| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erik P Pior. Current concepts in the pharmacotherapy of pseudobulbar affect. Drugs. vol 71. issue 9. 2011-10-11. PMID:21711063. |
advocates of a continuing role for antidepressants, notably selective serotonin reuptake inhibitors, can point to numerous positive case reports and trials, the potential benefit of attempting to treat pba and concomitant depression without using multiple drugs, and the ever-present need to tailor treatment to the individual patient. |
2011-10-11 |
2023-08-12 |
human |
| Seth J Gillihan, Hengyi Rao, Lauretta Brennan, Danny J J Wang, John A Detre, Geena Mary V Sankoorikal, Edward S Brodkin, Martha J Fara. Serotonin transporter genotype modulates the association between depressive symptoms and amygdala activity among psychiatrically healthy adults. Psychiatry research. vol 193. issue 3. 2011-10-11. PMID:21764567. |
recent attempts to understand the biological bases of depression vulnerability have revealed that both the short allele of the serotonin transporter-linked polymorphic region (5-httlpr) and activity in the amygdala are associated with depression. |
2011-10-11 |
2023-08-12 |
Not clear |
| Daniella J Furman, J Paul Hamilton, Jutta Joormann, Ian H Gotli. Altered timing of amygdala activation during sad mood elaboration as a function of 5-HTTLPR. Social cognitive and affective neuroscience. vol 6. issue 3. 2011-10-10. PMID:20360351. |
a functional variant of the serotonin transporter gene (5-httlpr) has been associated with increased risk for major depression in the context of stress. |
2011-10-10 |
2023-08-12 |
human |
| Liming Shao, Michael C Hewitt, Scott C Malcolm, Fengjiang Wang, Jianguo Ma, Una C Campbell, Nancy A Spicer, Sharon R Engel, Larry W Hardy, Zhi-Dong Jiang, Rudy Schreiber, Kerry L Spear, Mark A Varne. Synthesis and pharmacological characterization of bicyclic triple reuptake inhibitor 3-aryl octahydrocyclopenta[c]pyrrole analogues. Journal of medicinal chemistry. vol 54. issue 15. 2011-10-07. PMID:21739935. |
the present work expands the chemical space known to offer potent inhibition of the serotonin transporter (sert), norepinephrine transporter (net), and dopamine transporter (dat) and discloses novel bicyclic octahydrocyclopenta[c]pyrrole and octahydro-1h-isoindole scaffolds as potent triple reuptake inhibitors (tris) for the potential treatment of depression. |
2011-10-07 |
2023-08-12 |
mouse |
| Deepali Gupta, Thangaraj Devadoss, Shvetank Bhatt, Baldev Gautam, Ankur Jindal, Dilip Pandey, Radhakrishnan Mahes. Anti-depressant-like activity of a novel serotonin type-3 (5-HT3) receptor antagonist in rodent models of depression. Indian journal of experimental biology. vol 49. issue 8. 2011-09-29. PMID:21870430. |
anti-depressant-like activity of a novel serotonin type-3 (5-ht3) receptor antagonist in rodent models of depression. |
2011-09-29 |
2023-08-12 |
mouse |
| Mitsumasa Hata, Yuko Yagi, Akira Sezai, Isamu Yoshitake, Shinji Wakui, Ayako Takasaka, Hideomi Kawachi, Tomohiko Murakami, Kazutomo Minami, Motomi Shion. Efficacy of prophylactic treatment with selective serotonin reuptake inhibitors for depression after open-heart surgery. Surgery today. vol 41. issue 6. 2011-09-27. PMID:21626324. |
efficacy of prophylactic treatment with selective serotonin reuptake inhibitors for depression after open-heart surgery. |
2011-09-27 |
2023-08-12 |
Not clear |
| Mitsumasa Hata, Yuko Yagi, Akira Sezai, Isamu Yoshitake, Shinji Wakui, Ayako Takasaka, Hideomi Kawachi, Tomohiko Murakami, Kazutomo Minami, Motomi Shion. Efficacy of prophylactic treatment with selective serotonin reuptake inhibitors for depression after open-heart surgery. Surgery today. vol 41. issue 6. 2011-09-27. PMID:21626324. |
the aim of the present study was to evaluate the efficacy of prophylactic treatment with selective serotonin reuptake inhibitors (ssris) in female patients at high risk of suffering depression after cardiac surgery. |
2011-09-27 |
2023-08-12 |
Not clear |
| Masahiro Shibasaki, Kazuhiro Kurokawa, Seitaro Ohkum. [Functional homology between alcohol dependence and mood disorder]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 46. issue 3. 2011-09-22. PMID:21861331. |
we examined functional changes in serotonin transporter (sert) and serotonin receptors (5-ht(1a) and 5-ht(2a) receptors) related with depression using alcohol physical dependent mice and found correlated changes between depression and alcohol dependence. |
2011-09-22 |
2023-08-12 |
mouse |
| Whorra P Chander, Navdeep Singh, Gulshan K Mukhiy. Serotonin syndrome in maintenance haemodialysis patients following sertraline treatment for depression. Journal of the Indian Medical Association. vol 109. issue 1. 2011-09-22. PMID:21888157. |
serotonin syndrome in maintenance haemodialysis patients following sertraline treatment for depression. |
2011-09-22 |
2023-08-12 |
Not clear |
| Whorra P Chander, Navdeep Singh, Gulshan K Mukhiy. Serotonin syndrome in maintenance haemodialysis patients following sertraline treatment for depression. Journal of the Indian Medical Association. vol 109. issue 1. 2011-09-22. PMID:21888157. |
in our experience the use of ssri, sertraline for depression in esrd patients on maintenance haemodalysis was associated with a high incidence of serotonergic side-effects and toxic serotonin syndrome. |
2011-09-22 |
2023-08-12 |
Not clear |
| P C McHugh, P R Joyce, X Deng, M A Kenned. A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants. The pharmacogenomics journal. vol 11. issue 3. 2011-09-14. PMID:20351752. |
given the pivotal role of the serotonergic system in mood disorders and selective serotonin reuptake inhibitors (ssris) antidepressant function, we tested the hypothesis that gfrp gene (gchfr) variants would modify response to antidepressants in subjects with major depression. |
2011-09-14 |
2023-08-12 |
human |
| Ruth Kohen, Kevin C Cain, Ann Buzaitis, Vicki Johnson, Kyra J Becker, Linda Teri, David L Tirschwell, Richard C Veith, Pamela H Mitchel. Response to psychosocial treatment in poststroke depression is associated with serotonin transporter polymorphisms. Stroke. vol 42. issue 7. 2011-09-09. PMID:21847802. |
response to psychosocial treatment in poststroke depression is associated with serotonin transporter polymorphisms. |
2011-09-09 |
2023-08-12 |
Not clear |
| Vilazodone (Viibryd)--a new antidepressant. The Medical letter on drugs and therapeutics. vol 53. issue 1368. 2011-09-06. PMID:21738107. |
vilazodone (viibryd--forest), a selective serotonin reuptake inhibitor (ssri) and partial 5-ht(1a) receptor agonist, has been approved by the fda for treatment of depression. |
2011-09-06 |
2023-08-12 |
Not clear |
| B K Sharma, P Singh, M Shekhawat, K Sarbhai, Y S Prabhaka. Modelling of serotonin reuptake inhibitory and histamine H₃antagonistic activity of piperazine and diazepane amides: QSAR rationales for co-optimization of the activity profiles. SAR and QSAR in environmental research. vol 22. issue 3. 2011-08-31. PMID:21598199. |
selective human serotonin reuptake transporter (hsert) inhibition is the first line of treatment to deal with the depression. |
2011-08-31 |
2023-08-12 |
human |
| B K Sharma, P Singh, M Shekhawat, K Sarbhai, Y S Prabhaka. Modelling of serotonin reuptake inhibitory and histamine H₃antagonistic activity of piperazine and diazepane amides: QSAR rationales for co-optimization of the activity profiles. SAR and QSAR in environmental research. vol 22. issue 3. 2011-08-31. PMID:21598199. |
recently, histamine h(3) antagonists with serotonin reuptake inhibition activity have been proposed as alternative approach for the treatment of depression. |
2011-08-31 |
2023-08-12 |
human |
| Fanny Mochel, Brandon Durant, Alexandra Durr, Raphael Schiffman. Altered dopamine and serotonin metabolism in motorically asymptomatic R6/2 mice. PloS one. vol 6. issue 3. 2011-08-25. PMID:21483838. |
in addition, little is known about serotonin metabolism despite the early occurrence of anxiety and depression in hd. |
2011-08-25 |
2023-08-12 |
mouse |
| Andréa D E Zomkowski, Daiane Engel, Nelson H Gabilan, Ana Lúcia S Rodrigue. Involvement of NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 11. 2011-08-24. PMID:20810255. |
escitalopram is a serotonin reuptake inhibitor used in the treatment of depression and anxiety disorders. |
2011-08-24 |
2023-08-12 |
mouse |
| Solomon H Snyde. Serotonin, cytokines, p11, and depression. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 22. 2011-08-23. PMID:21593414. |
serotonin, cytokines, p11, and depression. |
2011-08-23 |
2023-08-12 |
Not clear |
| Paulo R Shiroma, Yonas E Geda, Amit Mohan, Jarrett Richardso. Antidepressant prescription pattern in a hospice program. The American journal of hospice & palliative care. vol 28. issue 3. 2011-08-22. PMID:21051782. |
depression and selective serotonin reuptake inhibitors (ssris) were the most common clinical indication and class of antidepressant, respectively. |
2011-08-22 |
2023-08-12 |
Not clear |
| Anne-Catherine Fétique-Will, Thierry Chevalley, René Rizzol. [Selective serotonin reuptake inhibitors (SSRI) and osteoporosis]. Revue medicale suisse. vol 7. issue 299. 2011-08-19. PMID:21793419. |
selective serotonin reuptake inhibitors (ssri) represent the first-line treatment of depression. |
2011-08-19 |
2023-08-12 |
Not clear |