| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rui Guo, Wei-Shuai Qin, Shuang-Yong Zhang, Shu-Ling Zhan. [Effects of modified Xiaoyao San on TLR4/NF-κB pathway in hippocampal microglia of LPS-induced depression model rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 36. issue 4. 2021-01-18. PMID:33167098. |
to investigate the effects of modified xiaoyao san on tlr4/nf-κb pathway in hippocampal microglia of lps-induced depression model rats, and to explore its antidepressant mechanism. |
2021-01-18 |
2023-08-13 |
rat |
| Donovan M Ashby, Stan B Floresco, Anthony G Phillips, Alexander McGirr, Jeremy K Seamans, Yu Tian Wan. LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields. Nature communications. vol 12. issue 1. 2021-01-14. PMID:33397954. |
we also show that exploration of a novel environment produces a widespread and pathway specific de novo synaptic depression in the dorsal hippocampus. |
2021-01-14 |
2023-08-13 |
rat |
| Suwarna Chakraborty, Sunil Jamuna Tripathi, B N Srikumar, T R Raju, B S Shankaranarayana Ra. N-acetyl cysteine ameliorates depression-induced cognitive deficits by restoring the volumes of hippocampal subfields and associated neurochemical changes. Neurochemistry international. vol 132. 2021-01-07. PMID:31751620. |
moreover, cognitive deficits associated with hippocampal dysfunction are central in depression and anxiety disorders. |
2021-01-07 |
2023-08-13 |
rat |
| Suwarna Chakraborty, Sunil Jamuna Tripathi, B N Srikumar, T R Raju, B S Shankaranarayana Ra. N-acetyl cysteine ameliorates depression-induced cognitive deficits by restoring the volumes of hippocampal subfields and associated neurochemical changes. Neurochemistry international. vol 132. 2021-01-07. PMID:31751620. |
furthermore, depression is accompanied by glutamatergic dysfunction which can further impair the functioning of the hippocampus. |
2021-01-07 |
2023-08-13 |
rat |
| Suwarna Chakraborty, Sunil Jamuna Tripathi, B N Srikumar, T R Raju, B S Shankaranarayana Ra. N-acetyl cysteine ameliorates depression-induced cognitive deficits by restoring the volumes of hippocampal subfields and associated neurochemical changes. Neurochemistry international. vol 132. 2021-01-07. PMID:31751620. |
accordingly, we investigated whether chronic nac treatment could reverse cognitive deficits, and associated hippocampal volume loss and monoaminergic alterations in the neonatal clomipramine (cli) model of depression. |
2021-01-07 |
2023-08-13 |
rat |
| Xin-Ya Qin, Hui Fang, Qing-Hong Shan, Cong-Cong Qi, Jiang-Ning Zho. All-trans Retinoic Acid-induced Abnormal Hippocampal Expression of Synaptic Genes International journal of molecular sciences. vol 21. issue 8. 2021-01-05. PMID:32290523. |
all-trans retinoic acid-induced abnormal hippocampal expression of synaptic genes clinical reports suggest a potential link between excess retinoids and development of depression. |
2021-01-05 |
2023-08-13 |
Not clear |
| Xin-Ya Qin, Hui Fang, Qing-Hong Shan, Cong-Cong Qi, Jiang-Ning Zho. All-trans Retinoic Acid-induced Abnormal Hippocampal Expression of Synaptic Genes International journal of molecular sciences. vol 21. issue 8. 2021-01-05. PMID:32290523. |
the hippocampus seems to be a major target of retinoids, and abnormal synaptic plasticity of the hippocampus is involved in depression. |
2021-01-05 |
2023-08-13 |
Not clear |
| Yi-Fan Jiang, Jian Liu, Jie Yang, Yuan Guo, Wei Hu, Jin Zhang, Xue-Mei La, Wen Xie, Hui-Sheng Wang, Li Zhan. Involvement of the Dorsal Hippocampus 5-HT1A Receptors in the Regulation of Depressive-Like Behaviors in Hemiparkinsonian Rats. Neuropsychobiology. vol 79. issue 3. 2021-01-04. PMID:31940619. |
lines of evidence have indicated that the hippocampus and serotonin 1a (5-ht1a) receptors are related to the regulation of depression. |
2021-01-04 |
2023-08-13 |
rat |
| Azadeh Yazdi, Mohammadmahdi Doostmohammadi, Farshid Pourhossein Majarshin, Siamak Behesht. Betahistine, prevents kindling, ameliorates the behavioral comorbidities and neurodegeneration induced by pentylenetetrazole. Epilepsy & behavior : E&B. vol 105. 2021-01-04. PMID:32062106. |
also, it decreased cell death in the hippocampus and cortex, ameliorated the memory deficit and depression induced by ptz in the kindled animals. |
2021-01-04 |
2023-08-13 |
mouse |
| Kuan-Yu Lin, Mu-N Liu, Pei-Hsuan Wang, Chi Ieong La. Positive Magnetic Resonance Imaging Evidence of Transient Global Amnesia Following the Use of Sildenafil. Clinical neuropharmacology. vol 43. issue 2. 2021-01-04. PMID:32106140. |
we speculate that sildenafil may precipitate tga by altering blood flow, inducing venous congestion or cortical spreading depression at the hippocampus. |
2021-01-04 |
2023-08-13 |
Not clear |
| David G Weissman, Hilary K Lambert, Alexandra M Rodman, Matthew Peverill, Margaret A Sheridan, Katie A McLaughli. Reduced hippocampal and amygdala volume as a mechanism underlying stress sensitization to depression following childhood trauma. Depression and anxiety. vol 37. issue 9. 2020-12-31. PMID:32579793. |
reduced hippocampal and amygdala volume as a mechanism underlying stress sensitization to depression following childhood trauma. |
2020-12-31 |
2023-08-13 |
Not clear |
| Weixu Luo, Yuanshan Han, Pan Meng, Qin Yang, Hongqing Zhao, Jia Ling, Yuhong Wan. Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway. Cancer management and research. vol 12. 2020-12-31. PMID:33376394. |
resatorvid relieves breast cancer complicated with depression by inactivating hippocampal microglia through tlr4/nf-κb/nlrp3 signaling pathway. |
2020-12-31 |
2023-08-13 |
Not clear |
| Weixu Luo, Yuanshan Han, Pan Meng, Qin Yang, Hongqing Zhao, Jia Ling, Yuhong Wan. Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway. Cancer management and research. vol 12. 2020-12-31. PMID:33376394. |
we aim to identify a new drug and identify its functional mechanism in the regulation of hippocampal microglia (mg) in breast cancer complicated with depression (bccd). |
2020-12-31 |
2023-08-13 |
Not clear |
| Rui Wang, Wei Wang, Jingjing Xu, Dexiang Liu, Huiran Wu, Xiaqing Qin, Hong Jiang, Fang Pa. Jmjd3 is involved in the susceptibility to depression induced by maternal separation via enhancing the neuroinflammation in the prefrontal cortex and hippocampus of male rats. Experimental neurology. vol 328. 2020-12-30. PMID:32084453. |
jmjd3 is involved in the susceptibility to depression induced by maternal separation via enhancing the neuroinflammation in the prefrontal cortex and hippocampus of male rats. |
2020-12-30 |
2023-08-13 |
rat |
| Rui Wang, Wei Wang, Jingjing Xu, Dexiang Liu, Huiran Wu, Xiaqing Qin, Hong Jiang, Fang Pa. Jmjd3 is involved in the susceptibility to depression induced by maternal separation via enhancing the neuroinflammation in the prefrontal cortex and hippocampus of male rats. Experimental neurology. vol 328. 2020-12-30. PMID:32084453. |
thus, our data indicate that jmjd3 is involved in the susceptibility to depression induced by ms via enhancement of neuroinflammation in the prefrontal cortex and hippocampus of rats. |
2020-12-30 |
2023-08-13 |
rat |
| Nikita Nogovitsyn, Meghan Muller, Roberto Souza, Stefanie Hassel, Stephen R Arnott, Andrew D Davis, Geoffrey B Hall, Jacqueline K Harris, Mojdeh Zamyadi, Paul D Metzak, Zahinoor Ismail, Jonathan Downar, Sagar V Parikh, Claudio N Soares, Jean M Addington, Roumen Milev, Kate L Harkness, Benicio N Frey, Raymond W Lam, Stephen C Strother, Susan Rotzinger, Sidney H Kennedy, Glenda M MacQuee. Hippocampal tail volume as a predictive biomarker of antidepressant treatment outcomes in patients with major depressive disorder: a CAN-BIND report. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-28. PMID:31610545. |
baseline hippocampal tail (ht) volumes were significantly smaller in patients with depression compared to healthy participants. |
2020-12-28 |
2023-08-13 |
human |
| Tomonari Sumi, Kouji Harad. Mechanism underlying hippocampal long-term potentiation and depression based on competition between endocytosis and exocytosis of AMPA receptors. Scientific reports. vol 10. issue 1. 2020-12-24. PMID:32895399. |
mechanism underlying hippocampal long-term potentiation and depression based on competition between endocytosis and exocytosis of ampa receptors. |
2020-12-24 |
2023-08-13 |
Not clear |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
[effect of xiaoyao san on ovx combined with cus anxiety and depression model rats based on hippocampal microglia m1 polarization]. |
2020-12-23 |
2023-08-13 |
rat |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
the model of perimenopausal depression was established by ovx and cus; the level of anxiety and depression was evaluated by open field test; the levels of interleukin-1β(il-1β) and interleukin-6(il-6) mrna in rat hippocampus were detected by real-time qpcr; double staining immunofluorescence was used to detect the expression of ionized calcium binding adaptor molecule-1(iba-1) and inducible nitric oxide synthase(inos) in microglia of rat dentate gyrus(dg); western blot was used to detect the protein expression of iba-1 and inos of microglia in dg region of rat hippocampus. |
2020-12-23 |
2023-08-13 |
rat |
| Katarzyna Głombik, Jan Detka, Anna Kurek, Bogusława Budziszewsk. Impaired Brain Energy Metabolism: Involvement in Depression and Hypothyroidism. Frontiers in neuroscience. vol 14. 2020-12-22. PMID:33343282. |
since metabolic changes are reported to be a key player in the manifestation of depressive disorder, we investigated whether there are differences in selected metabolic markers in the frontal cortex and hippocampus of wistar kyoto rats (wky; an animal model of depression) compared to those of control wistar rats and whether the induction of hypothyroidism by propylthiouracil (ptu) elicits similar effects in these animals or intensifies some parameters in the wky rats. |
2020-12-22 |
2023-08-13 |
rat |