| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thu Lan Nguyen, Arnaud Duchon, Antigoni Manousopoulou, Nadège Loaëc, Benoît Villiers, Guillaume Pani, Meltem Karatas, Anna E Mechling, Laura-Adela Harsan, Emmanuelle Limanton, Jean-Pierre Bazureau, François Carreaux, Spiros D Garbis, Laurent Meijer, Yann Heraul. Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A. Disease models & mechanisms. vol 11. issue 9. 2019-03-18. PMID:30115750. |
growing evidence supports the implication of dyrk1a in the development of cognitive deficits seen in down syndrome (ds) and alzheimer's disease (ad). |
2019-03-18 |
2023-08-13 |
mouse |
| Olga Cregenzán-Royo, Carme Brun-Gasca, Albert Fornieles-De. Expressed emotion and impulsiveness in mothers of children with Fragile X Syndrome and Down Syndrome: The relation to behavioral problems in their offspring. Research in developmental disabilities. vol 83. 2019-03-18. PMID:30240913. |
fragile x syndrome (fxs) and down syndrome (ds) are common causes of intellectual disability (id). |
2019-03-18 |
2023-08-13 |
Not clear |
| Emily Seager, Emily Mason-Apps, Vesna Stojanovik, Courtenay Norbury, Laura Bozicevic, Lynne Murra. How do maternal interaction style and joint attention relate to language development in infants with Down syndrome and typically developing infants? Research in developmental disabilities. vol 83. 2019-03-18. PMID:30248582. |
down syndrome (ds) is more detrimental to language acquisition compared to other forms of learning disability. |
2019-03-18 |
2023-08-13 |
Not clear |
| Eugenio Barone, Andrea Arena, Elizabeth Head, D Allan Butterfield, Marzia Perluig. Disturbance of redox homeostasis in Down Syndrome: Role of iron dysmetabolism. Free radical biology & medicine. vol 114. 2019-03-13. PMID:28705658. |
down syndrome (ds) is the most common genetic form of intellectual disability that leads in the majority of cases to development of early-onset alzheimer-like dementia (ad). |
2019-03-13 |
2023-08-13 |
Not clear |
| Fiorenza Stagni, Andrea Giacomini, Marco Emili, Sandra Guidi, Renata Bartesagh. Neurogenesis impairment: An early developmental defect in Down syndrome. Free radical biology & medicine. vol 114. 2019-03-13. PMID:28756311. |
down syndrome (ds) is characterized by brain hypotrophy and intellectual disability starting from early life stages. |
2019-03-13 |
2023-08-13 |
mouse |
| Fabio Di Domenico, Antonella Tramutola, Cesira Foppoli, Elizabeth Head, Marzia Perluigi, D Allan Butterfiel. mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia. Free radical biology & medicine. vol 114. 2019-03-13. PMID:28807816. |
numerous studies linked the alterations of mtor pathway to age-dependent cognitive decline, pathogenesis of alzheimer disease (ad) and ad-like dementia in down syndrome (ds). |
2019-03-13 |
2023-08-13 |
human |
| Daniela Valenti, Nady Braidy, Domenico De Rasmo, Anna Signorile, Leonardo Rossi, A G Atanasov, Mariateresa Volpicella, Alexandra Henrion-Caude, S M Nabavi, R A Vacc. Mitochondria as pharmacological targets in Down syndrome. Free radical biology & medicine. vol 114. 2019-03-13. PMID:28838841. |
indeed, dysfunctional mitochondria and mitochondrial-dependent activation of intracellular stress cascades are critical initiating events in many human neurodegenerative or neurodevelopmental diseases including down syndrome (ds). |
2019-03-13 |
2023-08-13 |
human |
| Panagiotis Zis, Andre Strydo. Clinical aspects and biomarkers of Alzheimer's disease in Down syndrome. Free radical biology & medicine. vol 114. 2019-03-13. PMID:28870521. |
alzheimer's disease (ad) may affect in excess of 90% of individuals with down syndrome (ds) after age 60, due to duplication of the app gene in trisomy of chromosome 21, with neuropathology that is comparable to sporadic ad and familial ad (fad). |
2019-03-13 |
2023-08-13 |
Not clear |
| Eric D Hamlett, Aurélie Ledreux, Huntington Potter, Heidi J Chial, David Patterson, Joaquin M Espinosa, Brianne M Bettcher, Ann-Charlotte Granhol. Exosomal biomarkers in Down syndrome and Alzheimer's disease. Free radical biology & medicine. vol 114. 2019-03-13. PMID:28882786. |
every person with down syndrome (ds) has the characteristic features of alzheimer's disease (ad) neuropathology in their brain by the age of forty, and most go on to develop ad dementia. |
2019-03-13 |
2023-08-13 |
mouse |
| M Fructuoso, L Rachdi, E Philippe, R G Denis, C Magnan, H Le Stunff, N Janel, M Diersse. Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome. Free radical biology & medicine. vol 114. 2019-03-13. PMID:28958596. |
down syndrome (ds) is caused by the trisomy of human chromosome 21 and is the most common genetic cause of intellectual disability. |
2019-03-13 |
2023-08-13 |
mouse |
| Maria D Torres, Octavio Garcia, Cindy Tang, Jorge Buscigli. Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome. Free radical biology & medicine. vol 114. 2019-03-13. PMID:28965914. |
abnormal dendritic spine structure and function is one of the most prominent features associated with neurodevelopmental disorders including down syndrome (ds). |
2019-03-13 |
2023-08-13 |
Not clear |
| Daniel J Colacurcio, Anna Pensalfini, Ying Jiang, Ralph A Nixo. Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease. Free radical biology & medicine. vol 114. 2019-03-13. PMID:28988799. |
individuals with down syndrome (ds) have an increased risk of early-onset alzheimer's disease (ad), largely owing to a triplication of the app gene, located on chromosome 21. |
2019-03-13 |
2023-08-13 |
mouse |
| Javier Zorrilla de San Martin, Jean-Maurice Delabar, Alberto Bacci, Marie-Claude Potie. GABAergic over-inhibition, a promising hypothesis for cognitive deficits in Down syndrome. Free radical biology & medicine. vol 114. 2019-03-13. PMID:28993272. |
down syndrome (ds), also known as trisomy 21, is the most common genetic cause of intellectual disability. |
2019-03-13 |
2023-08-13 |
mouse |
| Xu-Qiao Chen, Mariko Sawa, William C Moble. Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome. Free radical biology & medicine. vol 114. 2019-03-13. PMID:29031834. |
changes in endosome structure in alzheimer disease (ad) and down syndrome (ds) are present early in these disorders. |
2019-03-13 |
2023-08-13 |
Not clear |
| Fernando Cesar Gimenes Barbosa Santos, Ulisses Alexandre Croti, Carlos Henrique De Marchi, Alexandre Noboru Murakami, Juliana Dane Pereira Brachine, Bruna Cury Borim, Renata Geron Finoti, Moacir Fernandes de Godo. Surgical Treatment for Congenital Heart Defects in Down Syndrome Patients. Brazilian journal of cardiovascular surgery. vol 34. issue 1. 2019-03-11. PMID:30810666. |
to analyze data related to surgical treatment in patients with congenital heart defects (chd) and down syndrome (ds) based on information from international quality improvement collaborative database for congenital heart disease (iqic). |
2019-03-11 |
2023-08-13 |
Not clear |
| Talya Miron-Shatz, Sivan R Rapaport, Naama Srebnik, Yaniv Hanoch, Jonina Rabinowitz, Glen M Doniger, Linda Levi, Jonathan J Rolison, Avi Tsafri. Invasive Prenatal Diagnostic Testing Recommendations are Influenced by Maternal Age, Statistical Misconception and Perceived Liability. Journal of genetic counseling. vol 27. issue 1. 2019-03-04. PMID:28616831. |
amniocentesis) for down syndrome (ds), and its association with the physician's assessment of the risk of liability for medical malpractice unless they recommend amniocentesis. |
2019-03-04 |
2023-08-13 |
Not clear |
| b' Ver\\xc3\\xb3nica Vidal, Susana Garc\\xc3\\xada-Cerro, Paula Mart\\xc3\\xadnez, Andrea Corrales, Sara Lantigua, Rebeca Vidal, Noem\\xc3\\xad Rueda, Laurence Ozmen, Maria-Clemencia Hern\\xc3\\xa1ndez, Carmen Mart\\xc3\\xadnez-Cu\\xc3\\xa. Decreasing the Expression of GABA Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28717969.' |
decreasing the expression of gaba trisomy 21 or down syndrome (ds) is the most common cause of intellectual disability of a genetic origin. |
2019-02-26 |
2023-08-13 |
mouse |
| Chung Eun Lee, Meghan M Burke, Catherine K Arnold, Aleksa Owe. Comparing differences in support needs as perceived by parents of adult offspring with down syndrome, autism spectrum disorder and cerebral palsy. Journal of applied research in intellectual disabilities : JARID. vol 32. issue 1. 2019-02-22. PMID:30101573. |
this study compared parents of adults with down syndrome (ds), autism spectrum disorder (asd) and cerebral palsy (cp) regarding support needs of their offspring with intellectual and developmental disabilities (idd) and their families. |
2019-02-22 |
2023-08-13 |
Not clear |
| Nobuhiro Kurabayashi, Minh Dang Nguyen, Kamon Sanad. Triple play of DYRK1A kinase in cortical progenitor cells of Trisomy 21. Neuroscience research. vol 138. 2019-02-22. PMID:30227164. |
down syndrome (ds) also known as trisomy 21 is a genetic disorder that occurs in ∼1 in 800 live births. |
2019-02-22 |
2023-08-13 |
mouse |
| J Levenga, D J Peterson, P Cain, C A Hoeffe. Sleep Behavior and EEG Oscillations in Aged Dp(16)1Yey/+ Mice: A Down Syndrome Model. Neuroscience. vol 376. 2019-02-21. PMID:29454635. |
down syndrome (ds) results from the triplication of genes located on human chromosome 21 (hsa21). |
2019-02-21 |
2023-08-13 |
mouse |