| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Mazur-Kolecka, A Golabek, K Nowicki, M Flory, J Frackowia. Amyloid-beta impairs development of neuronal progenitor cells by oxidative mechanisms. Neurobiology of aging. vol 27. issue 9. 2006-08-28. PMID:16105709. |
neuronal progenitor cells (npcs) are being considered for treatment of neurodegenerative diseases associated with beta-amyloidosis: alzheimer's disease (ad) and down syndrome (ds). |
2006-08-28 |
2023-08-12 |
human |
| Kyoung-Jin Ahn, Hey Kyeong Jeong, Han-Saem Choi, Soo-Ryoon Ryoo, Yeon Ju Kim, Jun-Seo Goo, Se-Young Choi, Jung-Soo Han, Ilho Ha, Woo-Joo Son. DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects. Neurobiology of disease. vol 22. issue 3. 2006-08-24. PMID:16455265. |
among the various phenotypes seen in down syndrome (ds), mental retardation is the most common and most debilitating condition suffered by individuals with ds. |
2006-08-24 |
2023-08-12 |
mouse |
| Gita V Massey, Alvin Zipursky, Myron N Chang, John J Doyle, Suhail Nasim, Jeffrey W Taub, Yaddanapudi Ravindranath, Gary Dahl, Howard J Weinstei. A prospective study of the natural history of transient leukemia (TL) in neonates with Down syndrome (DS): Children's Oncology Group (COG) study POG-9481. Blood. vol 107. issue 12. 2006-08-14. PMID:16469874. |
a prospective study of the natural history of transient leukemia (tl) in neonates with down syndrome (ds): children's oncology group (cog) study pog-9481. |
2006-08-14 |
2023-08-12 |
Not clear |
| Gita V Massey, Alvin Zipursky, Myron N Chang, John J Doyle, Suhail Nasim, Jeffrey W Taub, Yaddanapudi Ravindranath, Gary Dahl, Howard J Weinstei. A prospective study of the natural history of transient leukemia (TL) in neonates with Down syndrome (DS): Children's Oncology Group (COG) study POG-9481. Blood. vol 107. issue 12. 2006-08-14. PMID:16469874. |
a unique transient leukemia (tl) has been described in newborns with down syndrome (ds; or trisomy 21 mosaics). |
2006-08-14 |
2023-08-12 |
Not clear |
| Xiulian Sun, Yigang Tong, Hong Qing, Chia-Hsiung Chen, Weihong Son. Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 9. 2006-07-31. PMID:16816111. |
almost all down syndrome (ds) patients develop characteristic alzheimer's disease (ad) neuropathology, including neuritic plaques and neurofibrillary tangles, after middle age. |
2006-07-31 |
2023-08-12 |
Not clear |
| Xiulian Sun, Guiqiong He, Weihong Son. BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 9. 2006-07-31. PMID:16816112. |
the majority of people with down syndrome (ds), also called trisomy 21 syndrome, will develop ad neuropathology after middle age. |
2006-07-31 |
2023-08-12 |
mouse |
| Edmund C Jenkins, Milen T Velinov, Lingling Ye, Hong Gu, Shuyun Li, Edmund C Jenkins, Susan Sklower Brooks, Deborah Pang, Darlynne A Devenny, Warren B Zigman, Nicole Schupf, Wayne P Silverma. Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia. Neurobiology of aging. vol 27. issue 7. 2006-07-27. PMID:16046031. |
therefore, we hypothesized that a possible association might exist for adults with down syndrome (ds). |
2006-07-27 |
2023-08-12 |
human |
| b' D Satg\\xc3\\xa9, L Honor\\xc3\\xa9, A J Sasco, M Vekemans, A Chompret, M-O R\\xc3\\xa9thor\\xc3\\xa. An ovarian dysgerminoma in Down syndrome. Hypothesis about the association. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 16 Suppl 1. 2006-07-26. PMID:16515627.' |
an 11-year-old girl with down syndrome (ds) was operated for a stage i right ovary dysgerminoma. |
2006-07-26 |
2023-08-12 |
Not clear |
| Sonja A Rasmussen, Lee-Yang Wong, Adolfo Correa, Don Gambrell, J M Friedma. Survival in infants with Down syndrome, Metropolitan Atlanta, 1979-1998. The Journal of pediatrics. vol 148. issue 6. 2006-07-26. PMID:16769392. |
factors influencing survival among persons with down syndrome (ds) are not well understood. |
2006-07-26 |
2023-08-12 |
Not clear |
| Marialuisa Pellegrini-Calace, Anna Tramontan. Identification of a novel putative mitogen-activated kinase cascade on human chromosome 21 by computational approaches. Bioinformatics (Oxford, England). vol 22. issue 7. 2006-07-14. PMID:16428264. |
down syndrome (ds) is the most frequent form of mental retardation and is caused by chromosome 21 (hsa21) trisomy. |
2006-07-14 |
2023-08-12 |
human |
| Fabio Coppedè, Giulia Marini, Stefania Bargagna, Liborio Stuppia, Fabrizio Minichilli, Ilaria Fontana, Renato Colognato, Guia Astrea, Giandomenico Palka, Lucia Miglior. Folate gene polymorphisms and the risk of Down syndrome pregnancies in young Italian women. American journal of medical genetics. Part A. vol 140. issue 10. 2006-07-10. PMID:16596679. |
maternal impairments in folate metabolism and elevated homocysteinemia are known risk factors for having a child with down syndrome (ds) at a young age. |
2006-07-10 |
2023-08-12 |
Not clear |
| Sue Cotton, Amanda Richdal. Brief report: parental descriptions of sleep problems in children with autism, Down syndrome, and Prader-Willi syndrome. Research in developmental disabilities. vol 27. issue 2. 2006-07-06. PMID:15975763. |
this study examined and compared parental descriptions of sleep problems in children with autism (n = 37), down syndrome (ds; n = 15), prader-willi syndrome (pws; n = 29), presumed familial intellectual disability (fid; n = 29), and typically developing children (td; n = 55) in order to determine any influences of disorder on sleep patterns. |
2006-07-06 |
2023-08-12 |
Not clear |
| Hei-Jen Jou, Yih-Shing Kuo, Jenn-Jeih Hsu, Ming-Kwang Shyu, T'sang-T'ang Hsieh, Fon-Jou Hsie. The evolving national birth prevalence of Down syndrome in Taiwan. A study on the impact of second-trimester maternal serum screening. Prenatal diagnosis. vol 25. issue 8. 2006-06-29. PMID:16049991. |
the aim of the present study was to determine whether the liberal use of second-trimester maternal serum screening in taiwan started in 1994 had a measurable impact on birth prevalence of infants with down syndrome (ds) in the past decade. |
2006-06-29 |
2023-08-12 |
Not clear |
| Katherine Saud, Christian Arriagada, Ana María Cárdenas, Takeshi Shimahara, David D Allen, Raúl Caviedes, Pablo Caviede. Neuronal dysfunction in Down syndrome: contribution of neuronal models in cell culture. Journal of physiology, Paris. vol 99. issue 2-3. 2006-06-28. PMID:16646156. |
down syndrome (ds) in humans, or trisomy of autosome 21, represents the hyperdiploidy that most frequently survives gestation, reaching an incidence of 1 in 700 live births. |
2006-06-28 |
2023-08-12 |
mouse |
| Francesca Argellati, Sara Massone, Cristina d'Abramo, Umberto M Marinari, Maria A Pronzato, Cinzia Domenicotti, Roberta Ricciarell. Evidence against the overexpression of APP in Down syndrome. IUBMB life. vol 58. issue 2. 2006-06-27. PMID:16608822. |
down syndrome (ds) is the most common genetic disorder with mental retardation and is caused by trisomy 21. |
2006-06-27 |
2023-08-12 |
Not clear |
| Eliahu G Stoupel, Helena Frimer, Zvi Appelman, Ziva Ben-Neriah, Hanna Dar, Moshe D Fejgin, Ruth Gershoni-Baruch, Esther Manor, Gad Barkai, Stavit Shalev, Zully Gelman-Kohan, Orit Reish, Dorit Lev, Bella Davidov, Boleslaw Goldman, Mordechai Shoha. Chromosome aberration and environmental physical activity: Down syndrome and solar and cosmic ray activity, Israel, 1990-2000. International journal of biometeorology. vol 50. issue 1. 2006-06-23. PMID:15988607. |
the aim of this study was to investigate a possible link between the number of down syndrome (ds) cases detected prenatally or at birth yearly in israel over a 10-year period compared with the levels of solar and cosmic ray activity 1 year before the detection or birth of each affected child. |
2006-06-23 |
2023-08-12 |
Not clear |
| Thomas Cushing, Carol L Clericuzio, Carla S Wilson, Jeffrey W Taub, Yubin Ge, Kaaren K Reichard, Stuart S Winte. Risk for leukemia in infants without Down syndrome who have transient myeloproliferative disorder. The Journal of pediatrics. vol 148. issue 5. 2006-06-22. PMID:16737888. |
transient myeloproliferative disorder (tmd) occurs in 10% of infants with down syndrome (ds). |
2006-06-22 |
2023-08-12 |
Not clear |
| Melicia C Whitt-Glover, Kristen L O'Neill, Nicolas Stettle. Physical activity patterns in children with and without Down syndrome. Pediatric rehabilitation. vol 9. issue 2. 2006-06-14. PMID:16449075. |
to describe physical activity (pa) patterns in children with down syndrome (ds) compared to their unaffected siblings. |
2006-06-14 |
2023-08-12 |
Not clear |
| María-Luisa Martínez-Frías, Belén Pérez, Lourdes R Desviat, Margarita Castro, Fátima Leal, Laura Rodríguez, Elena Mansilla, María-Luisa Martínez-Fernández, Eva Bermejo, Elvira Rodríguez-Pinilla, David Prieto, Magdalena Ugart. Maternal polymorphisms 677C-T and 1298A-C of MTHFR, and 66A-G MTRR genes: is there any relationship between polymorphisms of the folate pathway, maternal homocysteine levels, and the risk for having a child with Down syndrome? American journal of medical genetics. Part A. vol 140. issue 9. 2006-06-13. PMID:16575899. |
this study was aimed at analyzing the effect of mutations in three non-synonymous snp genes (677c > t and 1298a > c of the methylenetetrahydrofolate reductase (mthfr) gene, and 66a > g in the mtrr gene) on total plasmatic homocysteine (hcy), in 91 mothers of down syndrome (ds) infants and 90 control mothers. |
2006-06-13 |
2023-08-12 |
Not clear |
| Xianfang Meng, Jing Shi, Bin Peng, Xiaojing Zou, Chun Zhan. Effect of mouse Sim2 gene on the cell cycle of PC12 cells. Cell biology international. vol 30. issue 4. 2006-06-07. PMID:16530433. |
sim2 gene plays an important role in the pathogenesis of down syndrome (ds). |
2006-06-07 |
2023-08-12 |
mouse |