| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kisang Kwon, Young-Sook Kwon, Seung-Whan Kim, Kweon Yu, Kyung-Ho Lee, O-Yu Kwo. Luteolin-induced apoptosis through activation of endoplasmic reticulum stress sensors in pheochromocytoma cells. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28498401. |
the results suggested that the understanding of the molecular mechanisms underlying luteolin‑induced apoptosis may be useful in cancer therapeutics, chemoprevention and neurodegenerative diseases, such as parkinson's disease and alzheimer's disease. |
2018-03-26 |
2023-08-13 |
rat |
| Yinan Nan, Shaoqing Wang, William Ji. Caspase independent cleavages of TDP-43 generates 35kD fragment that cause apoptosis of breast cancer cells. Biochemical and biophysical research communications. vol 497. issue 1. 2018-03-23. PMID:29421661. |
due to its central role in neurodegenerative disease pathogenesis, most research recently has focused on its role associated with neurodegeneration disease, research on neuron and glial cell showed that pathological tdp-43 is associated with cell apoptosis which lead to loss of functional neurons and glial cells. |
2018-03-23 |
2023-08-13 |
Not clear |
| Niels H Skotte, Shaun S Sanders, Roshni R Singaraja, Dagmar E Ehrnhoefer, Kuljeet Vaid, Xiaofan Qiu, Srinivasaragavan Kannan, Chandra Verma, Michael R Hayde. Palmitoylation of caspase-6 by HIP14 regulates its activation. Cell death and differentiation. vol 24. issue 3. 2018-01-19. PMID:27911442. |
caspase-6 (casp6) has an important role in axonal degeneration during neuronal apoptosis and in the neurodegenerative diseases alzheimer and huntington disease. |
2018-01-19 |
2023-08-13 |
Not clear |
| Kristian K Starheim, Thomas V Kalvik, Geir Bjørkøy, Thomas Arnese. Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization. Bioscience reports. vol 37. issue 2. 2018-01-16. PMID:28356483. |
golgi stack scattering is observed in cellular processes such as apoptosis and mitosis, and has also been associated with disruption of cellular lipid metabolism and neurodegenerative diseases. |
2018-01-16 |
2023-08-13 |
human |
| Yingting Wang, Shulong Jiang, Hongli Wang, Haiyan Bi. A mucoadhesive, thermoreversible in situ nasal gel of geniposide for neurodegenerative diseases. PloS one. vol 12. issue 12. 2018-01-16. PMID:29240797. |
geniposide could inhibit oxidative stress, reduce apoptosis, protect neuron, and has been used for therapy of the neurodegenerative diseases. |
2018-01-16 |
2023-08-13 |
Not clear |
| Yi Cui, Nuo Xu, Wei Xu, Guoxing X. Mesenchymal stem cells attenuate hydrogen peroxide-induced oxidative stress and enhance neuroprotective effects in retinal ganglion cells. In vitro cellular & developmental biology. Animal. vol 53. issue 4. 2018-01-15. PMID:27864663. |
the apoptosis of retinal ganglion cells leads to visual impairment and blindness in ocular neurodegenerative diseases, especially in diabetic retinopathy (dr). |
2018-01-15 |
2023-08-13 |
Not clear |
| Ankit Shah, Anil Kuma. Methamphetamine-mediated endoplasmic reticulum (ER) stress induces type-1 programmed cell death in astrocytes via ATF6, IRE1α and PERK pathways. Oncotarget. vol 7. issue 29. 2018-01-08. PMID:27323860. |
conversely, the er stress-mediated apoptosis has been implicated in several neurodegenerative diseases. |
2018-01-08 |
2023-08-13 |
mouse |
| Pandian Nagakannan, Mohamed Ariff Iqbal, Albert Yeung, James A Thliveris, Mojgan Rastegar, Saeid Ghavami, Eftekhar Eftekharpou. Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells. Free radical biology & medicine. vol 101. 2017-12-25. PMID:27693380. |
our study provides evidence that excessive oxidative stress inhibits protein degradation systems and affects the final stages of autophagy by inhibiting autolysosome maturation: a novel mechanistic link between protein aggregation and conversion of autophagy to apoptosis that can be applicable to neurodegenerative diseases. |
2017-12-25 |
2023-08-13 |
Not clear |
| Yang Yu, Linjing Feng, Junnan Li, Xiaoxin Lan, Lixiang A, Xiaoyan Lv, Ming Zhang, Li Che. The alteration of autophagy and apoptosis in the hippocampus of rats with natural aging-dependent cognitive deficits. Behavioural brain research. vol 334. 2017-12-11. PMID:28688896. |
the present study was aim to explore aging-dependent changes in hippocampal autophagy and apoptosis in a natural aging rat model from adult to old stages and to discover a suitable age for treating neurodegenerative diseases. |
2017-12-11 |
2023-08-13 |
rat |
| Setsuko Tsuboi, Takashi Ji. Bioluminescence Resonance Energy Transfer (BRET)-coupled Annexin V-functionalized Quantum Dots for Near-Infrared Optical Detection of Apoptotic Cells. Chembiochem : a European journal of chemical biology. vol 18. issue 22. 2017-12-05. PMID:28901721. |
deregulation in apoptosis induces numerous diseases such as cancer, cardiovascular, and neurodegenerative diseases. |
2017-12-05 |
2023-08-13 |
Not clear |
| Hitoshi Shimano, Ryuichiro Sat. SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology. Nature reviews. Endocrinology. vol 13. issue 12. 2017-11-16. PMID:28849786. |
in addition, srebps are implicated in numerous pathogenic processes such as endoplasmic reticulum stress, inflammation, autophagy and apoptosis, and in this way, they contribute to obesity, dyslipidaemia, diabetes mellitus, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, chronic kidney disease, neurodegenerative diseases and cancers. |
2017-11-16 |
2023-08-13 |
Not clear |
| Sun-Oh Jeong, Yong Son, Ju Hwan Lee, Seung Won Choi, Sung Hun Kim, Yong-Kwan Cheong, Hun-Taeg Chung, Hyun-Ock Pa. Both nitric oxide and nitrite prevent homocysteine-induced endoplasmic reticulum stress and subsequent apoptosis via cGMP-dependent pathway in neuronal cells. Biochemical and biophysical research communications. vol 493. issue 1. 2017-10-23. PMID:28917840. |
growing evidence indicates that endoplasmic reticulum (er) stress and/or er stress-mediated apoptosis may play a role in the pathogenesis of neurodegenerative diseases such as alzheimer's disease. |
2017-10-23 |
2023-08-13 |
Not clear |
| Sun-Oh Jeong, Yong Son, Ju Hwan Lee, Seung Won Choi, Sung Hun Kim, Yong-Kwan Cheong, Hun-Taeg Chung, Hyun-Ock Pa. Both nitric oxide and nitrite prevent homocysteine-induced endoplasmic reticulum stress and subsequent apoptosis via cGMP-dependent pathway in neuronal cells. Biochemical and biophysical research communications. vol 493. issue 1. 2017-10-23. PMID:28917840. |
these findings provide the first evidence showing that both no and nitrite can reduce er stress and subsequent apoptosis via no-sgc-cgmp pathway in neuronal cells and suggesting that no and/or nitrite may have therapeutic value in the treatment of er stress-associated neurodegenerative diseases. |
2017-10-23 |
2023-08-13 |
Not clear |
| Sercan Ergun, Serdar Oztuzc. Sequence-based analysis of 5'UTR and coding regions of CASP3 in terms of miRSNPs and SNPs in targetting miRNAs. Computational biology and chemistry. vol 62. 2017-10-16. PMID:27107179. |
deregulation of apoptosis occurs in many human conditions such as autoimmune disorders, ischemic damage, neurodegenerative diseases and different cancer types. |
2017-10-16 |
2023-08-13 |
human |
| Rajeev Gupt. Phosphorylation of rat brain purified mitochondrial Voltage-Dependent Anion Channel by c-Jun N-terminal kinase-3 modifies open-channel noise. Biochemical and biophysical research communications. vol 490. issue 4. 2017-09-21. PMID:28676395. |
it has been shown that c-jun n-terminal kinase-3 (jnk3) becomes activated by phosphorylation in various neurodegenerative diseases and phosphorylates outer mitochondrion associated proteins leading to neuronal apoptosis. |
2017-09-21 |
2023-08-13 |
rat |
| Liu-Hong Li, Qiu-Yun Tu, Xiao-Hua Deng, Jian Xia, De-Ren Hou, Ke Guo, Xiao-Hong Z. Mutant presenilin2 promotes apoptosis through the p53/miR-34a axis in neuronal cells. Brain research. vol 1662. 2017-09-05. PMID:28189560. |
the p53/mir-34a axis triggers apoptosis and suppresses viability in multiple types of cells, but little is known about its role in neurodegenerative diseases. |
2017-09-05 |
2023-08-13 |
mouse |
| Navya Lakkappa, Praveen T Krishnamurthy, Bruce D Hammock, D Velmurugan, M M Srinivas Bharat. Possible role of Epoxyeicosatrienoic acid in prevention of oxidative stress mediated neuroinflammation in Parkinson disorders. Medical hypotheses. vol 93. 2017-06-15. PMID:27372879. |
parkinson's disease (pd) is a multifactorial neurodegenerative disease involving oxidative stress, neuroinflammation and apoptosis. |
2017-06-15 |
2023-08-13 |
Not clear |
| Theetat Ruangjaroon, Daranee Chokchaichamnankit, Chantragan Srisomsap, Jisnuson Svasti, N Monique Paricharttanaku. Involvement of vimentin in neurite outgrowth damage induced by fipronil in SH-SY5Y cells. Biochemical and biophysical research communications. vol 486. issue 3. 2017-06-02. PMID:28322794. |
fipronil induced apoptosis involving caspase-6, which is an apoptotic effector highly implicated in neurodegenerative diseases. |
2017-06-02 |
2023-08-13 |
human |
| Danya Ben-Hail, Racheli Begas-Shvartz, Moran Shalev, Anna Shteinfer-Kuzmine, Arie Gruzman, Simona Reina, Vito De Pinto, Varda Shoshan-Barmat. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. The Journal of biological chemistry. vol 291. issue 48. 2017-05-26. PMID:27738100. |
apoptosis is thought to play a critical role in several pathological processes, such as neurodegenerative diseases (i.e. |
2017-05-26 |
2023-08-13 |
Not clear |
| Zhengmao Li, Fenzan Wu, Xie Zhang, Yi Chai, Daqing Chen, Yuetao Yang, Kebin Xu, Jiayu Yin, Rui Li, Hongxue Shi, Zhouguang Wang, Xiaokun Li, Jian Xiao, Hongyu Zhan. Valproate Attenuates Endoplasmic Reticulum Stress-Induced Apoptosis in SH-SY5Y Cells via the AKT/GSK3β Signaling Pathway. International journal of molecular sciences. vol 18. issue 2. 2017-04-28. PMID:28208696. |
endoplasmic reticulum (er) stress-induced apoptosis plays an important role in a range of neurological disorders, such as neurodegenerative diseases, spinal cord injury, and diabetic neuropathy. |
2017-04-28 |
2023-08-13 |
rat |