| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julia A Hamer, Daniela Testani, Rodrigo B Mansur, Yena Lee, Mehala Subramaniapillai, Roger S McIntyr. Brain insulin resistance: A treatment target for cognitive impairment and anhedonia in depression. Experimental neurology. vol 315. 2020-02-24. PMID:30695707. |
brain insulin resistance: a treatment target for cognitive impairment and anhedonia in depression. |
2020-02-24 |
2023-08-13 |
Not clear |
| Julia A Hamer, Daniela Testani, Rodrigo B Mansur, Yena Lee, Mehala Subramaniapillai, Roger S McIntyr. Brain insulin resistance: A treatment target for cognitive impairment and anhedonia in depression. Experimental neurology. vol 315. 2020-02-24. PMID:30695707. |
based on this evidence, it is possible that repurposing therapies approved for treating insulin resistance may be useful in treating cognitive and anhedonia symptoms in depression. |
2020-02-24 |
2023-08-13 |
Not clear |
| Sophia Frangou, Masoud Shirali, Mark J Adams, David M Howard, Jude Gibson, Lynsey S Hall, Blair H Smith, Sandosh Padmanabhan, Alison D Murray, David J Porteous, Chris S Haley, Ian J Deary, Toni-Kim Clarke, Andrew M McIntos. Insulin resistance: Genetic associations with depression and cognition in population based cohorts. Experimental neurology. vol 316. 2020-02-21. PMID:30965038. |
insulin resistance: genetic associations with depression and cognition in population based cohorts. |
2020-02-21 |
2023-08-13 |
Not clear |
| Sophia Frangou, Masoud Shirali, Mark J Adams, David M Howard, Jude Gibson, Lynsey S Hall, Blair H Smith, Sandosh Padmanabhan, Alison D Murray, David J Porteous, Chris S Haley, Ian J Deary, Toni-Kim Clarke, Andrew M McIntos. Insulin resistance: Genetic associations with depression and cognition in population based cohorts. Experimental neurology. vol 316. 2020-02-21. PMID:30965038. |
insulin resistance, broadly defined as the reduced ability of insulin to exert its biological action, has been associated with depression and cognitive dysfunction in observational studies. |
2020-02-21 |
2023-08-13 |
Not clear |
| Sophia Frangou, Masoud Shirali, Mark J Adams, David M Howard, Jude Gibson, Lynsey S Hall, Blair H Smith, Sandosh Padmanabhan, Alison D Murray, David J Porteous, Chris S Haley, Ian J Deary, Toni-Kim Clarke, Andrew M McIntos. Insulin resistance: Genetic associations with depression and cognition in population based cohorts. Experimental neurology. vol 316. 2020-02-21. PMID:30965038. |
specifically, we determined the association between quantitative measures of cognitive function and depression and genetic instruments of insulin resistance traits in two large-scale population samples, the generation scotland: scottish family health study (gs: sfhs; n = 19,994) and in the uk biobank (n = 331,374). |
2020-02-21 |
2023-08-13 |
Not clear |
| Sophia Frangou, Masoud Shirali, Mark J Adams, David M Howard, Jude Gibson, Lynsey S Hall, Blair H Smith, Sandosh Padmanabhan, Alison D Murray, David J Porteous, Chris S Haley, Ian J Deary, Toni-Kim Clarke, Andrew M McIntos. Insulin resistance: Genetic associations with depression and cognition in population based cohorts. Experimental neurology. vol 316. 2020-02-21. PMID:30965038. |
in the gs:sfhs, the polygenic risk score (prs) for fasting insulin was associated with verbal intelligence and depression while the prs for the homeostasis model assessment of insulin resistance was associated with verbal intelligence. |
2020-02-21 |
2023-08-13 |
Not clear |
| Sophia Frangou, Masoud Shirali, Mark J Adams, David M Howard, Jude Gibson, Lynsey S Hall, Blair H Smith, Sandosh Padmanabhan, Alison D Murray, David J Porteous, Chris S Haley, Ian J Deary, Toni-Kim Clarke, Andrew M McIntos. Insulin resistance: Genetic associations with depression and cognition in population based cohorts. Experimental neurology. vol 316. 2020-02-21. PMID:30965038. |
despite this overlap in genetic architecture, mendelian randomization analyses in the gs:sfhs and in the uk biobank samples did not yield evidence for causal associations from insulin resistance traits to either depression or cognition. |
2020-02-21 |
2023-08-13 |
Not clear |
| Sophia Frangou, Masoud Shirali, Mark J Adams, David M Howard, Jude Gibson, Lynsey S Hall, Blair H Smith, Sandosh Padmanabhan, Alison D Murray, David J Porteous, Chris S Haley, Ian J Deary, Toni-Kim Clarke, Andrew M McIntos. Insulin resistance: Genetic associations with depression and cognition in population based cohorts. Experimental neurology. vol 316. 2020-02-21. PMID:30965038. |
these findings may be due to weak genetic instruments, limited cognitive measures and insufficient power but they may also indicate the need to identify other biological mechanisms that may mediate the relationship from insulin resistance to depression and cognition. |
2020-02-21 |
2023-08-13 |
Not clear |
| Fangli Zhao, Jason J Siu, Wei Huang, Candice Askwith, Lei Ca. Insulin Modulates Excitatory Synaptic Transmission and Synaptic Plasticity in the Mouse Hippocampus. Neuroscience. vol 411. 2020-02-04. PMID:31146008. |
although insulin-induced inhibition of field excitatory post-synaptic potentials (fepsps) was previously termed insulin-long-term depression (insulin-ltd), insulin application potentiated recovery from classically induced ltd. further analysis suggests suppression of presynaptic neurotransmitter release contributed to the insulin-ltd. at low concentrations, insulin primarily inhibited fepsps; however, at high concentration, its effects were of mixed inhibition and enhancement in different recordings. |
2020-02-04 |
2023-08-13 |
mouse |
| Fangli Zhao, Jason J Siu, Wei Huang, Candice Askwith, Lei Ca. Insulin Modulates Excitatory Synaptic Transmission and Synaptic Plasticity in the Mouse Hippocampus. Neuroscience. vol 411. 2020-02-04. PMID:31146008. |
insulin also caused depotentiation during ltp expression and triggered depression during ltd recovery. |
2020-02-04 |
2023-08-13 |
mouse |
| Xiaosu Bai, Zhiming Liu, Zhisen Li, Dewen Ya. The association between insulin therapy and depression in patients with type 2 diabetes mellitus: a meta-analysis. BMJ open. vol 8. issue 11. 2020-02-03. PMID:30498035. |
the association between insulin therapy and depression in patients with type 2 diabetes mellitus: a meta-analysis. |
2020-02-03 |
2023-08-13 |
Not clear |
| Xiaosu Bai, Zhiming Liu, Zhisen Li, Dewen Ya. The association between insulin therapy and depression in patients with type 2 diabetes mellitus: a meta-analysis. BMJ open. vol 8. issue 11. 2020-02-03. PMID:30498035. |
whether insulin treatment was associated with increased risk of depression remains controversial. |
2020-02-03 |
2023-08-13 |
Not clear |
| Xiaosu Bai, Zhiming Liu, Zhisen Li, Dewen Ya. The association between insulin therapy and depression in patients with type 2 diabetes mellitus: a meta-analysis. BMJ open. vol 8. issue 11. 2020-02-03. PMID:30498035. |
we performed a meta-analysis to evaluate the association of insulin therapy and depression. |
2020-02-03 |
2023-08-13 |
Not clear |
| Manpreet K Singh, Sara M Leslie, Mary Melissa Packer, Yevgeniya V Zaiko, Owen R Phillips, Elizabeth F Weisman, Danielle M Wall, Booil Jo, Natalie Rasgo. Brain and behavioral correlates of insulin resistance in youth with depression and obesity. Hormones and behavior. vol 108. 2020-01-22. PMID:29596854. |
brain and behavioral correlates of insulin resistance in youth with depression and obesity. |
2020-01-22 |
2023-08-13 |
Not clear |
| Manpreet K Singh, Sara M Leslie, Mary Melissa Packer, Yevgeniya V Zaiko, Owen R Phillips, Elizabeth F Weisman, Danielle M Wall, Booil Jo, Natalie Rasgo. Brain and behavioral correlates of insulin resistance in youth with depression and obesity. Hormones and behavior. vol 108. 2020-01-22. PMID:29596854. |
the acc-hippocampal motivational network that subserves depression and insulin resistance separately, may represent a critical neural interaction that link these syndromes together. |
2020-01-22 |
2023-08-13 |
Not clear |
| Annelies Brouwer, Daniel H van Raalte, Hoang-Ton Nguyen, Femke Rutters, Peter M van de Ven, Petra J M Elders, Annette C Moll, Eus J W Van Someren, Frank J Snoek, Aartjan T F Beekman, Marijke A Bremme. Effects of Light Therapy on Mood and Insulin Sensitivity in Patients With Type 2 Diabetes and Depression: Results From a Randomized Placebo-Controlled Trial. Diabetes care. vol 42. issue 4. 2019-12-24. PMID:30796110. |
effects of light therapy on mood and insulin sensitivity in patients with type 2 diabetes and depression: results from a randomized placebo-controlled trial. |
2019-12-24 |
2023-08-13 |
Not clear |
| Annelies Brouwer, Daniel H van Raalte, Hoang-Ton Nguyen, Femke Rutters, Peter M van de Ven, Petra J M Elders, Annette C Moll, Eus J W Van Someren, Frank J Snoek, Aartjan T F Beekman, Marijke A Bremme. Effects of Light Therapy on Mood and Insulin Sensitivity in Patients With Type 2 Diabetes and Depression: Results From a Randomized Placebo-Controlled Trial. Diabetes care. vol 42. issue 4. 2019-12-24. PMID:30796110. |
we assessed whether light therapy, an antidepressant, improves mood and insulin sensitivity in patients with depression and type 2 diabetes. |
2019-12-24 |
2023-08-13 |
Not clear |
| Qian Sun, Qianlei Yang, Hui Xu, Junchao Xue, Chao Chen, Xingfen Yang, Xiaohua Gao, Qizhan Li. miR-149 Negative Regulation of mafA Is Involved in the Arsenite-Induced Dysfunction of Insulin Synthesis and Secretion in Pancreatic Beta Cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 167. issue 1. 2019-12-19. PMID:29905828. |
after cd1 mice were treated with 20 or 40 ppm arsenite in the drinking water for 12 months, the mice showed reduced fasting insulin levels, a depression in glucose clearance, and lower insulin content in the pancreas. |
2019-12-19 |
2023-08-13 |
mouse |
| Johann Steiner, Brisa S Fernandes, Paul C Guest, Henrik Dobrowolny, Gabriela Meyer-Lotz, Sabine Westphal, Katrin Borucki, Kolja Schiltz, Zoltán Sarnyai, Hans-Gert Bernstei. Glucose homeostasis in major depression and schizophrenia: a comparison among drug-naïve first-episode patients. European archives of psychiatry and clinical neuroscience. vol 269. issue 4. 2019-12-03. PMID:29352386. |
we have tested whether impaired insulin homeostasis is also present in first-episode patients with major depression (md) and if this can be discerned from stress-related and medication effects. |
2019-12-03 |
2023-08-13 |
human |
| Marc J Weigensberg, Donna Spruijt-Metz, Cheng K Fred Wen, Jaimie N Davis, Quintilia Ávila, Magaly Juarez, Niquelle Brown-Wadé, Christianne J Lan. Protocol for the Imagine HEALTH Study: Guided imagery lifestyle intervention to improve obesity-related behaviors and salivary cortisol patterns in predominantly Latino adolescents. Contemporary clinical trials. vol 72. 2019-12-02. PMID:30076988. |
secondary aims assess changes compared to controls in psychosocial outcomes (stress, well-being, depression), diabetes-related metabolic outcomes (adiposity, insulin resistance), maintenance of outcome changes for one year post-intervention, and sdt-based mediation of intervention effects. |
2019-12-02 |
2023-08-13 |
human |