| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong-Qing Zhao, Jian Liu, Pan Meng, Hui Yang, Xiao-Yuan Lin, Hong-Ping Long, Xi-Ming Yu, Yu-Hong Wan. [Effect of Baihe Dihuang Decoction on synaptic plasticity of hippocampus in rats with anxious depression]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 5. 2021-04-02. PMID:33787116. |
[effect of baihe dihuang decoction on synaptic plasticity of hippocampus in rats with anxious depression]. |
2021-04-02 |
2023-08-13 |
rat |
| Hong-Qing Zhao, Jian Liu, Pan Meng, Hui Yang, Xiao-Yuan Lin, Hong-Ping Long, Xi-Ming Yu, Yu-Hong Wan. [Effect of Baihe Dihuang Decoction on synaptic plasticity of hippocampus in rats with anxious depression]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 5. 2021-04-02. PMID:33787116. |
to explore the effect of baihe dihuang decoction on the synaptic plasticity of hippocampal neurons in rats with anxious depression. |
2021-04-02 |
2023-08-13 |
rat |
| Hong-Qing Zhao, Jian Liu, Pan Meng, Hui Yang, Xiao-Yuan Lin, Hong-Ping Long, Xi-Ming Yu, Yu-Hong Wan. [Effect of Baihe Dihuang Decoction on synaptic plasticity of hippocampus in rats with anxious depression]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 5. 2021-04-02. PMID:33787116. |
therefore, we believe that baihe dihuang decoction can improve anxiety and depression behaviors by regulating the synaptic plasticity of hippocampal neurons. |
2021-04-02 |
2023-08-13 |
rat |
| Tamara Stojanovic, Hannah Benes, Amena Awad, Daniel Bormann, Francisco J Monj. Nicotine abolishes memory-related synaptic strengthening and promotes synaptic depression in the neurogenic dentate gyrus of miR-132/212 knockout mice. Addiction biology. vol 26. issue 2. 2021-03-30. PMID:32293776. |
using mirna knockout mice and biochemical, electrophysiological and pharmacological approaches, we examined the effects of mir-132/212 gene disruption on the levels of hippocampal nicotinic acetylcholine receptors, total erk and phosphorylated erk (perk) and mecp2 protein levels, and studied the impact of nicotine stimulation on hippocampal synaptic transmission and synaptic depression and strengthening. |
2021-03-30 |
2023-08-13 |
mouse |
| Alessandra Berry, Monica Mazzelli, Chiara Musillo, Marco Andrea Riva, Annamaria Cattaneo, Francesca Cirull. High-fat diet during adulthood interacts with prenatal stress, affecting both brain inflammatory and neuroendocrine markers in male rats. The European journal of neuroscience. 2021-03-26. PMID:33711185. |
changes in the expression levels of inflammatory (il-1β, tnf-α, il-6) and of stress response mediators (nr3c1, fkbp5) as well as of mood and metabolic regulators (bdnf, ghs-r) were investigated in the hippocampus, prefrontal cortex and hypothalamus, brain regions involved in the pathogenesis of depression and prone to inflammation in response to stress. |
2021-03-26 |
2023-08-13 |
rat |
| Fahime Zavvari, Arezo Nahavandi, Mina Goudarz. Fluoxetine attenuates stress-induced depressive-like behavior through modulation of hippocampal GAP43 and neurogenesis in male rats. Journal of chemical neuroanatomy. vol 103. 2021-03-23. PMID:31705954. |
this study provides evidence that fluoxetine is a potent enhancer of gap-43, a protein related to the neuronal plasticity, in the hippocampus of the rat model of depression. |
2021-03-23 |
2023-08-13 |
rat |
| Huigang Jiang, Li Xiao, Kunlin Jin, Bei Sha. Estrogen administration attenuates post-stroke depression by enhancing CREB/BDNF/TrkB signaling in the rat hippocampus. Experimental and therapeutic medicine. vol 21. issue 5. 2021-03-23. PMID:33747172. |
estrogen administration attenuates post-stroke depression by enhancing creb/bdnf/trkb signaling in the rat hippocampus. |
2021-03-23 |
2023-08-13 |
rat |
| Charlene N Rivera Bonet, Gyujoon Hwang, Bruce Hermann, Aaron F Struck, Cole J Cook, Veena A Nair, Jedidiah Mathis, Linda Allen, Dace N Almane, Karina Arkush, Rasmus Birn, Lisa L Conant, Edgar A DeYoe, Elizabeth Felton, Rama Maganti, Andrew Nencka, Manoj Raghavan, Umang Shah, Veronica N Sosa, Candida Ustine, Vivek Prabhakaran, Jeffrey R Binder, Mary E Meyeran. Neuroticism in temporal lobe epilepsy is associated with altered limbic-frontal lobe resting-state functional connectivity. Epilepsy & behavior : E&B. vol 110. 2021-03-18. PMID:32554180. |
increased neuroticism was significantly associated with hyposynchrony between the right hippocampus and brodmann area (ba) 9 (region of prefrontal cortex (pfc)) (p < 0.005), representing a unique relationship independent of symptoms of depression and anxiety. |
2021-03-18 |
2023-08-13 |
Not clear |
| Charlene N Rivera Bonet, Gyujoon Hwang, Bruce Hermann, Aaron F Struck, Cole J Cook, Veena A Nair, Jedidiah Mathis, Linda Allen, Dace N Almane, Karina Arkush, Rasmus Birn, Lisa L Conant, Edgar A DeYoe, Elizabeth Felton, Rama Maganti, Andrew Nencka, Manoj Raghavan, Umang Shah, Veronica N Sosa, Candida Ustine, Vivek Prabhakaran, Jeffrey R Binder, Mary E Meyeran. Neuroticism in temporal lobe epilepsy is associated with altered limbic-frontal lobe resting-state functional connectivity. Epilepsy & behavior : E&B. vol 110. 2021-03-18. PMID:32554180. |
hyposynchrony of connection between the right hippocampus and ba47 (anterior frontal operculum) was associated with high neuroticism and with higher depression and anxiety scores (p < 0.05), making it a shared abnormal connection for the three measures. |
2021-03-18 |
2023-08-13 |
Not clear |
| Alessandra Borsini, Maria Grazia Di Benedetto, Juliette Giacobbe, Carmine M Pariant. Pro- and anti-inflammatory properties of interleukin (IL6) in vitro: relevance for major depression and for human hippocampal neurogenesis. The international journal of neuropsychopharmacology. 2021-03-17. PMID:32726406. |
pro- and anti-inflammatory properties of interleukin (il6) in vitro: relevance for major depression and for human hippocampal neurogenesis. |
2021-03-17 |
2023-08-13 |
human |
| Paulina Misztak, Magdalena Sowa-Kućma, Bernadeta Szewczyk, Gabriel Nowa. Vorinostat (SAHA) May Exert Its Antidepressant-Like Effects Through the Modulation of Oxidative Stress Pathways. Neurotoxicity research. vol 39. issue 2. 2021-03-10. PMID:33400178. |
the study was carried out in the prefrontal cortex (pfc) and hippocampus (hp), brain regions implicated in depression. |
2021-03-10 |
2023-08-13 |
Not clear |
| Linghong Chen, Yuting Ke, Hong Ma, Lei Gao, Yiying Zhou, Huaqiang Zhu, Huifen Liu, Fuqiang Zhang, Wenhua Zho. Fluoxetine and Ketamine Reverse the Depressive but Not Anxiety Behavior Induced by Lesion of Cholinergic Neurons in the Horizontal Limb of the Diagonal Band of Broca in Male Rat. Frontiers in behavioral neuroscience. vol 15. 2021-03-10. PMID:33679340. |
the present results demonstrate that a lesion of hdb cholinergic neurons results in depressive-like and anxiety-like behaviors and that antidepressants such as fluoxetine or ketamine, can reverse these depressive-like behaviors but not anxiety-like behaviors, and suggest that a lesion of hdb cholinergic neurons and followed hippocampus damage may be involved in the pathogenesis of depression. |
2021-03-10 |
2023-08-13 |
rat |
| Lauren C Pawley, Cara M Hueston, James D O'Leary, Danka A Kozareva, John F Cryan, Olivia F O'Leary, Yvonne M Nola. Chronic intrahippocampal interleukin-1β overexpression in adolescence impairs hippocampal neurogenesis but not neurogenesis-associated cognition. Brain, behavior, and immunity. vol 83. 2021-03-08. PMID:31604142. |
the hippocampus is particularly vulnerable to altered concentrations of the pro-inflammatory cytokine interleukin-1β (il-1β), with elevated levels implicated in the aetiology of neurodegenerative disorders such as alzheimer's and parkinson's, and stress-related disorders such as depression. |
2021-03-08 |
2023-08-13 |
rat |
| Jiayu Liu, Lei Li, Lei Chen, Ruen Liu, Yongan Jiang, Jixia Fang, Dongliang Wang, Zhi Liu, Jia Ouyan. Grey matter changes in Meige syndrome: a voxel-based morphology analysis. Scientific reports. vol 10. issue 1. 2021-03-08. PMID:32884000. |
comparing vbm-mri measures in meige syndrome patients with and without depression, decreased gm volume was found in the left hemisphere in the cuneus and hippocampus and in the right hemisphere in the angular gyrus, middle frontal gyrus and middle occipital gyrus in the definite depression group. |
2021-03-08 |
2023-08-13 |
human |
| Jiayu Liu, Lei Li, Lei Chen, Ruen Liu, Yongan Jiang, Jixia Fang, Dongliang Wang, Zhi Liu, Jia Ouyan. Grey matter changes in Meige syndrome: a voxel-based morphology analysis. Scientific reports. vol 10. issue 1. 2021-03-08. PMID:32884000. |
additionally, our findings suggest that the hippocampus plays a role in the pathogenesis of depression in patients with meige syndrome. |
2021-03-08 |
2023-08-13 |
human |
| Yuhua Zhan, Jiyang Han, Jing Xia, Xumei Wan. Berberine Suppresses Mice Depression Behaviors and Promotes Hippocampal Neurons Growth Through Regulating the miR-34b-5p/miR-470-5p/BDNF Axis. Neuropsychiatric disease and treatment. vol 17. 2021-03-05. PMID:33654403. |
berberine suppresses mice depression behaviors and promotes hippocampal neurons growth through regulating the mir-34b-5p/mir-470-5p/bdnf axis. |
2021-03-05 |
2023-08-13 |
mouse |
| Hui Wang, Ling Xiao, Huiling Wang, Gaohua Wan. Involvement of chronic unpredictable mild stress-induced hippocampal LRP1 up-regulation in microtubule instability and depressive-like behavior in a depressive-like adult male rat model. Physiology & behavior. vol 215. 2021-03-04. PMID:31770536. |
hence, lrp1 might impair the microtubule dynamics accompanied by depressive-like behavior via the pi3k/ akt /gsk3β pathway in adult depressive-like rats, and hippocampal lrp1 might be involved in the development of depression. |
2021-03-04 |
2023-08-13 |
rat |
| Zhong-Fu Mao, Shu-Hua Ouyang, Qiong-Yi Zhang, Yan-Ping Wu, Guo-En Wang, Long-Fang Tu, Zhuo Luo, Wei-Xi Li, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong H. New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT-induced microglia activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-02-25. PMID:32619083. |
chronic stress-evoked depression has been implied to associate with the decline of adult hippocampal neurogenesis. |
2021-02-25 |
2023-08-13 |
mouse |
| Zhong-Fu Mao, Shu-Hua Ouyang, Qiong-Yi Zhang, Yan-Ping Wu, Guo-En Wang, Long-Fang Tu, Zhuo Luo, Wei-Xi Li, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong H. New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT-induced microglia activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-02-25. PMID:32619083. |
herein, we aim to investigate whether the protective effect of caffeine on depression is related with improving adult hippocampus neurogenesis and explore the mechanisms. |
2021-02-25 |
2023-08-13 |
mouse |
| Naijun Yuan, Kairui Tang, Xiaoli Da, Hua Gan, Liangliang He, Xiaojuan Li, Qingyu Ma, Jiaxu Che. Integrating Clinical and Genomic Analyses of Hippocampal-Prefrontal Circuit Disorder in Depression. Frontiers in genetics. vol 11. 2021-02-23. PMID:33613615. |
hippocampus (hip)-prefrontal cortex (pfc) neural circuit abnormalities have been confirmed to exist in mdd; however, the gene-related molecular features of this circuit in the context of depression remain unclear. |
2021-02-23 |
2023-08-13 |
Not clear |