| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingya Zhang, Yueting Zhang, Dipankar J Dutta, Azeb T Argaw, Virginie Bonnamain, Jeremy Seto, David A Braun, Andleeb Zameer, Fernand Hayot, Carolina B Lòpez, Cedric S Raine, Gareth R Joh. Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 3. 2011-10-24. PMID:21709156. |
current therapies for multiple sclerosis target inflammation but do not directly address oligodendrocyte protection or myelin repair. |
2011-10-24 |
2023-08-12 |
mouse |
| Jingya Zhang, Yueting Zhang, Dipankar J Dutta, Azeb T Argaw, Virginie Bonnamain, Jeremy Seto, David A Braun, Andleeb Zameer, Fernand Hayot, Carolina B Lòpez, Cedric S Raine, Gareth R Joh. Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 3. 2011-10-24. PMID:21709156. |
collectively, these findings reveal novel mechanisms underlying the actions of a neuroprotective and immunoregulatory member of the gp130 cytokine family, suggesting avenues to enhance oligodendrocyte viability and restrict cns inflammation in multiple sclerosis. |
2011-10-24 |
2023-08-12 |
mouse |
| Olatz Pampliega, María Domercq, Federico N Soria, Pablo Villoslada, Alfredo Rodríguez-Antigüedad, Carlos Matut. Increased expression of cystine/glutamate antiporter in multiple sclerosis. Journal of neuroinflammation. vol 8. 2011-10-03. PMID:21639880. |
glutamate excitotoxicity contributes to oligodendrocyte and tissue damage in multiple sclerosis (ms). |
2011-10-03 |
2023-08-12 |
Not clear |
| Axinia Doring, Voon Wee Yon. The good, the bad and the ugly. Macrophages/microglia with a focus on myelin repair. Frontiers in bioscience (Scholar edition). vol 3. 2011-09-26. PMID:21622236. |
spontaneous remyelination by oligodendrocytes that mature from oligodendrocyte precursor cells occurs following demyelination, even in the chronic inflammatory disorder of the central nervous system, multiple sclerosis. |
2011-09-26 |
2023-08-12 |
Not clear |
| Khadir Raddassi, Sally C Kent, Junbao Yang, Kasia Bourcier, Elizabeth M Bradshaw, Vicki Seyfert-Margolis, Gerald T Nepom, William W Kwok, David A Hafle. Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 2. 2011-09-23. PMID:21653833. |
increased frequencies of myelin oligodendrocyte glycoprotein/mhc class ii-binding cd4 cells in patients with multiple sclerosis. |
2011-09-23 |
2023-08-12 |
human |
| Stephen P J Fancy, Emily P Harrington, Tracy J Yuen, John C Silbereis, Chao Zhao, Sergio E Baranzini, Charlotte C Bruce, Jose J Otero, Eric J Huang, Roel Nusse, Robin J M Franklin, David H Rowitc. Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nature neuroscience. vol 14. issue 8. 2011-09-23. PMID:21706018. |
we found that axin2 was expressed in immature oligodendrocyte progenitor cells (olps) in white matter lesions of human newborns with neonatal hypoxic-ischemic and gliotic brain damage, as well as in active multiple sclerosis lesions in adults. |
2011-09-23 |
2023-08-12 |
human |
| Sha Mi, Xinhua Lee, Yinghui Hu, Benxiu Ji, Zhaohui Shao, Weixing Yang, Guanrong Huang, Lee Walus, Kenneth Rhodes, Bang Jian Gong, Robert H Miller, R Blake Pepinsk. Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination. Nature medicine. vol 17. issue 7. 2011-09-20. PMID:21725297. |
these studies reveal a pivotal role for dr6 signaling in immature oligodendrocyte maturation and myelination that may provide new therapeutic avenues for the treatment of demyelination disorders such as multiple sclerosis. |
2011-09-20 |
2023-08-12 |
mouse |
| Mark R Kotter, Christine Stadelmann, Hans-Peter Hartun. Enhancing remyelination in disease--can we wrap it up? Brain : a journal of neurology. vol 134. issue Pt 7. 2011-08-26. PMID:21507994. |
however, multiple sclerosis lesions also contain factors that inhibit the differentiation of oligodendrocyte precursor cells into myelinating oligodendrocytes. |
2011-08-26 |
2023-08-12 |
Not clear |
| Mark R Kotter, Christine Stadelmann, Hans-Peter Hartun. Enhancing remyelination in disease--can we wrap it up? Brain : a journal of neurology. vol 134. issue Pt 7. 2011-08-26. PMID:21507994. |
the pattern by which remyelination inducers and inhibitors are expressed in multiple sclerosis lesions may determine a window of opportunity during which oligodendrocyte precursor cells can successfully differentiate. |
2011-08-26 |
2023-08-12 |
Not clear |
| Mark R Kotter, Christine Stadelmann, Hans-Peter Hartun. Enhancing remyelination in disease--can we wrap it up? Brain : a journal of neurology. vol 134. issue Pt 7. 2011-08-26. PMID:21507994. |
as the first molecules aiming at promoting remyelination are about to enter clinical trials, this review critically evaluates recent advances in our understanding of the biology of oligodendrocyte precursor cells and of the stage-dependent molecular pathology of multiple sclerosis lesions relevant to the regeneration of myelin sheaths. |
2011-08-26 |
2023-08-12 |
Not clear |
| Carlos Matut. Glutamate and ATP signalling in white matter pathology. Journal of anatomy. vol 219. issue 1. 2011-08-24. PMID:21250988. |
in addition to glutamate, atp signalling can directly trigger oligodendrocyte excitotoxicity via activation of ca(2+) -permeable p2x7 purinergic receptors, which mediates ischaemic damage to white matter (wm) and causes lesions that are reminiscent of multiple sclerosis (ms) plaques. |
2011-08-24 |
2023-08-12 |
Not clear |
| Alexandra Kotsiari, Elke Verena Voss, Refik Pul, Thomas Skripuletz, Daniela Ragancokova, Corinna Trebst, Martin Stange. Interferon-β treatment normalises the inhibitory effect of serum from multiple sclerosis patients on oligodendrocyte progenitor proliferation. Neuroscience letters. vol 485. issue 2. 2011-08-15. PMID:20816724. |
interferon-β treatment normalises the inhibitory effect of serum from multiple sclerosis patients on oligodendrocyte progenitor proliferation. |
2011-08-15 |
2023-08-12 |
Not clear |
| Jingya Zhang, Elisabeth G Kramer, Sean Mahase, Dipankar J Dutta, Virginie Bonnamain, Azeb T Argaw, Gareth R Joh. Targeting oligodendrocyte protection and remyelination in multiple sclerosis. The Mount Sinai journal of medicine, New York. vol 78. issue 2. 2011-07-27. PMID:21425268. |
targeting oligodendrocyte protection and remyelination in multiple sclerosis. |
2011-07-27 |
2023-08-12 |
human |
| Jingya Zhang, Elisabeth G Kramer, Sean Mahase, Dipankar J Dutta, Virginie Bonnamain, Azeb T Argaw, Gareth R Joh. Targeting oligodendrocyte protection and remyelination in multiple sclerosis. The Mount Sinai journal of medicine, New York. vol 78. issue 2. 2011-07-27. PMID:21425268. |
studies in genetically modified animals have improved our understanding of mechanisms underlying central nervous system pathology in multiple sclerosis models, and have identified pathways that regulate oligodendrocyte viability and myelin repair. |
2011-07-27 |
2023-08-12 |
human |
| P H Lalive, M G Häusler, H Maurey, Y Mikaeloff, M Tardieu, H Wiendl, M Schroeter, H P Hartung, B C Kieseier, T Meng. Highly reactive anti-myelin oligodendrocyte glycoprotein antibodies differentiate demyelinating diseases from viral encephalitis in children. Multiple sclerosis (Houndmills, Basingstoke, England). vol 17. issue 3. 2011-06-24. PMID:21177754. |
myelin oligodendrocyte glycoprotein (mog) may be implicated in the immunopathogenesis of multiple sclerosis (ms) inducing demyelination in the animal model of ms. |
2011-06-24 |
2023-08-12 |
Not clear |
| Ajaib S Paintlia, Manjeet K Paintlia, Avtar K Singh, John K Orak, Inderjit Sing. Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells. Glia. vol 58. issue 14. 2011-06-01. PMID:20578043. |
previously, we and others documented that statins including-lovastatin (lov) promote the differentiation of oligodendrocyte progenitor cells (opcs) and remyelination in experimental autoimmune encephalomyelitis (eae), an multiple sclerosis (ms) model. |
2011-06-01 |
2023-08-12 |
rat |
| Maria Domercq, Elena Alberdi, Maria Victoria Sánchez-Gómez, Usue Ariz, Alberto Pérez-Samartín, Carlos Matut. Dual-specific phosphatase-6 (Dusp6) and ERK mediate AMPA receptor-induced oligodendrocyte death. The Journal of biological chemistry. vol 286. issue 13. 2011-06-01. PMID:21300799. |
therefore, targeting dusp6 may be a useful strategy to prevent oligodendrocyte death in multiple sclerosis and other diseases involving cns white matter. |
2011-06-01 |
2023-08-12 |
Not clear |
| Yasir A Syed, Elisabeth Hand, Wiebke Möbius, Chao Zhao, Matthias Hofer, Klaus A Nave, Mark R Kotte. Inhibition of CNS remyelination by the presence of semaphorin 3A. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 10. 2011-05-11. PMID:21389227. |
failure of oligodendrocyte precursor cell (opc) differentiation has been recognized as the leading cause for the failure of myelin regeneration in diseases such as multiple sclerosis (ms). |
2011-05-11 |
2023-08-12 |
rat |
| Ralf A Linker, De-Hyung Lee, Sarah Ryan, Anne M van Dam, Rebecca Conrad, Pradeep Bista, Weike Zeng, Xiaoping Hronowsky, Alex Buko, Sowmya Chollate, Gisa Ellrichmann, Wolfgang Brück, Kate Dawson, Susan Goelz, Stefan Wiese, Robert H Scannevin, Matvey Lukashev, Ralf Gol. Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain : a journal of neurology. vol 134. issue Pt 3. 2011-04-15. PMID:21354971. |
first we have studied effects of dimethylfumarate on the disease course, central nervous system, tissue integrity and the molecular mechanism of action in an animal model of chronic multiple sclerosis: myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis in c57bl/6 mice. |
2011-04-15 |
2023-08-12 |
mouse |
| Shogo Sakuma, Tsuyoshi Endo, Takashi Kanda, Hideki Nakamura, Satomi Yamasaki, Tomio Yamakaw. Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation. Bioorganic & medicinal chemistry letters. vol 21. issue 1. 2011-04-14. PMID:21112784. |
further, it stimulated differentiation of primary oligodendrocyte precursor cells in vitro, indicating that it may be an effective drug in the treatment of demyelinating disorders such as multiple sclerosis. |
2011-04-14 |
2023-08-12 |
human |