| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amelia J Eisch, David Petri. Depression and hippocampal neurogenesis: a road to remission? Science (New York, N.Y.). vol 338. issue 6103. 2012-10-11. PMID:23042885. |
depression and hippocampal neurogenesis: a road to remission? |
2012-10-11 |
2023-08-12 |
Not clear |
| Amelia J Eisch, David Petri. Depression and hippocampal neurogenesis: a road to remission? Science (New York, N.Y.). vol 338. issue 6103. 2012-10-11. PMID:23042885. |
adult-generated hippocampal neurons are required for mood control and antidepressant efficacy, raising hopes that someday we can harness the power of new neurons to treat mood disorders such as depression. |
2012-10-11 |
2023-08-12 |
Not clear |
| Kari Suzanne Kraus, Barbara Canlo. Neuronal connectivity and interactions between the auditory and limbic systems. Effects of noise and tinnitus. Hearing research. vol 288. issue 1-2. 2012-10-10. PMID:22440225. |
tinnitus, typically induced by hearing malfunctions, is associated with emotional stress, depression and anatomical changes of the hippocampus. |
2012-10-10 |
2023-08-12 |
Not clear |
| Maria Maddalena Valente, Valeria Bortolotto, Bruna Cuccurazzu, Federica Ubezio, Vasco Meneghini, Maria Teresa Francese, Pier Luigi Canonico, Mariagrazia Grill. α2δ ligands act as positive modulators of adult hippocampal neurogenesis and prevent depression-like behavior induced by chronic restraint stress. Molecular pharmacology. vol 82. issue 2. 2012-10-09. PMID:22572885. |
although the role of adult hippocampal neurogenesis remains to be fully elucidated, several studies suggested that the process is involved in cognitive and emotional functions and is deregulated in various neuropsychiatric disorders, including major depression. |
2012-10-09 |
2023-08-12 |
mouse |
| Hyeon Son, Mounira Banasr, Miyeon Choi, Seung Yeon Chae, Pawel Licznerski, Boyoung Lee, Bhavya Voleti, Nanxin Li, Ashley Lepack, Neil M Fournier, Ka Rim Lee, In Young Lee, Juhyun Kim, Joung-Hun Kim, Yong Ho Kim, Sung Jun Jung, Ronald S Duma. Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stress. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 28. 2012-10-05. PMID:22733766. |
decreased neuronal dendrite branching and plasticity of the hippocampus, a limbic structure implicated in mood disorders, is thought to contribute to the symptoms of depression. |
2012-10-05 |
2023-08-12 |
Not clear |
| Michael Foy, Michel Baudry, Richard Thompso. Estrogen and hippocampal synaptic plasticity. Neuron glia biology. vol 1. issue 4. 2012-10-02. PMID:18634593. |
in this review, we examine recent evidence from experimental and clinical research on the rapid effects of estrogen on several mechanisms that involve synaptic plasticity in the nervous system,including hippocampal excitability, long-term potentiation and depression related to sex and aging differences, cellular neuroprotection and probable molecular mechanisms of the action of estrogen in brain tissue. |
2012-10-02 |
2023-08-12 |
Not clear |
| L Jakobartl, J P Husto. Spreading depression in hippocampus and neocortex of rats induced by ACTH(1-24). Neuroscience letters. vol 5. issue 3-4. 2012-10-02. PMID:19604992. |
spreading depression in hippocampus and neocortex of rats induced by acth(1-24). |
2012-10-02 |
2023-08-12 |
rat |
| L Jakobartl, J P Husto. Spreading depression in hippocampus and neocortex of rats induced by ACTH(1-24). Neuroscience letters. vol 5. issue 3-4. 2012-10-02. PMID:19604992. |
microinjection of synthetic acth(1-24) solution into the neocortex or hippocampus of anesthetized rats elicited waves of spreading depression in both structures. |
2012-10-02 |
2023-08-12 |
rat |
| L Jakobartl, J P Husto. Spreading depression in hippocampus and neocortex of rats induced by ACTH(1-24). Neuroscience letters. vol 5. issue 3-4. 2012-10-02. PMID:19604992. |
the average effective doses for eliciting spreading depression were 6.22 mug (range 2.5-15.0 mug) in neocortex and 1.38 mug (range 0.24-2.88 mug) in hippocampus. |
2012-10-02 |
2023-08-12 |
rat |
| L Jakobartl, J P Husto. Spreading depression in hippocampus and neocortex of rats induced by ACTH(1-24). Neuroscience letters. vol 5. issue 3-4. 2012-10-02. PMID:19604992. |
this suggests that some of the behaviors elicited by intracranial injection of acth may be due to hippocampal (and possibly also neocortical) spreading depression. |
2012-10-02 |
2023-08-12 |
rat |
| António Mateus-Pinheiro, Luísa Pinto, Nuno Sous. Epigenetic (de)regulation of adult hippocampal neurogenesis: implications for depression. Clinical epigenetics. vol 3. 2012-10-02. PMID:22414227. |
epigenetic (de)regulation of adult hippocampal neurogenesis: implications for depression. |
2012-10-02 |
2023-08-12 |
Not clear |
| António Mateus-Pinheiro, Luísa Pinto, Nuno Sous. Epigenetic (de)regulation of adult hippocampal neurogenesis: implications for depression. Clinical epigenetics. vol 3. 2012-10-02. PMID:22414227. |
in particular, the active regulation of hippocampal neurogenesis and its repercussions in global hippocampal function are of special interest for the biomedical field, since imbalances at this level have been strongly related to the precipitation of several neuropsychyatric disorders, such as depression. |
2012-10-02 |
2023-08-12 |
Not clear |
| Philippe Taupi. Adult neurogenesis and neural stem cells as a model for the discovery and development of novel drugs. Expert opinion on drug discovery. vol 5. issue 10. 2012-10-02. PMID:22823987. |
this reveals that adult neurogenesis and newly generated neuronal cells of the adult hippocampus are involved in neurological diseases and disorders and that adult neurogenesis and neural stem cells (nscs) of the adult hippocampus are the target of drugs used for treating ad and depression. |
2012-10-02 |
2023-08-12 |
Not clear |
| Dong Hoon Oh, In Young Lee, Miyeon Choi, Seok Hyeon Kim, Hyeon So. Comparison of Neurite Outgrowth Induced by Erythropoietin (EPO) and Carbamylated Erythropoietin (CEPO) in Hippocampal Neural Progenitor Cells. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 16. issue 4. 2012-10-02. PMID:22915994. |
these suggest that epo and cepo could be a good candidate for treating neuropsychiatric disorders such as depression and anxiety associated with neuronal atrophy and reduced hippocampal neurogenesis. |
2012-10-02 |
2023-08-12 |
mouse |
| Margarita Ivanova, Stiliana Belcheva, Iren Belcheva, Negrin Negrev, Roman Tashe. Lateralized hippocampal effects of vasoactive intestinal peptide on learning and memory in rats in a model of depression. Psychopharmacology. vol 221. issue 4. 2012-09-28. PMID:22160165. |
lateralized hippocampal effects of vasoactive intestinal peptide on learning and memory in rats in a model of depression. |
2012-09-28 |
2023-08-12 |
rat |
| Anthony D Ormerod, Chamandeep K Thind, Shantini A Rice, Ian C Reid, Justin H G Williams, Peter J A McCaffer. Influence of isotretinoin on hippocampal-based learning in human subjects. Psychopharmacology. vol 221. issue 4. 2012-09-28. PMID:22193726. |
changes induced by isotretinoin to hippocampal function could contribute to depression but may be more evident in altered visuospatial learning and memory, the primary function of the hippocampus. |
2012-09-28 |
2023-08-12 |
human |
| B S Hemanth Kumar, Sushanta Kumar Mishra, Poonam Rana, Sadhana Singh, Subash Khush. Neurodegenerative evidences during early onset of depression in CMS rats as detected by proton magnetic resonance spectroscopy at 7 T. Behavioural brain research. vol 232. issue 1. 2012-09-27. PMID:22449862. |
these metabolite fluctuations revealed by proton mrs indicate that there might be change in the neuronal integrity of the glial cells and neurons within prefrontal cortex and hippocampus in cms model of depression. |
2012-09-27 |
2023-08-12 |
rat |
| Lingxiao Wang, Daihui Peng, Bin Xie, Kaida Jiang, Yiru Fan. The extracellular signal-regulated kinase pathway may play an important role in mediating antidepressant-stimulated hippocampus neurogenesis in depression. Medical hypotheses. vol 79. issue 1. 2012-09-25. PMID:22546758. |
the extracellular signal-regulated kinase pathway may play an important role in mediating antidepressant-stimulated hippocampus neurogenesis in depression. |
2012-09-25 |
2023-08-12 |
Not clear |
| P M Pitychoutis, C Dalla, A C Sideris, P A Tsonis, Z Papadopoulou-Daifot. 5-HT(1A), 5-HT(2A), and 5-HT(2C) receptor mRNA modulation by antidepressant treatment in the chronic mild stress model of depression: sex differences exposed. Neuroscience. vol 210. 2012-09-21. PMID:22441040. |
cms and clomipramine's effects on 5-ht(1a)r, 5-ht(2a)r, and 5-ht(2c)r mrna expression were assessed by in situ hybridization histochemistry in selected subfields of the hippocampus and in the lateral orbitofrontal cortex (ofc), two regions implicated in the pathophysiology of major depression. |
2012-09-21 |
2023-08-12 |
rat |
| Stephanie L Willard, Carol A Shivel. Modeling depression in adult female cynomolgus monkeys (Macaca fascicularis). American journal of primatology. vol 74. issue 6. 2012-09-20. PMID:22076882. |
social stress-associated behavioral depression in adult female cynomolgus macaques closely resembles human depression in physiological, neurobiological, and behavioral characteristics, including reduced body mass, hypothalamic-pituitary-adrenal axis perturbations, autonomic dysfunction, increased cardiovascular disease risk, reduced hippocampal volume, altered serotonergic function, decreased activity levels, and increased mortality. |
2012-09-20 |
2023-08-12 |
human |