| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Martínez de Lagrán, X Altafaj, X Gallego, E Martí, X Estivill, I Sahún, C Fillat, M Diersse. Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction. Neurobiology of disease. vol 15. issue 1. 2004-04-07. PMID:14751778. |
motor deficits are among the most frequent impairments in down syndrome (ds), but their neuropathological and molecular bases remain elusive. |
2004-04-07 |
2023-08-12 |
mouse |
| Yubin Ge, Tanya L Jensen, Mark L Stout, Robin M Flatley, Patrick J Grohar, Yaddanapudi Ravindranath, Larry H Matherly, Jeffrey W Tau. The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines. Cancer research. vol 64. issue 2. 2004-04-02. PMID:14744791. |
myeloblasts from down syndrome (ds) children with acute myeloid leukemia (aml) are significantly more sensitive in vitro to 1-beta-d-arabinofuranosylcytosine (ara-c) and generate higher 1-beta-d-arabinofuranosylcytosine 5'-triphosphate (ara-ctp) than non-ds aml myeloblasts. |
2004-04-02 |
2023-08-12 |
drosophila_melanogaster |
| Bindu N Patel, Deborah Pang, Yaakov Stern, Wayne Silverman, Jennie K Kline, Richard Mayeux, Nicole Schup. Obesity enhances verbal memory in postmenopausal women with Down syndrome. Neurobiology of aging. vol 25. issue 2. 2004-03-31. PMID:14749133. |
we compared the performance of healthy nondemented obese and non-obese women with down syndrome (ds) on a broad spectrum of cognitive tests. |
2004-03-31 |
2023-08-12 |
Not clear |
| M S Cheon, S H Kim, M-L Yaspo, F Blasi, Y Aoki, K Melen, G Lube. Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part I). Amino acids. vol 24. issue 1-2. 2004-03-30. PMID:12624742. |
down syndrome (ds) is the most significant genetic disorder with mental retardation and is caused by trisomy 21. |
2004-03-30 |
2023-08-12 |
human |
| M S Cheon, M Bajo, S H Kim, J O Claudio, A K Stewart, D Patterson, W D Kruger, H Kondoh, G Lube. Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part II). Amino acids. vol 24. issue 1-2. 2004-03-30. PMID:12624743. |
down syndrome (ds) is the most common genetic cause of mental retardation. |
2004-03-30 |
2023-08-12 |
Not clear |
| M S Cheon, S H Kim, V Ovod, N Kopitar Jerala, J I Morgan, Y Hatefi, T Ijuin, T Takenawa, G Lube. Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part III). Amino acids. vol 24. issue 1-2. 2004-03-30. PMID:12624744. |
down syndrome (ds) is the most frequent genetic disorder with mental retardation and caused by trisomy 21. |
2004-03-30 |
2023-08-12 |
human |
| Hans-Gert Bernstein, Alicja Bukowska, Dieter Krell, Bernhard Bogerts, Siegfried Ansorge, Uwe Lendecke. Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and Down syndrome. Journal of neurocytology. vol 32. issue 2. 2004-03-18. PMID:14707550. |
using immunohistochemical techniques we studied the light microscopic localization of adams (a disintegrin and metalloprotease) 10 and 15 in different neocortical areas of the human brain during normal aging, and also in patients with alzheimer disease (ad) and down syndrome (ds). |
2004-03-18 |
2023-08-12 |
human |
| A Strydom, A Hassioti. Diagnostic instruments for dementia in older people with intellectual disability in clinical practice. Aging & mental health. vol 7. issue 6. 2004-03-12. PMID:14578004. |
the most promising informant rated screening tool in most adults with id including down syndrome (ds) diagnosis is the dementia questionnaire for persons with mental retardation (dmr). |
2004-03-12 |
2023-08-12 |
Not clear |
| A Strydom, A Hassioti. Diagnostic instruments for dementia in older people with intellectual disability in clinical practice. Aging & mental health. vol 7. issue 6. 2004-03-12. PMID:14578004. |
in those with ds, the dementia scale for down syndrome (dsds) has good specificity but mediocre sensitivity. |
2004-03-12 |
2023-08-12 |
Not clear |
| Carolyn L Olsen, Philip K Cross, Lenore J Gensbur. Down syndrome: interaction between culture, demography, and biology in determining the prevalence of a genetic trait. Human biology. vol 75. issue 4. 2004-03-12. PMID:14655874. |
the incidence of down syndrome (ds) at conception is highly dependent upon the maternal age distribution and age-specific pregnancy rates. |
2004-03-12 |
2023-08-12 |
Not clear |
| Ann-Charlotte Granholm, Linda Sanders, Hyemyung Seo, Ling Lin, Kerstin Ford, Ole Isacso. Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome. Hippocampus. vol 13. issue 8. 2004-03-12. PMID:14750653. |
individuals with down syndrome (ds) develop the pathological hallmarks of alzheimer's disease at an early age, later followed by memory decline and dementia. |
2004-03-12 |
2023-08-12 |
mouse |
| Claudine P Torfs, Roberta E Christianso. Socioeconomic effects on the risk of having a recognized pregnancy with Down syndrome. Birth defects research. Part A, Clinical and molecular teratology. vol 67. issue 7. 2004-03-09. PMID:14565624. |
appoximately 95% of down syndrome (ds) cases are caused by an error in germ cell division (meiosis), resulting in an extra chromosome 21. |
2004-03-09 |
2023-08-12 |
Not clear |
| Chi Chiu Wang, Mitsutaka Kadota, Ryuichi Nishigaki, Yasuhiro Kazuki, Yasuaki Shirayoshi, Michael Scott Rogers, Takashi Gojobori, Kazuho Ikeo, Mitsuo Oshimur. Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21. Biochemical and biophysical research communications. vol 314. issue 2. 2004-03-05. PMID:14733910. |
defects in neurogenesis and neuronal differentiation in the fetal brain of down syndrome (ds) patients lead to the apparent neuropathological abnormalities and contribute to the phenotypic characters of mental retardation, and premature development of alzheimer's disease, those being the most common phenotype in ds. |
2004-03-05 |
2023-08-12 |
mouse |
| Sandeep Gurbuxani, Paresh Vyas, John D Crispin. Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome. Blood. vol 103. issue 2. 2004-02-26. PMID:14512321. |
recently, we and others have reported that mutagenesis of gata1 is an early event in down syndrome (ds) leukemogenesis. |
2004-02-26 |
2023-08-12 |
human |
| Bodil Edman Ahlbom, Jan Wahlström, Robert Saalman, Claes Wadelius, Göran Anneré. Severe psychomotor retardation in a boy with a supernumerary derivative chromosome resulting in partial trisomy 21 and partial trisomy 7p. Annales de genetique. vol 46. issue 1. 2004-02-20. PMID:12818527. |
although he has most of chromosome 21 in three copies, he does not have a phenotype of down syndrome (ds). |
2004-02-20 |
2023-08-12 |
Not clear |
| Maire E Percy, Zoya Potyomkina, Arthur J Dalton, Bettye Fedor, Pankaj Mehta, David F Andrews, Tony Mazzulli, Lillian Murk, Andrew C Warren, Robyn A Wallace, Hien Chau, Winnie Jeng, Sharon Moalem, Lisa O'Brien, Sonia Schellenberger, Helen Tran, Linda W. Relation between apolipoprotein E genotype, hepatitis B virus status, and thyroid status in a sample of older persons with Down syndrome. American journal of medical genetics. Part A. vol 120A. issue 2. 2004-02-20. PMID:12833399. |
dementia of the alzheimer type (dat) is common in older persons with down syndrome (ds). |
2004-02-20 |
2023-08-12 |
human |
| Martine Hennequin, Denise Faulks, Paul J Alliso. Parents' ability to perceive pain experienced by their child with Down syndrome. Journal of orofacial pain. vol 17. issue 4. 2004-02-18. PMID:14737880. |
to investigate parents' ability to perceive pain experienced by their offspring with down syndrome (ds). |
2004-02-18 |
2023-08-12 |
Not clear |
| Jesús de Rubens Figueroa, Blanca del Pozzo Magaña, José L Pablos Hach, Claudia Calderón Jiménez, Rocío Castrejón Urbin. [Heart malformations in children with Down syndrome]. Revista espanola de cardiologia. vol 56. issue 9. 2004-02-13. PMID:14519277. |
a longitudinal, retrospective, observational descriptive study was done at the national institute of pediatrics in mexico city to determine the incidence, type of heart disease and clinical course in patients with down syndrome (ds), and to compare the findings with data from other countries. |
2004-02-13 |
2023-08-12 |
Not clear |
| Jinmin Mia. Margareta Mikkelsen. American journal of medical genetics. Part A. vol 120A. issue 1. 2004-02-10. PMID:12794709. |
dr. mikkelsen played a pioneering role in research on down syndrome (ds) and exploring the source of the extra chromosome 21 remains her main interest. |
2004-02-10 |
2023-08-12 |
human |
| Ana Tereza de A Oliveira, Carlos A Longui, Eduardo P Luis Calliari, Eduardo de A Ferone, Fábio S Kawaguti, Osmar Mont. [Evaluation of the hypothalamic-pituitary-thyroid axis in children with Down syndrome]. Jornal de pediatria. vol 78. issue 4. 2004-02-09. PMID:14647760. |
to determine the thyroid stimulating hormone (tsh) secretion in children with down syndrome (ds), who do not present clinical and laboratory evidence of classical hypothyroidism and concomitant undetectable antibodies. |
2004-02-09 |
2023-08-12 |
Not clear |