| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyriaki Markoullis, Irene Sargiannidou, Natasa Schiza, Andreas Hadjisavvas, Federico Roncaroli, Richard Reynolds, Kleopas A Kleop. Gap junction pathology in multiple sclerosis lesions and normal-appearing white matter. Acta neuropathologica. vol 123. issue 6. 2012-09-24. PMID:22484441. |
oligodendrocyte gap junctions (gjs) are vital for central nervous system myelination, but their involvement in multiple sclerosis (ms) pathology remains unknown. |
2012-09-24 |
2023-08-12 |
Not clear |
| Laura-Jane Oluich, Jo Anne S Stratton, Yao Lulu Xing, Sze Woei Ng, Holly S Cate, Pankaj Sah, François Windels, Trevor J Kilpatrick, Tobias D Merso. Targeted ablation of oligodendrocytes induces axonal pathology independent of overt demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 24. 2012-09-24. PMID:22699912. |
these findings have clear implications for the understanding of the pathogenesis of diseases of the cns such as multiple sclerosis in which the oligodendrocyte is potentially targeted. |
2012-09-24 |
2023-08-12 |
mouse |
| Lin Xiao, Dazhi Guo, Chun Hu, Weiran Shen, Lei Shan, Cui Li, Xiuyun Liu, Wenjing Yang, Weidong Zhang, Cheng H. Diosgenin promotes oligodendrocyte progenitor cell differentiation through estrogen receptor-mediated ERK1/2 activation to accelerate remyelination. Glia. vol 60. issue 7. 2012-09-20. PMID:22461009. |
taking together, our results suggest that diosgenin promotes the differentiation of opc into mature oligodendrocyte through an er-mediated erk1/2 activation pathway to accelerate remyelination, which implicates a novel therapeutic usage of this steroidal natural product in demyelinating diseases such as multiple sclerosis (ms). |
2012-09-20 |
2023-08-12 |
rat |
| Kyriaki Markoullis, Irene Sargiannidou, Christopher Gardner, Andreas Hadjisavvas, Richard Reynolds, Kleopas A Kleop. Disruption of oligodendrocyte gap junctions in experimental autoimmune encephalomyelitis. Glia. vol 60. issue 7. 2012-09-20. PMID:22461072. |
in order to examine how different stages of inflammatory demyelination affect oligodendrocyte gjs, we studied the expression of oligodendrocytic connexin32 (cx32) and cx47 and astrocytic cx43 in the experimental autoimmune encephalomyelitis (eae) mouse model of multiple sclerosis (ms) induced by recombinant myelin oligodendrocyte glycoprotein. |
2012-09-20 |
2023-08-12 |
mouse |
| Nathali Kaushansky, Daniel M Altmann, Chella S David, Hans Lassmann, Avraham Ben-Nu. DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP). Journal of neuroinflammation. vol 9. 2012-08-14. PMID:22316121. |
multiple sclerosis (ms) is associated with pathogenic autoimmunity primarily focused on major cns-myelin target antigens including myelin basic protein (mbp), proteolipidprotein (plp), myelin oligodendrocyte protein (mog). |
2012-08-14 |
2023-08-12 |
mouse |
| Christine Konradi, Stephanie E Sillivan, Hayley B Cla. Mitochondria, oligodendrocytes and inflammation in bipolar disorder: evidence from transcriptome studies points to intriguing parallels with multiple sclerosis. Neurobiology of disease. vol 45. issue 1. 2012-07-23. PMID:21310238. |
these studies also show variabilities in the extent of oligodendrocyte stress, which can vary from a downregulation of oligodendrocyte genes, such as observed in psychiatric disorders, to cell death and brain lesions seen in multiple sclerosis. |
2012-07-23 |
2023-08-12 |
Not clear |
| Eileah Loda, Roumen Balabano. Interferon regulatory factor 1 regulation of oligodendrocyte injury and inflammatory demyelination. Reviews in the neurosciences. vol 23. issue 2. 2012-07-13. PMID:22499673. |
oligodendrocyte injury and inflammatory demyelination are key pathological abnormalities of multiple sclerosis (ms), and its animal model, i.e., the experimental autoimmune encephalomyelitis (eae). |
2012-07-13 |
2023-08-12 |
human |
| Marija Sajic, Norman Gregson, Christopher Linington, Richard A C Hughes, Kenneth J Smit. The role of CD8(+) T cells in a model of multiple sclerosis induced with recombinant myelin oligodendrocyte glycoprotein. Multiple sclerosis (Houndmills, Basingstoke, England). vol 18. issue 3. 2012-06-19. PMID:21952095. |
the role of cd8(+) t cells in a model of multiple sclerosis induced with recombinant myelin oligodendrocyte glycoprotein. |
2012-06-19 |
2023-08-12 |
rat |
| Marija Sajic, Norman Gregson, Christopher Linington, Richard A C Hughes, Kenneth J Smit. The role of CD8(+) T cells in a model of multiple sclerosis induced with recombinant myelin oligodendrocyte glycoprotein. Multiple sclerosis (Houndmills, Basingstoke, England). vol 18. issue 3. 2012-06-19. PMID:21952095. |
since cd8(+) t cells may be important in the pathogenesis of multiple sclerosis (ms), we examined their role in the da rat experimental autoimmune encephalomyelitis (eae) model induced by immunization with recombinant myelin oligodendrocyte glycoprotein (rmog). |
2012-06-19 |
2023-08-12 |
rat |
| Robert P Lisak, Joyce A Benjamins, Liljana Nedelkoska, Jennifer L Barger, Samia Ragheb, Boli Fan, Nadia Ouamara, Trina A Johnson, Sathyanath Rajasekharan, Amit Bar-O. Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro. Journal of neuroimmunology. vol 246. issue 1-2. 2012-06-19. PMID:22458983. |
secretory products of multiple sclerosis b cells are cytotoxic to oligodendroglia in vitro. |
2012-06-19 |
2023-08-12 |
rat |
| Tetsuryu Mitsuyama, Taku Yoneyama, Sakiko Suzuki, Mizuo Kagawa, Takakazu Kawamat. [Neuromyelitis optica spectrum disorder: a case report]. No shinkei geka. Neurological surgery. vol 40. issue 4. 2012-06-19. PMID:22466233. |
nmo is a disease caused by astrocyte disorder and is distinct from multiple sclerosis (ms), which is a primarily demyelinating disease caused by oligodendrocyte disorder. |
2012-06-19 |
2023-08-12 |
Not clear |
| Sara Palumbo, Christopher D Toscano, Laura Parente, Roberto Weigert, Francesca Bosett. The cyclooxygenase-2 pathway via the PGE₂ EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone-induced demyelination. Journal of neurochemistry. vol 121. issue 3. 2012-05-24. PMID:21699540. |
these data indicate that the pge₂ ep2 receptor contributes to oligodendrocyte apoptosis and open possible new therapeutic approaches for multiple sclerosis. |
2012-05-24 |
2023-08-12 |
Not clear |
| Lakshmi Devi Kandagaddala, Min-Jung Kang, Bong Chul Chung, Tucker A Patterson, Oh-Seung Kwo. Expression and activation of matrix metalloproteinase-9 and NADPH oxidase in tissues and plasma of experimental autoimmune encephalomyelitis in mice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 64. issue 1-2. 2012-05-14. PMID:20810258. |
experimental autoimmune encephalomyelitis (eae) is a widely used animal model for multiple sclerosis (ms) that can be induced by immunization with myelin antigens such as myelin oligodendrocyte glycoprotein (mog). |
2012-05-14 |
2023-08-12 |
mouse |
| Si-Fan Huang, Ying Ding, Jing-Wen Ruan, Wei Zhang, Jin-Lang Wu, Bing He, Yu-Jiao Zhang, Yan Li, Yuan-Shan Zen. An experimental electro-acupuncture study in treatment of the rat demyelinated spinal cord injury induced by ethidium bromide. Neuroscience research. vol 70. issue 3. 2012-05-04. PMID:21470565. |
oligodendrocyte precursor cells (opcs) are one of the potential treating tools for multiple sclerosis (ms). |
2012-05-04 |
2023-08-12 |
rat |
| Til Menge, Patrice H Lalive, H Christian von Büdingen, Claude P Genai. Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis. Journal of neuroinflammation. vol 8. 2012-04-16. PMID:22093619. |
conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis. |
2012-04-16 |
2023-08-12 |
Not clear |
| Gareth R Joh. Investigation of astrocyte - oligodendrocyte interactions in human cultures. Methods in molecular biology (Clifton, N.J.). vol 814. 2012-03-27. PMID:22144322. |
multiple sclerosis (ms) is characterized by cns demyelination and oligodendrocyte depletion, axonal loss, and reactive astrogliosis. |
2012-03-27 |
2023-08-12 |
human |
| Julie Joseph, Stefan Bittner, Fabian M P Kaiser, Heinz Wiendl, Stephan Kissle. IL-17 silencing does not protect nonobese diabetic mice from autoimmune diabetes. Journal of immunology (Baltimore, Md. : 1950). vol 188. issue 1. 2012-02-16. PMID:22116823. |
in contrast, il-17 silencing in transgenic nod mice was sufficient to reduce the severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis, consistent with reports that il-17 deficiency is protective in this experimental model of multiple sclerosis. |
2012-02-16 |
2023-08-12 |
mouse |
| S Nischwitz, B Müller-Myhsok, F Webe. Risk conferring genes in multiple sclerosis. FEBS letters. vol 585. issue 23. 2012-01-10. PMID:21439284. |
multiple sclerosis (ms) is characterized by inflammation, axonal and oligodendrocyte pathology and progressive neurological disability. |
2012-01-10 |
2023-08-12 |
Not clear |
| Fadi J Najm, Anita Zaremba, Andrew V Caprariello, Shreya Nayak, Eric C Freundt, Peter C Scacheri, Robert H Miller, Paul J Tesa. Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells. Nature methods. vol 8. issue 11. 2011-12-14. PMID:21946668. |
myelin-related disorders such as multiple sclerosis and leukodystrophies, for which restoration of oligodendrocyte function would be an effective treatment, are poised to benefit greatly from stem cell biology. |
2011-12-14 |
2023-08-12 |
mouse |
| Emanuele Tirotta, Richard M Ransohoff, Thomas E Lan. CXCR2 signaling protects oligodendrocyte progenitor cells from IFN-γ/CXCL10-mediated apoptosis. Glia. vol 59. issue 10. 2011-11-29. PMID:21656856. |
these findings demonstrate a previously unappreciated role for cxcl10 in contributing to neuropathology by promoting oligodendrocyte apoptosis and emphasize the potential relevance in targeting cxcl10 in treating human demyelinating diseases including multiple sclerosis (ms). |
2011-11-29 |
2023-08-12 |
mouse |