| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sophia Frangou, Masoud Shirali, Mark J Adams, David M Howard, Jude Gibson, Lynsey S Hall, Blair H Smith, Sandosh Padmanabhan, Alison D Murray, David J Porteous, Chris S Haley, Ian J Deary, Toni-Kim Clarke, Andrew M McIntos. Insulin resistance: Genetic associations with depression and cognition in population based cohorts. Experimental neurology. vol 316. 2020-02-21. PMID:30965038. |
these findings may be due to weak genetic instruments, limited cognitive measures and insufficient power but they may also indicate the need to identify other biological mechanisms that may mediate the relationship from insulin resistance to depression and cognition. |
2020-02-21 |
2023-08-13 |
Not clear |
| Fangli Zhao, Jason J Siu, Wei Huang, Candice Askwith, Lei Ca. Insulin Modulates Excitatory Synaptic Transmission and Synaptic Plasticity in the Mouse Hippocampus. Neuroscience. vol 411. 2020-02-04. PMID:31146008. |
although insulin-induced inhibition of field excitatory post-synaptic potentials (fepsps) was previously termed insulin-long-term depression (insulin-ltd), insulin application potentiated recovery from classically induced ltd. further analysis suggests suppression of presynaptic neurotransmitter release contributed to the insulin-ltd. at low concentrations, insulin primarily inhibited fepsps; however, at high concentration, its effects were of mixed inhibition and enhancement in different recordings. |
2020-02-04 |
2023-08-13 |
mouse |
| Fangli Zhao, Jason J Siu, Wei Huang, Candice Askwith, Lei Ca. Insulin Modulates Excitatory Synaptic Transmission and Synaptic Plasticity in the Mouse Hippocampus. Neuroscience. vol 411. 2020-02-04. PMID:31146008. |
insulin also caused depotentiation during ltp expression and triggered depression during ltd recovery. |
2020-02-04 |
2023-08-13 |
mouse |
| Xiaosu Bai, Zhiming Liu, Zhisen Li, Dewen Ya. The association between insulin therapy and depression in patients with type 2 diabetes mellitus: a meta-analysis. BMJ open. vol 8. issue 11. 2020-02-03. PMID:30498035. |
the association between insulin therapy and depression in patients with type 2 diabetes mellitus: a meta-analysis. |
2020-02-03 |
2023-08-13 |
Not clear |
| Xiaosu Bai, Zhiming Liu, Zhisen Li, Dewen Ya. The association between insulin therapy and depression in patients with type 2 diabetes mellitus: a meta-analysis. BMJ open. vol 8. issue 11. 2020-02-03. PMID:30498035. |
whether insulin treatment was associated with increased risk of depression remains controversial. |
2020-02-03 |
2023-08-13 |
Not clear |
| Xiaosu Bai, Zhiming Liu, Zhisen Li, Dewen Ya. The association between insulin therapy and depression in patients with type 2 diabetes mellitus: a meta-analysis. BMJ open. vol 8. issue 11. 2020-02-03. PMID:30498035. |
we performed a meta-analysis to evaluate the association of insulin therapy and depression. |
2020-02-03 |
2023-08-13 |
Not clear |
| Manpreet K Singh, Sara M Leslie, Mary Melissa Packer, Yevgeniya V Zaiko, Owen R Phillips, Elizabeth F Weisman, Danielle M Wall, Booil Jo, Natalie Rasgo. Brain and behavioral correlates of insulin resistance in youth with depression and obesity. Hormones and behavior. vol 108. 2020-01-22. PMID:29596854. |
brain and behavioral correlates of insulin resistance in youth with depression and obesity. |
2020-01-22 |
2023-08-13 |
Not clear |
| Manpreet K Singh, Sara M Leslie, Mary Melissa Packer, Yevgeniya V Zaiko, Owen R Phillips, Elizabeth F Weisman, Danielle M Wall, Booil Jo, Natalie Rasgo. Brain and behavioral correlates of insulin resistance in youth with depression and obesity. Hormones and behavior. vol 108. 2020-01-22. PMID:29596854. |
the acc-hippocampal motivational network that subserves depression and insulin resistance separately, may represent a critical neural interaction that link these syndromes together. |
2020-01-22 |
2023-08-13 |
Not clear |
| Annelies Brouwer, Daniel H van Raalte, Hoang-Ton Nguyen, Femke Rutters, Peter M van de Ven, Petra J M Elders, Annette C Moll, Eus J W Van Someren, Frank J Snoek, Aartjan T F Beekman, Marijke A Bremme. Effects of Light Therapy on Mood and Insulin Sensitivity in Patients With Type 2 Diabetes and Depression: Results From a Randomized Placebo-Controlled Trial. Diabetes care. vol 42. issue 4. 2019-12-24. PMID:30796110. |
effects of light therapy on mood and insulin sensitivity in patients with type 2 diabetes and depression: results from a randomized placebo-controlled trial. |
2019-12-24 |
2023-08-13 |
Not clear |
| Annelies Brouwer, Daniel H van Raalte, Hoang-Ton Nguyen, Femke Rutters, Peter M van de Ven, Petra J M Elders, Annette C Moll, Eus J W Van Someren, Frank J Snoek, Aartjan T F Beekman, Marijke A Bremme. Effects of Light Therapy on Mood and Insulin Sensitivity in Patients With Type 2 Diabetes and Depression: Results From a Randomized Placebo-Controlled Trial. Diabetes care. vol 42. issue 4. 2019-12-24. PMID:30796110. |
we assessed whether light therapy, an antidepressant, improves mood and insulin sensitivity in patients with depression and type 2 diabetes. |
2019-12-24 |
2023-08-13 |
Not clear |
| Qian Sun, Qianlei Yang, Hui Xu, Junchao Xue, Chao Chen, Xingfen Yang, Xiaohua Gao, Qizhan Li. miR-149 Negative Regulation of mafA Is Involved in the Arsenite-Induced Dysfunction of Insulin Synthesis and Secretion in Pancreatic Beta Cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 167. issue 1. 2019-12-19. PMID:29905828. |
after cd1 mice were treated with 20 or 40 ppm arsenite in the drinking water for 12 months, the mice showed reduced fasting insulin levels, a depression in glucose clearance, and lower insulin content in the pancreas. |
2019-12-19 |
2023-08-13 |
mouse |
| Johann Steiner, Brisa S Fernandes, Paul C Guest, Henrik Dobrowolny, Gabriela Meyer-Lotz, Sabine Westphal, Katrin Borucki, Kolja Schiltz, Zoltán Sarnyai, Hans-Gert Bernstei. Glucose homeostasis in major depression and schizophrenia: a comparison among drug-naïve first-episode patients. European archives of psychiatry and clinical neuroscience. vol 269. issue 4. 2019-12-03. PMID:29352386. |
we have tested whether impaired insulin homeostasis is also present in first-episode patients with major depression (md) and if this can be discerned from stress-related and medication effects. |
2019-12-03 |
2023-08-13 |
human |
| Marc J Weigensberg, Donna Spruijt-Metz, Cheng K Fred Wen, Jaimie N Davis, Quintilia Ávila, Magaly Juarez, Niquelle Brown-Wadé, Christianne J Lan. Protocol for the Imagine HEALTH Study: Guided imagery lifestyle intervention to improve obesity-related behaviors and salivary cortisol patterns in predominantly Latino adolescents. Contemporary clinical trials. vol 72. 2019-12-02. PMID:30076988. |
secondary aims assess changes compared to controls in psychosocial outcomes (stress, well-being, depression), diabetes-related metabolic outcomes (adiposity, insulin resistance), maintenance of outcome changes for one year post-intervention, and sdt-based mediation of intervention effects. |
2019-12-02 |
2023-08-13 |
human |
| Lauren B Shomaker, Lauren Gulley, Allison M Hilkin, Emma Clark, Shelly Annameier, Sangeeta Rao, Bonny Rockette-Wagner, Andrea Kriska, Kenneth P Wright, Eric Stice, Kristen J Nadeau, Megan M Kelse. Design of a randomized controlled trial to decrease depression and improve insulin sensitivity in adolescents: Mood and INsulin sensitivity to prevent Diabetes (MIND). Contemporary clinical trials. vol 75. 2019-11-25. PMID:30342256. |
design of a randomized controlled trial to decrease depression and improve insulin sensitivity in adolescents: mood and insulin sensitivity to prevent diabetes (mind). |
2019-11-25 |
2023-08-13 |
Not clear |
| Jose A Santiago, Alyssa M Littlefield, Judith A Potashki. Integrative transcriptomic meta-analysis of Parkinson's disease and depression identifies NAMPT as a potential blood biomarker for de novo Parkinson's disease. Scientific reports. vol 6. 2019-11-20. PMID:27680512. |
transcriptomic meta-analysis and network analysis of blood microarrays from untreated patients with pd and depression identified genes enriched in pathways related to the immune system, metabolism of lipids, glucose, fatty acids, nicotinamide, lysosome, insulin signaling and type 1 diabetes. |
2019-11-20 |
2023-08-13 |
Not clear |
| Anna Kurek, Katarzyna Głombik, Jan Detka, Agnieszka Basta-Kaim, Marta Kubera, Władysław Lasoń, Bogusława Budziszewsk. Regulators of glucocorticoid receptor function in an animal model of depression and obesity. Journal of neuroendocrinology. 2019-11-20. PMID:29524264. |
the decrease in mr density in the hippocampus and increased plasma insulin level seemed to be the most significant changes observed in the model of the co-occurrence of depression and obesity, which could limit the neuroprotective effects associated with the activation of mr and be a marker of peripheral insulin resistance, respectively. |
2019-11-20 |
2023-08-13 |
Not clear |
| Natalie Nanayakkara, Anthony Pease, Sanjeeva Ranasinha, Natalie Wischer, Sofianos Andrikopoulos, Jane Speight, Barbora de Courten, Sophia Zounga. Depression and diabetes distress in adults with type 2 diabetes: results from the Australian National Diabetes Audit (ANDA) 2016. Scientific reports. vol 8. issue 1. 2019-10-04. PMID:29777153. |
female gender, increasing hba1c, insulin use, difficulty following dietary recommendations and depression were all associated with greater odds of diabetes distress & older age, higher own health rating and monitoring blood glucose levels as recommended were associated with lower odds (all p < 0.04). |
2019-10-04 |
2023-08-13 |
Not clear |
| Paul L Mueller, Carolyn E Pritchett, Tyler N Wiechman, Alevtina Zharikov, Andras Hajna. Antidepressant-like effects of insulin and IGF-1 are mediated by IGF-1 receptors in the brain. Brain research bulletin. vol 143. 2019-09-30. PMID:30278200. |
depression is associated with uncontrolled diabetes, which indicates a lack of insulin effect, yet the role of the insulin receptor in mediating depression is not clearly established because insulin receptors are not required for glucose entry into the brain. |
2019-09-30 |
2023-08-13 |
mouse |
| Paul L Mueller, Carolyn E Pritchett, Tyler N Wiechman, Alevtina Zharikov, Andras Hajna. Antidepressant-like effects of insulin and IGF-1 are mediated by IGF-1 receptors in the brain. Brain research bulletin. vol 143. 2019-09-30. PMID:30278200. |
further, administration of the igf-1 receptor antagonist jb-1 blocked the antidepressive-like activity of the insulin and igf-1, indicating a strong relationship between insulin, igf-1 and depression. |
2019-09-30 |
2023-08-13 |
mouse |
| Marion Soto, Clémence Herzog, Julian A Pacheco, Shiho Fujisaka, Kevin Bullock, Clary B Clish, C Ronald Kah. Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism. Molecular psychiatry. vol 23. issue 12. 2019-09-17. PMID:29910467. |
treatment with oral metronidazole or vancomycin decreases inflammation, improves insulin signaling in the brain and reduces signs of anxiety and depression. |
2019-09-17 |
2023-08-13 |
mouse |