| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heidi Klakk, Peter Lund Kristensen, Lars Bo Andersen, Karsten Froberg, Niels Christian Møller, Anders Grøntve. Symptoms of depression in young adulthood is associated with unfavorable clinical- and behavioral cardiovascular disease risk factors. Preventive medicine reports. vol 11. 2020-10-01. PMID:30003016. |
women with depression had higher odds of overweight (or = 2.2, 95%ci: 1.01-4.0), abdominal adiposity (or = 2.5, 95%ci: 1.2-4.8), low crf (or = 2.5, 95%ci: 1.2-5.5), insulin resistance (or = 2.3, 95%ci: 1.1-4.6), low hdl (or = 2.0, 95%ci: 1.01-4.1) and high ldl (or = 2.2, 95%ci: 1.04-4.5) compared to women without depression. |
2020-10-01 |
2023-08-13 |
Not clear |
| Kevin L Sun, Kathleen T Watson, Sarthak Angal, Baylee F Bakkila, Aaron J Gorelik, Sara M Leslie, Natalie L Rasgon, Manpreet K Sing. Neural and Endocrine Correlates of Early Life Abuse in Youth With Depression and Obesity. Frontiers in psychiatry. vol 9. 2020-10-01. PMID:30622489. |
depression and insulin resistance are becoming increasingly prevalent in younger populations. |
2020-10-01 |
2023-08-13 |
human |
| Hui Yang, Wei Li, Pan Meng, Zhuo Liu, Jian Liu, Yuhong Wan. Chronic Unpredictable Mild Stress Aggravates Mood Disorder, Cognitive Impairment, and Brain Insulin Resistance in Diabetic Rat. Evidence-based complementary and alternative medicine : eCAM. vol 2018. 2020-10-01. PMID:30622594. |
diabetes-induced brain insulin resistance is associated with many mental diseases, including depression. |
2020-10-01 |
2023-08-13 |
rat |
| Natalia de M Lyra E Silva, Minh P Lam, Claudio N Soares, Douglas P Munoz, Roumen Milev, Fernanda G De Felic. Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:30837902. |
insulin resistance as a shared pathogenic mechanism between depression and type 2 diabetes. |
2020-10-01 |
2023-08-13 |
Not clear |
| Natalia de M Lyra E Silva, Minh P Lam, Claudio N Soares, Douglas P Munoz, Roumen Milev, Fernanda G De Felic. Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:30837902. |
evidences of the involvement of insulin signaling on brain mechanisms related to depression indicate that insulin resistance, a hallmark of type 2 diabetes, could develop in the brains of depressive patients. |
2020-10-01 |
2023-08-13 |
Not clear |
| Natalia de M Lyra E Silva, Minh P Lam, Claudio N Soares, Douglas P Munoz, Roumen Milev, Fernanda G De Felic. Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:30837902. |
in this article, we briefly review possible molecular mechanisms associating defective brain insulin signaling with reward system, neurogenesis, synaptic plasticity and hypothalamic-pituitary-adrenal (hpa) stress axis in depression. |
2020-10-01 |
2023-08-13 |
Not clear |
| Natalia de M Lyra E Silva, Minh P Lam, Claudio N Soares, Douglas P Munoz, Roumen Milev, Fernanda G De Felic. Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:30837902. |
finally, due to the high resistant rate of anti-depressants, novel insights into the link between insulin resistance and depression may advance the development of alternative treatments for this disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jonathan M Gregory, Joshua D Rosenblat, Roger S McIntyr. Deconstructing Diabetes and Depression: Clinical Context, Treatment Strategies, and New Directions. Focus (American Psychiatric Publishing). vol 14. issue 2. 2020-09-30. PMID:31975802. |
novel depression interventions targeting inflammation or insulin resistance underscore the common biological underpinnings of mood and metabolism. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zahra D Khan, Janet Lutale, Sibtain M Moledin. Prevalence of Depression and Associated Factors among Diabetic Patients in an Outpatient Diabetes Clinic. Psychiatry journal. vol 2019. 2020-09-29. PMID:30775378. |
factors independently associated with a diagnosis of mild to moderate depression were being on insulin therapy and being a current smoker. |
2020-09-29 |
2023-08-13 |
human |
| Xiaojuan Li, Wenqi Qiu, Nan Li, Xiaoli Da, Qingyu Ma, Yajing Hou, Tingye Wang, Ming Song, Jiaxu Che. Susceptibility to Hyperglycemia in Rats With Stress-Induced Depressive-Like Behavior: Involvement of IL-6 Mediated Glucose Homeostasis Signaling. Frontiers in psychiatry. vol 11. 2020-09-28. PMID:32655424. |
cytokine-mediated inflammation in brain may play important roles in the pathogenesis of depression and insulin resistance. |
2020-09-28 |
2023-08-13 |
rat |
| Young-Kook Kim, Oh Yoen Kim, Juhyun Son. Alleviation of Depression by Glucagon-Like Peptide 1 Through the Regulation of Neuroinflammation, Neurotransmitters, Neurogenesis, and Synaptic Function. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32922295. |
the onset and recurrence of depression have been linked to diverse metabolic factors, including hyperglycemia, dyslipidemia, and insulin resistance. |
2020-09-28 |
2023-08-13 |
Not clear |
| Qing Zhang, Peng Zhang, Rui Yan, Xianghong Xu, Cunnan Mao, Xiaomei Liu, Fengfei Li, Jianhua Ma, Lei Ye, Zhijian Yao, Jindan W. A Single-Blinded Trial Using Resting-State Functional Magnetic Resonance Imaging of Brain Activity in Patients with Type 2 Diabetes and Painful Neuropathy. Diabetes therapy : research, treatment and education of diabetes and related disorders. vol 10. issue 1. 2020-09-28. PMID:30506341. |
our data showed that patients with pdn had increased insulin resistance (p = 0.03), increased depression (p = 0.02) and increased anxiety (p < 0.001) compared with the controls and that all of these conditions were associated with abnormal spontaneous activities in several regions of the brain, including the somatosensory, cognitive and emotional regions. |
2020-09-28 |
2023-08-13 |
Not clear |
| Fan Wang, Shunying Yu, Rubai Zhou, Ruizhi Mao, Guoqing Zhao, Xiaoyun Guo, Qingqing Xu, Jun Chen, Chen Zhang, Yiru Fan. Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population. Neuropsychiatric disease and treatment. vol 16. 2020-09-28. PMID:32110024. |
insulin receptor substrate-1 (irs-1) is one of the critical downstream molecules in the insulin resistance signaling pathway, linking depression and diabetes. |
2020-09-28 |
2023-08-13 |
Not clear |
| Geoffrey Hacket. Should All Men with Type 2 Diabetes Be Routinely Prescribed a Phosphodiesterase Type 5 Inhibitor? The world journal of men's health. vol 38. issue 3. 2020-09-28. PMID:32378365. |
important health problems in men such as type 2 diabetes (t2dm), insulin resistance, erectile dysfunction, benign prostatic hyperplasia and depression have been shown to have to share common pathological processes, such as endothelial dysfunction and inflammation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Andrea D Mekonnen, Aubrey A Mills, Andrea L Wilhite, Theresa K Hoffma. Desvenlafaxine-associated hyperglycemia: A case report and literature review. The mental health clinician. vol 10. issue 3. 2020-09-28. PMID:32420005. |
over the course of 3 months after desvenlafaxine initiation, insulin glargine was increased and insulin lispro was initiated as the patient refused alternative antidepressant therapy due to favorable improvements in anxiety and depression. |
2020-09-28 |
2023-08-13 |
Not clear |
| Qais S Dirar, Hebah M Musalem, Selwa A F Al-Hazzaa, Abdulaziz A Al Zoba, Amal A Almalk. Effect of Pegylated Interferon and Mitomycin C on Ocular Surface Squamous Neoplasia in Xeroderma Pigmentosum: A Case Series. The American journal of case reports. vol 21. 2020-09-24. PMID:32251268. |
transient mental depression was reported in 2 of our patients, and only 1 patient developed autoimmune diabetes mellitus, which required insulin therapy after the discontinuation of the peg-ifn-alpha-2b. |
2020-09-24 |
2023-08-13 |
Not clear |
| Senthil Kumaran Satyanarayanan, Yin-Hwa Shih, Yeong-Ray Wen, Mahalakshmi Palani, Yi-Wen Lin, Huanxing Su, Piotr Gałecki, Kuan-Pin S. miR-200a-3p modulates gene expression in comorbid pain and depression: Molecular implication for central sensitization. Brain, behavior, and immunity. vol 82. 2020-09-16. PMID:31479730. |
only the mir-200a-3p level was continuously elevated under prolonged stress, suggesting roles of reduced neurogenesis, inflammatory activation, disturbed circadian rhythm, lipid metabolism, and insulin secretion in the co-existence of pain and depression. |
2020-09-16 |
2023-08-13 |
rat |
| Hayato Akimoto, Kotoe Tezuka, Yayoi Nishida, Tomohiro Nakayama, Yasuo Takahashi, Satoshi Asa. Association between use of oral hypoglycemic agents in Japanese patients with type 2 diabetes mellitus and risk of depression: A retrospective cohort study. Pharmacology research & perspectives. vol 7. issue 6. 2020-07-06. PMID:31768258. |
since brain insulin resistance plays a potential role in depression, the future risk of depression in patients with t2dm may be altered depending on the class of oral hypoglycemic agent (oha) used for t2dm therapy. |
2020-07-06 |
2023-08-13 |
Not clear |
| Janice K Kiecolt-Glaser, Stephanie J Wilson, Annelise Madiso. Marriage and Gut (Microbiome) Feelings: Tracing Novel Dyadic Pathways to Accelerated Aging. Psychosomatic medicine. vol 81. issue 8. 2020-07-02. PMID:30308579. |
chronic marital stress and depression can elevate the risk for obesity, metabolic syndrome, and cardiovascular disease by altering resting energy expenditure, insulin production, and triglyceride responses after unhealthy meals. |
2020-07-02 |
2023-08-13 |
Not clear |
| Juliane Zemdegs, Hugo Martin, Hiranya Pintana, Sebastien Bullich, Stella Manta, Marie A Marqués, Cédric Moro, Sophie Layé, Fabien Ducrocq, Nipon Chattipakorn, Siriporn C Chattipakorn, Claire Rampon, Luc Pénicaud, Xavier Fioramonti, Bruno P Guiar. Metformin Promotes Anxiolytic and Antidepressant-Like Responses in Insulin-Resistant Mice by Decreasing Circulating Branched-Chain Amino Acids. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 30. 2020-06-17. PMID:31160539. |
epidemiological studies indicate that insulin resistance (ir), a hallmark of type 2 diabetes, is associated with an increased risk of major depression. |
2020-06-17 |
2023-08-13 |
mouse |