| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel L Morris, Nico Tjandr. Inducible fold-switching as a mechanism to fibrillate pro-apoptotic BCL-2 proteins. Biopolymers. vol 112. issue 10. 2021-10-26. PMID:33764501. |
neurodegenerative diseases often are associated with cellular dysregulation that results in premature cell death or apoptosis. |
2021-10-26 |
2023-08-13 |
Not clear |
| Qi Wu, Zhi-Han Tang, Juan Peng, Ling Liao, Li-Hong Pan, Chun-Yan Wu, Zhi-Sheng Jiang, Gui-Xue Wang, Lu-Shan Li. The dual behavior of PCSK9 in the regulation of apoptosis is crucial in Alzheimer's disease progression (Review). Biomedical reports. vol 2. issue 2. 2021-10-21. PMID:24649090. |
neuronal apoptosis is crucial in neurodegenerative diseases. |
2021-10-21 |
2023-08-12 |
human |
| Qi Wu, Zhi-Han Tang, Juan Peng, Ling Liao, Li-Hong Pan, Chun-Yan Wu, Zhi-Sheng Jiang, Gui-Xue Wang, Lu-Shan Li. The dual behavior of PCSK9 in the regulation of apoptosis is crucial in Alzheimer's disease progression (Review). Biomedical reports. vol 2. issue 2. 2021-10-21. PMID:24649090. |
human and animal studies demonstrated that a high concentration of oxidized ldl (ox-ldl) in the brain, which is associated with hyperlipidemia, is one of the key apoptosis inducers in neurodegenerative diseases. |
2021-10-21 |
2023-08-12 |
human |
| Qi Wu, Zhi-Han Tang, Juan Peng, Ling Liao, Li-Hong Pan, Chun-Yan Wu, Zhi-Sheng Jiang, Gui-Xue Wang, Lu-Shan Li. The dual behavior of PCSK9 in the regulation of apoptosis is crucial in Alzheimer's disease progression (Review). Biomedical reports. vol 2. issue 2. 2021-10-21. PMID:24649090. |
aβ is another key apoptosis inducer in neurodegenerative diseases. |
2021-10-21 |
2023-08-12 |
human |
| Altmash Khan, Gifty Kuriachan, Radhakrishnan Mahalakshm. Cellular Interactome of Mitochondrial Voltage-Dependent Anion Channels: Oligomerization and Channel (Mis)Regulation. ACS chemical neuroscience. vol 12. issue 19. 2021-10-21. PMID:34503333. |
however, research findings in the past decade have revealed the multifaceted regulatory roles of vdacs, from governing cellular physiology and mitochondria-mediated apoptosis to directly regulating debilitating cancers and neurodegenerative diseases. |
2021-10-21 |
2023-08-13 |
human |
| Srikanth Ranganathan, Robert Bowse. p53 and Cell Cycle Proteins Participate in Spinal Motor Neuron Cell Death in ALS. The open pathology journal. vol 4. 2021-10-20. PMID:21572928. |
apoptosis has been implicated in many neurodegenerative diseases, including amyotrophic lateral sclerosis (als). |
2021-10-20 |
2023-08-12 |
human |
| Chong Xu, Sujuan Chen, Ming Xu, Xiaoling Chen, Xiaoxue Wang, Hai Zhang, Xiaoqing Dong, Ruijie Zhang, Xin Chen, Wei Gao, Shile Huang, Long Che. Cadmium Impairs Autophagy Leading to Apoptosis by Ca Neurochemical research. vol 46. issue 8. 2021-10-18. PMID:34021889. |
cadmium impairs autophagy leading to apoptosis by ca autophagy, a process for self-degradation of intracellular components and dysfunctional organelles, is closely related with neurodegenerative diseases. |
2021-10-18 |
2023-08-13 |
Not clear |
| Łucja Justyna Walczak-Nowicka, Mariola Herbe. Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis. International journal of molecular sciences. vol 22. issue 17. 2021-10-18. PMID:34502198. |
acetylcholinesterase (ache) plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins. |
2021-10-18 |
2023-08-13 |
Not clear |
| Li-Ling He, Yun-Cui Wang, Ya-Ting Ai, Ling Wang, Si-Meng Gu, Ping Wang, Qing-Hua Long, Hui H. Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630111. |
qiangji decoction alleviates neurodegenerative changes and hippocampal neuron apoptosis induced by d-galactose qiangji decoction (qjd), a classic formula, has been widely used to treat brain aging-related neurodegenerative diseases. |
2021-10-12 |
2023-08-13 |
mouse |
| Bhawna Pandey, Aditya Dev, Debamitra Chakravorty, Vishwambhar Vishnu Bhandare, Smarajit Polley, Siddhartha Roy, Gautam Bas. Insights on the disruption of the complex between human positive coactivator 4 and p53 by small molecules. Biochemical and biophysical research communications. vol 578. 2021-10-11. PMID:34534740. |
in certain neurodegenerative diseases pc4 assisted-p53-dependent apoptosis may play a central role. |
2021-10-11 |
2023-08-13 |
human |
| Fei Wang, Juan Li, Shengjie Fan, Zhigang Jin, Cheng Huan. Targeting stress granules: A novel therapeutic strategy for human diseases. Pharmacological research. vol 161. 2021-09-01. PMID:32814168. |
sgs participate in various biological functions including response to apoptosis, inflammation, immune modulation, and signalling pathways; moreover, sgs are involved in pathogenesis of neurodegenerative diseases, viral infection, aging, cancers and many other diseases. |
2021-09-01 |
2023-08-13 |
human |
| Haifan Gong, Julia Bandura, Guan-Lei Wang, Zhong-Ping Feng, Hong-Shuo Su. Xyloketal B: A marine compound with medicinal potential. Pharmacology & therapeutics. 2021-08-18. PMID:34375691. |
xyloketal b and its derivatives exhibit cytoprotective effects in cardiovascular and neurodegenerative diseases by reducing oxidative stress, regulating the apoptosis pathway, maintaining ionic balance, mitigating inflammatory responses, and preventing protein aggregation. |
2021-08-18 |
2023-08-13 |
Not clear |
| Zhonghao Su, Lanyue Sheng, Ping Yu, Na Ren, Yajuan Li, Zhenxia Qi. Regulation of microRNAs by IRE1α in apoptosis: implications for the pathomechanism of neurodegenerative diseases. The International journal of neuroscience. vol 130. issue 12. 2021-08-16. PMID:32070174. |
regulation of micrornas by ire1α in apoptosis: implications for the pathomechanism of neurodegenerative diseases. |
2021-08-16 |
2023-08-13 |
Not clear |
| Zhonghao Su, Lanyue Sheng, Ping Yu, Na Ren, Yajuan Li, Zhenxia Qi. Regulation of microRNAs by IRE1α in apoptosis: implications for the pathomechanism of neurodegenerative diseases. The International journal of neuroscience. vol 130. issue 12. 2021-08-16. PMID:32070174. |
this review provides an overview of recent progress in unfolded protein response (upr) during apoptosis induced by abnormal protein aggregation and emphasizes on the potential role of inositol requiring enzyme 1 alpha (ire1α)-micrornas (mirnas) mediated apoptosis in nds, which will provide new insights in the pathogenesis of neurodegenerative diseases and novel therapeutic targets for the treatment of nds. |
2021-08-16 |
2023-08-13 |
Not clear |
| Yanting Shen, Jing Yue, Weiqing Xu, Shuping X. Recent progress of surface-enhanced Raman spectroscopy for subcellular compartment analysis. Theranostics. vol 11. issue 10. 2021-08-16. PMID:33754033. |
organelles are involved in many cell life activities, and their metabolic or functional disorders are closely related to apoptosis, neurodegenerative diseases, cardiovascular diseases, and the development and metastasis of cancers. |
2021-08-16 |
2023-08-13 |
Not clear |
| V L Shliapina, S V Yurtaeva, M P Rubtsova, O A Dontsov. At the Crossroads: Mechanisms of Apoptosis and Autophagy in Cell Life and Death. Acta naturae. vol 13. issue 2. 2021-08-12. PMID:34377561. |
the signaling pathways involved in the regulation of apoptosis and autophagy largely overlap, leading to both competition and unidirectional interaction, which is of particular interest in investigating them as potential targets for cancer, autoimmune, and neurodegenerative disease therapies. |
2021-08-12 |
2023-08-13 |
Not clear |
| Jianhua Su, Junhua Zhang, Rui Bao, Changbo Xia, Yu Zhang, Zhujun Zhu, Qi Lv, Yingjie Qi, Jianqin Xu. Mitochondrial dysfunction and apoptosis are attenuated through activation of AMPK/GSK-3β/PP2A pathway in Parkinson's disease. European journal of pharmacology. vol 907. 2021-08-03. PMID:34048739. |
adenosine 5'-monophosphate-activated protein kinase (ampk), glycogen synthase kinase 3 (gsk-3β) and protein phosphatase 2a (pp2a) are all key proteins that regulate mitochondrial metabolism and apoptosis, and they are involved in a variety of neurodegenerative diseases. |
2021-08-03 |
2023-08-13 |
mouse |
| Juepu Zhou, Yao Jin, Yuhong Lei, Tianyi Liu, Zheng Wan, Hao Meng, Honglei Wan. Ferroptosis Is Regulated by Mitochondria in Neurodegenerative Diseases. Neuro-degenerative diseases. vol 20. issue 1. 2021-08-02. PMID:32814328. |
previous research has revealed that many forms of cell death, such as apoptosis and necrosis, occur in neurodegenerative diseases. |
2021-08-02 |
2023-08-13 |
Not clear |
| Mei L. The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases. Apoptosis : an international journal on programmed cell death. vol 26. issue 5-6. 2021-07-27. PMID:33783663. |
the role of p53 up-regulated modulator of apoptosis (puma) in ovarian development, cardiovascular and neurodegenerative diseases. |
2021-07-27 |
2023-08-13 |
Not clear |
| Mei L. The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases. Apoptosis : an international journal on programmed cell death. vol 26. issue 5-6. 2021-07-27. PMID:33783663. |
it also induces excessive apoptosis in cardiovascular and/or neurodegenerative diseases. |
2021-07-27 |
2023-08-13 |
Not clear |