| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander M Kleschevnikov, Pavel V Belichenko, Mehrdad Faizi, Lucia F Jacobs, Khin Htun, Mehrdad Shamloo, William C Moble. Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 27. 2012-09-18. PMID:22764230. |
cognitive impairment in down syndrome (ds) is characterized by deficient learning and memory. |
2012-09-18 |
2023-08-12 |
mouse |
| Matthew G Bartley, Kristin Marquardt, Danielle Kirchhof, Heather M Wilkins, David Patterson, Daniel A Linsema. Overexpression of amyloid-β protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade. Journal of Alzheimer's disease : JAD. vol 28. issue 4. 2012-09-17. PMID:22133762. |
interestingly, individuals with down syndrome (ds) frequently develop early onset ad as a major co-morbid phenotype. |
2012-09-17 |
2023-08-12 |
Not clear |
| Xiaolu Sturgeon, Thanh Le, Md Mahiuddin Ahmed, Katheleen J Gardine. Pathways to cognitive deficits in Down syndrome. Progress in brain research. vol 197. 2012-09-14. PMID:22541289. |
major efforts in down syndrome (ds) research have been directed at the identification and functional characterization of genes encoded by human chromosome 21 (hsa21). |
2012-09-14 |
2023-08-12 |
mouse |
| Jamie O Edgin, Gina M Mason, Goffredina Spanò, Andrea Fernández, Lynn Nade. Human and mouse model cognitive phenotypes in Down syndrome: implications for assessment. Progress in brain research. vol 197. 2012-09-14. PMID:22541291. |
the study of cognitive function in down syndrome (ds) has advanced rapidly in the past decade. |
2012-09-14 |
2023-08-12 |
mouse |
| Ira T Lot. Neurological phenotypes for Down syndrome across the life span. Progress in brain research. vol 197. 2012-09-14. PMID:22541290. |
this chapter reviews the neurological phenotype of down syndrome (ds) in early development, childhood, and aging. |
2012-09-14 |
2023-08-12 |
mouse |
| Yann Herault, Arnaud Duchon, Emilie Velot, Damien Maréchal, Véronique Braul. The in vivo Down syndrome genomic library in mouse. Progress in brain research. vol 197. 2012-09-14. PMID:22541293. |
mouse models are key elements to better understand the genotype-phenotype relationship and the physiopathology of down syndrome (ds). |
2012-09-14 |
2023-08-12 |
mouse |
| A M Kleschevnikov, P V Belichenko, A Salehi, C W. Discoveries in Down syndrome: moving basic science to clinical care. Progress in brain research. vol 197. 2012-09-14. PMID:22541294. |
this review describes recent discoveries in neurobiology of down syndrome (ds) achieved with use of mouse genetic models and provides an overview of experimental approaches aimed at development of pharmacological restoration of cognitive function in people with this developmental disorder. |
2012-09-14 |
2023-08-12 |
mouse |
| Cristina Fillat, Xavier Altafa. Gene therapy for Down syndrome. Progress in brain research. vol 197. 2012-09-14. PMID:22541296. |
the presence of an additional copy of hsa21 chromosome in down syndrome (ds) individuals leads to the overexpression of 30-50% of hsa21 genes. |
2012-09-14 |
2023-08-12 |
mouse |
| Duane G Currier, Renita C Polk, Roger H Reeve. A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome. Progress in brain research. vol 197. 2012-09-14. PMID:22541295. |
given its very broad range of effects in development, it is not surprising that many of the structures affected by a disruption in shh signaling are also affected in down syndrome (ds). |
2012-09-14 |
2023-08-12 |
mouse |
| Mario A Acuña, Ramón Pérez-Nuñez, Jorge Noriega, Ana María Cárdenas, Juan Bacigalupo, Ricardo Delgado, Christian Arriagada, Juan Segura-Aguilar, Raúl Caviedes, Pablo Caviede. Altered voltage dependent calcium currents in a neuronal cell line derived from the cerebral cortex of a trisomy 16 fetal mouse, an animal model of Down syndrome. Neurotoxicity research. vol 22. issue 1. 2012-09-13. PMID:22203612. |
human down syndrome (ds) is determined by the trisomy of autosome 21 and is expressed by multiple abnormalities, being mental retardation the most striking feature. |
2012-09-13 |
2023-08-12 |
mouse |
| Jie Lu, Gewei Lian, Hui Zhou, Giuseppe Esposito, Luca Steardo, Laurent C Delli-Bovi, Jonathan L Hecht, Q Richard Lu, Volney Shee. OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors. Human molecular genetics. vol 21. issue 10. 2012-09-13. PMID:22343408. |
mental retardation and early alzheimer's disease (ad) have generally been attributed to progressive neuronal loss in the developing and mature down syndrome (ds) brain. |
2012-09-13 |
2023-08-12 |
mouse |
| Tao Jiang, Ling Lv, Bing Yang, Yi-jun Sun, Xiao-juan Zhang, Yun Sun, Qian-jun Xu, Zheng-feng X. [Second trimester screening for trisomy 21 using ADAM12-S as a maternal serum marker]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 29. issue 3. 2012-09-11. PMID:22678798. |
to investigate the value of a disintegrin and metalloproteinase 12 secreting form (adam12-s) as a maternal serum marker in second trimester screening for trisomy 21 (down syndrome, ds), and to develop an appropriate prenatal ds screening protocol. |
2012-09-11 |
2023-08-12 |
Not clear |
| Angela L Rachubinski, Shannon K Crowley, John R Sladek, Kenneth N Maclean, Kimberly B Bjugsta. Effects of neonatal neural progenitor cell implantation on adult neuroanatomy and cognition in the Ts65Dn model of Down syndrome. PloS one. vol 7. issue 4. 2012-09-07. PMID:22558337. |
as much of the aberrant neural development in down syndrome (ds) occurs postnatally, an early opportunity exists to intervene and influence life-long cognitive development. |
2012-09-07 |
2023-08-12 |
mouse |
| Alka V Gosavi, Prashant S Murarkar, Dhaneshwar N Lanjewar, Ravishankar V Ravika. Transient leukemia in down syndrome: report of two cases with review of literature. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion. vol 27. issue 3. 2012-09-06. PMID:22942569. |
transient leukemia (tl) also referred to as transient abnormal myelopoiesis (tam) or transient myeloproliferative disorder (tmd) is a unique syndrome that frequently occurs in newborns with down syndrome (ds). |
2012-09-06 |
2023-08-12 |
Not clear |
| Danielle Bauer, Carla A Evans, Ellen A Begole, Larry Salzman. Severity of occlusal disharmonies in down syndrome. International journal of dentistry. vol 2012. 2012-08-30. PMID:22934114. |
to quantify the severity of malocclusion and dental esthetic problems in untreated down syndrome (ds) and untreated non-down syndrome children age 8-14 years old using the par and icon indices. |
2012-08-30 |
2023-08-12 |
Not clear |
| Marzia Perluigi, D Allan Butterfiel. Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia. Current gerontology and geriatrics research. vol 2012. 2012-08-23. PMID:22203843. |
down syndrome (ds) is one of the most frequent genetic abnormalities characterized by multiple pathological phenotypes. |
2012-08-23 |
2023-08-12 |
Not clear |
| Randall A Phelps, Joseph D Pinter, Donald J Lollar, Joan Guthrie Medlen, Christina D Bethel. Health care needs of children with Down syndrome and impact of health system performance on children and their families. Journal of developmental and behavioral pediatrics : JDBP. vol 33. issue 3. 2012-08-23. PMID:22249385. |
the functional, financial, and social impact on families of children with down syndrome (ds) in the united states and the role of the us health care system in ameliorating these impacts have not been well characterized. |
2012-08-23 |
2023-08-12 |
Not clear |
| Arlene Reed-Cossairt, Xiongwei Zhu, Hyoung-Gon Lee, Charles Reed, George Perry, Robert B Peterse. Alzheimer's disease and vascular deficiency: lessons from imaging studies and down syndrome. Current gerontology and geriatrics research. vol 2012. 2012-08-23. PMID:22400025. |
down syndrome (ds) individuals are at high risk for developing alzheimer's disease (ad) and consequently provide a unique opportunity to examine the factors leading to the onset of ad. |
2012-08-23 |
2023-08-12 |
Not clear |
| Donna M Wilcoc. Neuroinflammation in the aging down syndrome brain; lessons from Alzheimer's disease. Current gerontology and geriatrics research. vol 2012. 2012-08-23. PMID:22454637. |
down syndrome (ds) is the most genetic cause of mental retardation and is caused by the triplication of chromosome 21. |
2012-08-23 |
2023-08-12 |
Not clear |
| Robin L Webb, M Paul Murph. β-Secretases, Alzheimer's Disease, and Down Syndrome. Current gerontology and geriatrics research. vol 2012. 2012-08-23. PMID:22481915. |
individuals with down syndrome (ds), or trisomy 21, develop alzheimer's disease (ad) pathology by approximately 40 years of age. |
2012-08-23 |
2023-08-12 |
Not clear |