| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eunice Y Yuen, Luye Qin, Jing Wei, Wenhua Liu, Aiyi Liu, Zhen Ya. Synergistic regulation of glutamatergic transmission by serotonin and norepinephrine reuptake inhibitors in prefrontal cortical neurons. The Journal of biological chemistry. vol 289. issue 36. 2015-01-28. PMID:25056951. |
moreover, the depression of ampar-mediated excitatory postsynaptic currents by snris required p38 kinase activity, which was increased by 5-ht(1a) and α2-adrenergic receptor co-activation in an activator of g protein signaling 3-dependent manner. |
2015-01-28 |
2023-08-13 |
Not clear |
| Cláudia Maria Padova. Serotonin in anxiety and depression. Journal of psychopharmacology (Oxford, England). vol 27. issue 12. 2015-01-27. PMID:24227796. |
serotonin in anxiety and depression. |
2015-01-27 |
2023-08-12 |
Not clear |
| Zeng-liang Jin, Nana Gao, Jian-rui Zhang, Xiao-rong Li, Hong-xia Chen, Jie Xiong, Yun-feng Li, Yu Tan. The discovery of Yuanzhi-1, a triterpenoid saponin derived from the traditional Chinese medicine, has antidepressant-like activity. Progress in neuro-psychopharmacology & biological psychiatry. vol 53. 2015-01-22. PMID:24614095. |
the minimal effective dose of yuanzhi-1 (2.5 mg/kg) was lower than that of duloxetine (5mg/kg), a serotonin and norepinephrine reuptake inhibitor commonly used in the treatment of depression. |
2015-01-22 |
2023-08-12 |
mouse |
| Zhang-Jin Zhang, Di Wang, Sui Cheung Man, Roger Ng, Grainne M McAlonan, Hei Kiu Wong, Wendy Wong, Jade Lee, Qing-Rong Ta. Platelet 5-HT(1A) receptor correlates with major depressive disorder in drug-free patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 53. 2015-01-22. PMID:24657886. |
patients with mdd had significantly higher expression of platelet 5-ht1a receptors but significantly lower contents of platelet 5-ht, platelet-poor plasma (ppp) 5-ht and ppp 5-hiaa compared to healthy controls, and this was correlated with the severity of depression. |
2015-01-22 |
2023-08-12 |
Not clear |
| Zhang-Jin Zhang, Di Wang, Sui Cheung Man, Roger Ng, Grainne M McAlonan, Hei Kiu Wong, Wendy Wong, Jade Lee, Qing-Rong Ta. Platelet 5-HT(1A) receptor correlates with major depressive disorder in drug-free patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 53. 2015-01-22. PMID:24657886. |
thus overexpression of platelet 5-ht1a receptors and reduced 5-ht tone may function as a peripheral marker of depression. |
2015-01-22 |
2023-08-12 |
Not clear |
| Li Wen, Yahong Jin, Lei Li, Shuangyu Sun, Shixiang Cheng, Sai Zhang, Yong Zhang, Per Svenningsso. Exercise prevents raphe nucleus mitochondrial overactivity in a rat depression model. Physiology & behavior. vol 132. 2015-01-21. PMID:24813829. |
this study used chronic unpredictable stress (cus) in rats as a model of depression to assess the effects of cus, exercise and fluoxetine on mitochondrial function and serotonin levels in the raphe nuclei. |
2015-01-21 |
2023-08-13 |
rat |
| Katja Karg, Srijan Se. Gene × environment interaction models in psychiatric genetics. Current topics in behavioral neurosciences. vol 12. 2015-01-20. PMID:22241248. |
finally, we discuss recent developments in g × e interaction research on the most heavily investigated example in psychiatric genetics, the interaction between a serotonin transporter gene promoter variant (5-httlpr) and stress on depression. |
2015-01-20 |
2023-08-12 |
Not clear |
| Valeria Carola, Cornelius Gros. Mouse models of the 5-HTTLPR × stress risk factor for depression. Current topics in behavioral neurosciences. vol 12. 2015-01-20. PMID:22331694. |
the best studied of such measured gene-by-environment risk factors for mental illness is the increased risk for major depression reported among persons carrying the short variant (s allele) of a functional polymorphism in the serotonin transporter (5-htt, slc6a4) gene promoter and who have been exposed to stressful life events. |
2015-01-20 |
2023-08-12 |
mouse |
| Ling Shan, Pieter Schipper, Lourens J P Nonkes, Judith R Homber. Impaired fear extinction as displayed by serotonin transporter knockout rats housed in open cages is disrupted by IVC cage housing. PloS one. vol 9. issue 3. 2015-01-16. PMID:24658187. |
a well-known example for gene x environment interactions in psychiatry is the low activity (s) allelic variant of the serotonin transporter (5-htt) promoter polymorphism (5-httlpr) that in the context of stress increases risk for depression and post-traumatic stress disorder (ptsd). |
2015-01-16 |
2023-08-12 |
rat |
| Christoph van Amsterdam, Christoph A Seyfrie. Mechanism of action of the bimodal antidepressant vilazodone: evidence for serotonin1A-receptor-mediated auto-augmentation of extracellular serotonin output. Psychopharmacology. vol 231. issue 12. 2015-01-15. PMID:24419272. |
the recently approved antidepressant vilazodone, a serotonin (5-ht)1a receptor partial agonist/selective 5-ht reuptake inhibitor offers new possibilities to study the underlying mechanisms of depression pharmacotherapy and of 5-ht augmenting antidepressants. |
2015-01-15 |
2023-08-12 |
Not clear |
| Huirong Guo, Yuming Ren, Ning Zhao, Yali Wang, Shuying Li, He Cui, Sijia Zhang, Jianhua Zhan. Synergistic effect of 5-HT2A receptor gene and MAOA gene on the negative emotion of patients with depression. Clinical physiology and functional imaging. vol 34. issue 4. 2015-01-14. PMID:24314147. |
to analyse the synergistic effect of polymorphism of the tandem repeat sequence u-vntr of 5-hydroxytryptamine 2a (5-ht2a) receptor gene and monoamine oxidase a (maoa) gene on the negative emotion in frontal lobe of patients with depression through functional magnetic resonance imaging (fmri) technique. |
2015-01-14 |
2023-08-12 |
Not clear |
| David E Comings, James P MacMurra. Maternal age as a potential explanation of the role of the L allele of the serotonin transporter gene in anxiety and depression in Asians. Neuroscience bulletin. vol 30. issue 3. 2015-01-12. PMID:24764118. |
maternal age as a potential explanation of the role of the l allele of the serotonin transporter gene in anxiety and depression in asians. |
2015-01-12 |
2023-08-13 |
Not clear |
| Haixia Long, Bing Liu, Bing Hou, Chao Wang, Jin Li, Tianzi Jian. Authors' response to "Maternal age as a potential explanation of the role of the L allele of the serotonin transporter gene in anxiety and depression in Asians". Neuroscience bulletin. vol 30. issue 3. 2015-01-12. PMID:24764119. |
authors' response to "maternal age as a potential explanation of the role of the l allele of the serotonin transporter gene in anxiety and depression in asians". |
2015-01-12 |
2023-08-13 |
Not clear |
| Mark J Milla. On 'polypharmacy' and multi-target agents, complementary strategies for improving the treatment of depression: a comparative appraisal. The international journal of neuropsychopharmacology. vol 17. issue 7. 2015-01-06. PMID:23719026. |
the melatonin mt1/mt2 agonist and 5-ht(2c) antagonist, agomelatine, which is effective in the short- and long-term treatment of depression, exemplifies the former approach, while evidence-based polypharmacy is illustrated by the adjunctive use of second-generation antipsychotics with serotonin reuptake inhibitors for treatment of resistant depression. |
2015-01-06 |
2023-08-12 |
Not clear |
| Jennifer A Sumner, Suzanne Vrshek-Schallhorn, Susan Mineka, Richard E Zinbarg, Michelle G Craske, Eva E Redei, Kate Wolitzky-Taylor, Emma K Ada. Effects of the serotonin transporter polymorphism and history of major depression on overgeneral autobiographical memory. Cognition & emotion. vol 28. issue 5. 2015-01-05. PMID:24341893. |
effects of the serotonin transporter polymorphism and history of major depression on overgeneral autobiographical memory. |
2015-01-05 |
2023-08-12 |
Not clear |
| Rani K Vasudeva, Barry D Waterhous. Cellular profile of the dorsal raphe lateral wing sub-region: relationship to the lateral dorsal tegmental nucleus. Journal of chemical neuroanatomy. vol 57-58. 2015-01-05. PMID:24704911. |
as one of the main serotonergic (5ht) projections to the forebrain, the dorsal raphe nucleus (drn) has been implicated in disorders of anxiety and depression. |
2015-01-05 |
2023-08-13 |
human |
| Rani K Vasudeva, Barry D Waterhous. Cellular profile of the dorsal raphe lateral wing sub-region: relationship to the lateral dorsal tegmental nucleus. Journal of chemical neuroanatomy. vol 57-58. 2015-01-05. PMID:24704911. |
as such the present study suggests a link between 5ht signaling, activation of cholinergic/nos neurons, and the stress response including the pathophysiology underlying anxiety and depression. |
2015-01-05 |
2023-08-13 |
human |
| Herng-Nieng Chan, Philip B Mitchell, Colleen K A Loo, Samuel B Harve. Pharmacological treatment approaches to difficult-to-treat depression. The Medical journal of Australia. vol 199. issue S6. 2014-12-31. PMID:25370287. |
in the sequenced treatment alternatives to relieve depression (star*d) trial of almost 3000 patients with depression in the united states, 50% responded to the initial trial of a selective serotonin reuptake inhibitor antidepressant, but only a third achieved remission (nil or minimal depressive symptoms). |
2014-12-31 |
2023-08-13 |
Not clear |
| A V Akhmadeev, L B Kalimullin. [Serotonine and sex steroids in the system of neuroendocrine regulation of amygdala functions]. Uspekhi fiziologicheskikh nauk. vol 44. issue 4. 2014-12-31. PMID:25438560. |
systematizes the data on the role of serotonin and sex steroids in the mechanisms involved in the stress response of amygdala, and its participation in the formation of mood, emotions and the genesis of depression. |
2014-12-31 |
2023-08-13 |
Not clear |
| Yi-Ju Pan, Kuei-Hong Kuo, Hung-Yu Chan, Paul McCron. Cost-effectiveness and cost-utility of selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, and tricyclic antidepressants in depression with comorbid cardiovascular disease. Journal of psychiatric research. vol 54. 2014-12-30. PMID:24679672. |
cost-effectiveness and cost-utility of selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, and tricyclic antidepressants in depression with comorbid cardiovascular disease. |
2014-12-30 |
2023-08-12 |
Not clear |