| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhihao Qi, Zhen Huang, Feng Xie, Linxi Che. Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30515821. |
in addition, increasing reports indicate that the drp1 is involved in some cellular events of neuronal cells causing some neural system dysfunctions and neurodegenerative diseases, including impaired mitochondrial dynamics, apoptosis, and several posttranslational modification induced increased mitochondrial divisions. |
2020-05-04 |
2023-08-13 |
mouse |
| Dominique R Perez, Larry A Sklar, Alexandre Chigae. Clioquinol: To harm or heal. Pharmacology & therapeutics. vol 199. 2020-04-27. PMID:30898518. |
further understanding of clioquinol's role in the inhibition of camp efflux and promoting apoptosis might offer promise for the treatment of cancer and/or neurodegenerative diseases. |
2020-04-27 |
2023-08-13 |
Not clear |
| Haiyang Zhang, Mian Wei, Xiangyu Lu, Qinghong Sun, Chuqiao Wang, Jiuyan Zhang, Honggang Fa. Aluminum trichloride caused hippocampal neural cells death and subsequent depression-like behavior in rats via the activation of IL-1β/JNK signaling pathway. The Science of the total environment. vol 715. 2020-04-03. PMID:32007895. |
aluminum (al) is an inorganic pollutant that induces nerve cells apoptosis and necroptosis, thereby causing depression and neurodegenerative diseases. |
2020-04-03 |
2023-08-13 |
rat |
| Parvaneh Mehrbod, Sudharsana R Ande, Javad Alizadeh, Shahrzad Rahimizadeh, Aryana Shariati, Hadis Malek, Mohammad Hashemi, Kathleen K M Glover, Affan A Sher, Kevin M Coombs, Saeid Ghavam. The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections. Virulence. vol 10. issue 1. 2020-03-05. PMID:30966844. |
abbreviation: aids: acquired immunodeficiency syndrome; atf6: activating transcription factor 6; atg6: autophagy-specific gene 6; bag3: bcl associated athanogene 3; bak: bcl-2-anatagonist/killer1; bax; bcl-2: associated x protein; bcl-2: b cell lymphoma 2x; bip: chaperon immunoglobulin heavy chain binding protein; card: caspase recruitment domain; cart: combination antiretroviral therapy; ccr5: c-c chemokine receptor type 5; cd4: cluster of differentiation 4; chop: c/ebp homologous protein; cxcr4: c-x-c chemokine receptor type 4; cyto c: cytochrome c; dcs: dendritic cells; edem1: er-degradation enhancing-a-mannosidase-like protein 1; env: envelope; er: endoplasmic reticulum; fasr: fas receptor;g2: gap 2; g2/m: gap2/mitosis; gfap: glial fibrillary acidic protein; gp120: glycoprotein120; gp41: glycoprotein41; hand: hiv associated neurodegenerative disease; hek: human embryonic kidney; hela: human cervical epithelial carcinoma; hiv: human immunodeficiency virus; ips-1: ifn-β promoter stimulator 1; ire-1: inositol requiring enzyme 1; irgm: immunity related gtpase family m protein; lamp2a: lysosome associated membrane protein 2a; lc3: microtubule associated light chain 3; mda5: melanoma differentiation associated gene 5; mef: mouse embryonic fibroblast; mmp: mitochondrial membrane permeabilization; nef: negative regulatory factor; oasis: old astrocyte specifically induced substrate; pamp: pathogen-associated molecular pattern; perk: pancreatic endoplasmic reticulum kinase; prr: pattern recognition receptor; puma: p53 upregulated modulator of apoptosis; rig-i: retinoic acid-inducible gene-i; tat: transactivator protein of hiv; tlr: toll-like receptor; ulk1: unc51 like autophagy activating kinase 1; upr: unfolded protein response; vpr: viral protein regulatory; xbp1: x-box binding protein 1. |
2020-03-05 |
2023-08-13 |
mouse |
| Hao Lin, Wan-Qi Yang, Zi Ye, Chong-Jing Zhan. Identification of Potent Caspase-8 Inhibitors from a Library of Fluorescent Natural Products Screened by an AIEgen-Based Light-Up Probe. Chembiochem : a European journal of chemical biology. vol 20. issue 10. 2020-02-25. PMID:30648790. |
caspase-8 is a key player in apoptosis, its inhibition having been found to be beneficial for treatment of inflammatory and neurodegenerative diseases. |
2020-02-25 |
2023-08-13 |
Not clear |
| Wensu Yuan, Carlos F Ibáñez, Zhi Li. Death domain of p75 neurotrophin receptor: a structural perspective on an intracellular signalling hub. Biological reviews of the Cambridge Philosophical Society. vol 94. issue 4. 2020-02-25. PMID:30762293. |
it is a primary mediator of a variety of biological activities, including apoptosis, cell survival and cytoskeletal changes, which are related to many neurodegenerative diseases, neurotrauma, and cancers. |
2020-02-25 |
2023-08-13 |
Not clear |
| Yujeong Lee, Jung-Hyun Cho, Seulah Lee, Wonjong Lee, Seung-Cheol Chang, Hae Young Chung, Hyung Ryong Moon, Jaewon Le. Neuroprotective effects of MHY908, a PPAR α/γ dual agonist, in a MPTP-induced Parkinson's disease model. Brain research. vol 1704. 2020-02-11. PMID:30273550. |
a number of ppar agonists have been shown to have neuroprotective properties in the presence of oxidative stress, neuroinflammatory response, and apoptosis in various neurodegenerative disease. |
2020-02-11 |
2023-08-13 |
mouse |
| Yogesh Kumar Dhuriya, Divakar Sharma, Aijaz A Nai. Cellular demolition: Proteins as molecular players of programmed cell death. International journal of biological macromolecules. vol 138. 2020-01-28. PMID:31330212. |
furthermore, diminished forms of apoptosis result in cancer and autoimmune diseases, whereas unregulated apoptosis may also lead to the development of a myriad of neurodegenerative diseases. |
2020-01-28 |
2023-08-13 |
Not clear |
| Hadhemi Kaddour, Yosra Hamdi, Fatma Amri, Seyma Bahdoudi, Ibtissem Bouannee, Jérôme Leprince, Sami Zekri, Hubert Vaudry, Marie-Christine Tonon, David Vaudry, Mohamed Amri, Sana Mezghani, Olfa Masmoudi-Kouk. Antioxidant and Anti-Apoptotic Activity of Octadecaneuropeptide Against 6-OHDA Toxicity in Cultured Rat Astrocytes. Journal of molecular neuroscience : MN. vol 69. issue 1. 2020-01-21. PMID:30343367. |
oxidative stress, associated with various neurodegenerative diseases, promotes ros generation, impairs cellular antioxidant defenses, and finally, triggers both neurons and astroglial cell death by apoptosis. |
2020-01-21 |
2023-08-13 |
rat |
| Randa Sghaier, Thomas Nury, Valerio Leoni, Claudio Caccia, Jean-Paul Pais De Barros, Ameur Cherif, Anne Vejux, Thibault Moreau, Khalifa Limem, Mohammad Samadi, John J Mackrill, Ahmed Slaheddine Masmoudi, Gérard Lizard, Amira Zarrou. Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol. The Journal of steroid biochemistry and molecular biology. vol 194. 2020-01-14. PMID:31344443. |
oxidative stress and mitochondrial dysfunction contribute to the pathogenesis of neurodegenerative diseases and favor lipid peroxidation, leading to increased levels of 7β-hydroxycholesterol (7β-ohc) which induces oxiapoptophagy (oxidative stress, apoptosis, autophagy). |
2020-01-14 |
2023-08-13 |
cat |
| Nami Kim, Dongmei Chen, Xiao Zhen Zhou, Tae Ho Le. Death-Associated Protein Kinase 1 Phosphorylation in Neuronal Cell Death and Neurodegenerative Disease. International journal of molecular sciences. vol 20. issue 13. 2019-12-06. PMID:31248062. |
however, the deregulation of neuronal apoptosis by various factors leads to neurodegenerative diseases such as ischemic stroke and alzheimer's disease (ad). |
2019-12-06 |
2023-08-13 |
Not clear |
| Dong Guo, Wenting Xie, Pan Xiong, Huifang Li, Siqi Wang, Guimiao Chen, Yuehong Gao, Jiechao Zhou, Ye Zhang, Guojun Bu, Maoqiang Xue, Jie Zhan. Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death. Cell death & disease. vol 9. issue 10. 2019-11-25. PMID:30237421. |
oxidative stress can cause apoptosis in neurons and may result in neurodegenerative diseases. |
2019-11-25 |
2023-08-13 |
Not clear |
| Othman Ghribi, David A. DeWitt, Michael S. Forbes, Ayala Arad, Mary M. Herman, John Savor. Cyclosporin A inhibits Al-induced cytochrome c release from mitochondria in aged rabbits. Journal of Alzheimer's disease : JAD. vol 3. issue 4. 2019-11-20. PMID:12214041. |
neurodegenerative diseases including alzheimer's disease are characterized by a progressive and selective neuronal loss via an apoptosis mechanism, and there is a growing body of evidence which supports a central role of mitochondria in this apoptotic cell death. |
2019-11-20 |
2023-08-12 |
rabbit |
| D Cervia, C Perrotta, C Moscheni, C De Palma, E Clement. Nitric oxide and sphingolipids control apoptosis and autophagy with a significant impact on Alzheimer's disease. Journal of biological regulators and homeostatic agents. vol 27. issue 2 Suppl. 2019-11-20. PMID:24813312. |
aberrant regulation of signalling pathways promoting and regulating apoptosis and autophagy contributes to the development of most human neurodegenerative diseases characterised by progressive dysfunction and death of neuronal and glial cells. |
2019-11-20 |
2023-08-13 |
human |
| Zahida Parveen, Zohra Bibi, Nousheen Bibi, Juergen Neesen, Sajid Rashi. Disruption of murine Tcte3-3 induces tissue specific apoptosis via co-expression of Anxa5 and Pebp1. Computational biology and chemistry. vol 53PB. 2019-11-20. PMID:25462330. |
any discrepancy in apoptosis may trigger testicular and neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. |
2019-11-20 |
2023-08-13 |
mouse |
| Joelle Makoukji, Fadi Saadeh, Karl Albert Mansour, Sally El-Sitt, Jamal Al Ali, Nihar Kinarivala, Paul C Trippier, Rose-Mary Boustan. Flupirtine derivatives as potential treatment for the neuronal ceroid lipofuscinoses. Annals of clinical and translational neurology. vol 5. issue 9. 2019-11-20. PMID:30250865. |
neuronal ceroid lipofuscinoses (ncl) are fatal inherited neurodegenerative diseases with established neuronal cell death and increased ceramide levels in brain, hence, a need for disease-modifying drug candidates, with potential to enhance growth, reduce apoptosis and lower ceramide in neuronal precursor pc12 cells and human ncl cell lines using enhanced flupirtine aromatic carbamate derivatives in vitro. |
2019-11-20 |
2023-08-13 |
human |
| Yong-Yue Gao, Zi-Huan Zhang, Zong Zhuang, Yue Lu, Ling-Yun Wu, Zhen-Nan Ye, Xiang-Sheng Zhang, Chun-Lei Chen, Wei Li, Chun-Hua Han. Recombinant milk fat globule-EGF factor-8 reduces apoptosis via integrin β3/FAK/PI3K/AKT signaling pathway in rats after traumatic brain injury. Cell death & disease. vol 9. issue 9. 2019-11-15. PMID:30154436. |
previous studies have established that milk fat globule-egf factor-8 (mfg-e8) provides neuroprotection through modulation of inflammation, oxidative stress, and especially apoptosis in cerebral ischemia and neurodegenerative disease. |
2019-11-15 |
2023-08-13 |
human |
| N V Ivanisenko, I N Lavri. [Mechanisms of Procaspase-8 Activation in the Extrinsic Programmed Cell Death Pathway]. Molekuliarnaia biologiia. vol 53. issue 5. 2019-11-01. PMID:31661481. |
dysregulation of the apoptosis mechanisms is associated with the pathogenesis and progression of a number of oncological and neurodegenerative diseases. |
2019-11-01 |
2023-08-13 |
Not clear |
| Qi Xiong, Qin Ru, Xiang Tian, Mei Zhou, Lin Chen, Yi Li, Chaoying L. Krill oil protects PC12 cells against methamphetamine-induced neurotoxicity by inhibiting apoptotic response and oxidative stress. Nutrition research (New York, N.Y.). vol 58. 2019-10-17. PMID:30340818. |
oxidative stress and apoptosis are linked in the pathophysiology of many neurodegenerative diseases. |
2019-10-17 |
2023-08-13 |
human |
| Eduardo Duarte-Silva, Shyrlene Meiry da Rocha Araújo, Wilma Helena Oliveira, Deniele Bezerra de Lós, Maria Eduarda Rocha de França, Amanda Pires Bonfanti, Gabriela Peron, Livia de Lima Thomaz, Liana Verinaud, Ana Karolina de Santana Nunes, Christina Alves Peixot. Sildenafil ameliorates EAE by decreasing apoptosis in the spinal cord of C57BL/6 mice. Journal of neuroimmunology. vol 321. 2019-10-03. PMID:29957383. |
in most neuroinflammatory and/or neurodegenerative diseases, apoptosis is associated with disease development and pathology and inhibition of this process leads to considerable amelioration. |
2019-10-03 |
2023-08-13 |
mouse |