| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mireia Vilardell, Sergi Civit, Ralf Herwi. An integrative computational analysis provides evidence for FBN1-associated network deregulation in trisomy 21. Biology open. vol 2. issue 8. 2013-08-16. PMID:23951402. |
although approximately 50% of down syndrome (ds) patients have heart abnormalities, they exhibit an overprotection against cardiac abnormalities related with the connective tissue, for example a lower risk of coronary artery disease. |
2013-08-16 |
2023-08-12 |
Not clear |
| Stephanie A Hayes, Shelley L Watso. The impact of parenting stress: a meta-analysis of studies comparing the experience of parenting stress in parents of children with and without autism spectrum disorder. Journal of autism and developmental disorders. vol 43. issue 3. 2013-08-15. PMID:22790429. |
researchers commonly report that families of children with autism spectrum disorder (asd) experience more parenting stress than families of typically developing (td) children or those diagnosed with other disabilities [e.g., down syndrome (ds), cerebral palsy, intellectual disability]. |
2013-08-15 |
2023-08-12 |
Not clear |
| Sandra Guidi, Fiorenza Stagni, Patrizia Bianchi, Elisabetta Ciani, Elena Ragazzi, Stefania Trazzi, Gabriele Grossi, Chiara Mangano, Laura Calzà, Renata Bartesagh. Early pharmacotherapy with fluoxetine rescues dendritic pathology in the Ts65Dn mouse model of down syndrome. Brain pathology (Zurich, Switzerland). vol 23. issue 2. 2013-08-15. PMID:22817700. |
down syndrome ds is a genetic pathology characterized by brain hypotrophy and severe cognitive impairment. |
2013-08-15 |
2023-08-12 |
mouse |
| Angel Matute-Llorente, Alejandro González-Agüero, Alba Gómez-Cabello, Germán Vicente-Rodríguez, José Antonio Casajú. Decreased levels of physical activity in adolescents with down syndrome are related with low bone mineral density: a cross-sectional study. BMC endocrine disorders. vol 13. 2013-08-13. PMID:23826810. |
down syndrome (ds) has been described as one of the main contributors for low bone mineral density (bmd). |
2013-08-13 |
2023-08-12 |
Not clear |
| Breland Smith, Federico Medda, Vijay Gokhale, Travis Dunckley, Christopher Hulm. Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's? ACS chemical neuroscience. vol 3. issue 11. 2013-08-09. PMID:23173067. |
the dyrk1a gene is located within the down syndrome critical region (dscr) on human chromosome 21 and current research suggests that overexpression of dyrk1a may be a significant factor leading to cognitive deficits in people with alzheimer's disease (ad) and down syndrome (ds). |
2013-08-09 |
2023-08-12 |
human |
| Filippo Carducci, Paolo Onorati, Claudia Condoluci, Giancarlo Di Gennaro, Pier Paolo Quarato, Alberto Pierallini, Marco Sarà, Silvia Miano, Riccardo Cornia, Giorgio Albertin. Whole-brain voxel-based morphometry study of children and adolescents with Down syndrome. Functional neurology. vol 28. issue 1. 2013-08-08. PMID:23731912. |
in order to investigate alterations in brain morphology and a possible temporal pattern of neuroanatomical abnormalities in the gray matter (gm), white matter (wm) and cerebrospinal fluid (csf) of young patients with down syndrome (ds), high-resolution magnetic resonance imaging (mri) voxel-based morphometry (vbm) was performed on 21 children and adolescents with this chromosomal aberration and 27 age-matched participants as controls. |
2013-08-08 |
2023-08-12 |
human |
| Xavier Altafaj, Eduardo D Martín, Jon Ortiz-Abalia, Aitana Valderrama, Cristina Lao-Peregrín, Mara Dierssen, Cristina Filla. Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome. Neurobiology of disease. vol 52. 2013-08-05. PMID:23220201. |
the cognitive dysfunctions of down syndrome (ds) individuals are the most disabling alterations caused by the trisomy of human chromosome 21 (hsa21). |
2013-08-05 |
2023-08-12 |
mouse |
| Branka Stirn Kranj. Ocular abnormalities and systemic disease in Down syndrome. Strabismus. vol 20. issue 2. 2013-08-02. PMID:22612356. |
ocular problems as refractive errors, strabismus, accommodation, and cataract are well known in children with down syndrome (ds). |
2013-08-02 |
2023-08-12 |
Not clear |
| Gloria Arque, Anna Casanovas, Mara Diersse. Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome. PloS one. vol 8. issue 1. 2013-08-02. PMID:23342120. |
individuals with down syndrome (ds) present important motor deficits that derive from altered motor development of infants and young children. |
2013-08-02 |
2023-08-12 |
mouse |
| Lisa A Daunhauer, Deborah J Fidle. The down syndrome behavioral phenotype: implications for practice and research in occupational therapy. Occupational therapy in health care. vol 25. issue 1. 2013-08-01. PMID:23898980. |
abstract down syndrome (ds) is the most common chromosomal cause of intellectual disability. |
2013-08-01 |
2023-08-12 |
Not clear |
| Karina Pereira, Renata Pedrolongo Basso, Ana Raquel Rodrigues Lindquist, Louise Gracelli Pereira da Silva, Eloisa Tudell. Infants with Down syndrome: percentage and age for acquisition of gross motor skills. Research in developmental disabilities. vol 34. issue 3. 2013-07-26. PMID:23291506. |
the literature is bereft of information about the age at which infants with down syndrome (ds) acquire motor skills and the percentage of infants that do so by the age of 12 months. |
2013-07-26 |
2023-08-12 |
Not clear |
| Fabio Coppedè, Paolo Bosco, Pierpaola Tannorella, Carmelo Romano, Ivana Antonucci, Liborio Stuppia, Corrado Romano, Lucia Miglior. DNMT3B promoter polymorphisms and maternal risk of birth of a child with Down syndrome. Human reproduction (Oxford, England). vol 28. issue 2. 2013-07-25. PMID:23081874. |
are dnmt3b promoter polymorphisms among maternal risk factors for the birth of a child with down syndrome (ds)? |
2013-07-25 |
2023-08-12 |
Not clear |
| Luzhou Xing, Martha Salas, Hong Zhang, Julia Gittler, Thomas Ludwig, Chyuan-Sheng Lin, Vundavalli V Murty, Wayne Silverman, Ottavio Arancio, Benjamin Tyck. Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1). Mammalian genome : official journal of the International Mammalian Genome Society. vol 24. issue 1-2. 2013-07-25. PMID:23096997. |
the chromosome 21 gene rcan1, encoding a modulator of the calcineurin (can) phosphatase, is a candidate gene for contributing to cognitive disability in people with down syndrome (ds; trisomy 21). |
2013-07-25 |
2023-08-12 |
mouse |
| Mark Salinas, Nancy Elawabdeh, Jenny Lin, Mina M Naguib, Melissa G Hodge, Bahig M Shehat. The spectrum of pulmonary malformation in trisomy-21 patient. A review with emphasis on the molecular-genetic basis. Fetal and pediatric pathology. vol 31. issue 1. 2013-07-19. PMID:22497682. |
gene overexpression has been identified as a primary determining factor for the distinct down syndrome (ds) phenotypes. |
2013-07-19 |
2023-08-12 |
Not clear |
| N Virji-Babul, A Moiseev, W Sun, T Feng, N Moiseeva, K J Watt, M Huotilaine. Neural correlates of music recognition in Down syndrome. Brain and cognition. vol 81. issue 2. 2013-07-19. PMID:23274514. |
here we report the results of a magnetoencephalography experiment to determine the temporal dynamics and spatial distribution of brain regions activated during listening to a familiar and unfamiliar instrumental melody in control adults and adults with down syndrome (ds). |
2013-07-19 |
2023-08-12 |
Not clear |
| Karina Bonanato, Isabela A Pordeus, Thiago Compart, Ana Cristina Oliveira, Paul J Allison, Saul M Paiv. Cross-cultural adaptation and validation of a Brazilian version of an instrument to assess impairments related to oral functioning of people with Down syndrome. Health and quality of life outcomes. vol 11. 2013-07-12. PMID:23311915. |
an instrument was developed in canada to assess impairments related to oral functioning of individuals with four years of age or older with down syndrome (ds). |
2013-07-12 |
2023-08-12 |
Not clear |
| Shane M Tibby, Andrew Durward, Chong Tien Goh, Kentigern Thorburn, Kevin Morris, Mike Broadhead, Mark J Peter. Clinical course and outcome for critically ill children with Down syndrome: a retrospective cohort study. Intensive care medicine. vol 38. issue 8. 2013-07-08. PMID:22584799. |
children with down syndrome (ds) have several genetic anomalies within chromosome 21 which may influence their response to critical illness. |
2013-07-08 |
2023-08-12 |
Not clear |
| John M Starbuck, Theodore M Cole, Roger H Reeves, Joan T Richtsmeie. Trisomy 21 and facial developmental instability. American journal of physical anthropology. vol 151. issue 1. 2013-07-08. PMID:23505010. |
the most common live-born human aneuploidy is trisomy 21, which causes down syndrome (ds). |
2013-07-08 |
2023-08-12 |
human |
| David Keinan, Anna Radko, Patricia Smith, Uri Zilberma. Acid resistance of the enamel in primary second molars from children with down syndrome and cerebral palsy. The open dentistry journal. vol 3. 2013-07-04. PMID:19557152. |
this study was carried out to evaluate the extent of differences in mineralization of inner and outer enamel of the lower primary second molars of children with down syndrome (ds) and cerebral palsy (cp) as revealed by acid treatment of exfoliated teeth. |
2013-07-04 |
2023-08-12 |
Not clear |
| Evgenia Karousou, Xanthi Stachtea, Paola Moretto, Manuela Viola, Davide Vigetti, Maria Luisa D'Angelo, Luigi Raio, Fabio Ghezzi, Francesco Pallotti, Giancarlo De Luca, Nikos K Karamanos, Alberto Pass. New insights into the pathobiology of Down syndrome--hyaluronan synthase-2 overexpression is regulated by collagen VI α2 chain. The FEBS journal. vol 280. issue 10. 2013-07-02. PMID:23452080. |
down syndrome (ds) is a common birth defect characterized by the trisomy of chromosome 21. |
2013-07-02 |
2023-08-12 |
human |