| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anne Lesemann, Claudia Reinel, Petra Hühnchen, Maximilian Pilhatsch, Rainer Hellweg, Philipp Klaissle, Christine Winter, Barbara Steine. MPTP-induced hippocampal effects on serotonin, dopamine, neurotrophins, adult neurogenesis and depression-like behavior are partially influenced by fluoxetine in adult mice. Brain research. vol 1457. 2012-09-13. PMID:22520437. |
deficits in the generation and maturation of new neurons in the adult hippocampus seem to be key mechanisms of major depression and cognitive decline and are robustly influenced by serotonergic pharmacotherapy. |
2012-09-13 |
2023-08-12 |
mouse |
| Anna Schuhmacher, Rainald Mössner, Frank Jessen, Lukas Scheef, Wolfgang Block, Anna Christine Belloche, Leonhard Lennertz, Hanne Welper, Susanne Höfels, Ute Pfeiffer, Michael Wagner, Wolfgang Maier, Sybille Schwab, Astrid Zobe. Association of amygdala volumes with cortisol secretion in unipolar depressed patients. Psychiatry research. vol 202. issue 2. 2012-09-13. PMID:22698761. |
major depressive disorder (mdd) is accompanied by morphological changes of brain structures which are of great importance in the neural circuitry mediating depression like the hippocampus and the amygdala. |
2012-09-13 |
2023-08-12 |
Not clear |
| Anna Schuhmacher, Rainald Mössner, Frank Jessen, Lukas Scheef, Wolfgang Block, Anna Christine Belloche, Leonhard Lennertz, Hanne Welper, Susanne Höfels, Ute Pfeiffer, Michael Wagner, Wolfgang Maier, Sybille Schwab, Astrid Zobe. Association of amygdala volumes with cortisol secretion in unipolar depressed patients. Psychiatry research. vol 202. issue 2. 2012-09-13. PMID:22698761. |
we used magnetic resonance imaging to investigate alterations of amygdala and hippocampal volumes in 86 in-patients with unipolar depression and 87 healthy controls, and we then correlated amygdala and hippocampal volumes of 76 in-patients with the area under the curve of cortisol secretion in the dexamethasone/corticotropin releasing hormone (dex/crh) test at baseline and during short-term antidepressant therapy. |
2012-09-13 |
2023-08-12 |
Not clear |
| Mirjam I Geerlings, Adam M Brickman, Nicole Schupf, Davangere P Devanand, José A Luchsinger, Richard Mayeux, Scott A Smal. Depressive symptoms, antidepressant use, and brain volumes on MRI in a population-based cohort of old persons without dementia. Journal of Alzheimer's disease : JAD. vol 30. issue 1. 2012-09-10. PMID:22377782. |
multiple linear regression analyses adjusted for age, gender, ethnicity, education, cardiovascular disease history, and mri parameters showed that subjects with current depression had smaller relative total brain volume (b = -0.86%; 95% ci -1.68 to -0.05%; p < 0.05), smaller relative hippocampal volume (b = -0.07 ml; 95% ci -0.14 to 0.00 ml; p = 0.05), and larger relative wmh volume (natural logtransformed b = 0.19 ml; 95% ci 0.02 to 0.35 ml; p < 0.05). |
2012-09-10 |
2023-08-12 |
human |
| Jerome J Maller, Zafiris J Daskalakis, Richard H S Thomson, Melissa Daigle, Mera S Barr, Paul B Fitzgeral. Hippocampal volumetrics in treatment-resistant depression and schizophrenia: the devil's in de-tail. Hippocampus. vol 22. issue 1. 2012-09-06. PMID:20882552. |
hippocampal volumetrics in treatment-resistant depression and schizophrenia: the devil's in de-tail. |
2012-09-06 |
2023-08-12 |
human |
| Gabriele Masi, Paola Brovedan. The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression. CNS drugs. vol 25. issue 11. 2012-09-05. PMID:22054117. |
the hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression. |
2012-09-05 |
2023-08-12 |
Not clear |
| Gabriele Masi, Paola Brovedan. The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression. CNS drugs. vol 25. issue 11. 2012-09-05. PMID:22054117. |
recent studies indicate that an impairment of synaptic plasticity (neurogenesis, axon branching, dendritogenesis and synaptogenesis) in specific areas of the cns, particularly the hippocampus, may be a core factor in the pathophysiology of depression. |
2012-09-05 |
2023-08-12 |
Not clear |
| Gabriele Masi, Paola Brovedan. The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression. CNS drugs. vol 25. issue 11. 2012-09-05. PMID:22054117. |
the hippocampus is smaller in depressed patients, although it is unclear whether smaller size is a consequence of depression or a pre-existing, vulnerability marker for depression. |
2012-09-05 |
2023-08-12 |
Not clear |
| Gabriele Masi, Paola Brovedan. The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression. CNS drugs. vol 25. issue 11. 2012-09-05. PMID:22054117. |
environmental stressors triggering activation of the hypothalamic-pituitary-adrenal axis cause the brain to be exposed to corticosteroids, affecting neurobehavioural functions with a strong downregulation of hippocampal neurogenesis, and are a major risk factor for depression. |
2012-09-05 |
2023-08-12 |
Not clear |
| Gabriele Masi, Paola Brovedan. The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression. CNS drugs. vol 25. issue 11. 2012-09-05. PMID:22054117. |
the above findings suggest new possible targets for the pharmacotherapy of depression such as neurotrophic factors, their receptors and related intracellular signalling cascades; agents counteracting the effects of stress on hippocampal neurogenesis (including antagonists of corticosteroids, inflammatory cytokines and their receptors); and agents facilitating the activation of gene expression and increasing the transcription of neurotrophins in the brain. |
2012-09-05 |
2023-08-12 |
Not clear |
| Min-Lan Tsai, Melanie Crutchley, Richard Boyce, Jingyi Ma, Francis Boon, D Peter Cain, L Stan Leun. Long-lasting auditory gating deficit accompanied by GABA(B) receptor dysfunction in the hippocampus after early-life limbic seizures in rats. Physiology & behavior. vol 106. issue 4. 2012-09-04. PMID:22504497. |
heterosynaptic electric paired-pulse depression of hippocampal population excitatory postsynaptic potential in freely moving rats, a measure of hippocampal gaba(b)-receptor mediated inhibition, was decreased in seizure as compared to control rats. |
2012-09-04 |
2023-08-12 |
rat |
| Tomas Hajek, Jeffrey Cullis, Tomas Novak, Miloslav Kopecek, Cyril Höschl, Ryan Blagdon, Claire O'Donovan, Michael Bauer, L Trevor Young, Glenda Macqueen, Martin Ald. Hippocampal volumes in bipolar disorders: opposing effects of illness burden and lithium treatment. Bipolar disorders. vol 14. issue 3. 2012-08-31. PMID:22548899. |
hippocampal volume decrease associated with illness burden is among the most replicated findings in unipolar depression. |
2012-08-31 |
2023-08-12 |
Not clear |
| Guangjun Xi, Jiaojie Hui, Zhijun Zhang, Shanshan Liu, Xiangrong Zhang, Gaojun Teng, Kevin C Chan, Ed X Wu, Binbin Nie, Baoci Shan, Lingjiang Li, Gavin P Reynold. Learning and memory alterations are associated with hippocampal N-acetylaspartate in a rat model of depression as measured by 1H-MRS. PloS one. vol 6. issue 12. 2012-08-27. PMID:22194886. |
learning and memory alterations are associated with hippocampal n-acetylaspartate in a rat model of depression as measured by 1h-mrs. |
2012-08-27 |
2023-08-12 |
rat |
| Zheman Xiao, Wanhong Liu, Kai Gao, Qirong Wan, Can Yang, Huiling Wang, Xiaoping Wang, Gaohua Wang, Zhongchun Li. Interaction between CRHR1 and BDNF genes increases the risk of recurrent major depressive disorder in Chinese population. PloS one. vol 6. issue 12. 2012-08-27. PMID:22194899. |
an important etiological hypothesis about depression is stress has neurotoxic effects that damage the hippocampal cells. |
2012-08-27 |
2023-08-12 |
Not clear |
| Arnaud Tanti, Quentin Rainer, Frederic Minier, Alexandre Surget, Catherine Belzun. Differential environmental regulation of neurogenesis along the septo-temporal axis of the hippocampus. Neuropharmacology. vol 63. issue 3. 2012-08-27. PMID:22561281. |
here we investigate changes in cell proliferation and neurogenesis along the septo-temporal axis of the hippocampus induced by the unpredictable chronic mild stress model of depression (ucms), chronic fluoxetine treatment and enriched environment. |
2012-08-27 |
2023-08-12 |
mouse |
| Nobuaki Matsui, Yuki Kido, Hideki Okada, Miwa Kubo, Megumi Nakai, Nobuyuki Fukuishi, Yoshiyasu Fukuyama, Masaaki Akag. Phenylbutenoid dimers isolated from Zingiber purpureum exert neurotrophic effects on cultured neurons and enhance hippocampal neurogenesis in olfactory bulbectomized mice. Neuroscience letters. vol 513. issue 1. 2012-08-24. PMID:22343027. |
the in vivo effects of both comp.1 and comp.2 were evaluated on hippocampal neurogenesis in olfactory bulbectomized (obx) mice, an experimental depression and dementia animal model. |
2012-08-24 |
2023-08-12 |
mouse |
| Darakhshan Jabeen Halee. Raphe-Hippocampal Serotonin Neurotransmission In The Sex Related Differences of Adaptation to Stress: Focus on Serotonin-1A Receptor. Current neuropharmacology. vol 9. issue 3. 2012-08-23. PMID:22379463. |
a decrease in the function of 5-hydroxytryptamine (5-ht; serotonin) in the hippocampus and an increased function of the 5-ht-1a receptor in the raphe nucleus coexist in depression. |
2012-08-23 |
2023-08-12 |
Not clear |
| Murad Atmaca, Hanefi Yildiri. Altered neurochemical ingredient of hippocampus in patients with bipolar depression. Depression research and treatment. vol 2012. 2012-08-23. PMID:22500219. |
altered neurochemical ingredient of hippocampus in patients with bipolar depression. |
2012-08-23 |
2023-08-12 |
human |
| Murad Atmaca, Hanefi Yildiri. Altered neurochemical ingredient of hippocampus in patients with bipolar depression. Depression research and treatment. vol 2012. 2012-08-23. PMID:22500219. |
the findings of the present study also suggest that there may be a degenerative process concerning the hippocampus morphology in the patients with bipolar depression. |
2012-08-23 |
2023-08-12 |
human |
| Fani L Neto, Gisela Borges, Sonia Torres-Sanchez, Juan A Mico, Esther Berrocos. Neurotrophins role in depression neurobiology: a review of basic and clinical evidence. Current neuropharmacology. vol 9. issue 4. 2012-08-23. PMID:22654714. |
neuronal atrophy, mostly detected in limbic structures that regulate mood and cognition, like the hippocampus, is observed in depressed patients and in animal behavioural paradigms for depression. |
2012-08-23 |
2023-08-12 |
Not clear |