| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura J Mattie, Pamela A Hadle. Characterizing the Richness of Maternal Input for Word Learning in Neurogenetic Disorders. Seminars in speech and language. vol 42. issue 4. 2021-07-26. PMID:34311482. |
promoting language abilities, including early word learning, in children with neurogenetic disorders with associated language disorders, such as down syndrome (ds) and fragile x syndrome (fxs), is a main concern for caregivers and clinicians. |
2021-07-26 |
2023-08-13 |
Not clear |
| Marie Moore Channell, Rebekah Bosle. Mental State Language Use in Children with Down Syndrome and the Role of Caregivers. Seminars in speech and language. vol 42. issue 4. 2021-07-26. PMID:34311483. |
children with down syndrome (ds) have both strengths and difficulties in speech, language, and social communication. |
2021-07-26 |
2023-08-13 |
Not clear |
| D L Tudorascu, C M Laymon, M Zammit, D S Minhas, S J Anderson, P A Ellison, S Zaman, B M Ances, M Sabbagh, S C Johnson, C A Mathis, W E Klunk, B L Handen, B T Christian, A D Cohe. Relationship of amyloid beta and neurofibrillary tau deposition in Neurodegeneration in Aging Down Syndrome (NiAD) study at baseline. Alzheimer's & dementia (New York, N. Y.). vol 6. issue 1. 2021-07-23. PMID:33163613. |
adults with down syndrome (ds) are at high-risk of revealing alzheimer's disease (ad) pathology, in part due to the triplication of chromosome 21 encoding the amyloid precursor protein. |
2021-07-23 |
2023-08-13 |
Not clear |
| Rachel L Henson, Eric Doran, Bradley T Christian, Benjamin L Handen, William E Klunk, Florence Lai, Joseph H Lee, H Diana Rosas, Nicole Schupf, Shahid H Zaman, Ira T Lott, Anne M Faga. Cerebrospinal fluid biomarkers of Alzheimer's disease in a cohort of adults with Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands). vol 12. issue 1. 2021-07-22. PMID:32671183. |
virtually all individuals with down syndrome (ds) will develop alzheimer's disease (ad) pathology by age 40. |
2021-07-22 |
2023-08-13 |
Not clear |
| Carmela Rita Balistreri, Claudia Leonarda Ammoscato, Letizia Scola, Tiziana Fragapane, Rosa Maria Giarratana, Domenico Lio, Maria Piccion. Susceptibility to Heart Defects in Down Syndrome Is Associated with Single Nucleotide Polymorphisms in HAS 21 Interferon Receptor Cluster and VEGFA Genes. Genes. vol 11. issue 12. 2021-07-22. PMID:33260695. |
congenital heart defects (chds) are present in about 40-60% of newborns with down syndrome (ds). |
2021-07-22 |
2023-08-13 |
mouse |
| Anna Nyman, Sofia Strömbergsson, Katarina Lindström, Anette Lohmander, Carmela Miniscalc. Speech and Language in 5-year-olds with Different Neurological Disabilities and the Association between Early and Later Consonant Production. Developmental neurorehabilitation. vol 24. issue 6. 2021-07-22. PMID:33849395. |
the participants (n = 11, with down syndrome (ds), cerebral palsy, and chromosomal deletion syndromes) were tested with a battery of speech and language tests. |
2021-07-22 |
2023-08-13 |
human |
| Pooja Girish Mhatre, Joseph H Lee, Deborah Pang, Warren B Zigman, Benjamin Tycko, Sharon J Krinsky-McHale, Yuchen Yang, Wayne Silverman, Nicole Schup. The Association between Sex and Risk of Alzheimer's Disease in Adults with Down Syndrome. Journal of clinical medicine. vol 10. issue 13. 2021-07-22. PMID:34279450. |
sex differences in the risk of alzheimer's disease (ad) in adults with down syndrome (ds) have not been extensively investigated, and existing studies have found conflicting results. |
2021-07-22 |
2023-08-13 |
Not clear |
| Marta Ferrari, Stefano Stag. Oxidative Stress in Down and Williams-Beuren Syndromes: An Overview. Molecules (Basel, Switzerland). vol 26. issue 11. 2021-07-20. PMID:34073948. |
down syndrome (ds) and williams-beuren syndrome (wbs) are well-known and common genetic conditions with multi-systemic involvement. |
2021-07-20 |
2023-08-13 |
Not clear |
| Xu-Qiao Chen, Zhuo Xing, Quang-Di Chen, Richard J Salvi, Xuming Zhang, Benjamin Tycko, William C Mobley, Y Eugene Y. Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome. Frontiers in aging neuroscience. vol 13. 2021-07-20. PMID:34276349. |
down syndrome (ds) is the most common genetic cause of alzheimer's disease (ad) due to trisomy for all or part of human chromosome 21 (hsa21). |
2021-07-20 |
2023-08-13 |
human |
| L T Ptomey, E A Willis, J R Sherman, D A White, J E Donnell. Exploring the effectiveness of an 18-month weight management intervention in adults with Down syndrome using propensity score matching. Journal of intellectual disability research : JIDR. vol 64. issue 3. 2021-07-15. PMID:31944472. |
down syndrome (ds) is one of the most common birth defects in the usa associated with high levels of overweight and obesity. |
2021-07-15 |
2023-08-13 |
human |
| Yvette N Löwensteyn, Emily W E M Phijffer, Juliette V L Simons, Nienke M Scheltema, Natalie I Mazur, Harish Nair, Louis J Bon. Respiratory Syncytial Virus-related Death in Children With Down Syndrome: The RSV GOLD Study. The Pediatric infectious disease journal. vol 39. issue 8. 2021-07-15. PMID:32332221. |
systematic reviews have shown that down syndrome (ds) is an independent risk factor for severe rsv infection. |
2021-07-15 |
2023-08-13 |
Not clear |
| Dominik Szwajgier, Ewa Baranowska-Wójcik, Joanna Grzelczyk, Wioletta Żukiewicz-Sobcza. Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse. Disease markers. vol 2021. 2021-07-15. PMID:34257747. |
oxidative stress plays an important role in down syndrome (ds) pathology since the gene dose effect leads to abnormal levels of certain enzymes and metabolites. |
2021-07-15 |
2023-08-13 |
Not clear |
| Emily E Nightengale, Kristine Wolter-Warmerdam, Patricia J Yoon, Dee Daniels, Fran Hicke. Behavioral Audiology Procedures in Children With Down Syndrome. American journal of audiology. vol 29. issue 3. 2021-07-14. PMID:32539476. |
purpose normative data regarding behavioral audiologic testing procedures are based upon the general population and often do not apply to children with down syndrome (ds). |
2021-07-14 |
2023-08-13 |
Not clear |
| Chiara Lanzillotta, Fabio Di Domenic. Stress Responses in Down Syndrome Neurodegeneration: State of the Art and Therapeutic Molecules. Biomolecules. vol 11. issue 2. 2021-07-13. PMID:33670211. |
down syndrome (ds) is the most common genomic disorder characterized by the increased incidence of developing early alzheimer's disease (ad). |
2021-07-13 |
2023-08-13 |
Not clear |
| Miren Altuna, Sandra Giménez, Juan Forte. Epilepsy in Down Syndrome: A Highly Prevalent Comorbidity. Journal of clinical medicine. vol 10. issue 13. 2021-07-11. PMID:34202784. |
individuals with down syndrome (ds) have an increased risk for epilepsy during the whole lifespan, but especially after age 40 years. |
2021-07-11 |
2023-08-13 |
Not clear |
| Ruma Raha-Chowdhury, Animesh Alexander Raha, James Henderson, Seyedeh Deniz Ghaffari, Monika Grigorova, Jessica Beresford-Webb, Kieren Allinson, Subhojit Chakraborty, Anthony Holland, Shahid H Zama. Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia. Journal of clinical medicine. vol 10. issue 13. 2021-07-11. PMID:34209847. |
down syndrome (ds) subjects are more likely to develop the clinical features of alzheimer's disease (ad) very early in the disease process due to the additional impact of neuroinflammation and because of activation of innate immunity. |
2021-07-11 |
2023-08-13 |
human |
| Marco Emili, Fiorenza Stagni, Maria Elisa Salvalai, Beatrice Uguagliati, Andrea Giacomini, Christelle Albac, Marie-Claude Potier, Mariagrazia Grilli, Renata Bartesaghi, Sandra Guid. Neonatal therapy with clenbuterol and salmeterol restores spinogenesis and dendritic complexity in the dentate gyrus of the Ts65Dn model of Down syndrome. Neurobiology of disease. vol 140. 2021-07-08. PMID:32325119. |
down syndrome (ds), a neurodevelopmental disorder caused by triplication of chromosome 21, is characterized by intellectual disability. |
2021-07-08 |
2023-08-13 |
mouse |
| Alessandra C Martini, Alex M Helman, Katie L McCarty, Ira T Lott, Eric Doran, Frederick A Schmitt, Elizabeth Hea. Distribution of microglial phenotypes as a function of age and Alzheimer's disease neuropathology in the brains of people with Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands). vol 12. issue 1. 2021-07-08. PMID:33088896. |
people with down syndrome (ds) inevitably develop ad neuropathology (dsad) by 40 years of age. |
2021-07-08 |
2023-08-13 |
Not clear |
| Michael S Rafii, Beau M Ances, Nicole Schupf, Sharon J Krinsky-McHale, Mark Mapstone, Wayne Silverman, Ira Lott, William Klunk, Elizabeth Head, Brad Christian, Florence Lai, H Diana Rosas, Shahid Zaman, Melissa E Petersen, Andre Strydom, Juan Fortea, Benjamin Handen, Sid O'Bryan. The AT(N) framework for Alzheimer's disease in adults with Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands). vol 12. issue 1. 2021-07-08. PMID:33134477. |
by using these same biomarkers, individuals with down syndrome (ds), who are genetically predisposed to developing ad, can also be placed more precisely along the ad continuum. |
2021-07-08 |
2023-08-13 |
Not clear |
| Lisa Koehl, Jordan Harp, Kathryn L Van Pelt, Elizabeth Head, Frederick A Schmit. Longitudinal assessment of dementia measures in Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands). vol 12. issue 1. 2021-07-08. PMID:33225040. |
early detection of dementia symptoms is critical in down syndrome (ds) but complicated by clinical assessment barriers. |
2021-07-08 |
2023-08-13 |
Not clear |