| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Kellner, T Porseryd, I Porsch-Hällström, S H Hansen, K H Olsé. Environmentally relevant concentrations of citalopram partially inhibit feeding in the three-spine stickleback (Gasterosteus aculeatus). Aquatic toxicology (Amsterdam, Netherlands). vol 158. 2015-04-10. PMID:25438122. |
selective serotonin re-uptake inhibitors (ssri) are mood-altering, psychotropic drugs commonly used in the treatment of depression and other psychological illnesses. |
2015-04-10 |
2023-08-13 |
Not clear |
| Ya-Chin Yang, Chun-Chang Hu, Yi-Chen La. Non-additive modulation of synaptic transmission by serotonin, adenosine, and cholinergic modulators in the sensory thalamus. Frontiers in cellular neuroscience. vol 9. 2015-04-08. PMID:25852468. |
acetylcholine, acting via nicotinic receptors, can interact with either serotonin or adenosine to abolish most short-term synaptic depression. |
2015-04-08 |
2023-08-13 |
human |
| Bruno D Arbo, Susie Andrade, Gabriela Osterkamp, Rosane Gomez, Maria Flávia M Ribeir. Effect of low doses of progesterone in the expression of the GABA(A) receptor α4 subunit and procaspase-3 in the hypothalamus of female rats. Endocrine. vol 46. issue 3. 2015-04-02. PMID:24366640. |
depression is associated with the several neurotransmitters systems, including gaba and serotonin, and with neurodegeneration and cell death in some brain circuits. |
2015-04-02 |
2023-08-12 |
rat |
| Cesario Bellantuono, Laura Orsolini, Francesca Bozz. [The safety profile of escitalopram in pregnancy and breastfeeding]. Rivista di psichiatria. vol 48. issue 6. 2015-04-02. PMID:24441517. |
escitalopram (esc) is considered one of the most effective selective serotonin reuptake inhibitors (ssri) for the treatment of major depression disorder. |
2015-04-02 |
2023-08-12 |
Not clear |
| Tae Woon Kim, Baek Vin Lim, Dongjin Baek, Dong-Soo Ryu, Jin Hee Se. Stress-Induced Depression Is Alleviated by Aerobic Exercise Through Up-Regulation of 5-Hydroxytryptamine 1A Receptors in Rats. International neurourology journal. vol 19. issue 1. 2015-04-02. PMID:25833478. |
stress-induced depression is alleviated by aerobic exercise through up-regulation of 5-hydroxytryptamine 1a receptors in rats. |
2015-04-02 |
2023-08-13 |
rat |
| Tae Woon Kim, Baek Vin Lim, Dongjin Baek, Dong-Soo Ryu, Jin Hee Se. Stress-Induced Depression Is Alleviated by Aerobic Exercise Through Up-Regulation of 5-Hydroxytryptamine 1A Receptors in Rats. International neurourology journal. vol 19. issue 1. 2015-04-02. PMID:25833478. |
in the present study, we investigated the effect of treadmill exercise on stress-induced depression while focusing on the expression of 5-ht 1a (5-h1a) receptors in the dorsal raphe. |
2015-04-02 |
2023-08-13 |
rat |
| Ying Xin Wang, Xiang Rong Zhang, Zhi Jun Zhang, Lei Li, Guang Jun Xi, Di Wu, Yan Juan Wan. Protein kinase Mζ is involved in the modulatory effect of fluoxetine on hippocampal neurogenesis in vitro. The international journal of neuropsychopharmacology. vol 17. issue 9. 2015-03-30. PMID:24679950. |
the efficacy of chronic selective serotonin reuptake inhibitors (ssris) on depression is paralleled by the recovery of deficits in hippocampal neurogenesis related to sustained stress and elevated glucocorticoids. |
2015-03-30 |
2023-08-12 |
rat |
| Tianjun Wang, Lingling Wang, Wenjian Tao, Li Che. Acupuncture combined with an antidepressant for patients with depression in hospital: a pragmatic randomised controlled trial. Acupuncture in medicine : journal of the British Medical Acupuncture Society. vol 32. issue 4. 2015-03-30. PMID:24781054. |
to assess the effectiveness of acupuncture combined with selective serotonin reuptake inhibitors (ssris) for patients with depression in hospital using a pragmatic randomised controlled trial. |
2015-03-30 |
2023-08-13 |
Not clear |
| Valentina Mosienko, Susann Matthes, Natalie Hirth, Daniel Beis, Michael Flinders, Michael Bader, Anita C Hansson, Natalia Alenin. Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24863038. |
polymorphisms in the tph2 gene coding for the serotonin synthesizing enzyme in the brain are considered as risk factors associated with depression and anxiety in humans. |
2015-03-30 |
2023-08-13 |
mouse |
| Jui-Hsiu Tsai, Chang-Hung Kuo, Pinchen Yang, Kuang-Hung Cheng, Peng-Wei Wang, Cheng-Chung Chen, Chih-Hsing Hun. Effects of antidepressants on IP-10 production in LPS-activated THP-1 human monocytes. International journal of molecular sciences. vol 15. issue 8. 2015-03-30. PMID:25073092. |
selective serotonin reuptake inhibitors and norepinephrine-dopamine reuptake inhibitors may reduce the mortality of cardiovascular disease patients with comorbid depression. |
2015-03-30 |
2023-08-13 |
human |
| Philippe Huot, Susan H Fox, Jonathan M Brotchi. Monoamine reuptake inhibitors in Parkinson's disease. Parkinson's disease. vol 2015. 2015-03-26. PMID:25810948. |
despite wide discrepancy in the methodology of the studies reviewed, the following conclusions can be drawn: (1) selective serotonin transporter (sert), selective noradrenaline transporter (net), and dual sert/net inhibitors are effective against pd depression; (2) selective dopamine transporter (dat) and dual dat/net inhibitors exert an anti-parkinsonian effect when administered as monotherapy but do not enhance the anti-parkinsonian actions of l-3,4-dihydroxyphenylalanine (l-dopa); (3) dual dat/sert inhibitors might enhance the anti-parkinsonian actions of l-dopa without worsening dyskinesia; (4) triple dat/net/sert inhibitors might exert an anti-parkinsonian action as monotherapy and might enhance the anti-parkinsonian effects of l-dopa, though at the expense of worsening dyskinesia. |
2015-03-26 |
2023-08-13 |
Not clear |
| Aurora Silva, Lúcia H M L M Santos, Cristina Delerue-Matos, Sónia A Figueired. Impact of excipients in the chronic toxicity of fluoxetine on the alga Chlorella vulgaris. Environmental technology. vol 35. issue 21-24. 2015-03-20. PMID:25244140. |
fluoxetine is a selective serotonin reuptake inhibitor (ssri) widely used in the treatment of major depression. |
2015-03-20 |
2023-08-13 |
Not clear |
| M Kolcsar, Z Gáll, M T Dogar. Dose dependent effects of serotonergic agents on anxiety. Acta physiologica Hungarica. vol 101. issue 4. 2015-03-11. PMID:25532957. |
the role of serotonin in depression and anxiety is still highly controversial. |
2015-03-11 |
2023-08-13 |
rat |
| Masaki Kato, Toshifumi Kimura, Takeshi Kimura, Terufumi Har. Safety and effectiveness of controlled-release paroxetine in routine clinical practice: results of a postmarketing surveillance study of patients with depression. Neuropsychiatric disease and treatment. vol 11. 2015-03-11. PMID:25759586. |
selective serotonin reuptake inhibitors are commonly used in the pharmacotherapy of depression. |
2015-03-11 |
2023-08-13 |
Not clear |
| Dasiel O Borroto-Escuela, Manuel Narvaez, Mileidys Pérez-Alea, Alexander O Tarakanov, Antonio Jiménez-Beristain, Giuseppa Mudó, Luigi F Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fux. Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system. Biochemical and biophysical research communications. vol 456. issue 1. 2015-03-10. PMID:25485703. |
the ascending midbrain 5-ht neurons known to contain 5-ht1a autoreceptors may be dysregulated in depression due to a reduced trophic support. |
2015-03-10 |
2023-08-13 |
rat |
| Go Okada, Yasumasa Okamoto, Kazuhiro Shishida, Kazutaka Ueda, Keiichi Onoda, Yoshihiko Kunisato, Saori C Tanaka, Kenji Doya, Shigeto Yamawak. [Brain mechanisms of depression--preliminary evidence from fMRI studies]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 116. issue 10. 2015-03-09. PMID:25672209. |
although brain monoamines serotonin, noradrenaline, and dopamine have been repeatedly shown to be linked to depression, it remains unclear how monoamine dysfunction is mechanistically related to symptoms of depression. |
2015-03-09 |
2023-08-13 |
Not clear |
| Go Okada, Yasumasa Okamoto, Kazuhiro Shishida, Kazutaka Ueda, Keiichi Onoda, Yoshihiko Kunisato, Saori C Tanaka, Kenji Doya, Shigeto Yamawak. [Brain mechanisms of depression--preliminary evidence from fMRI studies]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 116. issue 10. 2015-03-09. PMID:25672209. |
our results suggest that parallel organization for reward prediction at different time scales in the striatum is under differential modulation by serotonin, and that depression is associated with a diminished recruitment of the dorsal striatum, involved in long-term reward prediction. |
2015-03-09 |
2023-08-13 |
Not clear |
| Leif Hertz, Douglas L Rothman, Baoman Li, Liang Pen. Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift. Frontiers in behavioral neuroscience. vol 9. 2015-03-09. PMID:25750618. |
it is firmly believed that the mechanism of action of ssris in major depression is to inhibit the serotonin transporter, sert, and increase extracellular concentration of serotonin. |
2015-03-09 |
2023-08-13 |
mouse |
| C C Watkins, A Sawa, M G Pompe. Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application. Translational psychiatry. vol 4. 2015-03-06. PMID:24448212. |
pharmacological studies of selective serotonin reuptake inhibitors and the monoamine system have helped us to clinically understand bipolar depression. |
2015-03-06 |
2023-08-12 |
Not clear |
| M Wankerl, R Miller, C Kirschbaum, J Hennig, T Stalder, N Alexande. Effects of genetic and early environmental risk factors for depression on serotonin transporter expression and methylation profiles. Translational psychiatry. vol 4. 2015-03-06. PMID:24937096. |
effects of genetic and early environmental risk factors for depression on serotonin transporter expression and methylation profiles. |
2015-03-06 |
2023-08-13 |
human |