| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lauren B Shomaker, Lauren Gulley, Allison M Hilkin, Emma Clark, Shelly Annameier, Sangeeta Rao, Bonny Rockette-Wagner, Andrea Kriska, Kenneth P Wright, Eric Stice, Kristen J Nadeau, Megan M Kelse. Design of a randomized controlled trial to decrease depression and improve insulin sensitivity in adolescents: Mood and INsulin sensitivity to prevent Diabetes (MIND). Contemporary clinical trials. vol 75. 2019-11-25. PMID:30342256. |
design of a randomized controlled trial to decrease depression and improve insulin sensitivity in adolescents: mood and insulin sensitivity to prevent diabetes (mind). |
2019-11-25 |
2023-08-13 |
Not clear |
| Jose A Santiago, Alyssa M Littlefield, Judith A Potashki. Integrative transcriptomic meta-analysis of Parkinson's disease and depression identifies NAMPT as a potential blood biomarker for de novo Parkinson's disease. Scientific reports. vol 6. 2019-11-20. PMID:27680512. |
transcriptomic meta-analysis and network analysis of blood microarrays from untreated patients with pd and depression identified genes enriched in pathways related to the immune system, metabolism of lipids, glucose, fatty acids, nicotinamide, lysosome, insulin signaling and type 1 diabetes. |
2019-11-20 |
2023-08-13 |
Not clear |
| Anna Kurek, Katarzyna Głombik, Jan Detka, Agnieszka Basta-Kaim, Marta Kubera, Władysław Lasoń, Bogusława Budziszewsk. Regulators of glucocorticoid receptor function in an animal model of depression and obesity. Journal of neuroendocrinology. 2019-11-20. PMID:29524264. |
the decrease in mr density in the hippocampus and increased plasma insulin level seemed to be the most significant changes observed in the model of the co-occurrence of depression and obesity, which could limit the neuroprotective effects associated with the activation of mr and be a marker of peripheral insulin resistance, respectively. |
2019-11-20 |
2023-08-13 |
Not clear |
| Natalie Nanayakkara, Anthony Pease, Sanjeeva Ranasinha, Natalie Wischer, Sofianos Andrikopoulos, Jane Speight, Barbora de Courten, Sophia Zounga. Depression and diabetes distress in adults with type 2 diabetes: results from the Australian National Diabetes Audit (ANDA) 2016. Scientific reports. vol 8. issue 1. 2019-10-04. PMID:29777153. |
female gender, increasing hba1c, insulin use, difficulty following dietary recommendations and depression were all associated with greater odds of diabetes distress & older age, higher own health rating and monitoring blood glucose levels as recommended were associated with lower odds (all p < 0.04). |
2019-10-04 |
2023-08-13 |
Not clear |
| Paul L Mueller, Carolyn E Pritchett, Tyler N Wiechman, Alevtina Zharikov, Andras Hajna. Antidepressant-like effects of insulin and IGF-1 are mediated by IGF-1 receptors in the brain. Brain research bulletin. vol 143. 2019-09-30. PMID:30278200. |
depression is associated with uncontrolled diabetes, which indicates a lack of insulin effect, yet the role of the insulin receptor in mediating depression is not clearly established because insulin receptors are not required for glucose entry into the brain. |
2019-09-30 |
2023-08-13 |
mouse |
| Paul L Mueller, Carolyn E Pritchett, Tyler N Wiechman, Alevtina Zharikov, Andras Hajna. Antidepressant-like effects of insulin and IGF-1 are mediated by IGF-1 receptors in the brain. Brain research bulletin. vol 143. 2019-09-30. PMID:30278200. |
further, administration of the igf-1 receptor antagonist jb-1 blocked the antidepressive-like activity of the insulin and igf-1, indicating a strong relationship between insulin, igf-1 and depression. |
2019-09-30 |
2023-08-13 |
mouse |
| Marion Soto, Clémence Herzog, Julian A Pacheco, Shiho Fujisaka, Kevin Bullock, Clary B Clish, C Ronald Kah. Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism. Molecular psychiatry. vol 23. issue 12. 2019-09-17. PMID:29910467. |
treatment with oral metronidazole or vancomycin decreases inflammation, improves insulin signaling in the brain and reduces signs of anxiety and depression. |
2019-09-17 |
2023-08-13 |
mouse |
| Weikang Cai, Chang Xue, Masaji Sakaguchi, Masahiro Konishi, Alireza Shirazian, Heather A Ferris, Mengyao E Li, Ruichao Yu, Andre Kleinridders, Emmanuel N Pothos, C Ronald Kah. Insulin regulates astrocyte gliotransmission and modulates behavior. The Journal of clinical investigation. vol 128. issue 7. 2019-09-16. PMID:29664737. |
thus, astrocytic insulin signaling plays an important role in dopaminergic signaling, providing a potential mechanism by which astrocytic insulin action may contribute to increased rates of depression in people with diabetes, obesity, and other insulin-resistant states. |
2019-09-16 |
2023-08-13 |
mouse |
| A B Kamrul-Hasan, M Palash-Molla, M Mainul-Ahsan, A J Gaffar, M Asaduzzaman, M Saifuddin, M S Rahman, F Akter, H Rahman, S K Talukder, M Islam, P K Chanda, N I Siddiqui, S Seli. Prevalence and Predictors of Depression among Patients with Type 2 Diabetes: A Multicenter Cross-sectional Study from Bangladesh. Mymensingh medical journal : MMJ. vol 28. issue 1. 2019-07-16. PMID:30755546. |
in t2dm subjects, diabetes in the family members, the presence of other comorbidities, diabetic complications, diabetes duration >5 years, insulin use, using insulin syringe for injection, albuminuria and ckd were the important predictors of depression. |
2019-07-16 |
2023-08-13 |
human |
| Igor Pomytkin, João P Costa-Nunes, Vladimir Kasatkin, Ekaterina Veniaminova, Anna Demchenko, Alexey Lyundup, Klaus-Peter Lesch, Eugene D Ponomarev, Tatyana Strekalov. Insulin receptor in the brain: Mechanisms of activation and the role in the CNS pathology and treatment. CNS neuroscience & therapeutics. vol 24. issue 9. 2019-07-15. PMID:29691988. |
deficiencies in ir activation, insulin availability, and downstream ir-related mechanisms may result in aberrant ir-mediated functions and, subsequently, a broad range of brain disorders, including neurodevelopmental syndromes, neoplasms, neurodegenerative conditions, and depression. |
2019-07-15 |
2023-08-13 |
Not clear |
| Jan Detka, Joanna Ślusarczyk, Anna Kurek, Mateusz Kucharczyk, Tomasz Adamus, Paweł Konieczny, Marta Kubera, Agnieszka Basta-Kaim, Władysław Lasoń, Bogusława Budziszewsk. Hypothalamic insulin and glucagon-like peptide-1 levels in an animal model of depression and their effect on corticotropin-releasing hormone promoter gene activity in a hypothalamic cell line. Pharmacological reports : PR. vol 71. issue 2. 2019-06-17. PMID:30831439. |
hypothalamic insulin and glucagon-like peptide-1 levels in an animal model of depression and their effect on corticotropin-releasing hormone promoter gene activity in a hypothalamic cell line. |
2019-06-17 |
2023-08-13 |
Not clear |
| Joe Alexander, Roger A Edwards, Marina Brodsky, Luigi Manca, Roberto Grugni, Alberto Savoldelli, Gianluca Bonfanti, Birol Emir, Ed Whalen, Steve Watt, Bruce Parson. Using time series analysis approaches for improved prediction of pain outcomes in subgroups of patients with painful diabetic peripheral neuropathy. PloS one. vol 13. issue 12. 2019-05-08. PMID:30521533. |
six clusters were identified according to baseline variables (gender, age, insulin use, body mass index, depression history, pregabalin monotherapy, prior gabapentin, pain score, and pain-related sleep interference score). |
2019-05-08 |
2023-08-13 |
Not clear |
| Dareen A Youssef, Hassan M El-Fayoumi, Mona F Mahmou. Beta-caryophyllene alleviates diet-induced neurobehavioral changes in rats: The role of CB2 and PPAR-γ receptors. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 110. 2019-04-18. PMID:30469079. |
this study was designed to examine the role of bcp in improving diet-induced metabolic (insulin resistance), neurobehavioral (anxiety, depression and memory deficit), and neurochemical (oxidative, inflammatory and neurotrophic factor) alterations in the prefrontal cortex of obese rats' brain. |
2019-04-18 |
2023-08-13 |
rat |
| S Roat-Shumway, T E Wroolie, K Watson, A F Schatzberg, N L Rasgo. Cognitive effects of mifepristone in overweight, euthymic adults with depressive disorders. Journal of affective disorders. vol 239. 2019-03-14. PMID:30025313. |
insulin resistance is posited to contribute to the cognitive deficits observed in individuals who have depression. |
2019-03-14 |
2023-08-13 |
Not clear |
| Tetsushi Hamaguchi, Yushi Hirota, Takehito Takeuchi, Yasushi Nakagawa, Atsuko Matsuoka, Masaaki Matsumoto, Hiroyuki Awano, Kazumoto Iijima, Pei Chieng Cha, Wataru Satake, Tatsushi Toda, Wataru Ogaw. Treatment of a case of severe insulin resistance as a result of a PIK3R1 mutation with a sodium-glucose cotransporter 2 inhibitor. Journal of diabetes investigation. vol 9. issue 5. 2019-03-12. PMID:29476696. |
a japanese woman aged in her late 30s with severe insulin resistance and bodily features including a triangular face, prominent forehead, small chin, large and low-set ears, and ocular depression was investigated. |
2019-03-12 |
2023-08-13 |
Not clear |
| Felix Day, Tugce Karaderi, Michelle R Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Magi, Richa Saxena, Triin Laisk, Margrit Urbanek, M Geoffrey Hayes, Gudmar Thorleifsson, Juan Fernandez-Tajes, Anubha Mahajan, Benjamin H Mullin, Bronwyn G A Stuckey, Timothy D Spector, Scott G Wilson, Mark O Goodarzi, Lea Davis, Barbara Obermayer-Pietsch, André G Uitterlinden, Verneri Anttila, Benjamin M Neale, Marjo-Riitta Jarvelin, Bart Fauser, Irina Kowalska, Jenny A Visser, Marianne Andersen, Ken Ong, Elisabet Stener-Victorin, David Ehrmann, Richard S Legro, Andres Salumets, Mark I McCarthy, Laure Morin-Papunen, Unnur Thorsteinsdottir, Kari Stefansson, Unnur Styrkarsdottir, John R B Perry, Andrea Dunaif, Joop Laven, Steve Franks, Cecilia M Lindgren, Corrine K Wel. Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria. PLoS genetics. vol 14. issue 12. 2019-03-04. PMID:30566500. |
mendelian randomization analyses suggested variants associated with body mass index, fasting insulin, menopause timing, depression and male-pattern balding play a causal role in pcos. |
2019-03-04 |
2023-08-13 |
human |
| Eleni A Greenwood, Lauri A Pasch, Marcelle I Cedars, Richard S Legro, Esther Eisenberg, Heather G Huddlesto. Insulin resistance is associated with depression risk in polycystic ovary syndrome. Fertility and sterility. vol 110. issue 1. 2019-01-28. PMID:29908775. |
insulin resistance is associated with depression risk in polycystic ovary syndrome. |
2019-01-28 |
2023-08-13 |
Not clear |
| Eleni A Greenwood, Lauri A Pasch, Marcelle I Cedars, Richard S Legro, Esther Eisenberg, Heather G Huddlesto. Insulin resistance is associated with depression risk in polycystic ovary syndrome. Fertility and sterility. vol 110. issue 1. 2019-01-28. PMID:29908775. |
to test the hypothesis that insulin resistance is associated with depression risk in polycystic ovary syndrome (pcos). |
2019-01-28 |
2023-08-13 |
Not clear |
| Han-Cheng Qiu, Hui-Zhen Liu, Xuemei Li, Xianwei Zeng, Ji-Zong Zha. Insulin resistance as estimated by homeostasis model assessment predicts incident post-stroke depression in Chinese subjects from ischemic stroke. Journal of affective disorders. vol 231. 2018-08-29. PMID:29408157. |
insulin resistance as estimated by homeostasis model assessment predicts incident post-stroke depression in chinese subjects from ischemic stroke. |
2018-08-29 |
2023-08-13 |
human |
| Han-Cheng Qiu, Hui-Zhen Liu, Xuemei Li, Xianwei Zeng, Ji-Zong Zha. Insulin resistance as estimated by homeostasis model assessment predicts incident post-stroke depression in Chinese subjects from ischemic stroke. Journal of affective disorders. vol 231. 2018-08-29. PMID:29408157. |
previous studies suggested that insulin resistance (ir) may be a significant causal risk factor for cardiovascular events and depression independent of other risk factors. |
2018-08-29 |
2023-08-13 |
human |