| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Biselli, B L Zampieri, E M Goloni-Bertollo, R Haddad, M F R Fonseca, M N Eberlin, H Vannucchi, V M Carvalho, E C Pavarin. Genetic polymorphisms modulate the folate metabolism of Brazilian individuals with Down syndrome. Molecular biology reports. vol 39. issue 10. 2013-01-14. PMID:22903356. |
individuals with down syndrome (ds) carry three copies of the cystathionine β-synthase (cβs) gene. |
2013-01-14 |
2023-08-12 |
Not clear |
| Xianfang Meng, Xiujuan Tian, Xiaolan Wang, Pan Gao, Chun Zhan. A novel binding protein of single-minded 2: the mitotic arrest-deficient protein MAD2B. Neurogenetics. vol 13. issue 3. 2013-01-11. PMID:22660985. |
single-minded 2 (sim2) gene, located at the down syndrome (ds) critical region, is thought to be particularly important because of its critical role in the development of the central nervous system (cns) and its overexpression resulting in impairment of learning and memory which is similar to that in ds. |
2013-01-11 |
2023-08-12 |
rat |
| Lícia Bezerra Cavalcante, Marcia Hiromi Tanaka, Juliana Rico Pires, Luciano Henrique Apponi, Elisa Maria Aparecida Giro, Sandro Roberto Valentini, Denise M Palomari Spolidório, Marisa Veiga Capela, Carlos Rossa, Raquel M Scarel-Caminag. Expression of the interleukin-10 signaling pathway genes in individuals with Down syndrome and periodontitis. Journal of periodontology. vol 83. issue 7. 2013-01-08. PMID:22050548. |
individuals with down syndrome (ds) have a higher prevalence and severity of periodontal disease, which cannot be explained by poor oral hygiene alone and is related to changes in the immune response. |
2013-01-08 |
2023-08-12 |
Not clear |
| Shervin S Churchill, Gail M Kieckhefer, Carol A Landis, Teresa M War. Sleep measurement and monitoring in children with Down syndrome: a review of the literature, 1960-2010. Sleep medicine reviews. vol 16. issue 5. 2013-01-08. PMID:22410159. |
children with down syndrome (ds) are at risk for sleep disturbances due to the anatomical features of the syndrome. |
2013-01-08 |
2023-08-12 |
Not clear |
| Robin Roberson, Thea Kuddo, Kari Horowitz, Madeline Caballero, Catherine Y Spon. Cytokine and chemokine alterations in Down syndrome. American journal of perinatology. vol 29. issue 9. 2013-01-08. PMID:22644827. |
down syndrome (ds) is the leading genetic cause of intellectual disability, affecting ~1/800 newborns. |
2013-01-08 |
2023-08-12 |
Not clear |
| Shenaz Ahmed, Louise D Bryant, Mushtaq Ahmed, Hussain Jafri, Yasmin Raashi. Experiences of parents with a child with Down syndrome in Pakistan and their views on termination of pregnancy. Journal of community genetics. vol 4. issue 1. 2013-01-08. PMID:23090504. |
it has been argued that down syndrome (ds) is as much a cultural creation as a biomedical condition, yet the majority of research in this area has been conducted in 'western' cultures. |
2013-01-08 |
2023-08-12 |
Not clear |
| Chantelle Jennifer Scott, Merle Futter, Ambroise Wonka. Prenatal diagnosis and termination of pregnancy: perspectives of South African parents of children with Down syndrome. Journal of community genetics. vol 4. issue 1. 2013-01-08. PMID:23096497. |
this study aims to evaluate the attitudes of a group of south african parents with a preschool child with down syndrome (ds) towards prenatal diagnosis (pnd) and termination of a down syndrome-affected pregnancy (tap). |
2013-01-08 |
2023-08-12 |
human |
| Claudia Fuchs, Elisabetta Ciani, Sandra Guidi, Stefania Trazzi, Renata Bartesagh. Early-occurring proliferation defects in peripheral tissues of the Ts65Dn mouse model of Down syndrome are associated with patched1 over expression. Laboratory investigation; a journal of technical methods and pathology. vol 92. issue 11. 2013-01-07. PMID:22890555. |
down syndrome (ds) is a genetic pathology due to the triplication of human chromosome 21. |
2013-01-07 |
2023-08-12 |
mouse |
| Kelly L Jones, Enikö K Pivnick, Stacy Hines-Dowell, Debra E Weese-Mayer, Elizabeth M Berry-Kravis, Teresa Santiago, Chukwuma Nnorom, Massroor Pourcyrou. A triple threat: Down syndrome, congenital central hypoventilation syndrome, and Hirschsprung disease. Pediatrics. vol 130. issue 5. 2013-01-07. PMID:23045564. |
down syndrome (ds) is recognized by characteristic facial features, intellectual disability, and an increased risk for cardiac malformations and duodenal atresia. |
2013-01-07 |
2023-08-12 |
Not clear |
| Annelyse Bruwier, Christophe F Chantrai. Hematological disorders and leukemia in children with Down syndrome. European journal of pediatrics. vol 171. issue 9. 2013-01-03. PMID:22113227. |
constitutional trisomy 21 inherent to down syndrome (ds) is associated with several hematological disorders occurring at different ages. |
2013-01-03 |
2023-08-12 |
Not clear |
| Disha Banerjee, Debarati Ghosh, Anindita Chatterjee, Swagata Sinha, Krishnadas Nandagopa. No Evidence for Mutations that Deregulate GARS-AIRS-GART Protein Levels in Children with Down Syndrome. Indian journal of clinical biochemistry : IJCB. vol 27. issue 1. 2013-01-02. PMID:23277712. |
gars-airs-gart is crucial in studies of down syndrome (ds)-related mental retardation due to its chromosomal location (21q22.1), involvement in de novo purine biosynthesis and over-expression in fetal ds brain postmortem samples. |
2013-01-02 |
2023-08-12 |
Not clear |
| Xiaoning Mou, Yuanbo Wu, Henghua Cao, Qingzhang Meng, Qihui Wang, Chengchao Sun, Shengshou Hu, Yue Ma, Hao Zhan. Generation of disease-specific induced pluripotent stem cells from patients with different karyotypes of Down syndrome. Stem cell research & therapy. vol 3. issue 2. 2012-12-31. PMID:22512921. |
down syndrome (ds), a major cause of mental retardation, is caused by trisomy of some or all of human chromosome 21 and includes three basic karyotypes: trisomy 21, translocation, and mosaicism. |
2012-12-31 |
2023-08-12 |
human |
| Shannon D R Ringenbach, Genna M Mulvey, Chih-Chia J J Chen, Michelle L Jun. Unimanual and bimanual continuous movements benefit from visual instructions in persons with Down syndrome. Journal of motor behavior. vol 44. issue 4. 2012-12-27. PMID:22616749. |
the authors' aim was to understand how persons with down syndrome (ds) perform different tasks and to assess if there were any differences in performance based on the type of instructions. |
2012-12-27 |
2023-08-12 |
human |
| Francisco Cammarata-Scalisi, Mariela Paoli-Valeri, Graciela Cammarata-Scalisi, José Javier Díaz, Raif Nasre, María Elena Cammarata-Scalis. [Frequency of imperforate anus and associated risk factors in patients with Down syndrome]. Acta gastroenterologica Latinoamericana. vol 42. issue 1. 2012-12-17. PMID:22616496. |
to establish the frequency of imperforate anus (ia) in the population with down syndrome (ds) and study the associated risk factors. |
2012-12-17 |
2023-08-12 |
Not clear |
| b' V Vidal, S Garc\\xc3\\xada, P Mart\\xc3\\xadnez, A Corrales, J Fl\\xc3\\xb3rez, N Rueda, A Sharma, C Mart\\xc3\\xadnez-Cu\\xc3\\xa. Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome. Neuroscience. vol 220. 2012-12-14. PMID:22728103.' |
the ts65dn (ts) mouse model of down syndrome (ds) displays a number of behavioral, neuromorphological and neurochemical phenotypes of the syndrome. |
2012-12-14 |
2023-08-12 |
mouse |
| Eugenie F A Gemen, Ruud H J Verstegen, Jacqueline Leuvenink, Esther de Vrie. Increased circulating apoptotic lymphocytes in children with Down syndrome. Pediatric blood & cancer. vol 59. issue 7. 2012-12-14. PMID:22811045. |
down syndrome (ds) resembles immunodeficiency with increased infections, auto-immune diseases, and hematological malignancies. |
2012-12-14 |
2023-08-12 |
Not clear |
| Yoav H Messinger, Rodney R Higgins, Meenakshi Devidas, Stephen P Hunger, Andrew J Carroll, Nyla A Heerem. Pediatric acute lymphoblastic leukemia with a t(8;14)(q11.2;q32): B-cell disease with a high proportion of Down syndrome: a Children's Oncology Group study. Cancer genetics. vol 205. issue 9. 2012-12-14. PMID:22939398. |
the rare translocation t(8;14)(q11.2;q32) has been described in patients with b-cell acute lymphoblastic leukemia (all), particularly patients with down syndrome (ds). |
2012-12-14 |
2023-08-12 |
Not clear |
| Katherine R Martin, Alicia Corlett, Daphne Dubach, Tomris Mustafa, Harold A Coleman, Helena C Parkington, Tobias D Merson, James A Bourne, Sílvia Porta, Maria L Arbonés, David I Finkelstein, Melanie A Pritchar. Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory. Human molecular genetics. vol 21. issue 13. 2012-12-13. PMID:22511596. |
people with down syndrome (ds) exhibit abnormal brain structure. |
2012-12-13 |
2023-08-12 |
mouse |
| Hanns Möhle. Cognitive enhancement by pharmacological and behavioral interventions: the murine Down syndrome model. Biochemical pharmacology. vol 84. issue 8. 2012-12-13. PMID:22898099. |
the cognitive deficits in down syndrome (ds) are attributed to an excessive hippocampal inhibition, which obstructs neuronal plasticity and normal learning and memory, a view which is largely based on studies of ts65dn mice, the best characterized mouse model of ds. |
2012-12-13 |
2023-08-12 |
mouse |
| Angela L Rachubinski, Kenneth N Maclean, Jeffrey R Evans, Kimberly B Bjugsta. Modulating cognitive deficits and tau accumulation in a mouse model of aging Down syndrome through neonatal implantation of neural progenitor cells. Experimental gerontology. vol 47. issue 9. 2012-12-10. PMID:22776132. |
although down syndrome (ds) is primarily considered as a pediatric disorder, all ds patients incur alzheimer's disease (ad)-like pathology and about 60% develop an additional ad-like dementia by 30-40 years of age. |
2012-12-10 |
2023-08-12 |
mouse |