| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheela N Magge, Kristen L O'Neill, Justine Shults, Virginia A Stallings, Nicolas Stettle. Leptin levels among prepubertal children with Down syndrome compared with their siblings. The Journal of pediatrics. vol 152. issue 3. 2008-03-18. PMID:18280834. |
to compare levels of leptin and other obesity-related hormones in prepubertal children with down syndrome (ds), a population at high obesity risk, and those in unaffected siblings to better understand the pathophysiology of obesity in children with ds. |
2008-03-18 |
2023-08-12 |
Not clear |
| Soo-Ryoon Ryoo, Hyun-Jeong Cho, Hye-Won Lee, Hey Kyeong Jeong, Chinzorig Radnaabazar, Yeun-Soo Kim, Min-Jeong Kim, Mi-Young Son, Hyemyung Seo, Sul-Hee Chung, Woo-Joo Son. Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease. Journal of neurochemistry. vol 104. issue 5. 2008-03-14. PMID:18005339. |
most individuals with down syndrome (ds) show an early-onset of alzheimer's disease (ad), which potentially results from the presence of an extra copy of a segment of chromosome 21. |
2008-03-14 |
2023-08-12 |
mouse |
| Andrea S McDuffie, Heidi A Sindberg, Linda J Hesketh, Robin S Chapma. Use of speaker intent and grammatical cues in fast-mapping by adolescents with Down syndrome. Journal of speech, language, and hearing research : JSLHR. vol 50. issue 6. 2008-03-13. PMID:18055772. |
the authors asked whether adolescents with down syndrome (ds) could fast-map novel nouns and verbs when word learning depended on using the speaker's pragmatic or syntactic cues. |
2008-03-13 |
2023-08-12 |
Not clear |
| Rosangela Viana Andrade, Suelly Cecília Olivan Limong. [The emergence of expressive communication in the child with Down syndrome]. Pro-fono : revista de atualizacao cientifica. vol 19. issue 4. 2008-03-13. PMID:18200389. |
expressive communication in the child with down syndrome (ds). |
2008-03-13 |
2023-08-12 |
Not clear |
| Giuseppe Esposito, Jaime Imitola, Jie Lu, Daniele De Filippis, Caterina Scuderi, Vijay S Ganesh, Rebecca Folkerth, Jonathan Hecht, Soojung Shin, Teresa Iuvone, Jonathan Chesnut, Luca Steardo, Volney Shee. Genomic and functional profiling of human Down syndrome neural progenitors implicates S100B and aquaporin 4 in cell injury. Human molecular genetics. vol 17. issue 3. 2008-03-12. PMID:17984171. |
down syndrome (ds) is caused by trisomy of chromosome 21 and is characterized by mental retardation, seizures and premature alzheimer's disease. |
2008-03-12 |
2023-08-12 |
human |
| Gina Kirsammer, Sarah Jilani, Hui Liu, Elizabeth Davis, Sandeep Gurbuxani, Michelle M Le Beau, John D Crispin. Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome. Blood. vol 111. issue 2. 2008-03-11. PMID:17901249. |
children with down syndrome (ds) display macrocytosis, thrombocytosis, and a 500-fold increased risk of developing megakaryocytic leukemia; however, the specific effects of trisomy 21 on hematopoiesis remain poorly defined. |
2008-03-11 |
2023-08-12 |
mouse |
| Anne Ronan, Kerry Fagan, Louise Christie, Jeffrey Conroy, Norma J Nowak, Gillian Turne. Familial 4.3 Mb duplication of 21q22 sheds new light on the Down syndrome critical region. Journal of medical genetics. vol 44. issue 7. 2008-03-06. PMID:17237124. |
all had the facial gestalt of down syndrome (ds). |
2008-03-06 |
2023-08-12 |
Not clear |
| Ana Lloret, Rita Calzone, Christina Dunster, Paola Manini, Marco d'Ischia, Paolo Degan, Frank J Kelly, Federico V Pallardó, Adriana Zatterale, Giovanni Pagan. Different patterns of in vivo pro-oxidant states in a set of cancer- or aging-related genetic diseases. Free radical biology & medicine. vol 44. issue 4. 2008-03-06. PMID:18053816. |
a comparative evaluation is reported of pro-oxidant states in 82 patients with ataxia telangectasia (at), bloom syndrome (bs), down syndrome (ds), fanconi anemia (fa), werner syndrome (ws), and xeroderma pigmentosum (xp) vs 98 control donors. |
2008-03-06 |
2023-08-12 |
Not clear |
| J Smigielska-Kuzia, W Sobanie. Brain metabolic profile obtained by proton magnetic resonance spectroscopy HMRS in children with Down syndrome. Advances in medical sciences. vol 52 Suppl 1. 2008-03-04. PMID:18229661. |
down syndrome (ds), or trisomia 21, is one of the most common autosomal mutations, with mental impairment as the constant symptom. |
2008-03-04 |
2023-08-12 |
Not clear |
| Machiko Kawamura, Hidefumi Kaku, Takeshi Taketani, Tomohiko Taki, Akira Shimada, Yasuhide Hayash. Mutations of GATA1, FLT3, MLL-partial tandem duplication, NRAS, and RUNX1 genes are not found in a 7-year-old Down syndrome patient with acute myeloid leukemia (FAB-M2) having a good prognosis. Cancer genetics and cytogenetics. vol 180. issue 1. 2008-02-26. PMID:18068539. |
the prognosis of leukemia developed in down syndrome (ds) patients has improved markedly. |
2008-02-26 |
2023-08-12 |
Not clear |
| Ming-Hua Chen, Shyh-Jye Chen, Li-Ying Su, Winnie Yan. Thyroid dysfunction in patients with Down syndrome. Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi. vol 48. issue 4. 2008-02-26. PMID:18265539. |
the close relationship between thyroid disorder and down syndrome (ds) had been widely reported in the literature. |
2008-02-26 |
2023-08-12 |
Not clear |
| M Lumbreras, C Baamonde, C Martínez-Cué, G Lubec, N Cairns, J Sallés, M Dierssen, J Flóre. Brain G protein-dependent signaling pathways in Down syndrome and Alzheimer's disease. Amino acids. vol 31. issue 4. 2008-02-19. PMID:16583316. |
premature aging and neuropathological features of alzheimer's disease (ad) are commonly observed in down syndrome (ds). |
2008-02-19 |
2023-08-12 |
mouse |
| Maureen M O'Brien, Jeffrey W Taub, Myron N Chang, Gita V Massey, Kimo C Stine, Susana C Raimondi, David Becton, Yaddanapudi Ravindranath, Gary V Dah. Cardiomyopathy in children with Down syndrome treated for acute myeloid leukemia: a report from the Children's Oncology Group Study POG 9421. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 26. issue 3. 2008-02-14. PMID:18202418. |
to determine the outcomes, with particular attention to toxicity, of children with down syndrome (ds) and acute myeloid leukemia (aml) treated on pediatric oncology group (pog) protocol 9421. |
2008-02-14 |
2023-08-12 |
Not clear |
| Eun-Sil Park, So-Young Kim, Jung-Suk Yeom, Jae-Young Lim, Chan-Hoo Park, Hee-Shang You. Extreme thrombocytosis associated with transient myeloproliferative disorder with Down Syndrome with t(11;17)(q13;q21). Pediatric blood & cancer. vol 50. issue 3. 2008-02-12. PMID:16941648. |
a female patient with down syndrome (ds) had neonatal thrombocytosis with platelet counts exceeding 2,000 x 10(3)/microl and transient myeloproliferative disorder (tmd). |
2008-02-12 |
2023-08-12 |
Not clear |
| H E Lockstone, L W Harris, J E Swatton, M T Wayland, A J Holland, S Bah. Gene expression profiling in the adult Down syndrome brain. Genomics. vol 90. issue 6. 2008-02-11. PMID:17950572. |
the mechanisms by which trisomy 21 leads to the characteristic down syndrome (ds) phenotype are unclear. |
2008-02-11 |
2023-08-12 |
human |
| Nagwa A Meguid, Ahmed A Dardir, Mohamed Khass, Lamia El Hossieny, Afaf Ezzat, Mostafa K El Awad. MTHFR genetic polymorphism as a risk factor in Egyptian mothers with Down syndrome children. Disease markers. vol 24. issue 1. 2008-02-07. PMID:18057532. |
recent reports linking down syndrome (ds) to maternal polymorphisms at the methylenetetrahydrofolate reductase (mthfr) gene locus have generated great interest among investigators in the field. |
2008-02-07 |
2023-08-12 |
Not clear |
| Dale A Ulrich, Meghann C Lloyd, Chad W Tiernan, Julia E Looper, Rosa M Angulo-Barros. Effects of intensity of treadmill training on developmental outcomes and stepping in infants with Down syndrome: a randomized trial. Physical therapy. vol 88. issue 1. 2008-02-05. PMID:17940103. |
infants with down syndrome (ds) are consistently late walkers. |
2008-02-05 |
2023-08-12 |
Not clear |
| Afua Mensah, Claire Mulligan, Jackie Linehan, Sandra Ruf, Aideen O'Doherty, Beata Grygalewicz, Janet Shipley, Juergen Groet, Victor Tybulewicz, Elizabeth Fisher, Sebastian Brandner, Dean Nizeti. An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model. BMC developmental biology. vol 7. 2008-02-04. PMID:18047653. |
down syndrome (ds), caused by trisomy of human chromosome 21 (hsa21), is the most common genetic cause of mental retardation in humans. |
2008-02-04 |
2023-08-12 |
mouse |
| Lilah M Besser, Mikyong Shin, James E Kucik, Adolfo Corre. Prevalence of down syndrome among children and adolescents in metropolitan Atlanta. Birth defects research. Part A, Clinical and molecular teratology. vol 79. issue 11. 2008-01-29. PMID:17990336. |
down syndrome (ds) prevalence estimates beyond infancy are needed to assess health service needs among those with ds. |
2008-01-29 |
2023-08-12 |
Not clear |
| Mikyong Shin, James E Kucik, Adolfo Corre. Causes of death and case fatality rates among infants with down syndrome in metropolitan Atlanta. Birth defects research. Part A, Clinical and molecular teratology. vol 79. issue 11. 2008-01-29. PMID:17990337. |
there is limited population-based information on the extent of underreporting of congenital heart defects (chd) as a cause of death among infants with down syndrome (ds) and on the variation in case fatality by presence of chd and age at death. |
2008-01-29 |
2023-08-12 |
Not clear |