| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xianfang Meng, Bin Peng, Jing Shi, Yao Zheng, Hao Chen, Jing Zhang, Lingli Li, Chun Zhan. Effects of overexpression of Sim2 on spatial memory and expression of synapsin I in rat hippocampus. Cell biology international. vol 30. issue 10. 2007-01-31. PMID:16963290. |
the single-minded 2 gene (sim2) plays a crucial role in the mental retardation of down syndrome (ds). |
2007-01-31 |
2023-08-12 |
mouse |
| Lotte Abildgaard, Eva Ellebaek, Göran Gustafsson, Jonas Abrahamsson, Liisa Hovi, Gudmundur Jonmundsson, Bernward Zeller, Henrik Hasl. Optimal treatment intensity in children with Down syndrome and myeloid leukaemia: data from 56 children treated on NOPHO-AML protocols and a review of the literature. Annals of hematology. vol 85. issue 5. 2007-01-25. PMID:16518605. |
children with down syndrome (ds) and myeloid leukaemia have a significantly higher survival rate than other children, but they also experience considerable treatment-related toxicity. |
2007-01-25 |
2023-08-12 |
Not clear |
| Tatyana Adayev, Mo-Chou Chen-Hwang, Noriko Murakami, Rong Wang, Yu-Wen Hwan. MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins. Biochemical and biophysical research communications. vol 351. issue 4. 2007-01-23. PMID:17097615. |
mnb/dyrk1a is a proline-directed serine/threonine kinase implicated in down syndrome (ds). |
2007-01-23 |
2023-08-12 |
human |
| Federico Licastro, Alessandro Marocchi, Silvana Penco, Elisa Porcellini, Domenico Lio, Giada Dogliotti, Massimiliano M Cors. Does Down's syndrome support the homocysteine theory of atherogenesis? Experience in elderly subjects with trisomy 21. Archives of gerontology and geriatrics. vol 43. issue 3. 2007-01-18. PMID:16533539. |
down syndrome (ds) is generally considered as an "atheroma-free model". |
2007-01-18 |
2023-08-12 |
human |
| Susana de la Luna, Xavier Estivil. Cooperation to amplify gene-dosage-imbalance effects. Trends in molecular medicine. vol 12. issue 10. 2007-01-18. PMID:16919501. |
trisomy 21, also known as down syndrome (ds), is a complex developmental disorder that affects many organs, including the brain, heart, skeleton and immune system. |
2007-01-18 |
2023-08-12 |
Not clear |
| Susana de la Luna, Xavier Estivil. Cooperation to amplify gene-dosage-imbalance effects. Trends in molecular medicine. vol 12. issue 10. 2007-01-18. PMID:16919501. |
there is now compelling evidence that the protein products of two genes on chromosome 21, down syndrome candidate region 1 (dscr1) and dual-specificity tyrosine-(y)-phosphorylation regulated kinase 1a (dyrk1a), interact functionally, and that their increased dosage cooperatively leads to dysregulation of the signaling pathways that are controlled by the nuclear factor of activated t cells (nfat) family of transcription factors, with potential consequences for several organs and systems that are affected in ds individuals. |
2007-01-18 |
2023-08-12 |
Not clear |
| Stylianos E Antonarakis, Charles J Epstei. The challenge of Down syndrome. Trends in molecular medicine. vol 12. issue 10. 2007-01-18. PMID:16935027. |
down syndrome (ds) has been recognized as a clinical entity for about 150 years, but it is only recently that there has been hope for the possibility to understand its pathogenesis and to use this information to devise approaches for the prevention and treatment of its numerous features. |
2007-01-18 |
2023-08-12 |
Not clear |
| Süreyya Savaşan, Steven Buck, Susana C Raimondi, David L Becton, Howard Weinstein, Myron Chang, Yaddanapudi Ravindranat. CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome. Leukemia & lymphoma. vol 47. issue 10. 2007-01-17. PMID:17071479. |
the outcome for children with acute megakaryoblastic leukemia (amkl) remains poor, except for cases associated with down syndrome (ds). |
2007-01-17 |
2023-08-12 |
Not clear |
| A S Paul van Trotsenburg, Marlies J E Kempers, Erik Endert, Jan G P Tijssen, Jan J M de Vijlder, Thomas Vulsm. Trisomy 21 causes persistent congenital hypothyroidism presumably of thyroidal origin. Thyroid : official journal of the American Thyroid Association. vol 16. issue 7. 2007-01-16. PMID:16889491. |
lowered neonatal plasma thyroxine (t(4)) and mildly elevated thyrotropin concentrations together with developmental benefits from neonatally started t(4) treatment in a randomized clinical trial demonstrated down syndrome (ds) neonates to be mildly hypothyroid, at least during their first weeks of life. |
2007-01-16 |
2023-08-12 |
Not clear |
| Mensuda Hasanhodzić, Husref Tahirović, Ljerka Lukina. Down Syndrome and thyroid gland. Bosnian journal of basic medical sciences. vol 6. issue 3. 2007-01-09. PMID:16995846. |
down syndrome (ds) or trisomy 21 (t21) is the most frequent and the best known malformation syndrome associated with mental deficiency that appears in human,. |
2007-01-09 |
2023-08-12 |
human |
| Mensuda Hasanhodzić, Husref Tahirović, Ljerka Lukina. Down Syndrome and thyroid gland. Bosnian journal of basic medical sciences. vol 6. issue 3. 2007-01-09. PMID:16995846. |
numerous researchers noted thyroid disorders in people with down syndrome but, clinical symptoms of thyroid dysfunction are difficult to separate from ds phenotype. |
2007-01-09 |
2023-08-12 |
human |
| Susan Blaser, Evan J Propst, Daniel Martin, Annette Feigenbaum, Adrian L James, Patrick Shannon, Blake C Papsi. Inner ear dysplasia is common in children with Down syndrome (trisomy 21). The Laryngoscope. vol 116. issue 12. 2007-01-09. PMID:17146381. |
middle and external ear anomalies are well recognized in down syndrome (ds, trisomy 21). |
2007-01-09 |
2023-08-12 |
Not clear |
| Patricia Opazo, Katherine Saud, Michelle de Saint Pierre, Ana María Cárdenas, David D Allen, Juan Segura-Aguilar, Raúl Caviedes, Pablo Caviede. Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of down syndrome. Journal of neuroscience research. vol 84. issue 6. 2007-01-04. PMID:16941497. |
we have generated immortal neuronal cell lines from normal and trisomy 16 (ts16) mice, a model for down syndrome (ds). |
2007-01-04 |
2023-08-12 |
mouse |
| Antonia Ypsilanti, George Grouios, Argiro Zikouli, Kostantinos Hatzinikolao. Speed of naming in children with Williams and Down syndromes. Journal of intellectual & developmental disability. vol 31. issue 2. 2006-12-19. PMID:16782593. |
williams syndrome (ws) and down syndrome (ds) are two neurodevelopmental genetically based disorders which exhibit mental retardation with a unique cognitive profile. |
2006-12-19 |
2023-08-12 |
Not clear |
| Damien J Keating, Chen Chen, Melanie A Pritchar. Alzheimer's disease and endocytic dysfunction: clues from the Down syndrome-related proteins, DSCR1 and ITSN1. Ageing research reviews. vol 5. issue 4. 2006-12-15. PMID:16442855. |
down syndrome (ds) is a genetically-based disorder which results in multiple conditions for sufferers. |
2006-12-15 |
2023-08-12 |
drosophila_melanogaster |
| R Nardone, R Marth, H Ausserer, A Bratti, F Tezzo. Reduced short latency afferent inhibition in patients with Down syndrome and Alzheimer-type dementia. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 117. issue 10. 2006-12-15. PMID:16931146. |
adults with down syndrome (ds) develop progressive cognitive impairment resembling the cognitive profile of alzheimer's disease (ad). |
2006-12-15 |
2023-08-12 |
human |
| Eun Joo Kim, Jee Young Sung, Hyun Jung Lee, Hyewhon Rhim, Masato Hasegawa, Takeshi Iwatsubo, Do Sik Min, Jongsun Kim, Seung R Paik, Kwang Chul Chun. Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16959772. |
alpha-synuclein, the major component of lbs, is observed in the brain of down syndrome (ds) patients with ad. |
2006-12-11 |
2023-08-12 |
human |
| David W Evans, Kristin Canavera, F Lee Kleinpeter, Elise Maccubbin, Ken Tag. The fears, phobias and anxieties of children with autism spectrum disorders and Down syndrome: comparisons with developmentally and chronologically age matched children. Child psychiatry and human development. vol 36. issue 1. 2006-12-07. PMID:16049642. |
this study compared the fears and behavior problems of 25 children with an autism spectrum disorder (asd), 43 children with down syndrome (ds), 45 mental age (ma) matched children, and 37 chronologically age (ca) matched children. |
2006-12-07 |
2023-08-12 |
human |
| Clara S Moor. Postnatal lethality and cardiac anomalies in the Ts65Dn Down syndrome mouse model. Mammalian genome : official journal of the International Mammalian Genome Society. vol 17. issue 10. 2006-12-07. PMID:17019652. |
the ts65dn mouse is a well-studied model for down syndrome (ds). |
2006-12-07 |
2023-08-12 |
mouse |
| Willemijn M Meijer, Martha M Werler, Carol Louik, Sonia Hernandez-Diaz, Lolkje T W de Jong-van den Berg, Allen A Mitchel. Can folic acid protect against congenital heart defects in Down syndrome? Birth defects research. Part A, Clinical and molecular teratology. vol 76. issue 10. 2006-12-07. PMID:17051586. |
down syndrome (ds) infants are known to have a high frequency of heart anomalies. |
2006-12-07 |
2023-08-12 |
Not clear |