| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sonali Lokuge, Benicio N Frey, Jane A Foster, Claudio N Soares, Meir Steine. Depression in women: windows of vulnerability and new insights into the link between estrogen and serotonin. The Journal of clinical psychiatry. vol 72. issue 11. 2012-01-18. PMID:22127200. |
depression in women: windows of vulnerability and new insights into the link between estrogen and serotonin. |
2012-01-18 |
2023-08-12 |
Not clear |
| Jennifer E Sanner, Lorraine Frazie. The role of serotonin in depression and clotting in the coronary artery disease population. The Journal of cardiovascular nursing. vol 26. issue 5. 2012-01-10. PMID:21372736. |
the role of serotonin in depression and clotting in the coronary artery disease population. |
2012-01-10 |
2023-08-12 |
Not clear |
| C Schüle, D Eser, T C Baghai, C Nothdurfter, J S Kessler, R Rupprech. Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs? Neuroscience. vol 191. 2012-01-10. PMID:21439354. |
antidepressant drugs such as selective serotonin reuptake inhibitors (ssris) or mirtazapine apparently have an impact on key enzymes of neurosteroidogenesis and have been shown to normalize the disequilibrium of neuroactive steroids in depression by increasing 3α-reduced pregnane steroids and decreasing 3β,5α-tetrahydroprogesterone. |
2012-01-10 |
2023-08-12 |
human |
| Ann Gardner, Richard G Bole. Beyond the serotonin hypothesis: mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 3. 2012-01-06. PMID:20691744. |
beyond the serotonin hypothesis: mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders. |
2012-01-06 |
2023-08-12 |
Not clear |
| Ann Gardner, Richard G Bole. Beyond the serotonin hypothesis: mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 3. 2012-01-06. PMID:20691744. |
for many years, a deficiency of monoamines including serotonin has been the prevailing hypothesis on depression, yet research has failed to confirm consistent relations between brain serotonin and depression. |
2012-01-06 |
2023-08-12 |
Not clear |
| M Maes, B E Leonard, A M Myint, M Kubera, R Verker. The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 3. 2012-01-06. PMID:21185346. |
the new '5-ht' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (trycats), both of which contribute to the onset of depression. |
2012-01-06 |
2023-08-12 |
Not clear |
| M Maes, B E Leonard, A M Myint, M Kubera, R Verker. The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 3. 2012-01-06. PMID:21185346. |
this paper reviews the body of evidence that not only tryptophan and consequent 5-ht depletion, but also induction of indoleamine 2,3-dioxygenase (ido) and the detrimental effects of tryptophan catabolites (trycats) play a role in the pathophysiology of depression. |
2012-01-06 |
2023-08-12 |
Not clear |
| Angela Getz, Fenglian Xu, Wali Zaidi, Naweed I Sye. The antidepressant fluoxetine but not citalopram suppresses synapse formation and synaptic transmission between Lymnaea neurons by perturbing presynaptic and postsynaptic machinery. The European journal of neuroscience. vol 34. issue 2. 2012-01-05. PMID:21722207. |
depression is a debilitating mental disorder, and selective serotonin reuptake inhibitors (ssris) constitute the first-line antidepressant treatment choice for the clinical management of this illness; however, the mechanisms underlying their therapeutic actions and side effects remain poorly understood. |
2012-01-05 |
2023-08-12 |
Not clear |
| Luke E Grzeskowiak, Andrew L Gilbert, Janna L Morriso. Investigating outcomes following the use of selective serotonin reuptake inhibitors for treating depression in pregnancy: a focus on methodological issues. Drug safety. vol 34. issue 11. 2012-01-05. PMID:21981432. |
investigating outcomes following the use of selective serotonin reuptake inhibitors for treating depression in pregnancy: a focus on methodological issues. |
2012-01-05 |
2023-08-12 |
Not clear |
| W N Marsde. Stressor-induced NMDAR dysfunction as a unifying hypothesis for the aetiology, pathogenesis and comorbidity of clinical depression. Medical hypotheses. vol 77. issue 4. 2011-12-29. PMID:21741771. |
typically the monoamine system has been the central focus of neurobiological research into depression and represents the major target of modern antidepressant medications; although the extent to which monoamines such as serotonin play a role in the pathogenesis of depression is still not clear. |
2011-12-29 |
2023-08-12 |
Not clear |
| Ine Rayen, Daniël L van den Hove, Jos Prickaerts, Harry W Steinbusch, Jodi L Pawlusk. Fluoxetine during development reverses the effects of prenatal stress on depressive-like behavior and hippocampal neurogenesis in adolescence. PloS one. vol 6. issue 9. 2011-12-29. PMID:21912658. |
currently, selective serotonin reuptake inhibitor (ssris) medications are commonly used for treatment of maternal depression. |
2011-12-29 |
2023-08-12 |
rat |
| Christopher Labos, Kaberi Dasgupta, Hacene Nedjar, Gustavo Turecki, Elham Rahm. Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infarction. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. vol 183. issue 16. 2011-12-29. PMID:21948719. |
patients prescribed antiplatelet treatment to prevent recurrent acute myocardial infarction are often also given a selective serotonin reuptake inhibitor (ssri) to treat coexisting depression. |
2011-12-29 |
2023-08-12 |
Not clear |
| E A Tret'iakova, Iu V Karakulov. [Clinical and biochemical mechanisms of the formation of chronic low back pain]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 111. issue 9. 2011-12-29. PMID:22027672. |
it was shown that patients with compressive syndromes of lumbar dorsopathy were characterized by the high intensity of pain, pronounced neuropathic pain component, lower quality of life as well as the significantly low serum serotonin content that was correlated with the degree of neuropathic pain severity and depression level. |
2011-12-29 |
2023-08-12 |
Not clear |
| Greta Wozniak, Aikaterini Toska, Maria Saridi, Odysseas Mouza. Serotonin reuptake inhibitor antidepressants (SSRIs) against atherosclerosis. Medical science monitor : international medical journal of experimental and clinical research. vol 17. issue 9. 2011-12-27. PMID:21873959. |
selective serotonin reuptake inhibitors (ssris) are a class of drug widely used for treatment of mood disorders, including depression and cardiovascular disease. |
2011-12-27 |
2023-08-12 |
Not clear |
| Sanjay Budhdeo, Shabna Rajapaks. Functional recovery in cerebral palsy may be potentiated by administration of selective serotonin reuptake inhibitors. Medical hypotheses. vol 77. issue 3. 2011-12-21. PMID:21683532. |
evidence suggests that this is the mechanism of action of selective serotonin reuptake inhibitors (ssris) in the treatment of depression. |
2011-12-21 |
2023-08-12 |
Not clear |
| M Danet, S Lapiz-Bluhm, David A Morila. A cognitive deficit induced in rats by chronic intermittent cold stress is reversed by chronic antidepressant treatment. The international journal of neuropsychopharmacology. vol 13. issue 8. 2011-12-19. PMID:20149267. |
this effect may be related to dysregulation of 5-ht function in orbitofrontal cortex, as a model of cognitive dysfunction in depression. |
2011-12-19 |
2023-08-12 |
rat |
| Linda Mah, Carlos A Zarate, Allison C Nugent, Jaskaran B Singh, Husseini K Manji, Wayne C Drevet. Neural mechanisms of antidepressant efficacy of the dopamine receptor agonist pramipexole in treatment of bipolar depression. The international journal of neuropsychopharmacology. vol 14. issue 4. 2011-12-16. PMID:21029512. |
these pramipexole-induced effects on regional metabolism suggest a mechanism of antidepressant action distinct from that previously reported under serotonin reuptake inhibitor treatment and appear compatible with evidence that the central dopaminergic system plays a role in the pathophysiology of bipolar depression. |
2011-12-16 |
2023-08-12 |
Not clear |
| Daniel Souery, Alessandro Serretti, Raffaella Calati, Pierre Oswald, Isabelle Massat, Anastasios Konstantinidis, Sylvie Linotte, Siegfried Kasper, Stuart Montgomery, Joseph Zohar, Julien Mendlewic. Citalopram versus desipramine in treatment resistant depression: effect of continuation or switching strategies: a randomized open study. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 12. issue 5. 2011-12-14. PMID:21718212. |
evidence in favour of switching between selective serotonin reuptake inhibitor (ssri) and tricyclic (tca) antidepressants in treatment resistant depression has been tested in a few studies only, consequently a prospective study was undertaken to evaluate the impact of switching strategies. |
2011-12-14 |
2023-08-12 |
Not clear |
| C Rob Markus, Rudi De Raed. Differential effects of 5-HTTLPR genotypes on inhibition of negative emotional information following acute stress exposure and tryptophan challenge. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 4. 2011-12-12. PMID:21150915. |
previous data suggest that a polymorphism at the serotonin (5-ht) transporter gene (5-httlpr) may influence stress resilience and stress-related depression symptoms due to interactions between brain 5-ht dysfunction and stress exposure. |
2011-12-12 |
2023-08-12 |
human |
| Julia C Lemos, Guojun Zhang, Teresa Walsh, Lynn G Kirby, Adaure Akanwa, Amy Brooks-Kayal, Sheryl G Bec. Stress-hyperresponsive WKY rats demonstrate depressed dorsal raphe neuronal excitability and dysregulated CRF-mediated responses. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 4. 2011-12-12. PMID:21160465. |
the crf modulation of 5-ht drn neurotransmission at the single-cell level is selectively disrupted in the wky animal model of depression and may be one of the cellular correlates underlying depression. |
2011-12-12 |
2023-08-12 |
rat |