| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antonella Daniele, Rosa Divella, Angelo Paradiso, Vittorio Mattioli, Francesca Romito, Francesco Giotta, Porzia Casamassima, Michele Quarant. Serotonin transporter polymorphism in major depressive disorder (MDD), psychiatric disorders, and in MDD in response to stressful life events: causes and treatment with antidepressant. In vivo (Athens, Greece). vol 25. issue 6. 2012-03-01. PMID:22021682. |
short allele (ss) variation decreases the transcriptional efficacy of serotonin, causing psychiatric disorders, major depressive disorder (mdd) and major depression in response to stressful life events. |
2012-03-01 |
2023-08-12 |
human |
| Frederick J Stoddard, Rohini Luthra, Erica A Sorrentino, Glenn N Saxe, Jennifer Drake, Yuchiao Chang, John B Levine, David S Chedekel, Robert L Sherida. A randomized controlled trial of sertraline to prevent posttraumatic stress disorder in burned children. Journal of child and adolescent psychopharmacology. vol 21. issue 5. 2012-03-01. PMID:22040192. |
this study evaluated the potential benefits of a centrally acting selective serotonin reuptake inhibitor, sertraline, versus placebo for prevention of symptoms of posttraumatic stress disorder (ptsd) and depression in burned children. |
2012-03-01 |
2023-08-12 |
Not clear |
| H-C Yan, X Cao, T-M Gao, X-H Zh. Promoting adult hippocampal neurogenesis: a novel strategy for antidepressant drug screening. Current medicinal chemistry. vol 18. issue 28. 2012-02-29. PMID:21861813. |
major depression is a common mood disorder that affects overall health; currently, almost all of the available antidepressants have the same core mechanisms of action through promotion of serotonin or noradrenaline function in the brain. |
2012-02-29 |
2023-08-12 |
Not clear |
| John D McCorvy, Aubrie A Harland, Rebecca Maglathlin, David E Nichol. A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference. Neuroscience letters. vol 505. issue 1. 2012-02-28. PMID:21827831. |
if the results can be translated to man, putative 5-ht(2c) receptor antagonist treatments for anxiety or depression may enhance or potentiate the rewarding effects of drugs of abuse such as amphetamine, which release dopamine. |
2012-02-28 |
2023-08-12 |
Not clear |
| Min Liu, Jiajie Hu, Tian Ma, Shi Wang, Hong Din. Application of a disposable screen-printed electrode to depression diagnosis for laboratory rats based on blood serotonin detection. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. vol 27. issue 8. 2012-02-27. PMID:21828923. |
application of a disposable screen-printed electrode to depression diagnosis for laboratory rats based on blood serotonin detection. |
2012-02-27 |
2023-08-12 |
rat |
| Min Liu, Jiajie Hu, Tian Ma, Shi Wang, Hong Din. Application of a disposable screen-printed electrode to depression diagnosis for laboratory rats based on blood serotonin detection. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. vol 27. issue 8. 2012-02-27. PMID:21828923. |
in this study, we prepared a 5-ht biosensor based on screen-printed electrode and applied it to a rat depression model caused by chronic unpredictable mild stress (cums). |
2012-02-27 |
2023-08-12 |
rat |
| Min Liu, Jiajie Hu, Tian Ma, Shi Wang, Hong Din. Application of a disposable screen-printed electrode to depression diagnosis for laboratory rats based on blood serotonin detection. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. vol 27. issue 8. 2012-02-27. PMID:21828923. |
during cums, the blood 5-ht and the depression behavior of the depressed rats and the rats treated by antidepressants were recorded. |
2012-02-27 |
2023-08-12 |
rat |
| Min Liu, Jiajie Hu, Tian Ma, Shi Wang, Hong Din. Application of a disposable screen-printed electrode to depression diagnosis for laboratory rats based on blood serotonin detection. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. vol 27. issue 8. 2012-02-27. PMID:21828923. |
results demonstrated that 5-ht level of the depressed rats declined while the depression behavior was aggravated. |
2012-02-27 |
2023-08-12 |
rat |
| Min Liu, Jiajie Hu, Tian Ma, Shi Wang, Hong Din. Application of a disposable screen-printed electrode to depression diagnosis for laboratory rats based on blood serotonin detection. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. vol 27. issue 8. 2012-02-27. PMID:21828923. |
mifepristone (20 mg/kg) and rhizoma coptidis water extract (10, 20, 100 mg/kg) quickly reversed 5-ht level and the depression behavior. |
2012-02-27 |
2023-08-12 |
rat |
| Min Liu, Jiajie Hu, Tian Ma, Shi Wang, Hong Din. Application of a disposable screen-printed electrode to depression diagnosis for laboratory rats based on blood serotonin detection. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. vol 27. issue 8. 2012-02-27. PMID:21828923. |
this sensor can accurately test blood 5-ht and might be applied to rapid diagnosis for depression and evaluation of antidepressants effect. |
2012-02-27 |
2023-08-12 |
rat |
| Jerry C Chang, Ian D Tomlinson, Michael R Warnement, Hideki Iwamoto, Louis J DeFelice, Randy D Blakely, Sandra J Rosentha. A fluorescence displacement assay for antidepressant drug discovery based on ligand-conjugated quantum dots. Journal of the American Chemical Society. vol 133. issue 44. 2012-02-27. PMID:21970724. |
the serotonin (5-hydroxytryptamine, 5-ht) transporter (sert) protein plays a central role in terminating 5-ht neurotransmission and is the most important therapeutic target for the treatment of major depression and anxiety disorders. |
2012-02-27 |
2023-08-12 |
human |
| Klaus Seppi, Daniel Weintraub, Miguel Coelho, Santiago Perez-Lloret, Susan H Fox, Regina Katzenschlager, Eva-Maria Hametner, Werner Poewe, Olivier Rascol, Christopher G Goetz, Cristina Sampai. The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 26 Suppl 3. 2012-02-27. PMID:22021174. |
this includes the tricyclic antidepressant amitriptyline, all selective serotonin reuptake inhibitors (ssris) reviewed (paroxetine, citalopram, sertraline, and fluoxetine), the newer antidepressants atomoxetine and nefazodone, pergolide, Ω-3 fatty acids as well as repetitive transcranial magnetic stimulation (rtms) for the treatment of depression or depressive symptoms; methylphenidate and modafinil for the treatment of fatigue; amantadine for the treatment of pathological gambling; donepezil, galantamine, and memantine for the treatment of dementia; quetiapine for the treatment of psychosis; fludrocortisone and domperidone for the treatment of orthostatic hypotension; sildenafil for the treatment of erectile dysfunction, ipratropium bromide spray for the treatment of sialorrhea; levodopa/carbidopa controlled release (cr), pergolide, eszopiclone, melatonin 3 to 5 mg and melatonin 50 mg for the treatment of insomnia and modafinil for the treatment of excessive daytime sleepiness. |
2012-02-27 |
2023-08-12 |
Not clear |
| Jana Strohmaier, Stefan Wüst, Rudolf Uher, Neven Henigsberg, Ole Mors, Joanna Hauser, Daniel Souery, Astrid Zobel, Mojca Z Dernovsek, Fabian Streit, Christine Schmäl, Dejan Kozel, Anna Placentino, Anne Farmer, Peter McGuffin, Katherine J Aitchison, Marcella Rietsche. Sexual dysfunction during treatment with serotonergic and noradrenergic antidepressants: clinical description and the role of the 5-HTTLPR. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 12. issue 7. 2012-02-23. PMID:21388237. |
in the multicentre clinical and pharmacogenetic gendep study (genome-based therapeutic drugs for depression), the effect of the serotonin transporter gene promoter polymorphism 5-httlpr on sexual function was investigated during treatment with escitalopram (ssri) and nortriptyline (tricyclic antidepressant). |
2012-02-23 |
2023-08-12 |
Not clear |
| T Christensen, C F Bisgaard, O Wibor. Biomarkers of anhedonic-like behavior, antidepressant drug refraction, and stress resilience in a rat model of depression. Neuroscience. vol 196. 2012-02-23. PMID:21889970. |
depression-related transcriptomic changes in gene expression profiles were investigated in laser-captured microdissected (lcm) rat hippocampal granular cell layers (gcl) using the chronic mild stress (cms) rat model of depression and chronic administration of two selective serotonin reuptake inhibitors (ssris), escitalopram and sertraline. |
2012-02-23 |
2023-08-12 |
rat |
| J-W Tian, W-L Jiang, Y Zhong, Q Meng, Y Gai, H-B Zhu, J Hou, Y Xing, Y-X L. Preclinical pharmacology of TP1, a novel potent triple reuptake inhibitor with antidepressant properties. Neuroscience. vol 196. 2012-02-23. PMID:21925241. |
the ability of tp1 to inhibit the reuptake of three biogenic amines closely linked to the etiology of depression may result in a therapeutic profile different from antidepressants that inhibit the reuptake of serotonin and/or ne. |
2012-02-23 |
2023-08-12 |
human |
| Rani K Vasudeva, Rick C S Lin, Kimberly L Simpson, Barry D Waterhous. Functional organization of the dorsal raphe efferent system with special consideration of nitrergic cell groups. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21640185. |
the serotonin (5ht) system of the brain is involved in many cns functions including sensory perception, stress responses and psychological disorders such as anxiety and depression. |
2012-02-22 |
2023-08-12 |
Not clear |
| Maria Waselus, Rita J Valentino, Elisabeth J Van Bockstael. Collateralized dorsal raphe nucleus projections: a mechanism for the integration of diverse functions during stress. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21658442. |
the midbrain dorsal raphe nucleus (dr) is the origin of the central serotonin (5-ht) system, a key neurotransmitter system that has been implicated in the expression of normal behaviors and in diverse psychiatric disorders, particularly affective disorders such as depression and anxiety. |
2012-02-22 |
2023-08-12 |
Not clear |
| J Cole, D R Weinberger, V S Mattay, X Cheng, A W Toga, P M Thompson, G Powell-Smith, S Cohen-Woods, A Simmons, P McGuffin, C H Y F. No effect of 5HTTLPR or BDNF Val66Met polymorphism on hippocampal morphology in major depression. Genes, brain, and behavior. vol 10. issue 7. 2012-02-22. PMID:21692988. |
imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5httlpr) and brain-derived neurotrophic factor (bdnf) val66met polymorphism on the hippocampus in healthy individuals and patients with depression (mdd). |
2012-02-22 |
2023-08-12 |
Not clear |
| Nadeeka N Dissanayaka, John D O'Sullivan, Peter A Silburn, George D Mellic. Assessment methods and factors associated with depression in Parkinson's disease. Journal of the neurological sciences. vol 310. issue 1-2. 2012-02-16. PMID:21764079. |
no associations were found between depression in pd and common genetic variations examined across the serotonin and dopamine transporter genes. |
2012-02-16 |
2023-08-12 |
Not clear |
| Michel Benoit, Philippe H Rober. Imaging correlates of apathy and depression in Parkinson's disease. Journal of the neurological sciences. vol 310. issue 1-2. 2012-02-16. PMID:21831400. |
depression in pd has been specifically associated with morphological and functional changes in prefrontal cortex, cingulate and thalamus, as with 5-ht transmission reduction in posterior cingulated and amygdala-hippocampus complex. |
2012-02-16 |
2023-08-12 |
Not clear |