| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yann S Mineur, Adetokunbo Obayemi, Mattis B Wigestrand, Gianna M Fote, Cali A Calarco, Alice M Li, Marina R Picciott. Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 9. 2013-05-02. PMID:23401542. |
these data demonstrate that ach signaling in the hippocampus promotes behaviors related to anxiety and depression. |
2013-05-02 |
2023-08-12 |
mouse |
| Javier Gilabert-Juan, Emilio Varea, Ramón Guirado, José Miguel Blasco-Ibáñez, Carlos Crespo, Juan Náche. Alterations in the expression of PSA-NCAM and synaptic proteins in the dorsolateral prefrontal cortex of psychiatric disorder patients. Neuroscience letters. vol 530. issue 1. 2013-04-30. PMID:23022470. |
different studies have found that psa-ncam expression in the hippocampus and the amygdala is altered in schizophrenia, major depression and animal models of these disorders, in parallel to changes in the expression of molecules related to inhibitory neurotransmission and synaptic plasticity. |
2013-04-30 |
2023-08-12 |
Not clear |
| Wei-Na Han, Christian Hölscher, Li Yuan, Wei Yang, Xiao-Hui Wang, Mei-Na Wu, Jin-Shun Q. Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats. Neurobiology of aging. vol 34. issue 2. 2013-04-29. PMID:22592020. |
we found that (1) bilateral intrahippocampal injection of aβ(25-35) resulted in a significant decline of spatial learning and memory of rats in water maze tests, together with a serious depression of in vivo hippocampal late-phase long-term potentiation (l-ltp) in ca1 region of rats; (2) pretreatment with liraglutide effectively and dose-dependently protected against the aβ(25-35)-induced impairment of spatial memory and deficit of l-ltp; (3) liraglutide injection also activated camp signal pathway in the brain, with a nearly doubled increase in the camp contents compared with control. |
2013-04-29 |
2023-08-12 |
rat |
| Jie Luo, Su Min, Ke Wei, Junfang Zhang, Yuanyuan Li. Propofol interacts with stimulus intensities of electroconvulsive shock to regulate behavior and hippocampal BDNF in a rat model of depression. Psychiatry research. vol 198. issue 2. 2013-04-23. PMID:22410590. |
propofol interacts with stimulus intensities of electroconvulsive shock to regulate behavior and hippocampal bdnf in a rat model of depression. |
2013-04-23 |
2023-08-12 |
rat |
| Jie Luo, Su Min, Ke Wei, Junfang Zhang, Yuanyuan Li. Propofol interacts with stimulus intensities of electroconvulsive shock to regulate behavior and hippocampal BDNF in a rat model of depression. Psychiatry research. vol 198. issue 2. 2013-04-23. PMID:22410590. |
to test our hypothesis that anesthetics interact with the intrinsic parameters of ect to differentially regulate its therapeutic efficacy, we investigated the effects of the anesthetic propofol and the stimulus intensities of ect on behavior and hippocampal brain-derived neurotrophic factor (bdnf) in a rodent model of depression. |
2013-04-23 |
2023-08-12 |
rat |
| K Ganea, A Menke, M V Schmidt, S Lucae, G Rammes, C Liebl, D Harbich, V Sterlemann, C Storch, M Uhr, F Holsboer, E B Binder, I Sillaber, M B Mülle. Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response. Translational psychiatry. vol 2. 2013-04-23. PMID:23092981. |
we investigated the effects of stereotaxic infusion of activin into the hippocampus and the amygdala in a behavioural model of depression. |
2013-04-23 |
2023-08-12 |
mouse |
| Bernd Lenz, Hans-Wolfgang Klafki, Thomas Hillemacher, Helge Frieling, Marion Clepce, Andrea Gossler, Norbert Thuerauf, Georg Winterer, Johannes Kornhuber, Stefan Bleic. ERK1/2 protein and mRNA levels in human blood are linked to smoking behavior. Addiction biology. vol 17. issue 6. 2013-04-15. PMID:21070506. |
accumulating evidence supports the importance of erk1/2 in the molecular pathophysiology of depression and affective regulation in the hippocampus. |
2013-04-15 |
2023-08-12 |
human |
| Aikaterini Xekardaki, Micaela Santos, Patrick Hof, Eniko Kövari, Constantin Bouras, Panteleimon Giannakopoulo. Neuropathological substrates and structural changes in late-life depression: the impact of vascular burden. Acta neuropathologica. vol 124. issue 4. 2013-04-15. PMID:22836715. |
however, they also provide data in favor of the neurotoxic theory of depression by showing that neuronal loss occurs in the hippocampus of chronically depressed patients. |
2013-04-15 |
2023-08-12 |
human |
| S Jha, B Dong, K Sakat. Enriched environment treatment reverses depression-like behavior and restores reduced hippocampal neurogenesis and protein levels of brain-derived neurotrophic factor in mice lacking its expression through promoter IV. Translational psychiatry. vol 1. 2013-04-04. PMID:22832656. |
these results suggest that decreased bdnf levels because of one impaired promoter can be compensated by other bdnf promoters and that bdnf levels may be one of the key factors regulating depression and antidepressant effects through hippocampal neurogenesis. |
2013-04-04 |
2023-08-12 |
mouse |
| Karim Malki, Anbarasu Lourdusamy, Elke Binder, Jose Payá-Cano, Frans Sluyter, Ian Craig, Robert Keers, Peter McGuffin, Rudolf Uher, Leonard C Schalkwy. Antidepressant-dependent mRNA changes in mouse associated with hippocampal neurogenesis in a mouse model of depression. Pharmacogenetics and genomics. vol 22. issue 11. 2013-04-04. PMID:23026812. |
antidepressant-dependent mrna changes in mouse associated with hippocampal neurogenesis in a mouse model of depression. |
2013-04-04 |
2023-08-12 |
mouse |
| Christine Delorenzo, Lauren Delaparte, Binod Thapa-Chhetry, Jeffrey M Miller, J John Mann, Ramin V Parse. Prediction of selective serotonin reuptake inhibitor response using diffusion-weighted MRI. Frontiers in psychiatry. vol 4. 2013-03-20. PMID:23508528. |
probabilistic tractography was performed between the midbrain/raphe and two target regions implicated in depression pathophysiology (amygdala and hippocampus). |
2013-03-20 |
2023-08-12 |
human |
| Hongying Zhang, Baojun Liu, Jinfeng Wu, Changqing Xu, Jiang Tao, Xiaohong Duan, Yuxue Cao, Jingcheng Don. Icariin inhibits corticosterone-induced apoptosis in hypothalamic neurons via the PI3-K/Akt signaling pathway. Molecular medicine reports. vol 6. issue 5. 2013-03-19. PMID:22923091. |
excessive corticosterone (cort) is acknowledged to induce neuronal damage in a number of regions of the brain, particularly the hippocampus, the main area implicated in depression. |
2013-03-19 |
2023-08-12 |
Not clear |
| V S Kudrin, P M Klodt, V B Narkevich, V A Shipilov, V I Poseva, G M Molodavkin, T A Voronin. [Behavioral and neurochemical aspects of the antidepressive action of GSB-106 dipeptide BDNF fragment]. Eksperimental'naia i klinicheskaia farmakologiia. vol 75. issue 10. 2013-03-18. PMID:23240151. |
a decrease in the norepinephrine (ne) content by 50% was detected in striatum and hippocampus of rats with depression model. |
2013-03-18 |
2023-08-12 |
rat |
| Vanja Duric, Ronald S Duma. Depression and treatment response: dynamic interplay of signaling pathways and altered neural processes. Cellular and molecular life sciences : CMLS. vol 70. issue 1. 2013-03-17. PMID:22585060. |
in this review, we focus on several neural mechanisms, primarily within the hippocampus and prefrontal cortex, which have recently been implicated in depression and treatment response. |
2013-03-17 |
2023-08-12 |
human |
| Zhao-Hui Zhang, Li-Na Wu, Jing-Gui Song, Wen-Qiang L. Correlations between cognitive impairment and brain‑derived neurotrophic factor expression in the hippocampus of post-stroke depression rats. Molecular medicine reports. vol 6. issue 4. 2013-03-14. PMID:22842820. |
correlations between cognitive impairment and brain‑derived neurotrophic factor expression in the hippocampus of post-stroke depression rats. |
2013-03-14 |
2023-08-12 |
rat |
| Zhao-Hui Zhang, Li-Na Wu, Jing-Gui Song, Wen-Qiang L. Correlations between cognitive impairment and brain‑derived neurotrophic factor expression in the hippocampus of post-stroke depression rats. Molecular medicine reports. vol 6. issue 4. 2013-03-14. PMID:22842820. |
bdnf expression in the hippocampus was significantly lower in the psd and depression groups compared with that in the normal control group (p<0.01). |
2013-03-14 |
2023-08-12 |
rat |
| Ming Guo, Yuan Lu, Jacob C Garza, Yuqing Li, Streamson C Chua, Wei Zhang, Bai Lu, Xin-Yun L. Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression. Translational psychiatry. vol 2. 2013-03-04. PMID:22408745. |
in addition, loss of lepr in forebrain glutamatergic neurons facilitates nmda-induced hippocampal long-term synaptic depression (ltd), whereas conventional ltd or long-term potentiation (ltp) was not affected. |
2013-03-04 |
2023-08-12 |
mouse |
| Naoki Ito, Atsushi Hori, Takeshi Yabe, Takayuki Nagai, Tetsuro Oikawa, Haruki Yamada, Toshihiko Hanaw. Involvement of neuropeptide Y signaling in the antidepressant-like effect and hippocampal cell proliferation induced by kososan, a Kampo medicine, in the stress-induced depression-like model mice. Biological & pharmaceutical bulletin. vol 35. issue 10. 2013-03-01. PMID:23037167. |
previous studies have revealed that kososan, a kampo (japanese herbal) medicine, has an antidepressant-like effect in behavioral animal models of depression; the mechanisms underlying this effect may involve the orexinergic system and subsequent upregulation of hippocampal cell proliferation. |
2013-03-01 |
2023-08-12 |
mouse |
| S Alisha Epps, David Weinshenke. Rhythm and blues: animal models of epilepsy and depression comorbidity. Biochemical pharmacology. vol 85. issue 2. 2013-02-25. PMID:22940575. |
studies on these animal models point to some potential mechanisms that could explain epilepsy and depression comorbidity, such as various components of the dopaminergic, noradrenergic, serotonergic, and gabaergic systems, as well as key brain regions, like the amygdala and hippocampus. |
2013-02-25 |
2023-08-12 |
rat |
| Ting-Ting Yuan, Hui Qiao, Su-Ping Dong, Shu-Cheng A. [Activation of hippocampal D1 dopamine receptor inhibits glutamate-mediated depression induced by chronic unpredictable mild stress in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 63. issue 4. 2013-02-21. PMID:21861052. |
[activation of hippocampal d1 dopamine receptor inhibits glutamate-mediated depression induced by chronic unpredictable mild stress in rats]. |
2013-02-21 |
2023-08-12 |
rat |