| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Douglas Ried, Huanguang Jia, Hua Feng, Randi Cameon, Xinping Wang, Michael Tueth, Samuel S W. Selective serotonin reuptake inhibitor treatment and depression are associated with poststroke mortality. The Annals of pharmacotherapy. vol 45. issue 7-8. 2011-12-07. PMID:21750310. |
selective serotonin reuptake inhibitor treatment and depression are associated with poststroke mortality. |
2011-12-07 |
2023-08-12 |
Not clear |
| C A C Coupland, P Dhiman, G Barton, R Morriss, A Arthur, T Sach, J Hippisley-Co. A study of the safety and harms of antidepressant drugs for older people: a cohort study using a large primary care database. Health technology assessment (Winchester, England). vol 15. issue 28. 2011-12-05. PMID:21810375. |
the study objectives were to (1) determine relative and absolute risks of predefined adverse events in older people with depression, comparing classes of antidepressant drugs [tricyclic and related antidepressants (tcas), selective serotonin reuptake inhibitors (ssris), monoamine oxidase inhibitors (maois) and other antidepressants] and commonly prescribed individual drugs with non-use of antidepressant drugs; (2) directly compare the risk of adverse events for ssris with tcas; (3) determine associations with dose and duration of antidepressant medication; (4) describe patterns of antidepressant use in older people with depression; and (5) estimate costs of antidepressant medication and primary care visits. |
2011-12-05 |
2023-08-12 |
Not clear |
| J D A Olivier, T Blom, T Arentsen, J R Homber. The age-dependent effects of selective serotonin reuptake inhibitors in humans and rodents: A review. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 6. 2011-11-29. PMID:20883714. |
the selective serotonin reuptake inhibitor (ssri) prozac® (fluoxetine) is widely prescribed for the treatment of depression and anxiety-related disorders. |
2011-11-29 |
2023-08-12 |
mouse |
| b' I D Neumann, G Wegener, J R Homberg, H Cohen, D A Slattery, J Zohar, J D A Olivier, A A Math\\xc3\\xa. Animal models of depression and anxiety: What do they tell us about human condition? Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 6. 2011-11-29. PMID:21129431.' |
in this review, the authors present four rodent models with good face-, construct-, and predictive-validity: the flinders sensitive rat line (fsl); the genetically "anxious" high anxiety-like behavior (hab) line; the serotonin transporter knockout 5-htt(-/-) rat and mouse lines; and the post-traumatic stress disorder (ptsd) model induced by exposure to predator scent, that they have employed to investigate the nature of depression and anxiety. |
2011-11-29 |
2023-08-12 |
mouse |
| Simona Scheggi, Giovanna Marchese, Franco Borsini, Fabio Bordi, Maria Graziella De Monti. Effects of the 5-HT(6) receptor agonist ST 1936 on depression- and anhedonia-like experimental models. Behavioural brain research. vol 224. issue 1. 2011-11-21. PMID:21645553. |
serotonin 5-ht(6) receptor agonists and antagonists have been proposed as possible useful compounds in the treatment of psychiatric disorders such as depression. |
2011-11-21 |
2023-08-12 |
rat |
| Simona Scheggi, Giovanna Marchese, Franco Borsini, Fabio Bordi, Maria Graziella De Monti. Effects of the 5-HT(6) receptor agonist ST 1936 on depression- and anhedonia-like experimental models. Behavioural brain research. vol 224. issue 1. 2011-11-21. PMID:21645553. |
this study was aimed at characterizing st 1936, a new 5-ht(6) receptor agonist, as a possible antidepressant/anti-anhedonic drug by studying its effects on three experimental models of depression. |
2011-11-21 |
2023-08-12 |
rat |
| Korona Nenadic Sviglin, Gordana Nedic, Matea Nikolac, Maja Mustapic, Dorotea Muck-Seler, Fran Borovecki, Nela Piva. Insomnia, platelet serotonin and platelet monoamine oxidase in chronic alcoholism. Neuroscience letters. vol 500. issue 3. 2011-11-14. PMID:21722708. |
the effects of early, middle and late insomnia (evaluated using the hamilton depression rating scale), as well as sex, age and smoking on platelet 5-ht concentration and platelet mao-b activity were evaluated using one-way anova and multiple regression analysis by the stepwise method. |
2011-11-14 |
2023-08-12 |
human |
| Francisco J de Abaj. Effects of selective serotonin reuptake inhibitors on platelet function: mechanisms, clinical outcomes and implications for use in elderly patients. Drugs & aging. vol 28. issue 5. 2011-11-11. PMID:21542658. |
among the antidepressants, the selective serotonin reuptake inhibitors (ssris) are often preferred to other classes of antidepressants in the treatment of depression in the elderly because of their better safety profile. |
2011-11-11 |
2023-08-12 |
Not clear |
| Prakash S Masand, Meera Narasimhan, Ashwin A Patka. Paroxetine for somatic pain associated with physical illness: a review. Primary care companion to the Journal of clinical psychiatry. vol 8. issue 3. 2011-11-10. PMID:16912814. |
the purpose of this article is to review the prevalence of somatic pain with and without depression or anxiety and the pharmacologic effects of the selective serotonin reuptake inhibitor paroxetine on pain in physical conditions with and without comorbid depression or anxiety. |
2011-11-10 |
2023-08-12 |
Not clear |
| Paul W Andrews, Susan G Kornstein, Lisa J Halberstadt, Charles O Gardner, Michael C Neal. Blue again: perturbational effects of antidepressants suggest monoaminergic homeostasis in major depression. Frontiers in psychology. vol 2. 2011-11-10. PMID:21779273. |
according to disorder advocates, neurochemicals like the monoamine neurotransmitters (serotonin, norepinephrine, and dopamine) are dysregulated in major depression. |
2011-11-10 |
2023-08-12 |
human |
| V Palaniappun, V Ramachandran, O Somasundara. Norepinephrine and serotonin metabolism and clinical response to combined imipramine and amitriptyline therapy in depression. Indian journal of psychiatry. vol 33. issue 3. 2011-11-10. PMID:21927500. |
norepinephrine and serotonin metabolism and clinical response to combined imipramine and amitriptyline therapy in depression. |
2011-11-10 |
2023-08-12 |
Not clear |
| Norbert Müller, Aye-Mu Myint, Markus J Schwar. Inflammatory biomarkers and depression. Neurotoxicity research. vol 19. issue 2. 2011-11-09. PMID:20658274. |
differences in the activation of the enzyme indoleamine 2,3-dioxygenase (ido) and in the tryptophan-kynurenine metabolism resulting in an increased tryptophan and serotonin degradation and probably in an increased production of quinolinic acid might play a key role in major depression (md). |
2011-11-09 |
2023-08-12 |
Not clear |
| Hee Jeong Seo, Eun-Jung Park, Min Ju Kim, Suk Youn Kang, Suk Ho Lee, Hyun Jung Kim, Ki Nam Lee, Myung Eun Jung, Minwoo Lee, Mi-Soon Kim, Eun-Jung Son, Woo-Kyu Park, Jeongmin Kim, Jinhwa Le. Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter. Journal of medicinal chemistry. vol 54. issue 18. 2011-11-09. PMID:21823597. |
the human 5-ht(2a/2c) receptor has been implicated in several neurological conditions, and potent selective 5-ht(2a/2c) ligands may have therapeutic potential for treatment of cns diseases such as depression. |
2011-11-09 |
2023-08-12 |
human |
| Ha Kyoung Kim, Seog Ju Kim, Yu Jin Lee, Heon-Jeong Lee, Seung-Gul Kang, Jung-Eun Choi, Kyu-Wol Yun, Weon-Jeong Li. Influence of the interaction between the serotonin 1A receptor C-1019G polymorphism and negative life stressors on the development of depression. Neuropsychobiology. vol 64. issue 1. 2011-11-03. PMID:21577007. |
influence of the interaction between the serotonin 1a receptor c-1019g polymorphism and negative life stressors on the development of depression. |
2011-11-03 |
2023-08-12 |
Not clear |
| Ha Kyoung Kim, Seog Ju Kim, Yu Jin Lee, Heon-Jeong Lee, Seung-Gul Kang, Jung-Eun Choi, Kyu-Wol Yun, Weon-Jeong Li. Influence of the interaction between the serotonin 1A receptor C-1019G polymorphism and negative life stressors on the development of depression. Neuropsychobiology. vol 64. issue 1. 2011-11-03. PMID:21577007. |
the current study aimed to investigate the interaction between the serotonin 1a receptor gene (htr1a) c-1019g polymorphism and recent negative life stressors on depression in a korean community sample. |
2011-11-03 |
2023-08-12 |
Not clear |
| Charles S Carver, Sheri L Johnson, Jutta Joormann, Joelle Lemoult, Michael L Cuccar. Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis. Journal of affective disorders. vol 132. issue 1-2. 2011-11-01. PMID:21420735. |
the serotonin transporter polymorphism (5-httlpr) and the brain-derived neurotrophic factor (bdnf) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (mdd) in interaction with adversity; there have also been failures to find the effects. |
2011-11-01 |
2023-08-12 |
Not clear |
| Jutta Mata, Ian H Gotli. 5-HTTLPR moderates the relation between changes in depressive and bulimic symptoms in adolescent girls: a longitudinal study. The International journal of eating disorders. vol 44. issue 5. 2011-10-28. PMID:21661000. |
depression and bulimia both are associated with low serotonin levels. |
2011-10-28 |
2023-08-12 |
Not clear |
| Pieter Schipper, Lourens J P Nonkes, Peter Karel, Amanda J Kiliaan, Judith R Homber. Serotonin transporter genotype x construction stress interaction in rats. Behavioural brain research. vol 223. issue 1. 2011-10-18. PMID:21549766. |
a well-known example for gene x environment interactions in psychiatry is the one involving the low activity (s) allelic variant of the serotonin transporter (5-htt) promoter polymorphism (5-httlpr) that in the context of stress increases risk for depression. |
2011-10-18 |
2023-08-12 |
rat |
| Sonny K H Tan, Henrike Hartung, Trevor Sharp, Yasin Teme. Serotonin-dependent depression in Parkinson's disease: a role for the subthalamic nucleus? Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21251918. |
here we propose low 5-ht combined with altered network activity within the basal ganglia as critically involved in depression in pd. |
2011-10-14 |
2023-08-12 |
Not clear |
| Sonny K H Tan, Henrike Hartung, Trevor Sharp, Yasin Teme. Serotonin-dependent depression in Parkinson's disease: a role for the subthalamic nucleus? Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21251918. |
this review provides an overview of 5-ht alterations in pd and a discussion of how these changes might combine with altered basal ganglia network activity to increase depression vulnerability. |
2011-10-14 |
2023-08-12 |
Not clear |