenerative Diseases. International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328644. |
however, whereas in cancer, these alterations lead to cell survival and proliferation, neurodegenerative diseases trigger cell death and apoptosis. |
2022-03-25 |
2023-08-13 |
Not clear |
| Kevin Puertas-Neyra, Nadia Galindo-Cabello, Leticia A Hernández-Rodríguez, Fernando González-Pérez, José Carlos Rodríguez-Cabello, Rogelio González-Sarmiento, José Carlos Pastor, Ricardo Usategui-Martín, Ivan Fernandez-Buen. Programmed Cell Death and Autophagy in an Frontiers in neuroanatomy. vol 16. 2022-02-28. PMID:35221932. |
in that sense, the study aimed to characterize the programmed cell death (in terms of apoptosis and necroptosis) and autophagy response and modulation in retinal neurodegenerative diseases, using an |
2022-02-28 |
2023-08-13 |
Not clear |
| Gejile Hu, Ting Wang, Chunjie M. EPO activates PI3K-IKKα-CDK1 signaling pathway to promote the proliferation of Glial Cells under hypoxia environment. Genetics and molecular biology. vol 45. issue 1. 2022-02-15. PMID:35167649. |
as a neuroprotective factor, epo is also used in the treatment of various diseases, such as neurodegenerative diseases, parkinson's disease, traumatic brain injury, by decreasing inflammatory reaction, resisting apoptosis, and lowering oxidative stress. |
2022-02-15 |
2023-08-13 |
human |
| Rahul Kumar, Amruthanjali T, Siva Singothu, Shashi Bala Singh, Vasundhra Bhandar. Uncoupling proteins as a therapeutic target for the development of new era drugs against neurodegenerative disorder. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 147. 2022-01-29. PMID:35091238. |
increased ros production is a common symptom reported in neurodegenerative diseases that affect several pathways concerned with neuronal death, either apoptosis or autophagy. |
2022-01-29 |
2023-08-13 |
Not clear |
| Wei Peng, Yunhui Chen, Steve Tumilty, Lizhou Liu, Ling Luo, Haiyan Yin, Yongmei Xi. Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca Current opinion in pharmacology. vol 62. 2021-12-27. PMID:34959127. |
paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of ca neurodegenerative diseases (ndds) are a range of neurological disorders featured by neuronal degeneration and apoptosis. |
2021-12-27 |
2023-08-13 |
Not clear |
| Nour S Ereka. Apoptosis and its therapeutic implications in neurodegenerative diseases. Clinical anatomy (New York, N.Y.). vol 35. issue 1. 2021-12-08. PMID:34558138. |
apoptosis and its therapeutic implications in neurodegenerative diseases. |
2021-12-08 |
2023-08-13 |
Not clear |
| Nour S Ereka. Apoptosis and its therapeutic implications in neurodegenerative diseases. Clinical anatomy (New York, N.Y.). vol 35. issue 1. 2021-12-08. PMID:34558138. |
apoptosis has been implicated in the pathogenesis of neurodegenerative diseases, including parkinson disease, alzheimer disease, huntington disease, and amyotrophic lateral sclerosis. |
2021-12-08 |
2023-08-13 |
Not clear |
| Fei Huan. Ursodeoxycholic acid as a potential alternative therapeutic approach for neurodegenerative disorders: Effects on cell apoptosis, oxidative stress and inflammation in the brain. Brain, behavior, & immunity - health. vol 18. 2021-12-03. PMID:34632427. |
in neurodegenerative diseases, increased cell apoptosis, oxidative stress and inflammation are frequently observed as well. |
2021-12-03 |
2023-08-13 |
Not clear |
| Tuladhar Sunanda, Bipul Ray, Arehally M Mahalakshmi, Abid Bhat, Luay Rashan, Wiramon Rungratanawanich, Byoung-Joon Song, Musthafa Mohamed Essa, Meena Kishore Sakharkar, Saravana Babu Chidambara. Mitochondria-Endoplasmic Reticulum Crosstalk in Parkinson's Disease: The Role of Brain Renin Angiotensin System Components. Biomolecules. vol 11. issue 11. 2021-11-30. PMID:34827667. |
various reports indicate the detrimental involvement of the brain renin-angiotensin system (ras) in oxidative stress, neuroinflammation, and apoptosis in various neurodegenerative diseases. |
2021-11-30 |
2023-08-13 |
Not clear |
| Marina Betancor, Laura Moreno-Martínez, Óscar López-Pérez, Alicia Otero, Adelaida Hernaiz, Tomás Barrio, Juan José Badiola, Rosario Osta, Rosa Bolea, Inmaculada Martín-Burrie. Therapeutic Assay with the Non-toxic C-Terminal Fragment of Tetanus Toxin (TTC) in Transgenic Murine Models of Prion Disease. Molecular neurobiology. vol 58. issue 10. 2021-11-27. PMID:34283400. |
previous in vivo studies have demonstrated the ability of this molecule to increase mice survival, inhibit apoptosis and regulate autophagy in murine models of neurodegenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy. |
2021-11-27 |
2023-08-13 |
mouse |
| Rohan Gupta, Rashmi K Ambasta, Pravir Kuma. Multifaced role of protein deacetylase sirtuins in neurodegenerative disease. Neuroscience and biobehavioral reviews. 2021-11-21. PMID:34742724. |
sirtuins regulate biological and cellular processes, for instance, mitochondrial biogenesis, lipid and fatty acid oxidation, oxidative stress, gene transcriptional activity, apoptosis, inflammatory response, dna repair mechanism, and autophagic cell degradation, which are known components for the progression of the neurodegenerative diseases (ndds). |
2021-11-21 |
2023-08-13 |
Not clear |
| Emily A Borden, Matthew Furey, Nicholas J Gattone, Vedangi D Hambardikar, Xiao Hua Liang, Ernest R Scoma, Antonella Abou Samra, LaKeshia R D-Gary, Dayshaun J Dennis, Daniel Fricker, Cindy Garcia, ZeCheng Jiang, Shariq A Khan, Dheenadhayalan Kumarasamy, Hasmitha Kuppala, Savannah Ringrose, Evan J Rosenheim, Kimberly Van Exel, Hemanth Sai Vudhayagiri, Jiarui Zhang, Zhaowen Zhang, Mariona Guitart-Mampel, Pedro Urquiza, Maria E Solesi. Is there a link between inorganic polyphosphate (polyP), mitochondria, and neurodegeneration? Pharmacological research. vol 163. 2021-11-17. PMID:33010423. |
mitochondrial dysfunction - including increased apoptosis, calcium and protein dyshomeostasis within the organelle, and dysfunctional bioenergetics and oxidative status - is a common, early feature in all the major neurodegenerative diseases, including alzheimer's disease (ad) and parkinson's disease (pd). |
2021-11-17 |
2023-08-13 |
Not clear |