| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E J Wolvetang, T J Wilson, E Sanij, J Busciglio, T Hatzistavrou, A Seth, P J Hertzog, I Kol. ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Human molecular genetics. vol 12. issue 3. 2003-09-24. PMID:12554679. |
ets2 is a transcription factor encoded by a gene on human chromosome 21 and alterations in its expression have been implicated in the pathophysiological features of down syndrome (ds). |
2003-09-24 |
2023-08-12 |
mouse |
| M F Sánchez-Font, J Sebastià, C Sanfeliu, R Cristòfol, G Marfany, R Gonzàlez-Duart. Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains. Cellular and molecular life sciences : CMLS. vol 60. issue 7. 2003-09-24. PMID:12943237. |
suppression subtractive hybridization performed on down syndrome (ds) versus control fetal brains revealed differential expression of peroxiredoxin 2 (prdx2), mapped at 13q12. |
2003-09-24 |
2023-08-12 |
Not clear |
| Liat Rainis, Dan Bercovich, Sabine Strehl, Andrea Teigler-Schlegel, Batia Stark, Jan Trka, Ninette Amariglio, Andrea Biondi, Inna Muler, Gideon Rechavi, Helena Kempski, Oskar A Haas, Shai Izrael. Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21. Blood. vol 102. issue 3. 2003-09-22. PMID:12649131. |
patients with down syndrome (ds) frequently develop 2 kinds of clonal megakaryocytosis: a common, congenital, spontaneously resolving, transient myeloproliferative disorder (tmd) and, less commonly, childhood acute megakaryoblastic leukemia (amkl). |
2003-09-22 |
2023-08-12 |
Not clear |
| Takashi Horiguchi, Kunihiro Uryu, Benoit I Giasson, Harry Ischiropoulos, Richard LightFoot, Christine Bellmann, Christiane Richter-Landsberg, Virginia M-Y Lee, John Q Trojanowsk. Nitration of tau protein is linked to neurodegeneration in tauopathies. The American journal of pathology. vol 163. issue 3. 2003-09-22. PMID:12937143. |
oxidative and nitrative injury is implicated in the pathogenesis of alzheimer's disease (ad) and down syndrome (ds), but no direct evidence links this type of injury to the formation of neurofibrillary tau lesions. |
2003-09-22 |
2023-08-12 |
Not clear |
| Bernard G Grel. Do children with Down syndrome have difficulty with argument structure? Journal of communication disorders. vol 36. issue 4. 2003-09-10. PMID:12837586. |
the language transcripts of seven children with down syndrome (ds) and seven typically developing children with comparable mean length of utterance (mlu) levels were examined for their use of verb argument structure. |
2003-09-10 |
2023-08-12 |
human |
| Linda L Bambrick, Paul J Yarowsky, Bruce K Kruege. Altered astrocyte calcium homeostasis and proliferation in theTs65Dn mouse, a model of Down syndrome. Journal of neuroscience research. vol 73. issue 1. 2003-09-04. PMID:12815712. |
genes from the down syndrome (ds) critical region of human chromosome 21, which contribute to the pathology of ds, are also found on mouse chromosome 16. |
2003-09-04 |
2023-08-12 |
mouse |
| Anne M Cataldo, Suzana Petanceska, Corrinne M Peterhoff, Nicole B Terio, Charles J Epstein, Angela Villar, Elaine J Carlson, Matthias Staufenbiel, Ralph A Nixo. App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890772. |
altered neuronal endocytosis is the earliest known pathology in sporadic alzheimer's disease (ad) and down syndrome (ds) brain and has been linked to increased abeta production. |
2003-09-03 |
2023-08-12 |
mouse |
| Roberto Del Bo, Giacomo Pietro Comi, Roberto Giorda, Marco Crimi, Federica Locatelli, Filippo Martinelli-Boneschi, Uberto Pozzoli, Enrico Castelli, Nereo Bresolin, Guglielmo Scarlat. The 129 codon polymorphism of the prion protein gene influences earlier cognitive performance in Down syndrome subjects. Journal of neurology. vol 250. issue 6. 2003-08-27. PMID:12796830. |
down syndrome (ds) is associated with mental retardation and development of alzheimer-like brain abnormalities. |
2003-08-27 |
2023-08-12 |
human |
| Andreas Peyrl, Rachel Weitzdoerfer, Talin Gulesserian, Michael Fountoulakis, Gert Lube. Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21). Electrophoresis. vol 23. issue 1. 2003-08-25. PMID:11824616. |
although down syndrome (ds, trisomy 21) is the most frequent isolated cause of mental retardation, information on brain protein expression and in particular protein expression of signaling-related proteins is limited. |
2003-08-25 |
2023-08-12 |
Not clear |
| M Dierssen, R Benavides-Piccione, C Martínez-Cué, X Estivill, J Flórez, G N Elston, J DeFelip. Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment. Cerebral cortex (New York, N.Y. : 1991). vol 13. issue 7. 2003-08-15. PMID:12816891. |
mental retardation in individuals with down syndrome (ds) is thought to result from anomalous development and function of the brain; however, the underlying neuropathological processes have yet to be determined. |
2003-08-15 |
2023-08-12 |
mouse |
| Marcella Folin, Silvia Baiguera, Maria Teresa Conconi, Tecla Pati, Claudio Grandi, Pier Paolo Parnigotto, Gastone G Nussdorfe. The impact of risk factors of Alzheimer's disease in the Down syndrome. International journal of molecular medicine. vol 11. issue 2. 2003-08-12. PMID:12525890. |
down syndrome (ds) patients, after the fourth decade of life, display some neurophatological features of the alzheimer's disease (ad). |
2003-08-12 |
2023-08-12 |
human |
| Denise Horn, Heidemarie Neitzel, Holger Tönnies, Vera Kalscheuer, Jürgen Kunze, Georg Klaus Hinkel, Oliver Bartsc. Familial MCA/MR syndrome due to inherited submicroscopic translocation t(18;21)(q22.1q21.3) with breakpoint at the Down syndrome critical region. American journal of medical genetics. Part A. vol 117A. issue 3. 2003-08-07. PMID:12599186. |
a clinical diagnosis could not be made in the propositus, but facial anomalies of down syndrome (ds) were recognized in the maternal uncle of the propositus. |
2003-08-07 |
2023-08-12 |
Not clear |
| Barbara Begni, Laura Brighina, Lorenzo Fumagalli, Simona Andreoni, Enrico Castelli, Claudia Francesconi, Roberto Del Bo, Nereo Bresolin, Carlo Ferrares. Altered glutamate uptake in peripheral tissues from Down syndrome patients. Neuroscience letters. vol 343. issue 2. 2003-08-07. PMID:12759167. |
overexpression of app and sod induces beta-amyloid deposition and oxidative stress in down syndrome (ds) patients. |
2003-08-07 |
2023-08-12 |
Not clear |
| Deepak Modi, Prajakta Berde, Deepa Bhartiy. Down syndrome: a study of chromosomal mosaicism. Reproductive biomedicine online. vol 6. issue 4. 2003-08-07. PMID:12831601. |
the aim of this study was to evaluate if chromosomal mosaicism is a possible mechanism of survival in down syndrome (ds) (trisomy 21) individuals. |
2003-08-07 |
2023-08-12 |
Not clear |
| Erik Forestier, Sverre Heim, Elisabeth Blennow, Georg Borgström, Gösta Holmgren, Kristiina Heinonen, Johann Johannsson, Gitte Kerndrup, Mette Klarskov Andersen, Catarina Lundin, Ann Nordgren, Richard Rosenquist, Birgitta Swolin, Bertil Johansso. Cytogenetic abnormalities in childhood acute myeloid leukaemia: a Nordic series comprising all children enrolled in the NOPHO-93-AML trial between 1993 and 2001. British journal of haematology. vol 121. issue 4. 2003-07-31. PMID:12752097. |
the patient group comprised 237 children < 15 years of age with de novo aml, 42 children < 15 years with down syndrome (ds) and de novo aml, 18 adolescents 15-18 years of age with de novo aml, and 21 children < 15 years with treatment-related aml (t-aml). |
2003-07-31 |
2023-08-12 |
Not clear |
| Carmela Lopes, Zoubida Chettouh, Jean Maurice Delabar, Mohammed Rachid. The differentially expressed C21orf5 gene in the medial temporal-lobe system could play a role in mental retardation in Down syndrome and transgenic mice. Biochemical and biophysical research communications. vol 305. issue 4. 2003-07-24. PMID:12767918. |
mental retardation represents the more invalidating pathological aspect of down syndrome, ds, and has a hard impact in public health. |
2003-07-24 |
2023-08-12 |
mouse |
| Bo Fernhall, Mari Otterstette. Attenuated responses to sympathoexcitation in individuals with Down syndrome. Journal of applied physiology (Bethesda, Md. : 1985). vol 94. issue 6. 2003-07-23. PMID:12576412. |
this study evaluated blood pressure and heart rate responses to exercise and nonexercise tasks as indexes of autonomic function in subjects with and without down syndrome (ds). |
2003-07-23 |
2023-08-12 |
human |
| Alice Borella, Reka Sumangali, Jacqueline Ko, Patricia M Whitaker-Azmiti. Characterization of social behaviors and oxytocinergic neurons in the S-100 beta overexpressing mouse model of Down Syndrome. Behavioural brain research. vol 141. issue 2. 2003-07-17. PMID:12742260. |
s-100 beta, a gene triplicated in down syndrome (ds), is thought to play a role in development of the brain in general, and in the serotonergic neuronal system in particular. |
2003-07-17 |
2023-08-12 |
mouse |
| Gina Mundschau, Sandeep Gurbuxani, Alan S Gamis, Marianne E Greene, Robert J Arceci, John D Crispin. Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis. Blood. vol 101. issue 11. 2003-07-11. PMID:12560215. |
as many as 10% of infants with down syndrome (ds) present with transient myeloproliferative disorder (tmd) at or shortly after birth. |
2003-07-11 |
2023-08-12 |
Not clear |
| Aya Hirayama, Yuko Horikoshi, Masahiro Maeda, Masayuki Ito, Sachio Takashim. Characteristic developmental expression of amyloid beta40, 42 and 43 in patients with Down syndrome. Brain & development. vol 25. issue 3. 2003-07-09. PMID:12689696. |
we immunohistochemically studied the expression of beta-amyloid precursor protein (app), abeta40, abeta42, and abeta43 in the frontal lobes of 20 down syndrome (ds) patients and 13 controls. |
2003-07-09 |
2023-08-12 |
Not clear |