| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Young Sup Woo, Hyun Kook Lim, Sheng-Min Wang, Won-Myong Bah. Clinical Evidence of Antidepressant Effects of Insulin and Anti-Hyperglycemic Agents and Implications for the Pathophysiology of Depression-A Literature Review. International journal of molecular sciences. vol 21. issue 18. 2021-02-24. PMID:32971941. |
disturbances in insulin sensitivity due to the disruption of various molecular pathways cause insulin resistance, which underpins many metabolic disorders, including diabetes, as well as depression. |
2021-02-24 |
2023-08-13 |
Not clear |
| Yanting Lu, Tao An, Hu Tian, Xueqin Gao, Furong Wang, Shijun Wang, Ke M. Depression with Comorbid Diabetes: What Evidence Exists for Treatments Using Traditional Chinese Medicine and Natural Products? Frontiers in pharmacology. vol 11. 2021-02-12. PMID:33568996. |
here, we reviewed the related literature on tcm and natural products that can remedy the comorbidity of diabetes and depression and presented them on the basis of their mechanism of action, focusing on shared risk factors, including insulin resistance, oxidative stress and inflammation, and nervous disturbances. |
2021-02-12 |
2023-08-13 |
Not clear |
| E Liu, M J VandeHaar, A L Loc. Effects of supplementing Holstein cows with soybean oil compared with palmitic acid-enriched triglycerides on milk production and nutrient partitioning. Journal of dairy science. vol 103. issue 9. 2020-12-09. PMID:32622595. |
both insulin and trans-10,cis-12 c18:2 (t10c12cla) can be increased by high-starch diets; thus, it is difficult to determine whether insulin or t10c12cla mediates nutrient partitioning toward body tissues during milk fat depression. |
2020-12-09 |
2023-08-13 |
Not clear |
| Katarzyna Głombik, Jan Detka, Joanna Góralska, Anna Kurek, Bogdan Solnica, Bogusława Budziszewsk. Brain Metabolic Alterations in Rats Showing Depression-Like and Obesity Phenotypes. Neurotoxicity research. vol 37. issue 2. 2020-11-12. PMID:31782099. |
in the case of the coexistence of depression and obesity, the most important changes were (1) the decrease in the membrane form of glut4, which may suggest weaker insulin action in the frontal cortex, and (2) the diminished glp-1r, which could cause neurodegenerative changes in the hippocampus. |
2020-11-12 |
2023-08-13 |
rat |
| Brian E Leonard, Gregers Wegene. Inflammation, insulin resistance and neuroprogression in depression. Acta neuropsychiatrica. vol 32. issue 1. 2020-11-09. PMID:31186075. |
inflammation, insulin resistance and neuroprogression in depression. |
2020-11-09 |
2023-08-13 |
Not clear |
| Laura Escoter-Torres, Giorgio Caratti, Aikaterini Mechtidou, Jan Tuckermann, Nina Henriette Uhlenhaut, Sabine Vettorazz. Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor. Frontiers in immunology. vol 10. 2020-10-15. PMID:31440248. |
unfortunately, their clinical use is limited by severe adverse effects such as insulin resistance, cardiometabolic diseases, muscle and skin atrophies, osteoporosis, and depression. |
2020-10-15 |
2023-08-13 |
mouse |
| Olaitan J Jeremiah, Gráinne Cousins, Fiona Boland, Brian P Kirby, Benedict K Rya. Evaluation of the effect of insulin sensitivity-enhancing lifestyle- and dietary-related adjuncts on antidepressant treatment response: A systematic review and meta-analysis. Heliyon. vol 6. issue 9. 2020-10-02. PMID:32995594. |
depression is associated with insulin resistance (ir). |
2020-10-02 |
2023-08-13 |
Not clear |
| Heidi Klakk, Peter Lund Kristensen, Lars Bo Andersen, Karsten Froberg, Niels Christian Møller, Anders Grøntve. Symptoms of depression in young adulthood is associated with unfavorable clinical- and behavioral cardiovascular disease risk factors. Preventive medicine reports. vol 11. 2020-10-01. PMID:30003016. |
women with depression had higher odds of overweight (or = 2.2, 95%ci: 1.01-4.0), abdominal adiposity (or = 2.5, 95%ci: 1.2-4.8), low crf (or = 2.5, 95%ci: 1.2-5.5), insulin resistance (or = 2.3, 95%ci: 1.1-4.6), low hdl (or = 2.0, 95%ci: 1.01-4.1) and high ldl (or = 2.2, 95%ci: 1.04-4.5) compared to women without depression. |
2020-10-01 |
2023-08-13 |
Not clear |
| Kevin L Sun, Kathleen T Watson, Sarthak Angal, Baylee F Bakkila, Aaron J Gorelik, Sara M Leslie, Natalie L Rasgon, Manpreet K Sing. Neural and Endocrine Correlates of Early Life Abuse in Youth With Depression and Obesity. Frontiers in psychiatry. vol 9. 2020-10-01. PMID:30622489. |
depression and insulin resistance are becoming increasingly prevalent in younger populations. |
2020-10-01 |
2023-08-13 |
human |
| Hui Yang, Wei Li, Pan Meng, Zhuo Liu, Jian Liu, Yuhong Wan. Chronic Unpredictable Mild Stress Aggravates Mood Disorder, Cognitive Impairment, and Brain Insulin Resistance in Diabetic Rat. Evidence-based complementary and alternative medicine : eCAM. vol 2018. 2020-10-01. PMID:30622594. |
diabetes-induced brain insulin resistance is associated with many mental diseases, including depression. |
2020-10-01 |
2023-08-13 |
rat |
| Natalia de M Lyra E Silva, Minh P Lam, Claudio N Soares, Douglas P Munoz, Roumen Milev, Fernanda G De Felic. Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:30837902. |
insulin resistance as a shared pathogenic mechanism between depression and type 2 diabetes. |
2020-10-01 |
2023-08-13 |
Not clear |
| Natalia de M Lyra E Silva, Minh P Lam, Claudio N Soares, Douglas P Munoz, Roumen Milev, Fernanda G De Felic. Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:30837902. |
evidences of the involvement of insulin signaling on brain mechanisms related to depression indicate that insulin resistance, a hallmark of type 2 diabetes, could develop in the brains of depressive patients. |
2020-10-01 |
2023-08-13 |
Not clear |
| Natalia de M Lyra E Silva, Minh P Lam, Claudio N Soares, Douglas P Munoz, Roumen Milev, Fernanda G De Felic. Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:30837902. |
in this article, we briefly review possible molecular mechanisms associating defective brain insulin signaling with reward system, neurogenesis, synaptic plasticity and hypothalamic-pituitary-adrenal (hpa) stress axis in depression. |
2020-10-01 |
2023-08-13 |
Not clear |
| Natalia de M Lyra E Silva, Minh P Lam, Claudio N Soares, Douglas P Munoz, Roumen Milev, Fernanda G De Felic. Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:30837902. |
finally, due to the high resistant rate of anti-depressants, novel insights into the link between insulin resistance and depression may advance the development of alternative treatments for this disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jonathan M Gregory, Joshua D Rosenblat, Roger S McIntyr. Deconstructing Diabetes and Depression: Clinical Context, Treatment Strategies, and New Directions. Focus (American Psychiatric Publishing). vol 14. issue 2. 2020-09-30. PMID:31975802. |
novel depression interventions targeting inflammation or insulin resistance underscore the common biological underpinnings of mood and metabolism. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zahra D Khan, Janet Lutale, Sibtain M Moledin. Prevalence of Depression and Associated Factors among Diabetic Patients in an Outpatient Diabetes Clinic. Psychiatry journal. vol 2019. 2020-09-29. PMID:30775378. |
factors independently associated with a diagnosis of mild to moderate depression were being on insulin therapy and being a current smoker. |
2020-09-29 |
2023-08-13 |
human |
| Fan Wang, Shunying Yu, Rubai Zhou, Ruizhi Mao, Guoqing Zhao, Xiaoyun Guo, Qingqing Xu, Jun Chen, Chen Zhang, Yiru Fan. Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population. Neuropsychiatric disease and treatment. vol 16. 2020-09-28. PMID:32110024. |
insulin receptor substrate-1 (irs-1) is one of the critical downstream molecules in the insulin resistance signaling pathway, linking depression and diabetes. |
2020-09-28 |
2023-08-13 |
Not clear |
| Geoffrey Hacket. Should All Men with Type 2 Diabetes Be Routinely Prescribed a Phosphodiesterase Type 5 Inhibitor? The world journal of men's health. vol 38. issue 3. 2020-09-28. PMID:32378365. |
important health problems in men such as type 2 diabetes (t2dm), insulin resistance, erectile dysfunction, benign prostatic hyperplasia and depression have been shown to have to share common pathological processes, such as endothelial dysfunction and inflammation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Andrea D Mekonnen, Aubrey A Mills, Andrea L Wilhite, Theresa K Hoffma. Desvenlafaxine-associated hyperglycemia: A case report and literature review. The mental health clinician. vol 10. issue 3. 2020-09-28. PMID:32420005. |
over the course of 3 months after desvenlafaxine initiation, insulin glargine was increased and insulin lispro was initiated as the patient refused alternative antidepressant therapy due to favorable improvements in anxiety and depression. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xiaojuan Li, Wenqi Qiu, Nan Li, Xiaoli Da, Qingyu Ma, Yajing Hou, Tingye Wang, Ming Song, Jiaxu Che. Susceptibility to Hyperglycemia in Rats With Stress-Induced Depressive-Like Behavior: Involvement of IL-6 Mediated Glucose Homeostasis Signaling. Frontiers in psychiatry. vol 11. 2020-09-28. PMID:32655424. |
cytokine-mediated inflammation in brain may play important roles in the pathogenesis of depression and insulin resistance. |
2020-09-28 |
2023-08-13 |
rat |