| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gordon Worley, Rolla Shbarou, Amy N Heffner, Karin M Belsito, George T Capone, Priya S Kishnan. New onset focal weakness in children with Down syndrome. American journal of medical genetics. Part A. vol 128A. issue 1. 2004-12-22. PMID:15211649. |
new onset focal weakness is relatively common in patients with down syndrome (ds), and has broad differential diagnosis. |
2004-12-22 |
2023-08-12 |
Not clear |
| Anne M Cataldo, Suzana Petanceska, Nicole B Terio, Corrinne M Peterhoff, Robert Durham, Marc Mercken, Pankaj D Mehta, Joseph Buxbaum, Vahram Haroutunian, Ralph A Nixo. Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiology of aging. vol 25. issue 10. 2004-12-15. PMID:15465622. |
neuronal endosome enlargement, reflecting altered endocytic function, is a disease-specific response that develops years before the earliest stage of ad and down syndrome (ds). |
2004-12-15 |
2023-08-12 |
Not clear |
| Melissa R Stasko, Alberto C S Cost. Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome. Behavioural brain research. vol 154. issue 1. 2004-12-08. PMID:15302106. |
the ts65dn mouse is the most studied and genetically the most complete animal model of down syndrome (ds) available. |
2004-12-08 |
2023-08-12 |
mouse |
| Adriano B L Tort, Luis V Portela, Maria da Purificação Tavares, Carlos A Gonçalves, Cristina Netto, Roberto Giugliani, Diogo O Souz. Specificity and sensitivity of S100B levels in amniotic fluid for Down syndrome diagnosis. Life sciences. vol 76. issue 4. 2004-12-07. PMID:15530500. |
down syndrome (ds) is the most common chromosomal abnormality and is associated with an extra copy of the chromosome 21. |
2004-12-07 |
2023-08-12 |
Not clear |
| Luigi Mazzone, Diego Mugno, Domenico Mazzon. The General Movements in children with Down syndrome. Early human development. vol 79. issue 2. 2004-12-02. PMID:15324992. |
aim of our study was to describe the character of general movements (gms) in children with down syndrome (ds). |
2004-12-02 |
2023-08-12 |
Not clear |
| Ugo H Buzzi, Beverly D Ulric. Dynamic stability of gait cycles as a function of speed and system constraints. Motor control. vol 8. issue 3. 2004-11-30. PMID:15322306. |
the stability of the lower extremity segments of preadolescent children (8-10 years old) with and without down syndrome (ds) was evaluated as children walked on a motorized treadmill at varying speeds. |
2004-11-30 |
2023-08-12 |
Not clear |
| L E Olson, J T Richtsmeier, J Leszl, R H Reeve. A chromosome 21 critical region does not cause specific Down syndrome phenotypes. Science (New York, N.Y.). vol 306. issue 5696. 2004-11-22. PMID:15499018. |
the "down syndrome critical region" (dscr) is a chromosome 21 segment purported to contain genes responsible for many features of down syndrome (ds), including craniofacial dysmorphology. |
2004-11-22 |
2023-08-12 |
mouse |
| Jules Kieser, Grant Townsend, Andrew Quic. The Down syndrome patient in dental practice, part I: Pathogenesis and general and dental features. The New Zealand dental journal. vol 99. issue 1. 2004-11-15. PMID:15330383. |
down syndrome (ds) is an autosomal chromosomal anomaly which results from trisomy of all or part of chromosome 21. |
2004-11-15 |
2023-08-12 |
Not clear |
| Koray Boduroğlu, Yasemin Alanay, Berrin Koldan, Ergül Tunçbile. Methylenetetrahydrofolate reductase enzyme polymorphisms as maternal risk for Down syndrome among Turkish women. American journal of medical genetics. Part A. vol 127A. issue 1. 2004-11-09. PMID:15103709. |
advanced maternal age is the only fully accepted risk factor for trisomy 21, while most children with down syndrome (ds) are born to younger mothers (<35 years). |
2004-11-09 |
2023-08-12 |
Not clear |
| Lee A Shapiro, Patricia M Whitaker-Azmiti. Expression levels of cytoskeletal proteins indicate pathological aging of S100B transgenic mice: an immunohistochemical study of MAP-2, drebrin and GAP-43. Brain research. vol 1019. issue 1-2. 2004-11-04. PMID:15306236. |
the gene for s100b is located on chromosome 21 and levels of the protein are elevated in down syndrome (ds) and alzheimer's disease (ad). |
2004-11-04 |
2023-08-12 |
mouse |
| Ji-Eun Oh, Michael Fountoulakis, Jean-François Juranville, Margit Rosner, Markus Hengstschläger, Gert Lubec, Markus Hengstschlaege. Proteomic determination of metabolic enzymes of the amnion cell: basis for a possible diagnostic tool? Proteomics. vol 4. issue 4. 2004-10-27. PMID:15048995. |
furthermore, we compared metabolic proteins in amnion cells from controls with those from down syndrome (ds). |
2004-10-27 |
2023-08-12 |
Not clear |
| Maina P Kava, Milind S Tullu, Mamta N Muranjan, K M Girish. Down syndrome: clinical profile from India. Archives of medical research. vol 35. issue 1. 2004-10-26. PMID:15036797. |
our objective was to study demographic features, clinical features, and karyotype analyses of patients with down syndrome (ds). |
2004-10-26 |
2023-08-12 |
Not clear |
| Dorothy Boyd, Andrew Quick, Colleen Murra. The Down syndrome patient in dental practice, Part II: clinical considerations. The New Zealand dental journal. vol 100. issue 1. 2004-10-04. PMID:15346875. |
down syndrome (ds), or trisomy 21, is a genetic disorder which results in intellectual impairment, typical craniofacial features and a wide spectrum of phenotypic abnormalities (reviewed by kieser et al, 2003). |
2004-10-04 |
2023-08-12 |
Not clear |
| Stefano Gotti, Silvana Chiavegatto, Monica Sica, Carla Viglietti-Panzica, Randy J Nelson, GianCarlo Panzic. Alteration of NO-producing system in the basal forebrain and hypothalamus of Ts65Dn mice: an immunohistochemical and histochemical study of a murine model for Down syndrome. Neurobiology of disease. vol 16. issue 3. 2004-09-24. PMID:15262268. |
ts65dn mice have been developed as a model for down syndrome (ds). |
2004-09-24 |
2023-08-12 |
mouse |
| Uri Zilberman, Smith Patricia, Ari Kupietzky, Eliyahu Mas. The effect of hereditary disorders on tooth components: a radiographic morphometric study of two syndromes. Archives of oral biology. vol 49. issue 8. 2004-09-16. PMID:15196980. |
the purpose of this study was to compare tooth components (enamel and dentin) in familial dysautonomia (fd) and down syndrome (ds) in order to assess the extent to which each was affected. |
2004-09-16 |
2023-08-12 |
Not clear |
| Tracy Baynard, Ken H Pitetti, Myriam Guerra, Bo Fernhal. Heart rate variability at rest and during exercise in persons with Down syndrome. Archives of physical medicine and rehabilitation. vol 85. issue 8. 2004-09-14. PMID:15295754. |
to determine whether autonomic dysfunction explains chronotropic incompetence observed in persons with down syndrome (ds) and to measure heart rate variability (hrv) at rest and during exercise in persons with mental retardation with and without ds. |
2004-09-14 |
2023-08-12 |
Not clear |
| Hisatomo Kowa, Tomoko Sakakura, Yusuke Matsuura, Tomoko Wakabayashi, David M A Mann, Karen Duff, Shoji Tsuji, Tadafumi Hashimoto, Takeshi Iwatsub. Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits. The American journal of pathology. vol 165. issue 1. 2004-09-03. PMID:15215182. |
here we characterize the chronological and spatial relationship of clac with other features of sp amyloid in the brains of patients with alzheimer's disease (ad), down syndrome (ds), and of psapp transgenic mice. |
2004-09-03 |
2023-08-12 |
mouse |
| Pascal Kahlem, Marc Sultan, Ralf Herwig, Matthias Steinfath, Daniela Balzereit, Barbara Eppens, Nidhi G Saran, Mathew T Pletcher, Sarah T South, Gail Stetten, Hans Lehrach, Roger H Reeves, Marie-Laure Yasp. Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome. Genome research. vol 14. issue 7. 2004-09-03. PMID:15231742. |
human trisomy 21, which results in down syndrome (ds), is one of the most complicated congenital genetic anomalies compatible with life, yet little is known about the molecular basis of ds. |
2004-09-03 |
2023-08-12 |
mouse |
| Lee A Shapiro, Alexander Marks, Patricia M Whitaker-Azmiti. Increased clusterin expression in old but not young adult S100B transgenic mice: evidence of neuropathological aging in a model of Down Syndrome. Brain research. vol 1010. issue 1-2. 2004-09-01. PMID:15126113. |
in humans, the gene for s100b is found on chromosome 21, within what is considered the obligate region for down syndrome (ds) and levels of s100b are increased in brain of both ds and alzheimer's disease (ad). |
2004-09-01 |
2023-08-12 |
mouse |
| Jerzy Wegiel, Izabela Kuchna, Krzysztof Nowicki, Janusz Frackowiak, Karol Dowjat, Wayne P Silverman, Barry Reisberg, Mony DeLeon, Thomas Wisniewski, Tatyana Adayev, Mo-Chou Chen-Hwang, Yu-Wen Hwan. Cell type- and brain structure-specific patterns of distribution of minibrain kinase in human brain. Brain research. vol 1010. issue 1-2. 2004-09-01. PMID:15126119. |
the minibrain kinase (mnb/dyrk1a) gene is localized in the down syndrome (ds) critical region of chromosome 21. |
2004-09-01 |
2023-08-12 |
human |