| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gen Shinozak. The integrated model of serotonin transporter gene variation (5HTTLPR) and the glial cell transporter in stress vulnerability and depression. Medical hypotheses. vol 78. issue 3. 2012-05-29. PMID:22236459. |
this integrated model of 5httlpr and glial cells suggests that the efficacy of serotonin reuptake in the synapse may play a crucial role in variability of neurotransmission, which can lead to differences in the stress response and the pathophysiology of depression. |
2012-05-29 |
2023-08-12 |
Not clear |
| Kerry A Waters, Tania O Stean, Beverley Hammond, David J Virley, Neil Upton, James N C Kew, Ishrut Hussai. Effects of the selective 5-HT(7) receptor antagonist SB-269970 in animal models of psychosis and cognition. Behavioural brain research. vol 228. issue 1. 2012-05-24. PMID:22189656. |
the 5-hydroxytryptamine7 (5-ht7) receptor is a g-protein coupled receptor for serotonin that has been implicated in the pathophysiology of psychiatric and neurological disorders including anxiety, depression and schizophrenia. |
2012-05-24 |
2023-08-12 |
rat |
| Brian Leonard, Michael Mae. Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neuroscience and biobehavioral reviews. vol 36. issue 2. 2012-05-24. PMID:22197082. |
concomitants and sequels of cmi activation and inflammation, were detected in depression: (1) induction of indoleamine 2,3-dioxygenase (ido) by ifnγ and some pics is associated with depleted plasma tryptophan, which may interfere with brain 5-ht synthesis, and increased production of anxiogenic and depressogenic tryptophan catabolites. |
2012-05-24 |
2023-08-12 |
Not clear |
| Candice R Quinn, Carol Dobson-Stone, Tim Outhred, Anthony Harris, Andrew H Kem. The contribution of BDNF and 5-HTT polymorphisms and early life stress to the heterogeneity of major depressive disorder: a preliminary study. The Australian and New Zealand journal of psychiatry. vol 46. issue 1. 2012-05-24. PMID:22247094. |
two reported genetic polymorphisms related to the production of brain-derived neurotrophic factor (bndf) and reuptake by the serotonin transporter (5-htt) appear to contribute to depression in combination with stressful life events. |
2012-05-24 |
2023-08-12 |
Not clear |
| Benedicte Ballanger, Helene Klinger, Julien Eche, Jérôme Lerond, Anne-Evelyne Vallet, Didier Le Bars, Leon Tremblay, Véronique Sgambato-Faure, Emmanuel Broussolle, Stéphane Thoboi. Role of serotonergic 1A receptor dysfunction in depression associated with Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 27. issue 1. 2012-05-21. PMID:21994070. |
the present imaging study suggests that abnormalities in serotonin 1a receptor neurotransmission in the limbic system may be involved in the neural mechanisms underlying depression in patients with parkinson's disease. |
2012-05-21 |
2023-08-12 |
human |
| Catherine A Hartley, Morgan C McKenna, Rabia Salman, Andrew Holmes, B J Casey, Elizabeth A Phelps, Charles E Glat. Serotonin transporter polyadenylation polymorphism modulates the retention of fear extinction memory. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 14. 2012-05-21. PMID:22431634. |
growing evidence suggests serotonin's role in anxiety and depression is mediated by its effects on learned fear associations. |
2012-05-21 |
2023-08-12 |
mouse |
| Fei Xue, Indiana Strombom, Bruce Turnbull, Shao Zhu, John D Seege. Duloxetine for depression and the incidence of hepatic events in adults. Journal of clinical psychopharmacology. vol 31. issue 4. 2012-05-15. PMID:21694615. |
this cohort study of adult duloxetine initiators between 2004 and 2006 based on the ingenix research data mart involved 6 matched comparator cohorts, including 4 antidepressant initiator groups (venlafaxine, nefazodone, selective serotonin reuptake inhibitors, and tricyclic antidepressants), depressed but untreated patients, and individuals without depression. |
2012-05-15 |
2023-08-12 |
Not clear |
| Fei Xue, Indiana Strombom, Bruce Turnbull, Shao Zhu, John D Seege. Duloxetine for depression and the incidence of hepatic events in adults. Journal of clinical psychopharmacology. vol 31. issue 4. 2012-05-15. PMID:21694615. |
venlafaxine initiators (incidence rate ratio [irr] = 0.34; 95% confidence interval [ci], 0.12-0.95) and the cohort without depression (irr = 0.30; 95% ci, 0.10-0.93) had lower incidences of combined hepatic events than duloxetine initiators, whereas no other differences in hepatic events were observed for duloxetine initiators relative to selective serotonin reuptake inhibitors, tricyclic antidepressants, and untreated depressed patients. |
2012-05-15 |
2023-08-12 |
Not clear |
| Hye Yoon Park, Byoung-Jo Lee, Jong-Hoon Kim, Jae-Nam Bae, Bong-Jin Hah. Rapid improvement of depression and quality of life with escitalopram treatment in outpatients with breast cancer: a 12-week, open-label prospective trial. Progress in neuro-psychopharmacology & biological psychiatry. vol 36. issue 2. 2012-05-08. PMID:22142651. |
because the efficacy of escitalopram, a potent serotonin reuptake inhibitor, has not been well evaluated in cancer patients, we investigated its effects on depression and quality of life in outpatients with breast cancer. |
2012-05-08 |
2023-08-12 |
Not clear |
| Mikaela I Nichkova, Han Huisman, Paul M Wynveen, David T Marc, Kelly L Olson, Gottfried H Kellerman. Evaluation of a novel ELISA for serotonin: urinary serotonin as a potential biomarker for depression. Analytical and bioanalytical chemistry. vol 402. issue 4. 2012-05-08. PMID:22160204. |
evaluation of a novel elisa for serotonin: urinary serotonin as a potential biomarker for depression. |
2012-05-08 |
2023-08-12 |
human |
| Mikaela I Nichkova, Han Huisman, Paul M Wynveen, David T Marc, Kelly L Olson, Gottfried H Kellerman. Evaluation of a novel ELISA for serotonin: urinary serotonin as a potential biomarker for depression. Analytical and bioanalytical chemistry. vol 402. issue 4. 2012-05-08. PMID:22160204. |
depression is a common disorder with physical and psychological manifestations often associated with low serotonin. |
2012-05-08 |
2023-08-12 |
human |
| Mikaela I Nichkova, Han Huisman, Paul M Wynveen, David T Marc, Kelly L Olson, Gottfried H Kellerman. Evaluation of a novel ELISA for serotonin: urinary serotonin as a potential biomarker for depression. Analytical and bioanalytical chemistry. vol 402. issue 4. 2012-05-08. PMID:22160204. |
since noninvasive diagnostic tools for depression are sparse, we evaluated the clinical utility of a novel elisa for the measurement of serotonin in urine from depressed subjects and from subjects under antidepressant therapy. |
2012-05-08 |
2023-08-12 |
human |
| Carla S Lima, André L Nunes-Freitas, Anderson Ribeiro-Carvalho, Cláudio C Filgueiras, Alex C Manhães, Armando Meyer, Yael Abreu-Villaç. Exposure to methamidophos at adulthood adversely affects serotonergic biomarkers in the mouse brain. Neurotoxicology. vol 32. issue 6. 2012-05-02. PMID:21871486. |
considering the association between depression and the serotonergic (5ht) system, in the present study we investigated whether a subchronic exposure to methamidophos affects the serotonergic system of adult mice. |
2012-05-02 |
2023-08-12 |
mouse |
| George W Brow. The promoter of the serotonin transporter genotype, environment and depression: a hypothesis supported? Journal of affective disorders. vol 137. issue 1-3. 2012-04-27. PMID:21978735. |
the promoter of the serotonin transporter genotype, environment and depression: a hypothesis supported? |
2012-04-27 |
2023-08-12 |
Not clear |
| Tania Rivera-Baltanas, Jose M Olivares, Maria Calado-Otero, Lisa E Kalynchuk, Jose R Martinez-Villamarin, Hector J Carunch. Serotonin transporter clustering in blood lymphocytes as a putative biomarker of therapeutic efficacy in major depressive disorder. Journal of affective disorders. vol 137. issue 1-3. 2012-04-27. PMID:22257570. |
serotonin transporter (sert) binding is decreased in lymphocytes of depression patients and this decrease is partially reversed by antidepressant medication. |
2012-04-27 |
2023-08-12 |
Not clear |
| Helen L Fisher, Sarah Cohen-Woods, Georgina M Hosang, Rudolf Uher, Georgia Powell-Smith, Robert Keers, Maria Tropeano, Ania Korszun, Lisa Jones, Ian Jones, Mike Owen, Nick Craddock, Ian W Craig, Anne E Farmer, Peter McGuffi. Stressful life events and the serotonin transporter gene (5-HTT) in recurrent clinical depression. Journal of affective disorders. vol 136. issue 1-2. 2012-04-26. PMID:21982504. |
stressful life events and the serotonin transporter gene (5-htt) in recurrent clinical depression. |
2012-04-26 |
2023-08-12 |
Not clear |
| Helen L Fisher, Sarah Cohen-Woods, Georgina M Hosang, Rudolf Uher, Georgia Powell-Smith, Robert Keers, Maria Tropeano, Ania Korszun, Lisa Jones, Ian Jones, Mike Owen, Nick Craddock, Ian W Craig, Anne E Farmer, Peter McGuffi. Stressful life events and the serotonin transporter gene (5-HTT) in recurrent clinical depression. Journal of affective disorders. vol 136. issue 1-2. 2012-04-26. PMID:21982504. |
an interaction between recent stressful life events (sles) and a serotonin transporter promoter polymorphism (5-httlpr) in depression has been inconsistently reported. |
2012-04-26 |
2023-08-12 |
Not clear |
| Jae-Min Kim, Sung-Wan Kim, Robert Stewart, Seon-Young Kim, Il-Seon Shin, Min-Ho Park, Jung-Han Yoon, Ji-Shin Lee, Sung-Woo Park, Young-Hoon Kim, Jin-Sang Yoo. Serotonergic and BDNF genes associated with depression 1 week and 1 year after mastectomy for breast cancer. Psychosomatic medicine. vol 74. issue 1. 2012-04-24. PMID:22210241. |
polymorphisms of serotonin transporter (5-htt) and brain-derived neurotrophic factor (bdnf) genes have been investigated as candidate genes for depression occurring in medical disorders. |
2012-04-24 |
2023-08-12 |
Not clear |
| Jae-Min Kim, Sung-Wan Kim, Robert Stewart, Seon-Young Kim, Il-Seon Shin, Min-Ho Park, Jung-Han Yoon, Ji-Shin Lee, Sung-Woo Park, Young-Hoon Kim, Jin-Sang Yoo. Serotonergic and BDNF genes associated with depression 1 week and 1 year after mastectomy for breast cancer. Psychosomatic medicine. vol 74. issue 1. 2012-04-24. PMID:22210241. |
the serotonin 2a receptor (5-htr2a) genes have been investigated as risk factors for depression but rarely in combination with medical conditions. |
2012-04-24 |
2023-08-12 |
Not clear |
| Sheldon H Preskor. What do the terms "drug-specific response/remission rate" and "placebo" really mean? Journal of psychiatric practice. vol 17. issue 6. 2012-04-23. PMID:22108399. |
viewed from this perspective, only about one out of four patients with major depression responds specifically to either selective serotonin or serotonin-norepinephrine reuptake inhibitors. |
2012-04-23 |
2023-08-12 |
Not clear |