| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manas Ranjan Sahu, Amal Chandra Monda. The emerging role of Hippo signaling in neurodegeneration. Journal of neuroscience research. vol 98. issue 5. 2021-07-14. PMID:31705587. |
however, aberrant and unrestricted apoptosis can lead to a variety of degenerative conditions including neurodegenerative diseases. |
2021-07-14 |
2023-08-13 |
drosophila_melanogaster |
| Zhi-Tong Zhang, Guang-Xiao Huang, Wen-Jiao He, Wen-Ting Gu, Xue Wang, Zhi-Quan Chen, Fu-Jun Bi, Lu-Yong Zhang, Shu-Mei Wang, Dan Tan. Rapid screening of neuroprotective components from Huang-Lian-Jie-Du Decoction by living cell biospecific extraction coupled with HPLC-Q-Orbitrap-HRMS/MS analysis. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1176. 2021-07-12. PMID:34052562. |
furthermore, three representative compounds named baicalin, wogonoside, and berberine were subsequently verified to exert cytoprotective effects on pc12 cells injured by hydrogen peroxide via inhibiting oxidative stress and cell apoptosis, indicating that these screened compounds may possess a potential for the treatment of neurodegenerative diseases and were responsible, in part at least, for the neuroprotective beneficial effects of hljdd. |
2021-07-12 |
2023-08-13 |
Not clear |
| Zahra Asefy, Sirus Hoseinnejhad, Zaker Cefero. Nanoparticles approaches in neurodegenerative diseases diagnosis and treatment. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 42. issue 7. 2021-07-09. PMID:33846881. |
current neurodegenerative diseases treatment protocols only help to treat symptoms nevertheless with nanotechnology approaches, can regress nerve cells apoptosis, reduce inflammation, and improve brain drug delivery. |
2021-07-09 |
2023-08-13 |
Not clear |
| Wanqing Du, Xiangjun Di, Qian Peter S. Studying Mitochondrial Network Formation by In Vivo and In Vitro Reconstitution Assay. Methods in molecular biology (Clifton, N.J.). vol 2276. 2021-07-08. PMID:34060053. |
the disruption of the mitochondrial network affects mitochondrial functions, such as atp production, integration of metabolism, calcium homeostasis, and regulation of apoptosis, leading to the abnormal development and several human diseases including neurodegenerative disease. |
2021-07-08 |
2023-08-13 |
human |
| Jordane Preto, Isabelle Krim. The intrinsically disordered N-terminus of the voltage-dependent anion channel. PLoS computational biology. vol 17. issue 2. 2021-07-06. PMID:33577583. |
in addition, vdac plays a central role in the control of apoptosis and is therefore of great interest in both cancer and neurodegenerative diseases. |
2021-07-06 |
2023-08-13 |
Not clear |
| Jin-Ha Choi, Jeong-Woo Cho. Metal-Enhanced Fluorescence by Bifunctional Au Nanoparticles for Highly Sensitive and Simple Detection of Proteolytic Enzyme. Nano letters. vol 20. issue 10. 2021-06-24. PMID:32809833. |
although fluorescence-based analytical methods have been used in intracellular analyses, their sensitivity is low for the precise analysis of intracellular proteolytic enzymes to observe cell apoptosis related to cancer and neurodegenerative diseases. |
2021-06-24 |
2023-08-13 |
Not clear |
| Mitchell J Brun, Kefan Song, Byunguk Kang, Cooper Lueck, Weitong Chen, Kaitlyn Thatcher, Erhe Gao, Walter J Koch, Joy Lincoln, Sudarsan Rajan, Junghae Su. Constructing and evaluating caspase-activatable adeno-associated virus vector for gene delivery to the injured heart. Journal of controlled release : official journal of the Controlled Release Society. vol 328. 2021-06-17. PMID:33157191. |
here, we have designed a provector that is activated by cysteine aspartic proteases (caspases), which have roles in inflammation and apoptosis and thus are elevated at sites of diseases such as heart failure, neurodegenerative diseases, and ischemic stroke. |
2021-06-17 |
2023-08-13 |
Not clear |
| Shao-Peng Lin, Jiasong Hu, Jue-Xian Wei, Shan Ye, Jingyi Bu, Weiqiang Xu, Shishi Chen, Yi Wu, Guohao Wu, Lidong Zhu, Pei-Yi Lin, Xiao-Hui Che. Silencing of circFoxO3 Protects HT22 Cells from Glutamate-Induced Oxidative Injury via Regulating the Mitochondrial Apoptosis Pathway. Cellular and molecular neurobiology. vol 40. issue 7. 2021-06-11. PMID:32140899. |
collectively, our study demonstrates that endogenous circfoxo3 plays a key role in inducing apoptosis and neuronal cell death and may act as a novel therapeutic target for neurodegenerative diseases. |
2021-06-11 |
2023-08-13 |
human |
| Gian Lucas M Arruda, Hugo Vigerelli, Michelle C Bufalo, Giovanna B Longato, Rodinei V Veloso, Vanessa O Zambelli, Gisele Picolo, Yara Cury, André C Morandini, Antonio Carlos Marques, Juliana Mozer Scian. Box Jellyfish (Cnidaria, Cubozoa) Extract Increases Neuron's Connection: A Possible Neuroprotector Effect. BioMed research international. vol 2021. 2021-05-25. PMID:33748281. |
neurodegenerative diseases are one of the major causes of death worldwide, characterized by neurite atrophy, neuron apoptosis, and synapse loss. |
2021-05-25 |
2023-08-13 |
Not clear |
| Muhammad Safdar, Sana Zaheer, Rozhgar A Khailany, Sadaf Parvez, Muhammad Naveed, Piplu Bhuiyan, Mehmet Ozaslan, Rebaz Moatasam, Mustafa S Al-Attar, Musarrat Abbas Khan, Yasmeen Junej. The Relevance of SNPs at 3'UTR Region of CASP7 and miR-371b-5p Associated Diseases: A Computational Analysis. Cell biochemistry and biophysics. vol 78. issue 4. 2021-05-19. PMID:32951155. |
disruption of apoptosis may lead to aberrant immune responses, cancer, and neurodegenerative diseases. |
2021-05-19 |
2023-08-13 |
human |
| Chenxing Fu, Jie Zhan, Junqi Huai, Shaodan Ma, Minghui Li, Guoqin Chen, Minsheng Chen, Yanbin Cai, Caiwen O. Furin-instructed molecular self-assembly actuates endoplasmic reticulum stress-mediated apoptosis for cancer therapy. Nanoscale. vol 12. issue 22. 2021-05-14. PMID:32484200. |
severe er stress-mediated apoptosis is the cause of neurodegenerative diseases and expected to be a new target for cancer therapy. |
2021-05-14 |
2023-08-13 |
Not clear |
| Cheng-Cheng Wang, Hao-Hao Shi, Jie Xu, Teruyoshi Yanagita, Chang-Hu Xue, Tian-Tian Zhang, Yu-Ming Wan. Docosahexaenoic acid-acylated astaxanthin ester exhibits superior performance over non-esterified astaxanthin in preventing behavioral deficits coupled with apoptosis in MPTP-induced mice with Parkinson's disease. Food & function. vol 11. issue 9. 2021-05-06. PMID:32845953. |
dha-ast was superior to ast in preventing behavioral deficits coupled with apoptosis rather than oxidative stress, and might provide a valuable reference for the prevention and treatment of neurodegenerative diseases. |
2021-05-06 |
2023-08-13 |
mouse |
| Saray Tabak, Sofia Schreiber-Avissar, Elie Beit-Yanna. Crosstalk between MicroRNA and Oxidative Stress in Primary Open-Angle Glaucoma. International journal of molecular sciences. vol 22. issue 5. 2021-04-30. PMID:33670885. |
reactive oxygen species (ros) plays a key role in the pathogenesis of primary open-angle glaucoma (poag), a chronic neurodegenerative disease that damages the trabecular meshwork (tm) cells, inducing apoptosis of the retinal ganglion cells (rgc), deteriorating the optic nerve head, and leading to blindness. |
2021-04-30 |
2023-08-13 |
Not clear |
| Liya Qin, Jian Zou, Alexandra Barnett, Ryan P Vetreno, Fulton T Crews, Leon G Colema. TRAIL Mediates Neuronal Death in AUD: A Link between Neuroinflammation and Neurodegeneration. International journal of molecular sciences. vol 22. issue 5. 2021-04-26. PMID:33806288. |
tlr7 and neuronal apoptosis are implicated in other neurodegenerative diseases, including alzheimer's disease. |
2021-04-26 |
2023-08-13 |
mouse |
| Paweł Łukasik, Michał Załuski, Izabela Gutowsk. Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development-Review. International journal of molecular sciences. vol 22. issue 6. 2021-04-23. PMID:33805800. |
deregulation of any of the stages of the cell cycle or transcription leads to apoptosis but, if uncorrected, can result in a series of diseases, such as cancer, neurodegenerative diseases (alzheimer's or parkinson's disease), and stroke. |
2021-04-23 |
2023-08-13 |
Not clear |
| b' Katarina \\xc5\\xbdivan\\xc4\\x8devi\\xc4\\x87, Katarina Barali\\xc4\\x87, Dragica Jorgovanovi\\xc4\\x87, Aleksandra Buha Djordjevi\\xc4\\x87, Marijana \\xc4\\x86ur\\xc4\\x8di\\xc4\\x87, Evica Antonijevi\\xc4\\x87 Miljakovi\\xc4\\x87, Biljana Antonijevi\\xc4\\x87, Zorica Bulat, Danijela \\xc4\\x90uki\\xc4\\x87-\\xc4\\x86osi\\xc4\\x8. Elucidating the influence of environmentally relevant toxic metal mixture on molecular mechanisms involved in the development of neurodegenerative diseases: In silico toxicogenomic data-mining. Environmental research. vol 194. 2021-04-21. PMID:33465344.' |
oxidative stress, folate metabolism, vitamin b12, age-rage, apoptosis were noted as the key disrupted molecular pathways that contribute to the neurodegenerative disease's development. |
2021-04-21 |
2023-08-13 |
Not clear |
| Mariano Catanesi, Michele d'Angelo, Maria Grazia Tupone, Elisabetta Benedetti, Antonio Giordano, Vanessa Castelli, Annamaria Cimin. MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases. International journal of molecular sciences. vol 21. issue 17. 2021-04-13. PMID:32825273. |
moreover, mirnas are crucial for different processes, including cell growth, signal transmission, apoptosis, cancer and aging-related neurodegenerative diseases. |
2021-04-13 |
2023-08-13 |
Not clear |
| Ge Yang, Pin Wan, Qi Xiang, Shanyu Huang, Siyu Huang, Jun Wang, Kailang Wu, Jianguo W. E3 Ubiquitin Ligase ASB17 Promotes Apoptosis by Ubiquitylating and Degrading BCLW and MCL1. Biology. vol 10. issue 3. 2021-04-13. PMID:33803505. |
altered apoptosis results in a disorder of cell death and is associated with many diseases such as neurodegenerative diseases and cancers. |
2021-04-13 |
2023-08-13 |
mouse |
| Mutsumi Yokota, Soichiro Kakuta, Takahiro Shiga, Kei-Ichi Ishikawa, Hideyuki Okano, Nobutaka Hattori, Wado Akamatsu, Masato Koik. Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons. Molecular brain. vol 14. issue 1. 2021-04-09. PMID:33757554. |
mitochondrial structural changes are associated with the regulation of mitochondrial function, apoptosis, and neurodegenerative diseases. |
2021-04-09 |
2023-08-13 |
Not clear |
| Abbas Mohammadipour, Hossein Haghir, Alireza Ebrahimzadeh Bideska. A link between nanoparticles and Parkinson's disease. Which nanoparticles are most harmful? Reviews on environmental health. vol 35. issue 4. 2021-03-30. PMID:32681785. |
pd is the second most common neurodegenerative disease in the world, and in patients, its symptoms progressively worsen day by day through different pathways including oxidative stress, neuroinflammation, mitochondrial dysfunction, α-synuclein increasing and aggregation, apoptosis and reduction of tyrosine hydroxylase positive cells. |
2021-03-30 |
2023-08-13 |
Not clear |