| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Colter Mitchell, Daniel Notterman, Jeanne Brooks-Gunn, John Hobcraft, Irwin Garfinkel, Kate Jaeger, Iulia Kotenko, Sara McLanaha. Role of mother's genes and environment in postpartum depression. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 20. 2011-07-26. PMID:21576482. |
using a nontruncated measure of a chronic environmental stressor--socioeconomic status--measured by education, and two polymorphisms (5-httlpr and stin2 vntr) of the serotonin transporter gene (5-htt), we find strong evidence that some women are genetically more reactive to the environment, resulting in a crossover of risks of postpartum depression for the most reactive groups. |
2011-07-26 |
2023-08-12 |
human |
| Trevor Sharp, Philip J Cowe. 5-HT and depression: is the glass half-full? Current opinion in pharmacology. vol 11. issue 1. 2011-07-25. PMID:21377932. |
5-ht and depression: is the glass half-full? |
2011-07-25 |
2023-08-12 |
Not clear |
| Trevor Sharp, Philip J Cowe. 5-HT and depression: is the glass half-full? Current opinion in pharmacology. vol 11. issue 1. 2011-07-25. PMID:21377932. |
a long-standing theory is that a breakdown in brain serotonin (5-hydroxytryptamine; 5-ht) signalling is critically involved in the symptoms and drug treatment of clinical depression. |
2011-07-25 |
2023-08-12 |
Not clear |
| Ian M Anderson, Gabriella Juhasz, Emma Thomas, Darragh Downey, Shane McKie, J F William Deakin, Rebecca Elliot. The effect of acute citalopram on face emotion processing in remitted depression: a pharmacoMRI study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 1. 2011-07-20. PMID:20599362. |
both reduced serotonergic (5-ht) function and negative emotional biases have been associated with vulnerability to depression. |
2011-07-20 |
2023-08-12 |
human |
| Yasuhiro Katoh, Shinya Uchida, Masayoshi Kawai, Noriyoshi Takei, Norio Mori, Junichi Kawakami, Yoshiyuki Kagawa, Shizuo Yamada, Noriyuki Namiki, Hisakuni Hashimot. Onset of clinical effects and plasma concentration of fluvoxamine in Japanese patients. Biological & pharmaceutical bulletin. vol 33. issue 12. 2011-07-19. PMID:21139240. |
it is widely accepted that selective serotonin reuptake inhibitors (ssris) require 2 to 4 weeks of administration before improvements in emotional symptoms of depression are seen. |
2011-07-19 |
2023-08-12 |
Not clear |
| Richard C Shelto. The return of fixed combinations in psychiatry: fluoxetine and olanzapine combination. Therapeutics and clinical risk management. vol 2. issue 2. 2011-07-14. PMID:18360592. |
more recently, a fixed combination of the atypical antipsychotic olanzapine and the serotonin selective reuptake inhibitor (ssri) fluoxetine has been approved in the us for the treatment of bipolar i depression. |
2011-07-14 |
2023-08-12 |
Not clear |
| Michel Di. Optimizing prophylactic treatment of migraine: Subtypes and patient matching. Therapeutics and clinical risk management. vol 4. issue 5. 2011-07-14. PMID:19209286. |
for example, understanding of the role of serotonin in the cerebrovascular circulation has led to the development of triptans for the acute relief of migraine headaches, and the identification of cortical spreading depression as an early central event associated wih migraine has brought renewed interest in antiepileptic drugs for migraine prophylaxis. |
2011-07-14 |
2023-08-12 |
Not clear |
| Se-Hoon Shim, Yeon-Jeong Lee, Eun-Chan Le. A case of galactorrhea associated with excitalopram. Psychiatry investigation. vol 6. issue 3. 2011-07-14. PMID:20046401. |
escitalopram is one of the most popular selective serotonin reuptake inhibitors (ssris) in current use as a first-line treatment for depression. |
2011-07-14 |
2023-08-12 |
Not clear |
| Deepak Kumar, Tanuj Saaraswat, S N Sengupta, Saurabh Mehrotr. Upper gastrointestinal bleeding in a patient with depression receiving selective serotonin reuptake inhibitor therapy. Indian journal of pharmacology. vol 41. issue 1. 2011-07-14. PMID:20177584. |
upper gastrointestinal bleeding in a patient with depression receiving selective serotonin reuptake inhibitor therapy. |
2011-07-14 |
2023-08-12 |
Not clear |
| Paul R Albert, Brice Le Françoi. Modifying 5-HT1A Receptor Gene Expression as a New Target for Antidepressant Therapy. Frontiers in neuroscience. vol 4. 2011-07-14. PMID:20661455. |
major depression is the most common form of mental illness, and is treated with antidepressant compounds that increase serotonin (5-ht) neurotransmission. |
2011-07-14 |
2023-08-12 |
Not clear |
| Friederike Klempin, Harish Babu, Davide De Pietri Tonelli, Edson Alarcon, Klaus Fabel, Gerd Kemperman. Oppositional effects of serotonin receptors 5-HT1a, 2, and 2c in the regulation of adult hippocampal neurogenesis. Frontiers in molecular neuroscience. vol 3. 2011-07-14. PMID:20721314. |
serotonin (5-ht) appears to play a major role in controlling adult hippocampal neurogenesis and thereby it is relevant for theories linking failing adult neurogenesis to the pathogenesis of major depression and the mechanisms of action of antidepressants. |
2011-07-14 |
2023-08-12 |
Not clear |
| Francesco Cresp. Further Electrochemical and Behavioural Evidence of a Direct Relationship Between Central 5-HT and Cytoskeleton in the Control of Mood. The open neurology journal. vol 4. 2011-07-14. PMID:20802812. |
reduced activity of cns serotonin is reported in unipolar depression and serotonin is the major target of recent antidepressant drugs. |
2011-07-14 |
2023-08-12 |
rat |
| Francesco Cresp. Further Electrochemical and Behavioural Evidence of a Direct Relationship Between Central 5-HT and Cytoskeleton in the Control of Mood. The open neurology journal. vol 4. 2011-07-14. PMID:20802812. |
however, an acute depletion of serotonin in healthy individuals does not induce depressive symptoms suggesting that depression does not correlate with the serotonin system only. |
2011-07-14 |
2023-08-12 |
rat |
| Francesco Cresp. Further Electrochemical and Behavioural Evidence of a Direct Relationship Between Central 5-HT and Cytoskeleton in the Control of Mood. The open neurology journal. vol 4. 2011-07-14. PMID:20802812. |
in depression neuronal plasticity is modified.here, in rats submitted to a behavioural test widely used to predict the efficacy of antidepressant drugs (forced swimming test: fst) a significant decrease of both cerebral tyrosinated alpha-tubulin expression and serotonin levels is monitored. |
2011-07-14 |
2023-08-12 |
rat |
| Francesco Cresp. Further Electrochemical and Behavioural Evidence of a Direct Relationship Between Central 5-HT and Cytoskeleton in the Control of Mood. The open neurology journal. vol 4. 2011-07-14. PMID:20802812. |
moreover, treatment with para-chlorophenylalanine (pcpa, compound that specifically depletes brain serotonin) but not alpha-methyl para tyrosine (alpha-mpt, compound that blocks synthesis of catechols: chemicals also implicated in depression) significantly reduced tyrosinated alpha-tubulin. |
2011-07-14 |
2023-08-12 |
rat |
| Francesco Cresp. Further Electrochemical and Behavioural Evidence of a Direct Relationship Between Central 5-HT and Cytoskeleton in the Control of Mood. The open neurology journal. vol 4. 2011-07-14. PMID:20802812. |
these data propose that direct relationship between serotonin and tyrosinated alpha-tubulin could be considered within the mechanism(s) involved in the pathogenesis of depression. |
2011-07-14 |
2023-08-12 |
rat |
| Helle Kiele. The Nordic health registers - an important source when evaluating the safety of antidepressants during pregnancy. Clinical epidemiology. vol 2. 2011-07-14. PMID:21042552. |
depression during pregnancy occurs frequently and selective serotonin reuptake inhibitors (ssris) are often the drug of choice when treating pregnant women. |
2011-07-14 |
2023-08-12 |
Not clear |
| Barbara L Parr. Optimal management of perimenopausal depression. International journal of women's health. vol 2. 2011-07-14. PMID:21072307. |
the selective serotonin reuptake inhibitors (ssris) in addition to estrogen are usually more beneficial in improving mood than ssris or estrogen treatment alone for major depression, whereas the selective norepinephrine and serotonin reuptake inhibitors do not require the addition of estrogen to exert their antidepressant effects in menopausal depression. |
2011-07-14 |
2023-08-12 |
Not clear |
| Massimo Cocchi, Lucio Tonello, Fabio Gabrielli, Massimo Pregnolat. Depression, osteoporosis, serotonin and cell membrane viscosity between biology and philosophical anthropology. Annals of general psychiatry. vol 10. 2011-07-14. PMID:21450092. |
moreover, it is believed that the hereditary or acquired involvement of tryptophan hydroxylase 2 (tph2) or 5-hydroxytryptamine transporter (5-htt) is responsible for the reduced concentration of serotonin in the central nervous system, causing depression and affective disorders. |
2011-07-14 |
2023-08-12 |
human |
| Massimo Cocchi, Lucio Tonello, Fabio Gabrielli, Massimo Pregnolat. Depression, osteoporosis, serotonin and cell membrane viscosity between biology and philosophical anthropology. Annals of general psychiatry. vol 10. 2011-07-14. PMID:21450092. |
this work studies the depression-osteoporosis relationship, with the aim of focusing on depressive disorders that concern the quantitative dynamic of platelet membrane viscosity and interactome cytoskeleton modifications (in particular tubulin and gsα protein) as a possible condition of the involvement of the serotonin axis (gut, brain and platelet), not only in depression but also in connection with osteoporosis. |
2011-07-14 |
2023-08-12 |
human |