| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Udo Dannlowski, Anja Stuhrmann, Victoria Beutelmann, Peter Zwanzger, Thomas Lenzen, Dominik Grotegerd, Katharina Domschke, Christa Hohoff, Patricia Ohrmann, Jochen Bauer, Christian Lindner, Christian Postert, Carsten Konrad, Volker Arolt, Walter Heindel, Thomas Suslow, Harald Kuge. Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging. Biological psychiatry. vol 71. issue 4. 2012-06-12. PMID:22112927. |
since both depression and ptsd have been associated with increased amygdala responsiveness to negative stimuli as well as reduced hippocampal gray matter volume, we speculated that childhood maltreatment results in similar functional and structural alterations in previously maltreated but healthy adults. |
2012-06-12 |
2023-08-12 |
Not clear |
| Alana Knapman, Sebastian F Kaltwasser, Daniel Martins-de-Souza, Florian Holsboer, Rainer Landgraf, Christoph W Turck, Michael Czisch, Chadi Toum. Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism. The European journal of neuroscience. vol 35. issue 3. 2012-05-29. PMID:22288479. |
patients suffering from major depression have repeatedly been reported to have dysregulations in hypothalamus-pituitary-adrenal (hpa) axis activity along with deficits in cognitive processes related to hippocampal and prefrontal cortex (pfc) malfunction. |
2012-05-29 |
2023-08-12 |
mouse |
| Yunan Zhao, Zhongli Wang, Jianguo Dai, Lin Chen, Yufang Huang, Zhen Zha. Beneficial effects of benzodiazepine diazepam on chronic stress-induced impairment of hippocampal structural plasticity and depression-like behavior in mice. Behavioural brain research. vol 228. issue 2. 2012-05-23. PMID:22198054. |
whether benzodiazepines (bzds) have beneficial effects on the progress of chronic stress-induced impairment of hippocampal structural plasticity and major depression is uncertain. |
2012-05-23 |
2023-08-12 |
mouse |
| Guan Cao, Kristen M Harri. Developmental regulation of the late phase of long-term potentiation (L-LTP) and metaplasticity in hippocampal area CA1 of the rat. Journal of neurophysiology. vol 107. issue 3. 2012-05-22. PMID:22114158. |
in contrast, at p8-11, tbs only reversed the synaptic depression that occurs from test-pulse stimulation in developing (p8-15) hippocampus. |
2012-05-22 |
2023-08-12 |
rat |
| Naren P Rao, Ganesan Venkatasubramanian, Bangalore N Gangadha. Proton magnetic resonance spectroscopy in depression. Indian journal of psychiatry. vol 53. issue 4. 2012-05-21. PMID:22303038. |
studies in depression report abnormalities in the frontal cortex, basal ganglia, hippocampus, anterior cingulate cortex, and the occipital cortex. |
2012-05-21 |
2023-08-12 |
Not clear |
| Kirk I Erickson, Destiny L Miller, Kathryn A Roecklei. The aging hippocampus: interactions between exercise, depression, and BDNF. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 18. issue 1. 2012-05-18. PMID:21531985. |
however, there is strong evidence that decreased bdnf is associated with age-related hippocampal dysfunction, memory impairment, and increased risk for depression, whereas increasing bdnf by aerobic exercise appears to ameliorate hippocampal atrophy, improve memory function, and reduce depression. |
2012-05-18 |
2023-08-12 |
Not clear |
| Ronald S Duman, Bhavya Volet. Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents. Trends in neurosciences. vol 35. issue 1. 2012-05-15. PMID:22217452. |
basic and clinical studies demonstrate that stress and depression are associated with atrophy and loss of neurons and glia, which contribute to the decreased size and function of limbic brain regions that control mood and depression, including the prefrontal cortex and hippocampus. |
2012-05-15 |
2023-08-12 |
Not clear |
| Jeffrey G Edwards, Helen E Gibson, Tyron Jensen, Fereshteh Nugent, Curtis Walther, Jacob Blickenstaff, Julie A Kaue. A novel non-CB1/TRPV1 endocannabinoid-mediated mechanism depresses excitatory synapses on hippocampal CA1 interneurons. Hippocampus. vol 22. issue 2. 2012-05-14. PMID:21069781. |
interestingly, however, neither dhpg-mediated nor r-methanandamide-mediated depression was blocked by the trpv1 antagonist capsazepine (10 μm), the cb1 antagonist am-251 (2 μm) or a combination of both, suggesting the presence of a novel ecb receptor or anandamide target at excitatory hippocampal synapses. |
2012-05-14 |
2023-08-12 |
rat |
| Jeffrey G Edwards, Helen E Gibson, Tyron Jensen, Fereshteh Nugent, Curtis Walther, Jacob Blickenstaff, Julie A Kaue. A novel non-CB1/TRPV1 endocannabinoid-mediated mechanism depresses excitatory synapses on hippocampal CA1 interneurons. Hippocampus. vol 22. issue 2. 2012-05-14. PMID:21069781. |
collectively, this study illustrates a novel cb1/trpv1-independent ecb pathway present in the hippocampus that mediates depression at excitatory synapses on ca1 stratum radiatum interneurons. |
2012-05-14 |
2023-08-12 |
rat |
| Nicole A Datson, Niels Speksnijder, Joseph L Mayer, Peter J Steenbergen, Oksana Korobko, Jelle Goeman, E Ronald de Kloet, Marian Joëls, Paul J Lucasse. The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus. Hippocampus. vol 22. issue 2. 2012-05-14. PMID:21184481. |
neurogenesis has further been implicated in hippocampal plasticity and depression. |
2012-05-14 |
2023-08-12 |
Not clear |
| B M Andrus, K Blizinsky, P T Vedell, K Dennis, P K Shukla, D J Schaffer, J Radulovic, G A Churchill, E E Rede. Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models. Molecular psychiatry. vol 17. issue 1. 2012-05-08. PMID:21079605. |
gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models. |
2012-05-08 |
2023-08-12 |
rat |
| Andrea M B Milne, Glenda M MacQueen, Geoffrey B C Hal. Abnormal hippocampal activation in patients with extensive history of major depression: an fMRI study. Journal of psychiatry & neuroscience : JPN. vol 37. issue 1. 2012-05-04. PMID:21745440. |
abnormal hippocampal activation in patients with extensive history of major depression: an fmri study. |
2012-05-04 |
2023-08-12 |
Not clear |
| Maya First, Irit Gil-Ad, Michal Taler, Igor Tarasenko, Nurit Novak, Abraham Weizma. The effects of fluoxetine treatment in a chronic mild stress rat model on depression-related behavior, brain neurotrophins and ERK expression. Journal of molecular neuroscience : MN. vol 45. issue 2. 2012-04-24. PMID:21479508. |
depression is associated with hippocampus (hc) volume loss. |
2012-04-24 |
2023-08-12 |
rat |
| Zhenghua Hou, Yonggui Yuan, Zhijun Zhang, Feng Bai, Gang Hou, Jiayong Yo. Longitudinal changes in hippocampal volumes and cognition in remitted geriatric depressive disorder. Behavioural brain research. vol 227. issue 1. 2012-04-23. PMID:22036698. |
growing evidences suggest that the abnormality of hippocampal volume may occur in the process of depression. |
2012-04-23 |
2023-08-12 |
human |
| Plinio C Casarotto, Valquiria C de Bortoli, Hélio Zangross. Intrahippocampal injection of brain-derived neurotrophic factor increases anxiety-related, but not panic-related defensive responses: involvement of serotonin. Behavioural pharmacology. vol 23. issue 1. 2012-04-23. PMID:22139606. |
changes in brain-derived neurotrophic factor (bdnf)-mediated signaling in the hippocampus have been implicated in the etiology of depression and in the mode of action of antidepressant drugs. |
2012-04-23 |
2023-08-12 |
rat |
| Gaga Kochlamazashvili, Olena Bukalo, Oleg Senkov, Benedikt Salmen, Rita Gerardy-Schahn, Andreas K Engel, Melitta Schachner, Alexander Dityate. Restoration of synaptic plasticity and learning in young and aged NCAM-deficient mice by enhancing neurotransmission mediated by GluN2A-containing NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 7. 2012-04-23. PMID:22396402. |
deficits in psa and/or ncam expression cause impairments in hippocampal long-term potentiation and depression (ltp and ltd) and are associated with schizophrenia and aging. |
2012-04-23 |
2023-08-12 |
mouse |
| Alexandra P Few, Evanthia Nanou, Hirofumi Watari, Jane M Sullivan, Todd Scheuer, William A Catteral. Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 7. 2012-04-20. PMID:22308469. |
in single-cultured hippocampal neurons, trains of depolarizations evoke excitatory postsynaptic currents that show facilitation followed by depression accompanied by asynchronous postsynaptic currents that increase steadily during the train in parallel with i(async). |
2012-04-20 |
2023-08-12 |
Not clear |
| Nancy Ho, Darrick T Balu, Monica R F Hilario, Julie A Blendy, Irwin Luck. Depressive phenotypes evoked by experimental diabetes are reversed by insulin. Physiology & behavior. vol 105. issue 3. 2012-04-16. PMID:21945451. |
changes in reward-related behaviors and hippocampal cell proliferation may be useful markers to identify therapeutic interventions for comorbid diabetes and depression. |
2012-04-16 |
2023-08-12 |
mouse |
| V F Low, M Dragunow, L J Tippett, R L M Faull, M A Curti. No change in progenitor cell proliferation in the hippocampus in Huntington's disease. Neuroscience. vol 199. 2012-04-06. PMID:21946006. |
we hypothesized that hd cases with mainly mood symptomatology would show a greater change in hippocampal proliferation, which has previously been implicated in mood disorders such as depression. |
2012-04-06 |
2023-08-12 |
mouse |
| Su'e Wang, Suiyu Hu, Chunhu Zhang, Juan Qiu, Yunhui L. Effect of Chaihu Shugan San and its components on expression of ERK1/2 mRNA in the hippocampus of rats with chronic mild unpredicted stress depression. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 36. issue 2. 2012-04-05. PMID:21368416. |
effect of chaihu shugan san and its components on expression of erk1/2 mrna in the hippocampus of rats with chronic mild unpredicted stress depression. |
2012-04-05 |
2023-08-12 |
rat |